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Wyświetlanie 1-15 z 62
Tytuł:
Evaluating the Prognostic Value of Selected Prognostic Scales in Patients Operated on Due to Peritonitis
Autorzy:
Paduszyńska, Katarzyna
Kaczka, Krzysztof
Dworzyńska, Agnieszka
Sieniawski, Karol
Pomorski, Lech
Powiązania:
https://bibliotekanauki.pl/articles/1395835.pdf
Data publikacji:
2014-12-18
Wydawca:
Index Copernicus International
Tematy:
peritonitis
mortality
prognostic scales
Opis:
The aim of the study was to assess the usefulness of prognostic scales: ASA (American Society of Anesthesiologist), MPI (Meinheim Peritonitis Index), MOFS (the Multiple Organ Failure Score) and SPI (the Simple Prognostic Index) in the prognosis of the course of disease in patients operated on for peritonitis. Material and methods. The study was conducted in the Clinical Department of General and Oncological Surgery of the Medical University in Łódź between January 2009 to December 2010. During this period 263 patients were operated on for peritonitis. Before surgery all patients were classifed into particular groups according to the above mentioned prognostic scales according to their criteria. Results. There were 29 (11%) deaths. ASA ≥4 (p<0.0001), MPI >30 (p<0.0001) MOFS ≥2 (p<0.0001), SPI II, III, IV (p<0.0001) were important risk factors of death. Conclusions. 1. ASA, MPI, MOFS and SPI scales are of high signifcance in predicting the outcome in patients operated on for peritonitis. 2. The ASA scale in spite and due to its simplicity is adequate enough to be used in everyday practice in patients operated on for peritonitis. 3. The MPI scale is most suitable in the scientifc aims and in comparing the outcomes of patients operated on for peritonitis.
Źródło:
Polish Journal of Surgery; 2014, 86, 9; 422-428
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Epidemiological profile and distribution of prognostic factors in invasive breast cancer among Algerian women
Autorzy:
Elbasyouni, Amel
Saadi, Leila
Baha, AbdelKarim
Powiązania:
https://bibliotekanauki.pl/articles/2047226.pdf
Data publikacji:
2021-09-22
Wydawca:
Medical Education
Tematy:
breast cancer
epidemiology
biomarkers
immunohistochemistry
prognostic
Opis:
Although the widespread of early screening and advanced medical therapies, the breast cancer incidence rate continues to rise among Algerian women. This retrospective study investigated mammary lesions’ epidemiological profile and histopathological characteristics and evaluated primary invasive breast cancer prognostic factors. We found that the incidence of breast cancer increases in middle- aged women between 40 and 60 years. Scarff Bloom Richardson grade II predominates in invasive breast cancer samples. In this study, molecular profiling shows that 82.1% of invasive tumours are hormone receptor-positive. A significant correlation is observed between the age of the patient and the SBR grade (p = 0.001) and with the hormone receptor expression (p = 0.001). In addition, the tumour grade is significantly correlated to oestrogen and progesterone receptor expression (p = 0.000; p = 0.000, respectively). Twenty-two per cent of cases were human epidermal growth factor receptor 2-positive. The Ki-67 proliferation index is expressed in 91% of breast cancer patients and was significantly associated with Scarff Bloom Richardson grade (p = 0.030), the progesterone receptor expression (p = 0.029) and with human epidermal growth factor receptor 2-positivity (p = 0.023). Primary breast cancer with a high grade is more frequent (31%) in young women under 40 years old, presenting 17% of our population. In summary, breast cancer patients in Algeria develop an unfavourable profile. Immunohistochemistry assay has played a pivotal role in assessing breast cancer predictive biomarkers improving the tumour behaviour and response to treatment.
Źródło:
OncoReview; 2021, 11, 4; 95-101
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Prognostic role of clinical presentation, cytological picture and response to treatment in canine centroblastic lymphoma
Autorzy:
Kliczkowska-Klarowicz, K.
