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Tytuł:
Zbozowe, bialkowe inhibitory enzymow hydrolitycznych i ich znaczenie. Czesc II: Bialkowe inhibitory proteinaz
Autorzy:
Piasecka-Kwiatkowska, D
Warchalewski, J.R.
Powiązania:
https://bibliotekanauki.pl/articles/826620.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Technologów Żywności
Tematy:
inhibitory enzymow
alfa-amylazy
enzymy hydrolityczne
zboza
enzymy amylolityczne
ziarno
bialka roslinne
proteinazy
inhibitory proteinaz
zywienie czlowieka
enzyme inhibitor
alpha-amylase
hydrolytic enzyme
cereal
amylolytic enzyme
grain
vegetable protein
proteinase
proteinase inhibitor
human nutrition
Opis:
W pracy przedstawiono przegląd danych literaturowych na temat zbożowych, białkowych inhibitorów enzymów proteolitycznych. Szczególną uwagę zwrócono na ich właściwości, formy wielorakie, a także ich znaczenie biochemiczne, fizjologiczne i żywieniowe.
The present state of knowledge on cereal proteinacious inhibitors of proteolytic enzymes is reviewed. Particular attention was given on their properties, multiple forms as well as significance from nutritional, physiological and biochemical point of view.
Źródło:
Żywność Nauka Technologia Jakość; 2000, 07, 3; 33-38
1425-6959
Pojawia się w:
Żywność Nauka Technologia Jakość
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The construction of recombinant vectors for a DNA vaccination of rats against fasciolosis
Autorzy:
Kofta, W.
Wedrychowicz, H.
Powiązania:
https://bibliotekanauki.pl/articles/838715.pdf
Data publikacji:
1998
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
parasite
vaccination
cattle
economic loss
fluke
fasciolosis
mRNA
Fasciola hepatica
liver
cysteine proteinase
cDNA
rat
Źródło:
Annals of Parasitology; 1998, 44, 3
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Non-conventional affinity chromatography of serine proteinases and their inhibitors.
Autorzy:
Polanowski, Antoni
Wilimowska-Pelc, Anna
Kowalska, Jolanta
Grybel, Joanna
Żelazko, Monika
Wilusz, Tadeusz
Powiązania:
https://bibliotekanauki.pl/articles/1043449.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
chymotrypsin
serine proteinase inhibitors
trypsin
proteolytic enzymes
affinity chromatography
Kazal-type inhibitors
high NaCl concetration
α1-proteinase inhibitor
Opis:
From among a wide variety of protein purification techniques affinity chromatography has proved to be particularly effective for separation of proteolytic enzymes and their inhibitors. In this article, following a general description of affinity adsorbents used for purification of proteinases, we overview a simple separation procedure for some serine proteinases and their inhibitors by way of affinity chromatography in the presence of high NaCl concentration. It has been shown that some highly specific trypsin inhibitors exhibit also antichymotrypsin activity when high concentration of Na+ but not K+ or Li+ ions are present in the reaction mixture. Taking advantage of this phenomenon the virgin forms of trypsin inhibitors from squash seeds, Kazal-type inhibitor from porcine pancreas and α1-proteinase inhibitor from human and sheep plasma, as an example, were separated using immobilized chymotrypsin or its inactive derivative methylchymotrypsin in the presence of 5 M NaCl.
