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    Wyświetlanie 1-9 z 9
    Tytuł:
    Patient with atypical chest pain and nephrotic range proteinuria finally diagnosed with non-secretory myeloma
    Autorzy:
    Holecki, Michał
    Fryźlewicz-Moska, Agata
    Strzałkowska, Dorota
    Chudek, Jerzy
    Duława, Jan
    Powiązania:
    https://bibliotekanauki.pl/articles/1039564.pdf
    Data publikacji:
    2010
    Wydawca:
    Śląski Uniwersytet Medyczny w Katowicach
    Tematy:
    chest pain
    myeloma
    proteinuria
    Opis:
    Multiple myeloma is the second most common neoplastic disease of lymphoid tissue in adults. However, its atypical non secretory form, is quite rare. We present a case of 70 year old male with atypical chest pain and nephrotic range proteinuria fi nally diagnosed as non secretory myeloma who did not present any of characteristic fi ndings when admitted to hospital. Despite the unusual course the diagnosis was established quickly enough to provide a proper treatment. One should remember that occasionally patients do not match typical criteria necessary for diagnosing a disease.
    Źródło:
    Annales Academiae Medicae Silesiensis; 2010, 64, 5-6; 89-91
    1734-025X
    Pojawia się w:
    Annales Academiae Medicae Silesiensis
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Atorvastatin improves tubular status in non-diabetic patients with chronic kidney disease - placebo controlled, randomized, cross-over study
    Autorzy:
    Renke, Marcin
    Tylicki, Leszek
    Rutkowski, Przemysław
    Neuwelt, Alexander
    Larczyński, Wojciech
    Ziętkiewicz, Marcin
    Aleksandrowicz, Ewa
    Łysiak-Szydłowska, Wiesława
    Rutkowski, Bolesław
    Powiązania:
    https://bibliotekanauki.pl/articles/1040322.pdf
    Data publikacji:
    2010
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    proteinuria
    kidney
    tubular injury
    chronic kidney disease
    Atorvastatin
    Opis:
    Background. There is evidence that dyslipidemia is associated with chronic kidney disease (CKD) and it has been implicated in the progression of renal damage. Optimal management of dyslipidemia should therefore lead to renal benefits. A number of experimental models demonstrate a beneficial effect of statins in ameliorating renal damage. However, the exact mechanism by which statins protect against renal damage remains unclear. Methods. In a placebo-controlled, randomized, cross-over study we evaluated the influence of atorvastatin (ATO) 40 mg/day added to the renin-angiotensin-aldosterone systeme (RAAS) blockade on proteinuria and surrogate biomarkers of tubular damage or injury in 14 non-diabetic patients with proteinuria (0.4-1.8 g per 24 h) with normal or declined kidney function (eGFR 55-153 ml/min). In the eight-week run-in period, therapy using angiotensin converting enzyme inhibitors (ACEI) and/or angiotensin II subtype 1 receptor antagonists (ARB) was adjusted to achieve a blood pressure below 130/80 mm Hg. Next, patients were randomly assigned to one of two treatment sequences: ATO/washout/placebo or placebo/washout/ATO. Clinical evaluation and laboratory tests were performed at the randomization point and after each period of the study. The primary end point of this study was a change in proteinuria measured as 24-h urine protein excretion (DPE). Secondary end points included urine N-acetyl-β-d-glucosaminidase (NAG) and α1-microglobulin (α1m) excretion. Results. The ATO therapy significantly reduced urine excretion of α1m (p=0.033) and NAG (p=0.038) as compared to placebo. There were no differences in proteinuria, blood pressure, eGFR and serum creatinine between the ATO and placebo groups. Conclusion. Atorvastatin treatment is safe and improves biomarkers of tubular damage or injury in non-diabetic patients with CKD.