Jagielski, D.
Czopowicz, M.
Sapierzyński, R.
Powiązania:
https://bibliotekanauki.pl/articles/2087233.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
lymphoma
prognostic factors
chemotherapy
asparaginase
mitoxantron
Źródło:
Polish Journal of Veterinary Sciences; 2021, 24, 1; 101-107
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Impact of tumour characteristic and treatment modality on the local recurrence and the survival in patients with oral squamous cell carcinoma
Autorzy:
Kos, Marcin
Łuczak, Klaudiusz
Brusco, Daniel
Engelke, Werner
Powiązania:
https://bibliotekanauki.pl/articles/1398799.pdf
Data publikacji:
2008
Wydawca:
Index Copernicus International
Tematy:
oral cancer
oral neoplasms
prognostic factors
Opis:
Purpose of the study. To evaluate the impact of tumour location, local and regional advancement, histological differentiation, status of the surgical margins and radiotherapy on the disease-free time and overall survival rates in patients with oral squamous cell carcinoma. Material and methods. A retrospective analysis of 67 patients treated with surgery (61 pts.), radiotherapy (6 pts.) and their combination (28 pts.). Follow time on average 40 months. The probabilities of survival were assessed using the Kaplan-Meier estimates, the differences were calculated with the log-rank test. An analysis of the infl uence of the neck recurrences on the prognosis was additionally performed. Relationship between independent categorical variables as: primary local advancement, location of the tumour, histological grading and lymph node metastases was evaluated with Fisher´s Exact Test. Results. Disease-free time rate amounted to 40,1%. There was no independent prognostic importance of primary location, T-staging and N-staging, histological grading of the tumour or radiation on disease-free time, just opposite to the status of the resection margins. However, the number of neck metastases was directly proportional to the tumour dimension and poor histological differentiation. Overall survival rate amounted to 87,5%. Posterior location in the oral cavity, involvement of cervical lymph nodes, surgical margins with the presence of tumour cells, poor histological differentiation and necessity of irradiation negatively correlated with the survival. Conclusions. A complete resection of the tumour was the most important independent prognostic parameter for the disease-free and overall survivals in oral squamous cell carcinomas in this study. An adjuvant radiation therapy could improve the results of treatment of oral squamous cell carcinoma also in cases were so far considered only for surgical management.
Źródło:
Polish Journal of Otolaryngology; 2008, 62, 6; 722-726
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Prognostic factors in traumatic brain injury and their association with outcome
Autorzy:
Kulesza, B.
Nogalski, A.
Kulesza, T.
Prystupa, A.
Powiązania:
https://bibliotekanauki.pl/articles/3091.pdf
Data publikacji:
2015
Wydawca:
Instytut Medycyny Wsi
Tematy:
prognostic factor
traumatic brain injury
outcome
prognosis
Opis:
Introduction. Traumatic brain injuries (TBI) are a real social problem, with an upward trend worldwide. TBI is the leading cause of death and disability, especially among young men. Each year in Europe, and also in Poland, 243 per 100,000 individuals suffer from TBI. Assessing prognosis after traumatic brain injury is very important in order to help clinicians to make a decision about the implementation of specific methods of treatment, and to make communication with the patient and the patient’s family easier. Objective. The objective of this review was to present prognostic factors, to assess outcomes within a short time after a moderate to severe traumatic brain injury, as well as to predict functional outcome. The most important independent variables were: age, Glasgow Coma Scale (GCS) motor score, pupil response, Marshall CT classification and traumatic subarachnoid haemorrhage. Other important prognostic factors included hypotension, hypoxia, glucose, coagulopathy, haemoglobin and category of CT characteristic, such as midline shift, mass lesion, basal cistern. Conclusions. Gender and intraventricular haemorrhage did not have predictive value. This subject needs much more research in the area of new prognostic factors which would be better associated with outcome after traumatic brain injury.
