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Wyświetlanie 1-10 z 32
Tytuł:
High throughput protein production
Autorzy:
Tworak, A.
Podkowinski, J.
Figlerowicz, M.
Powiązania:
https://bibliotekanauki.pl/articles/80317.pdf
Data publikacji:
2011
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
activity
cloning
DNA sequencing
expression
high throughput
human genome
Human Genome Project
large scale proteomics
new technology
protein folding
protein production
purification
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2011, 92, 2
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Forest tree research in post genomic era. Introduction to systems biology of broadleaves
Autorzy:
Staszak, A.M.
Pawlowski, T.A.
Powiązania:
https://bibliotekanauki.pl/articles/41059.pdf
Data publikacji:
2012
Wydawca:
Polska Akademia Nauk. Instytut Dendrologii PAN
Tematy:
forest tree
tree
genomics
proteomics
woody plant
biology
broadleaf
plant reproduction
plant physiology
Opis:
Trees are long living organisms, rarely used in molecular experiments because of large size of the genome and long time of reproduction cycle. Sequencing data from Populus trichocarpa genome allowed for the development of research on the processes associated with tree biology such as secondary wood formation, long-term perennial growth, seasonal changes, biotic interactions, evolution etc. Reference data enable the investigation of non-model trees such as Quercus or Fagus, having ecological and economic significance. During projects scientists use genomic, transcriptomic, proteomic and metabolomic approaches which contribute to better understanding of the physiological processes regulating tree biology. Data collected from these multiple studies need to be integrated. The integration of data is the subject of the newly established field of science called systems biology. This review presents progress in tree research after finishing the sequencing project of Populus. It concentrates on modern trends in 'omics' and systems biology study of temperate broadleave trees during the last 10 years of studies.
Źródło:
Dendrobiology; 2012, 68
1641-1307
Pojawia się w:
Dendrobiology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Corpora amylacea from multiple sclerosis brain tissue consists of aggregated neuronal cells
Autorzy:
Selmaj, Krzysztof
Pawłowska, Zofia
Walczak, Agata
Koziołkiewicz, Wiktor
Raine, Cedric
Cierniewski, Czesław
Powiązania:
https://bibliotekanauki.pl/articles/1040812.pdf
Data publikacji:
2008
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
proteomics
neuronal aggregates
corpora amylacea
multiple sclerosis
Opis:
In this report, we describe proteomic analysis of corpora amylacea collected by postmortem laser microdissection from multiple sclerosis (MS) brain lesions. Using low level protein loads (about 30 µg), a combination of two-dimensional electrophoresis with matrix-assisted laser desorption/ionization-time of flight mass spectrometry and database interrogations we identified 24 proteins of suspected neuronal origin. In addition to major cytoskeletal proteins like actin, tubulin, and vimentin, we identified a variety of proteins implicated specifically in cellular motility and plasticity (F-actin capping protein), regulation of apoptosis and senescence (tumor rejection antigen-1, heat shock proteins, valosin-containing protein, and ubiquitin-activating enzyme E1), and enzymatic pathways (glyceraldehyde-3-dehydrogenase, protein disulfide isomerase, protein disulfide isomerase related protein 5, lactate dehydrogenase). Samples taken from regions in the vicinity of corpora amylacea showed only traces of cellular proteins suggesting that these bodies may represent remnants of neuronal aggregates with highly polymerized cytoskeletal material. Our data provide evidence supporting the concept that biogenesis of corpora amylacea involves degeneration and aggregation of cells of neuronal origin.
Źródło:
Acta Biochimica Polonica; 2008, 55, 1; 43-50
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Mass spectrometry approaches in proteomic and metabolomic studies
Autorzy:
Rodziewicz, P.
Swarcewicz, B.
Chmielewska, K.
Powiązania:
https://bibliotekanauki.pl/articles/80650.pdf
Data publikacji:
2014
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
proteomics
metabolomics
genomic DNA
nuclear magnetic resonance
mass spectrometry
Fourier transform infrared spectroscopy
Raman spectroscopy
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2014, 95, 3
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Electronegativity and intrinsic disorder of preeclampsia-related proteins
Autorzy:
Polanco, Carlos
Castañón-González, Jorge
Uversky, Vladimir
Buhse, Thomas
Samaniego Mendoza, José
Calva, Juan
Powiązania:
https://bibliotekanauki.pl/articles/1038693.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
preeclampsia
intrinsically disordered proteins
structural proteomics
bioinformatics
antimicrobial peptides
polarity index method
lipoproteins
angiogenesis proteins
Opis:
Preeclampsia, hemorrhage, and infection are the leading causes of maternal death in underdeveloped countries. Since several proteins associated with preeclampsia are known, we conducted a computational study which evaluated the commonness and potential functionality of intrinsic disorder of these proteins and also made an attempt to characterize their origin. The origin of the preeclampsia-related proteins was assessed with a supervised technique, a Polarity Index Method (PIM), which evaluates the electronegativity of proteins based solely on their sequence. The commonness of intrinsic disorder was evaluated using several disorder predictors from the PONDR family, the charge-hydropathy plot (CH-plot) and cumulative distribution function (CDF) analyses, and using the MobiDB web-based tool, whereas potential functionality of intrinsic disorder was studied with the D2P2 resource and ANCHOR predictor of disorder-based binding sites, and the STRING tool was used to build the interactivity networks of the preeclampsia-related proteins. Peculiarities of the PIM-derived polar profile of the group of preeclampsia-related proteins were then compared with profiles of a group of lipoproteins, antimicrobial peptides, angiogenesis-related proteins, and the intrinsically disordered proteins. Our results showed a high graphical correlation between preeclampsia proteins, lipoproteins, and the angiogenesis proteins. We also showed that many preeclampsia-related proteins contain numerous functional disordered regions. Therefore, these bioinformatics results led us to assume that the preeclampsia proteins are highly associated with the lipoproteins group, and that some preeclampsia-related proteins contain significant amounts of functional disorders.