    Źródło:
    Acta Biochimica Polonica; 2010, 57, 4; 547-552
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Helicobacter pylori cytotoxin-associated gene A impairs the filtration barrier function of podocytes via p38 MAPK signaling pathway
    Autorzy:
    Yang, Man
    Wang, Ling
    Gu, Li-jie
    Yuan, Wei-jie
    Powiązania:
    https://bibliotekanauki.pl/articles/1038590.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    CagA
    ZO-1
    p38 MAPK
    podocyte
    proteinuria
    Opis:
    Helicobacter pylori (Hp) specific antigens were found deposited in the glomeruli in some kidney diseases. However, the underlying molecular mechanisms remain to be elucidated. The aim of this study was to investigate the effect of cytotoxin associated gene A protein (CagA), a key virulence factor of Hp, on mouse podocytes. Cells were cultured and treated with recombinant CagA protein. The expression of the tight junction protein ZO-1 and p38 MAPK signaling pathway activation were measured with real-time RT-PCR and western blotting. The filtration barrier function of podocytes was evaluated with albumin influx assay. CagA decreased the expression and membrane distribution of ZO-1, impaired the filtration barrier function of podocytes, while activating p38 MAPK signaling pathway in these cells. Selective p38 MAPK inhibition partly prevented CagA-induced filtration barrier dysfunction of podocytes through ameliorating ZO-1 downregulation. Taken together, the results suggested that CagA, at least via p38 MAPK signaling pathway, may induce podocyte injury. Anti-Hp therapy may be beneficial for the treatment of kidney diseases related to Hp antigen deposition.
    Źródło:
    Acta Biochimica Polonica; 2017, 64, 3; 471-475
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effect of pentoxifylline on proteinuria, markers of tubular injury and oxidative stress in non-diabetic patients with chronic kidney disease - placebo controlled, randomized, cross-over study
    Autorzy:
    Renke, Marcin
    Tylicki, Leszek
    Rutkowski, Przemysław
    Knap, Narcyz
    Ziętkiewicz, Marcin
    Neuwelt, Alexander
    Aleksandrowicz, Ewa
    Łysiak-Szydłowska, Wiesława
    Woźniak, Michał
    Rutkowski, Bolesław
    Powiązania:
    https://bibliotekanauki.pl/articles/1040438.pdf
    Data publikacji:
    2010
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    pentoxifylline
    oxidative stress
    kidney
    chronic kidney disease
    proteinuria
    tubular injury
    Opis:
    Background: Inhibition of the renin-angiotensin-aldosterone system (RAAS) with angiotensin converting enzyme inhibitors (ACEI) and/or angiotensin II subtype 1 receptor antagonists (ARB) is a common strategy used in the management of patients with chronic kidney disease (CKD). However, there is no universal therapy that can stop progression of CKD. Pentoxifylline (PTE) is a non-specific phosphodiesterase inhibitor with anti-inflammatory properties. It has been reported to have promising effects in CKD treatment. Methods: In a placebo-controlled, randomized, cross-over study we evaluated the influence of PTE (1200 mg/day) added to RAAS blockade on proteinuria, surrogate markers of tubular injury and oxidative stress-dependent products in 22 non-diabetic patients with proteinuria (0.4-4.3 g per 24h) with normal or declined kidney function [eGFR 37-178 mL/min]. In an eight-week run-in period, therapy using ACEI and/or ARB was adjusted to achieve a blood pressure below 130/80 mm Hg. Next, patients were randomly assigned to one of two treatment sequences: PTE/washout/placebo or placebo/washout/PTE. Clinical evaluation and laboratory tests were performed at the randomization point and after each period of the study. Results: The PTE therapy reduced proteinuria (by 26%) as compared to placebo. There were no differences in α1-microglobulin, urine excretion of N-acetyl-β-d-glucosaminidase (NAG), hsCRP, the urinary excretion of 15-F2t-isoprostane, blood pressure (BP), eGFR and serum creatinine between the PTE and placebo groups. Conclusion: Pentoxifylline may decrease proteinuria in non-diabetic patients with CKD.
    Źródło:
    Acta Biochimica Polonica; 2010, 57, 1; 119-123
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Aetiology, prophylaxis and management of preeclampsia
    Autorzy:
    Gronkowska, Karolina
    Powiązania:
    https://bibliotekanauki.pl/articles/1830661.pdf
    Data publikacji:
    2021-09-29
    Wydawca:
    Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
    Tematy:
    proteinuria
    gestational hypertension
    trophoblast invasion
    uteroplacental malperfusion
    endothelial dysfunction
    Opis:
    Although preeclampsia affects approximately 3%–8% of pregnancies worldwide and is a major contributor to maternal and neonatal mortality and morbidity, the aetiology of preeclampsia is still not fully understood. This review presents the current knowledge on the aetiology of preeclampsia, with a special emphasis on risk factors and their role, and describes recommendations for the prevention and treatment of preeclampsia.