Źródło:
Journal of Pre-Clinical and Clinical Research; 2015, 09, 2
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Chronic lymphocytic leukemia – clinical course, prognostic parameters, prognostic markers
Autorzy:
Surowiec, Iwona
Świderska-Kołacz, Graażyna
Zmorzyński, Szymon
Powiązania:
https://bibliotekanauki.pl/articles/472588.pdf
Data publikacji:
2016
Wydawca:
Uniwersytet Pedagogiczny im. Komisji Edukacji Narodowej w Krakowie
Tematy:
pathogenesis of CLL
prognostic factors
chromosomal abnormalities
Źródło:
Annales Universitatis Paedagogicae Cracoviensis. Studia ad Didacticam Biologiae Pertinentia; 2016, VI; 31-41
2083-7267
2450-3487
Pojawia się w:
Annales Universitatis Paedagogicae Cracoviensis. Studia ad Didacticam Biologiae Pertinentia
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Elevated preoperative levels of CA 19-9 and CA 125 predicts overall survival time in the pancreatic adenocarcinoma. Single institution series.
Autorzy:
Hogendorf, Piotr
Skulimowski, Aleksander
Durczyński, Adam
Kumor, Anna
Poznańska, Grażyna
Poznańska, Agnieszka
Oleśna, Aleksandra
Rut, Joanna
Øvereng Juliebø, Siri
Szmiel, Aneta
Pirowski, Wojciech
Strzelczyk, Janusz
Powiązania:
https://bibliotekanauki.pl/articles/1391695.pdf
Data publikacji:
2020
Wydawca:
Index Copernicus International
Tematy:
general surgery
pancreatic neoplasms
biomarkers
prognostic factors
Opis:
Introduction: Pancreatic cancer is a devastating disease, being the seventh cause of cancer-related deaths worldwide. Its aggressiveness is due to its specific biology and the late diagnosis of cancer. Therefore, the prognosis for patients suffering from this cancer is dismal, with 5-year overall survival rate of around 6–10%. Up to date, only a complete surgical resection of the cancerous entity warrants a significant improvement in patients’ survival. Nevertheless, the pancreatic cancer’s biology is still not fully elucidated, so that the accuracy of prognosis for certain patients is highly uncertain. Consequently, the importance of both clinical and basic research aiming to reveal the crucial molecular factors affecting long-term prognosis should be highlighted. There is a growing number of evidence that biomarkers of PC not only reflect the presence of tumor itself but also present a “hint” regarding its physiology. Thus the aim of this study was to assess the levels of commonly measured biomarkers and their influence on patients’ overall survival. Materials and methods: The retrospective analysis of data on 129 patients admitted to our Department due to the diagnosis of pancreatic cancer was carried out. On the day of admission all the patients had their levels of CA19-9, CA125, CEA and CA15-3 measured. The overall survival (OS) was defined as time elapsing from the day of admission to the day of death. The Kaplan- Meier curves were built for all potential factors, Cox regression model was applied to carry out a multivariate analysis. Results: We retrospectively analyzed 129 patients with a mean age of 62 years. As many as 95 of them had an unresectable lesion and 34 underwent curative operation. In total, the analyzed patient group was characterized by a median survival of 7 months and 12 days. Cumulative 1-year, 2-year and 4-year survival rates were 35%, 16% and 15%, respectively. In univariate analysis, factors such as age >= 60, inoperable lesion, CA19-9 >= 200, CA125 >= 20 and Neutrophile to Lymphocyte Ratio (NLR) >= 5 were associated with a lower median OS. In multivariate analysis, three factors, CA19-9 >= 200, CA125 >= 20 and age >= 60, were found to be statistically significant. Indeed, patients possessing all of them noted much poorer outcomes regarding OS factors: 89 days versus 235 days for the other patients (log rank test P = 0.02). Conclusions: Our study fortifies the evidence that preoperative levels of CA19-9 and CA125 have a direct influence on the longterm OS. Interestingly, in our patient group, the correlation of biomarkers with OS was higher than that of resectability. However, our study has some limitations regarding, for instance, the lack of data on chemotherapy, comorbidities etc. In the view of recent molecular studies on mucin involvement in PC development, it provides a strong clinical evidence to prove their importance.