Źródło:
Acta Biochimica Polonica; 2003, 50, 3; 765-773
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Molecules released by helminth parasites involved in host colonization
Autorzy:
Dzik, Jolanta
Powiązania:
https://bibliotekanauki.pl/articles/1041267.pdf
Data publikacji:
2006
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
ROS
kinases
superoxide dismutase
phosphorylcholine
proteinases
cytokines
helminths
peroxiredoxins
acetylcholinesterase
phosphatases
Th2 immune response
proteinase inhibitors
Opis:
Parasites are designed by evolution to invade the host and survive in its organism until they are ready to reproduce. Parasites release a variety of molecules that help them to penetrate the defensive barriers and avoid the immune attack of the host. In this respect, particularly interesting are enzymes and their inhibitors secreted by the parasites. Serine-, aspartic-, cysteine-, and metalloproteinases are involved in tissue invasion and extracellular protein digestion. Helminths secrete inhibitors of these enzymes (serpins, aspins, and cystatins) to inhibit proteinases, both of the host and their own. Proteinases and their inhibitors, as well as helminth homologues of cytokines and molecules containing phosphorylcholine, influence the immune response of the host biasing it towards the anti-inflammatory Th2 type. Nucleotide-metabolizing enzymes and cholinesterase are secreted by worms to reduce inflammation and expel the parasites from the gastrointestinal tract. An intracellular metazoan parasite, Trichinella spiralis, secretes, among others, protein kinases and phosphatases, endonucleases, and DNA-binding proteins, which are all thought to interfere with the host cellular signals for muscle cell differentiation. Secretion of antioxidant enzymes is believed to protect the parasite from reactive oxygen species which arise from the infection-stimulated host phagocytes. Aside from superoxide dismutase, catalase (rarely found in helminths), and glutathione peroxidase (selenium-independent, thus having a poor activity with H2O2), peroxiredoxins are probably the major H2O2-detoxifying enzymes in helminths. Secretion of antioxidant enzymes is stage-specific and there are examples of regulation of their expression by the concentration of reactive oxygen species surrounding the parasite. The majority of parasite-secreted molecules are commonly found in free-living organisms, thus parasites have only adapted them to use in their way of life.
Źródło:
Acta Biochimica Polonica; 2006, 53, 1; 33-64
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Investigation of the correlation between virulence factors and genotypic profiles of Candida albicans isolated from turkeys
Autorzy:
Sokół, I.
Gaweł, A.
Bobrek, K.
Powiązania:
https://bibliotekanauki.pl/articles/2087778.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
Candida albicans
turkeys
genotypic profile
RAPD
proteinase
haemolysin
phospholipase
Źródło:
Polish Journal of Veterinary Sciences; 2018, 21, 1; 29-33
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Inactivation of α1-proteinase inhibitor by Candida albicans aspartic proteases favors the epithelial and endothelial cell colonization in the presence of neutrophil extracellular traps
Autorzy:
Gogol, Mariusz
Ostrowska, Dominika
Klaga, Kinga
Bochenska, Oliwia
Wolak, Natalia
Aoki, Wataru
Ueda, Mitsuyoshi
Kozik, Andrzej
Rapala-Kozik, Maria
Powiązania:
https://bibliotekanauki.pl/articles/1038860.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Candida albicans
aspartic proteases
α1-proteinase inhibitor
elastase
neutrophil extracellular traps
inflammation
Opis:
Candida albicans, a causative agent of opportunistic fungal infections in immunocompromised patients, uses ten secreted aspartic proteases (SAPs) to deregulate the homeostasis of the host organism on many levels. One of these deregulation mechanisms involves a SAP-dependent disturbance of the control over proteolytic enzymes of the host by a system of dedicated proteinase inhibitors, with one important example being the neutrophil elastase and alpha1-proteinase inhibitor (A1PI). In this study, we found that soluble SAPs 1-4 and the cell membrane-anchored SAP9 efficiently cleaved A1PI, with the major cleavage points located at the C-terminal part of A1PI in a close vicinity to the reactive-site loop that plays a critical role in the inhibition mechanism. Elastase is released by neutrophils to the environment during fungal infection through two major processes, a degranulation or formation of neutrophil extracellular traps (NET). Both, free and NET-embedded elastase forms, were found to be controlled by A1PI. A local acidosis, resulting from the neutrophil activity at the infection sites, favors A1PI degradation by SAPs. The deregulation of NET-connected elastase affected a NET-dependent damage of epithelial and endothelial cells, resulting in the increased susceptibility of these host cells to candidal colonization. Moreover, the SAP-catalyzed cleavage of A1PI was found to decrease its binding affinity to a proinflammatory cytokine, interleukin-8. The findings presented here suggest a novel strategy used by C. albicans for the colonization of host tissues and overcoming the host defense.
Źródło:
Acta Biochimica Polonica; 2016, 63, 1; 167-175
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Identification and expression analysis of a novel phytocystatin in developing and germinating seeds of triticale (x Triticosecale Wittm.)
Autorzy:
Siminska, J.
Bielawski, W.