    Źródło:
    Acta Universitatis Lodziensis. Folia Biologica et Oecologica; 2021, 17; 111-121
    1730-2366
    2083-8484
    Pojawia się w:
    Acta Universitatis Lodziensis. Folia Biologica et Oecologica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Dent’s disease type 1 in a boy with severe hyperopia and mental dysfunction: a case report
    Autorzy:
    Sobieszczańska-Droździel, A.
    Sikora, P.
    Majewski, M.
    Ludwig, M.
    Matera, A.
    Zajączkowska, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/1916502.pdf
    Data publikacji:
    2014
    Wydawca:
    Uniwersytet Medyczny w Białymstoku
    Tematy:
    dent’s disease
    low-molecular-weight proteinuria
    CLCN5 gene
    hypercalciuria
    nephrocalcinosis
    hyperopia
    Opis:
    Dent’s disease is a rare X-linked recessive proximal tubulopathy. It is typically characterized by low-molecular-weight (LMW) proteinuria, hypercalciuria, nephrocalcinosis, nephrolithiasis, hypophosphatemia, rickets and slowly progressive renal failure. The laboratory and clinical features may occur in various combinations. The early diagnosis of Dent’s disease is often problematic because affected children may have mild clinical and biochemical signs, detecting LMW proteinuria is not available in many laboratories, and genetic results are not clear in all cases. We report on a 12- year-old boy with Dent’s disease type 1, severe hyperopia, and psychological dysfunction. To the best of our knowledge, he is the first patient with mutation in CLCN5 gene and extrarenal symptoms described so far.
    Źródło:
    Progress in Health Sciences; 2014, 4, 1; 273-276
    2083-1617
    Pojawia się w:
    Progress in Health Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Proteinuria - selected issues
    Proteinuria - wybrane zagadnienia
    Autorzy:
    Skrzypczak, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/3132607.pdf
    Data publikacji:
    2021
    Wydawca:
    Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
    Tematy:
    kidney
    kidney disease
    proteinuria
    low molecular weight protein
    high molecular weight protein
    uromodulin
    zonulin
    Źródło:
    Acta Scientiarum Polonorum. Zootechnica; 2021, 20, 3; 51-58
    1644-0714
    Pojawia się w:
    Acta Scientiarum Polonorum. Zootechnica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Post-exercise proteinuria in the cadets trained on Special Aerial Gymnastics Instruments
    Autorzy:
    Wochyński, Zbigniew
    Sobiech, Krzysztof
    Powiązania:
    https://bibliotekanauki.pl/articles/2177183.pdf
    Data publikacji:
    2015-07-17
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    proteinuria
    N-acetyl-β-D-glucosaminidase
    β-2-microglobulin
    albumin
    creatinine
    Special Aerial Gymnastics Instruments
    Opis:
    Objectives Assessment of the effect of training on Special Aerial Gymnastics Instruments (SAGI) on the urine β-2- microglobulin (β-2M), albumin (ALB), total protein (TP), N-acetyl-β-D-glucosaminidase EC.3.2.1.30 (NAG), expressed as creatinine (Cr) and on the physical fitness of the examined cadets in comparison with the control group. Material and Methods The study involved 55 cadets aged 20, divided into group A (N = 41) trained on SAGI, and group B (N = 14) – a control group. The urine was collected twice: before the training (BT) and after the training (AT) at the start (training I), during (training II), and after completion of the training program (training III). Urine proteins were assayed with commercially available kits. Results In group A, results obtained in trainings I, II and III showed a statistically significant increase in β-2M/Cr, NAG/Cr, TP/Cr, ALB/Cr indices in AT compared with the baseline BT values. Similarly in group B, a statistically significant increase in β-2M/Cr, NAG/Cr (trainings I, II), TP/Cr, AT compared with the baseline BT values in trainings I, II, and III was noted. Comparison of both groups showed a higher value of the post-exercise proteinuria in group B than in group A. In group A, a significant correlation between TP/Cr vs. ALB/Cr, NAG/Cr vs. TP/Cr, β-2M/Cr vs. TP/Cr, i.e., r = 0.62 at p < 0.001; r = 0.33 at p = 0.03; r = 0.60 at p < 0.001, and r = 0.52 at p < 0.001, respectively, was observed in group A, training III, AT. Conclusions Assayed urine proteins depend on the intensity of physical exercise, the type of exercise, and the level of physical fitness.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2015, 28, 5; 863-873