Źródło:
Polish Journal of Surgery; 2020, 92, 3; 32-38
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Estimation of rolling bearing life with damage curve approach
Autorzy:
Mehdigholi, H.
Mirzaei Rafsanjani, H.
Behzad, M.
Powiązania:
https://bibliotekanauki.pl/articles/260574.pdf
Data publikacji:
2011
Wydawca:
Politechnika Gdańska. Wydział Inżynierii Mechanicznej i Okrętownictwa
Tematy:
rolling bearing
prognostic
damage mechanics
Damage curve approach
Opis:
The ability to determine the bearing life time is one of the main purposes in maintenance of rotating machineries. Because of reliability, cost and productivity, the bearing life time prognostic is important. In this paper, a stiffness-based prognostic model for bearing systems is discussed. According to presumed model of bearing and fundamental of damage mechanics, damage curve approach is used to relate stiffness of vibratory system and bearing running life. Furthermore, using the relation between acceleration amplitude at natural frequency and stiffness, final relation between acceleration amplitude at natural frequency and running life time according to damage curve approach can be established and the final running time is predicted. Experiments have been performed on self alignment bearing under failures on inner race and outer race to calibrate and to validate the proposed model. The comparison between model-calculated data and experimental results indicates that this model can be used effectively to predict the failure lifetime and the remaining life of a bearing system.
Źródło:
Polish Maritime Research; 2011, 3; 66-70
1233-2585
Pojawia się w:
Polish Maritime Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Carcinoembryonic antigen as a tumor marker in lung cancer – is it clinically useful?
Autorzy:
Okuła, Agnieszka
Karczmarek-Borowska, Bożenna
Powiązania:
https://bibliotekanauki.pl/articles/454789.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
carcinoembryonic antigen
lung cancer
prognostic factor
tumor marker
Opis:
Introduction. Lung cancer is the most common cancer in the Western world. Annually there are approximately 1.8 million new cases worldwide. It is characterized by poor prognosis with a 5-year survival of 10-17% depending on the country. Contributing to this poor prognosis is a mainly late diagnosis, as well as a fairly frequent recurrence despite radical surgery. Over the years, scientists have been searching for a tumor marker that would be useful for patients with lung cancer. Aim. The aim of this study is to discuss the significance of carcinoembryonic antigen (CEA) in the diagnosis, prognosis of the disease course, and monitoring patients with lung cancer. Methods. Review of the literature using the PubMed database, Termedia, Via Medica and the key issue: carcinoembryonic antigen as a tumor marker in lung cancer. Conclusions. Serum CEA level can be a reliable complement to the diagnosis of lung cancer. It can be helpful in preoperative prediction of disease course and qualification for adjuvant treatment of non-small cell lung cancer especially adenocarcinoma. Trends and normalization of CEA during chemotherapy have an impact on progression-free survival and overall survival (OS) of patients. Various available publications describe CEA as a marker for metastatic lung cancer, which is the most specific for metastasis in the liver and brain.
Źródło:
European Journal of Clinical and Experimental Medicine; 2018, 1; 53-59
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Obszary prognostyczne kopalin pospolitych województwa śląskiego – zaplecze surowcowe czy kłopot?
Prospective areas of common mineral resources in the Śląskie Voivodship – a resources base or a trouble?
Autorzy:
Jochemczyk, L.
Olszewska, K.
Walentek, I.