Powiązania:
https://bibliotekanauki.pl/articles/58837.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Botaniczne
Tematy:
identification
expression analysis
phytocystatin
cysteine proteinase
seed development
germination
developing seed
germinating seed
triticale
Triticosecale
Opis:
In this paper the complete cDNA sequence of a newly identified triticale phytocystatin, TrcC-7, was analyzed. Because TrcC-7 transcripts were present in seeds, we hypothesized that it may regulate storage protein accumulation and degradation. Therefore, changes in mRNA and protein levels during the entire period of seed development and germination were examined. Expression of TrcC-7 increased during development and decreased at the end of maturation and subsequently increased during seed germination. Based on these results, TrcC-7 likely regulates cysteine proteinase activity during the accumulation and mobilization of storage proteins.
Źródło:
Acta Societatis Botanicorum Poloniae; 2015, 84, 1
0001-6977
2083-9480
Pojawia się w:
Acta Societatis Botanicorum Poloniae
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Humoral response in hamsters following vaccination with cDNA encoding ACEY-1 cysteine proteinase of Ancylostoma ceylanicum
Autorzy:
Mieszczanek, J
Swiderska, M.
Wedrychowicz, H.
Powiązania:
https://bibliotekanauki.pl/articles/836616.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
vaccination
Ancylostoma ceylanicum
ACEY-1 cysteine proteinase
humoral response
hamster
cDNA
IgG antibody response
antibody
Opis:
The humoral response in hamsters following vaccination against Ancylostoma ceylanicum infections with DNA construct was investigated. Groups of hamsters were injected intramuscularly with plasmid pcDNA 3.1, containing cDNA of ACEY-1 cysteine proteinase. Vaccination resulted in IgG antibody response to somatic extracts of adult A. ceylanicum. The highest level of antibodies was observed seven weeks after vaccination.
Źródło:
Annals of Parasitology; 2001, 47, 4
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Humoral response in hamsters following vaccination with cDNA encoding ACEY-1 cysteine proteinase of Ancylostoma ceylanicum
ODPOWIEDŹ HUMORALNA CHOMIKÓW IMMUNIZOWANYCH cDNA PROTEAZY CYSTEINOWEJ ACEY-1 ANCYLOSTOMA CEYLANICUM
Autorzy:
Mieszczanek, J.
Świderska, M.
Wędrychowicz, H.
Powiązania:
https://bibliotekanauki.pl/articles/2148293.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
vaccination
Ancylostoma ceylanicum
ACEY-1 cysteine proteinase
humoral response
hamster
cDNA
IgG antibody response
antibody
Opis:
The humoral response in hamsters following vaccination against Ancylostoma ceylanicum infections with DNA construct was investigated. Groups of hamsters were injected intramuscularly with plasmid pcDNA 3.1, containing cDNA of ACEY-1 cysteine proteinase. Vaccination resulted in IgG antibody response to somatic extracts of adult A. ceylanicum. The highest level of antibodies was observed seven weeks after vaccination.
Źródło:
Wiadomości Parazytologiczne; 2001, 47, 4; 603-608
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Engineered resistance against proteinases
Autorzy:
Milner, Malgorzata
Chroboczek, Jadwiga
Zagorski-Ostoja, Wlodzimierz
Powiązania:
https://bibliotekanauki.pl/articles/1040935.pdf
Data publikacji:
2007
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
fusion proteins
proteinase inhibitors
protein protection
Opis:
Exogenous proteinase inhibitors are valuable and economically interesting protective biotechnological tools. We examined whether small proteinase inhibitors when fused to a selected target protein can protect the target from proteolytic degradation without simultaneously affecting the function and activity of the target domain. Two proteinase inhibitors were studied: a Kazal-type silk proteinase inhibitor (SPI2) from Galleria mellonella, and the Cucurbita maxima trypsin inhibitor I (CMTI I). Both inhibitors target serine proteinases, are small proteins with a compact structure stabilized by a network of disulfide bridges, and are expressed as free polypeptides in their natural surroundings. Four constructs were prepared: the gene for either of the inhibitors was ligated to the 5' end of the DNA encoding one or the other of two selected target proteins, the coat protein (CP) of Potato potyvirus Y or the Escherichia coli β-glucuronidase (GUS). CMTI I fused to the target proteins strongly hampered their functions. Moreover, the inhibitory activity of CMTI I was retained only when it was fused to the CP. In contrast, when fused to SPI2, specific features and functions of both target proteins were retained and the inhibitory activity of SPI2 was fully preserved. Measuring proteolysis in the presence or absence of either inhibitor, we demonstrated that proteinase inhibitors can protect target proteins used either free or as a fusion domain. Interestingly, their inhibitory efficiency was superior to that of a commercial inhibitor of serine proteinases, AEBSF.