Źródło:
Acta Biochimica Polonica; 2017, 64, 1; 99-111
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Identification of serum proteome components associated with progression of non-small cell lung cancer
Autorzy:
Pietrowska, Monika
Jelonek, Karol
Michalak, Malwina
Roś, Małgorzata
Rodziewicz, Paweł
Chmielewska, Klaudia
Polański, Krzysztof
Polańska, Joanna
Gdowicz-Kłosok, Agnieszka
Giglok, Monika
Suwiński, Rafał
Tarnawski, Rafał
Dziadziuszko, Rafał
Rzyman, Witold
Widłak, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1039297.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
cancer staging
early detection
lung cancer
proteomics
serum biomarkers
Opis:
The aim of the present study was to perform comparative analysis of serum from patients with different stages of non-small cell lung cancer (NSCLC) using the three complementary proteomic approaches to identify proteome components associated with the progression of cancer. Serum samples were collected before any treatment from 200 patients with NSCLC, including 103 early stage, 64 locally advanced and 33 metastatic cancer samples, and from 200 donors without malignancy. The low-molecular-weight fraction of serum proteome was MALDI-profiled in all samples. Serum proteins were characterized using 2D-PAGE and LC-MS/MS approaches in a representative group of 30 donors. Several significant differences were detected between serum samples collected from patients with early stage cancer and patients with locally advanced cancer, as well as between patients with metastatic cancer and patients with local disease. Of note, serum components discriminating samples from early stage cancer and healthy persons were also detected. In general, about 70 differentiating serum proteins were identified, including inflammatory and acute phase proteins already reported to be associated with the progression of lung cancer (serum amyloid A or haptoglobin). Several differentiating proteins, including apolipoprotein H or apolipoprotein A1, were not previously associated with NSCLC. No significant differences in patterns of serum proteome components were detected between patients with adenocarcinoma and squamous cell carcinoma. In conclusion, we identified the biomarker candidates with potential importance for molecular proteomic staging of NSCLC. Additionally, several serum proteome components revealed their potential applicability in early detection of the lung cancer.
Źródło:
Acta Biochimica Polonica; 2014, 61, 2; 325-331
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Isolation and identification of zinc ions and heparin binding proteins in yellow fraction of the red deer Cervus Elaphus L. semen
Autorzy:
Orzołek, A.
Dyrda, K.
Rafalska, K.
Wysocki, P.
Kordan, W.
Giżejewski, W.
Powiązania:
https://bibliotekanauki.pl/articles/2087223.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
red deer
yellow fraction
ZnBPs
HBPs
proteomics
Źródło:
Polish Journal of Veterinary Sciences; 2021, 24, 1; 69-78
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A distributed algorithm for protein identification from tandem mass spectrometry data
Autorzy:
Orzechowska, Katarzyna
Rubel, Tymon
Kurjata, Robert
Zaremba, Krzysztof
Powiązania:
https://bibliotekanauki.pl/articles/2097435.pdf
Data publikacji:
2022
Wydawca:
Polskie Towarzystwo Promocji Wiedzy
Tematy:
proteomics
mass spectrometry
distributed computing
Apache Spark
Opis:
Tandem mass spectrometry is an analytical technique widely used in proteomics for the high-throughput characterization of proteins in biological samples. Modern in-depth proteomic studies require the collection of even millions of mass spectra representing short protein fragments (peptides). In order to identify the peptides, the measured spectra are most often scored against a database of amino acid sequences of known proteins. Due to the volume of input data and the sizes of proteomic databases, this is a resource-intensive task, which requires an efficient and scalable computational strategy. Here, we present SparkMS, an algorithm for peptide and protein identification from mass spectrometry data explicitly designed to work in a distributed computational environment. To achieve the required performance and scalability, we use Apache Spark, a modern framework that is becoming increasingly popular not only in the field of “big data” analysis but also in bioinformatics. This paper describes the algorithm in detail and demonstrates its performance on a large proteomic dataset. Experimental results indicate that SparkMS scales with the number of worker nodes and the increas-ing complexity of the search task. Furthermore, it exhibits a protein identification efficiency comparable to X!Tandem, a widely-used proteomic search engine.
Źródło:
Applied Computer Science; 2022, 18, 2; 16--27
1895-3735
Pojawia się w:
Applied Computer Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Sperm mitochondrial dysfunction and oxidative stress as possible reasons for isolated asthenozoospermia
Autorzy:
Nowicka-Bauer, K.
Lepczynski, A.
Ozgo, M.
Kamieniczna, M.
Fraczek, M.
Stanski, L.
Olszewska, M.
Malcher, A.
Skrzypczak, W.
Kurpisz, M.K.
Powiązania:
https://bibliotekanauki.pl/articles/70952.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
sperm motility
mitochondrial dysfunction
asthenozoospermia
oxidative stress
reactive oxygen species
proteomics
patient
Źródło:
Journal of Physiology and Pharmacology; 2018, 69, 3
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Immunogenic proteins in the somatic proteome of the adult cestode Hymenolepis diminuta - a proteomic approach
Autorzy:
Mlocicki, D.
Bien, J.
Salamatin, R.
Sulima, A.
Powiązania:
https://bibliotekanauki.pl/articles/6559.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
immunogenic protein
cestode
Hymenolepis diminuta
parasite
proteomics
Źródło:
Annals of Parasitology; 2016, 62, Suppl.
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-10 z 32

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