Powiązania:
https://bibliotekanauki.pl/articles/2063088.pdf
Data publikacji:
2010
Wydawca:
Państwowy Instytut Geologiczny – Państwowy Instytut Badawczy
Tematy:
obszary prognostyczne
kopaliny pospolite
zasoby prognostyczne
województwo śląskie
zasoby geologiczne bilansowe
prognostic areas
common minerals
prognostic resources
balance resources
Silesia district
Opis:
W artykule zaprezentowano prognozy udokumentowania nowych złóż kopalin pospolitych w obrębie województwa śląskiego oraz możliwość ich zagospodarowania, uwzględniając ograniczenia sozologiczne i zagospodarowanie terenu oraz zapotrzebowanie na określony surowiec.
Prognostic areas for documentation of new common mineral deposits within the Silesia district were presented together with conditions of their future exploitation, usually restricted due to sozological limitations, local land use patterns and market demand for each kind of raw material.
Źródło:
Biuletyn Państwowego Instytutu Geologicznego; 2010, 439 (2); 259--260
0867-6143
Pojawia się w:
Biuletyn Państwowego Instytutu Geologicznego
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Differential relationship between two hypoxia markers: HIF-1α and GLUT1 and classic prognostic factors in invasive breast carcinoma
Zróżnicowana zależność pomiędzy dwoma markerami hipoksji: HIF-1α i GLUT1 a klasycznymi czynnikami prognostycznymi w inwazyjnym raku piersi
Autorzy:
Żyromska, Agnieszka
Andrusewicz, Hanna
Łysik, Joanna
Jóźwicki, Wojciech
Wiśniewski, Tomasz
Powiązania:
https://bibliotekanauki.pl/articles/1029826.pdf
Data publikacji:
2016
Wydawca:
Medical Communications
Tematy:
GLUT1
HIF-1α
hypoxia
immunohistochemistry
prognostic factors
Opis:
Background: Tumor hypoxia is an adverse prognostic factor which promotes cancer aggressiveness and limits its radio- and chemosensitivity. The aim of our study was to explore the relationship between endogenous hypoxia markers and classic prognostic factors, including clinical stage and the expression of ER, PR, and HER2 in primary untreated breast carcinoma. Methods: A retrospective immunohistochemical analysis of archived tissue blocks collected from 153 women, who underwent total mastectomy and lymph node dissection, included the expression of two hypoxia-related proteins: HIF-1α and GLUT1. Results: GLUT1 labelling index (LI) showed a positive correlation with T stage (R = 0.18, p = 0.026) and HER2 status (R = 0.25, p = 0.002), and a negative correlation with the expression of ER (R = −0.19, p = 0.017) and PR (R = −0.17, p = 0.032). HIF-1α LI showed a positive correlation with ER expression (R = 0.16, p = 0.045). In the multivariate regression analysis, a different relationship between classic prognostic factors and the two tested hypoxia proteins was proven. Higher GLUT1 expression correlated with ER and PR negativity (p = 0.02 and p = 0.01, respectively) as well as with higher expression of HER2 (p = 0.04). HIF-1α showed no association with PR and HER2, but a positive correlation with ER (p = 0.02). Neither of the hypoxia proteins was associated with a tumor grade. Only one clinical feature, T stage, correlated with both of the hypoxia markers: positively with GLUT1 (p = 0.049) and negatively with HIF-1α (p = 0.01) expression. Conclusions: In breast cancer, GLUT1 expression may be considered an additional prognostic factor which correlates with an adverse status of HER2 and hormonal receptors, and indicates a more hypoxic, radio- and chemotherapy refractory profile of carcinoma.