Źródło:
Acta Biochimica Polonica; 2007, 54, 3; 523-536
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Defense against own arms: staphylococcal cysteine proteases and their inhibitors.
Autorzy:
Dubin, Grzegorz
Powiązania:
https://bibliotekanauki.pl/articles/1043443.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
staphostatin
staphylococcus
ssp
proteinase
protease inhibitor
staphopain
Opis:
Staphylococcus aureus is a human pathogen causing a wide range of diseases. Most staphylococcal infections, unlike those caused by other bacteria are not toxigenic and very little is known about their pathogenesis. It has been proposed that a core of secreted proteins common to many infectious strains is responsible for colonization and infection. Among those proteins several proteases are present and over the years many different functions in the infection process have been attributed to them. However, little direct, in vivo data has been presented. Two cysteine proteases, staphopain A (ScpA) and staphopain B (SspB) are important members of this group of enzymes. Recently, two cysteine protease inhibitors, staphostatin A and staphostatin B (ScpB and SspC, respectively) were described in S. aureus shedding new light on the complexity of the processes involving the two proteases. The scope of this review is to summarize current knowledge on the network of staphylococcal cysteine proteases and their inhibitors in view of their possible role as virulence factors.
Źródło:
Acta Biochimica Polonica; 2003, 50, 3; 715-724
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Contribution of phytocystatins to the processes of seed development and germination
Autorzy:
Siminska, J.
Sitnicka, D.
Bielawski, W.
Powiązania:
https://bibliotekanauki.pl/articles/80772.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
seed development
germination
storage protein
cysteine proteinase
cystatin
phytocystatin
gene encoding
phylogenetic analysis
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 3
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Computational analysis of Ancylostoma ceylanicum cysteine proteinase
Autorzy:
Baska, P
Wisniewski, M.
Mieszczanek, J.
Wedrychowicz, H.
Powiązania:
https://bibliotekanauki.pl/articles/839012.pdf
Data publikacji:
2006
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
parasite
parasitic disease
VAST programme
computational analysis
Ancylostoma ceylanicum
vaccine
parasitology
nematode
cysteine proteinase
animal disease
host-parasite interaction
Opis:
The potential tertiary structure of Ancylostoma ceylanicum cysteine proteinase was obtained by Automatic Program 3D-JIGSAW and used for finding homologues of known structure by VAST program. The results of computational analysis showed the presence of domains recognizing host immunoglobulins. Based on this analysis we suggest that this protein is involved in cleaving of host antibodies and therefore it may be promising vaccine candidate. In this paper we present the computational analysis of parasitic antigen which is very helpful in evaluation of the potential role of this protein.
Źródło:
Annals of Parasitology; 2006, 52, 4
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Computational analysis of Ancylostoma ceylanicum cysteine proteinase
Autorzy:
Bąska, P.
Wiśniewski, M.
Mieszczanek, J.
Wędrychowicz, H.
Powiązania:
https://bibliotekanauki.pl/articles/2146344.pdf
Data publikacji:
2006
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
parasite
parasitic disease
VAST programme
computational analysis
Ancylostoma ceylanicum
vaccine
parasitology
nematode
cysteine proteinase
animal disease
host-parasite interaction
Opis:
The potential tertiary structure of Ancylostoma ceylanicum cysteine proteinase was obtained by Automatic Program 3D-JIGSAW and used for finding homologues of known structure by VAST program. The results of computational analysis showed the presence of domains recognizing host immunoglobulins. Based on this analysis we suggest that this protein is involved in cleaving of host antibodies and therefore it may be promising vaccine candidate. In this paper we present the computational analysis of parasitic antigen which is very helpful in evaluation of the potential role of this protein.
Źródło:
Wiadomości Parazytologiczne; 2006, 52, 4; 277-281
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparison of aspartate proteinase activity of Candida albicans strains isolated from children with and without Helicobacter pylori
Autorzy:
Rozga, A.
Kurnatowski, M.
Wasowska-Krolikowska, K.
Powiązania:
https://bibliotekanauki.pl/articles/841572.pdf
Data publikacji:
1998
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
aspartate proteinase
gastrointestinal tract
child
Candida albicans
Helicobacter pylori
Źródło:
Annals of Parasitology; 1998, 44, 3
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 20

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