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Postępowanie diagnostyczno-lecznicze u dzieci z przewlekłą chorobą nerek w okresie przeddializacyjnym
    Diagnosis and treatment of children with chronic kidney disease in predialytic period
    Autorzy:
    Szczepańska, Maria
    Olesik-Śmietana, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/1039305.pdf
    Data publikacji:
    2010
    Wydawca:
    Śląski Uniwersytet Medyczny w Katowicach
    Tematy:
    dzieci
    przewlekła choroba nerek
    predializa
    białkomocz
    dializa otrzewnowa
    hemodializa
    przeszczep nerki
    children
    chronic kidney disease
    predialysis
    proteinuria
    peritoneal dialysis
    hemodialysis
    kidney transplantation
    Opis:
    Chronic Kidney Disease (CKD) in children could be initially maintained on conservative treatment but at the end it leads unavoidably to renal replacement therapy application. Disease progression in children not exclusively affects renal function but also causes systemic complications (proteinuria consequences, cardiovascular complications, anemia, calcium-phosphate metabolism disorders, metabolic acidosis, hypostature, hypertension, chronic systemic inflammation and malnutrition). Psychological aspect of CKD should not be forgotten because as other chronic illnesses, it affects both the quality of life of a child and the whole family. Early diagnosis of CKD gives a chance for the effective control of disease symptoms and for the prolongation of the period on conservative treatment. During the predialytic period the child and the family could be better prepared for renal replacement therapy or pre-emptive transplantation. In conclusion, diagnostic and treatment procedures require an achievement of good cooperation and close contact with the child and its family by the specialized team (pediatrician, nephrologist, dialysis nurse, psychologist, dietetician and social worker) at each treatment stage. Predialytic period is the time when child and his family inevitably experience the harmful consequences of CKD. The important task for the medical staff is the optimalization of the methods of treatment.
    Przewlekła choroba nerek (PChN) u dzieci, początkowo leczona zachowawczo w konsekwencji prowadzi do rozpoczęcia leczenia nerkozastępczego. Zaawansowanie procesu chorobowego wpływa nie tylko na czynność nerek, ale ma także u dzieci skutki ogólnoustrojowe, m.in. następstwa białkomoczu, powikłania w układzie sercowo - naczyniowym, niedokrwistość, zaburzenia gospodarki wapniowo - fosforanowej, kwasicę metaboliczną, niedobór wzrostu, nadciśnienie tętnicze, stan zapalny oraz zaburzenia odżywiania. Nie można także pominąć aspektu psychologicznego, gdyż jak każda choroba przewlekła wpływa zarówno na życie dziecka, jak i pozostałych członków rodziny. Wczesne wykrycie choroby to szansa na jej skuteczniejszą kontrolę, wydłużenie czasu leczenia zachowawczego a w okresie predializy lepsze przygotowanie młodego pacjenta i jego rodziny do podjęcia terapii nerkozastępczej lub przeprowadzenia przeszczepu wyprzedzającego nerki. Cały proces diagnostyczno - leczniczy wymaga dobrej współpracy z dzieckiem i jego rodziną na poszczególnych etapach leczenia poczynając od lekarza pierwszego kontaktu – pediatry poprzez specjalistę nefrologa, pielęgniarkę nefrologiczną, psychologa, dietetyka oraz pracownika socjalnego. Okres predializy to czas, w którym dziecko wraz z rodziną doświadcza nieuchronności następstw PChN, a zadaniem personelu medycznego jest konsolidacja działań w celu optymalizacji sposobu leczenia.
    Źródło:
    Annales Academiae Medicae Silesiensis; 2010, 64, 1-2; 66-74
    1734-025X
    Pojawia się w:
    Annales Academiae Medicae Silesiensis
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-9 z 9

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