Tło: Hipoksja w  guzie nowotworowym stanowi niekorzystny czynnik prognostyczny, ogranicza jego promienioi chemiowrażliwość oraz promuje bardziej agresywny przebieg choroby. Przewidywanie rokowania i odpowiedzi na leczenie wymaga wiedzy o związku hipoksji z uznanymi czynnikami prognostycznymi. Celem badania było określenie zależności pomiędzy endogennymi markerami hipoksji w  pierwotnym przewodowym raku piersi a  klasycznymi czynnikami prognostycznymi, takimi jak stopień zaawansowania klinicznego oraz ekspresja receptorów ER, PR i HER2. Metody: Retrospektywna analiza immunohistochemiczna archiwizowanych bloczków tkanek pobranych od 153 kobiet, poddanych mastektomii i limfadenektomii pachowej, objęła ekspresję dwóch związanych z hipoksją białek: HIF-1α i GLUT1. Wyniki: Indeks wiązania GLUT1 (GLUT1 LI) wykazał korelację dodatnią z wielkością guza (R = 0,18, p = 0,026) i ekspresją HER2 (R = 0,25, p = 0,002) oraz ujemną z ekspresją ER (R = −0,19, p = 0,017) i PR (R = −0,17, p = 0,032). HIF-1α LI korelował wyłącznie z ekspresją ER (R = 0,16, p = 0,045). W analizie wieloczynnikowej wykazano zróżnicowaną zależność pomiędzy klasycznymi czynnikami prognostycznymi i testowanymi markerami hipoksji. GLUT1 LI korelował negatywnie z ekspresją ER i PR (odpowiednio p = 0,02 i p = 0,01) oraz pozytywnie z ekspresją HER2 (p = 0,04). Nie udowodniono korelacji pomiędzy HIF-1α LI a ekspresją PR czy HER2, natomiast wykazano jego dodatnią zależność z ekspresją ER (p = 0,02). Żaden marker hipoksji nie korelował ze stopniem zróżnicowania histologicznego nowotworu. Tylko jeden kliniczny czynnik – wielkość guza (T) – korelował z ekspresją badanych białek: dodatnio z GLUT1 (p = 0,049), a ujemnie z HIF-1α (p = 0,01). Wnioski: Ekspresja GLUT1 w raku piersi może stanowić dodatkowy czynnik prognostyczny, korelujący z niekorzystnym statusem receptora HER2 i receptorów hormonalnych oraz wskazywać na bardziej hipoksyczny, oporny na radioi chemioterapię, profil raka.
Źródło:
Current Gynecologic Oncology; 2016, 14, 4; 197-203
2451-0750
Pojawia się w:
Current Gynecologic Oncology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Sequential organ failure assessment and modified early warning score system versus quick SOFA score to predict the length of hospital stay in sepsis patients – accuracy scoring study.
Autorzy:
Krishna, Gopala
Kumar, Siva
Sankar, Ravi
Raghu, Kondle
Sathynarayana, Vemula
Siripriya, Pasupuleti
Powiązania:
https://bibliotekanauki.pl/articles/1918242.pdf
Data publikacji:
2021-12-31
Wydawca:
Towarzystwo Pomocy Doraźnej
Tematy:
Sepsis
prognostic accuracy
SOFA score
qSOFA score
MEWS score
Opis:
INTRODUCTION: : Sepsis is a global healthcare challenge, and accurate scores are required to identify and stratify patients' risk. The current study aimed to compare the prognostic accuracy of quick SOFA (qSOFA) with comparison to SOFA and MEWS scores in order to identify the length of hospital stay and outcomes among patients with sepsis who presented to emergency department (EMD). MATERIAL AND METHODS: Between July and November 2018, 77 adult patients with sepsis were treated at EMD. The area under the receiver operating characteristic curve (AUROC) of quick SOFA (qSOFA), SOFA, and MEWS scores was used to compare prognostic accuracy for the outcome of hospital mortality and length of stay. RESULTS: The majority of patients (68%) were over the age of 50. Systemic Hypertension is the most common comorbid condition, accounting for 38.9% (n=30). Pneumonia is the most common diagnosis in 27.3 percent of cases (n=21). Patients required vasoactive support in 45.5 percent (n=35) of cases, and ventilator support in 50.6 percent (n=39) of cases. Mortality was observed in 34.1 percent (n=27) of the cases. Patients on vasopressor and ventilator support have a higher mortality rate [8(19%) vs. 21(50%)]. The mortality rate in patients with a qSOFA score of 3 is 71.4 percent. Patients with a SOFA score of >15 had higher mortality rate. The mortality rate in patients with MEWS score > 5 is 48.9%. A qSOFA score of 3 is associated with an increased risk of death, and the majority died in less than three days. Because of increased mortality, most patients with a SOFA score of 7 have a length of stay of 3 days. Most patients with a Mews score of 5 or higher have a length of stay of 3 days due to mortality. The AUC value for qSOFA is 0.721, the AUC value for SOFA is 0.714, and the AUC value for MEWS is 0.693, indicating that qSOFA is more sensitive in predicting the outcome than SOFA and MEWS. CONCLUSIONS: In all prediction scores, qSOFA outperformed than SOFA and MEWS in terms of hospital mortality and length of hospital stay. qSOFA is a simple, rapid bedside tool that does not require laboratory parameters and can be used to predict the prognosis of patients with sepsis in the EMD.
Źródło:
Critical Care Innovations; 2021, 4, 4; 9-18
2545-2533
Pojawia się w:
Critical Care Innovations
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
New directions in molecular diagnostics and therapy of vestibular schwannomas
Autorzy:
Litwiniuk, Malgorzata
Makuszewska, Maria
Bartoszewicz, Robert
Niemczyk, Kazimierz
Powiązania:
https://bibliotekanauki.pl/articles/1399284.pdf
Data publikacji:
2020
Wydawca:
Index Copernicus International
Tematy:
acoustic neuroma
bevacizumab
biological treatment
microRNAs
prognostic markers
vestibular schwannoma
Opis:
The molecular basis for the formation and growth of vestibular schwannomas (VS) has been elucidated in the recent years. The main genetic and epigenetic aberrations, changes in gene expression and specific signaling pathways involved in pathogenesis of sporadic VS and neurofibromatosis type II (NF2) have been defined. These findings facilitated the search for prognostic markers in VS and potential targets for biological therapy. This publication summarizes the main directions of research in the field of molecular diagnostics and pharmacotherapy of VS based on biological agents.
Źródło:
Polski Przegląd Otorynolaryngologiczny; 2020, 9, 4; 55-59
2084-5308
2300-7338
Pojawia się w:
Polski Przegląd Otorynolaryngologiczny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Precision medicine and improving the outcomes of atrial tachycardia ablation: a comprehensive review
Autorzy:
Młyński, Mikołaj
Sławiński, Grzegorz
Kozłowski, Dariusz
Powiązania:
https://bibliotekanauki.pl/articles/33894933.pdf
Data publikacji:
2024-06-28
Wydawca:
Gdański Uniwersytet Medyczny
Tematy:
atrial tachycardia
catheter ablation
prognostic factors
procedural technique
precision medicine
Opis:
Atrial tachycardia (AT) is a prevalent cardiac arrhythmia characterized by rapid, abnormal electrical activity originating from the atria. It represents a significant clinical challenge due to its potential for recurrence, adverse cardiovascular outcomes, and impact on patients' quality of life. Catheter ablation has emerged as a primary therapeutic modality for AT, offering the potential for rhythm control and symptom alleviation. Despite advancements in ablation techniques and technology, the success of AT ablation can vary widely among patients. Identifying prognostic factors associated with successful ablation and potential outcome improving techniques is imperative for optimizing patient care.
Źródło:
European Journal of Translational and Clinical Medicine; 2024, 7, 1; 5-15
2657-3148
2657-3156
Pojawia się w:
European Journal of Translational and Clinical Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Prognozowanie przedziału czasowego z maksymalnym w ciągu doby z użyciem gazu przez kotłownię
Forecasting the time interval of the day with the maximum boilers gas consumption
Autorzy:
Nowak, Bogdan
Bartnicki, Grzegorz
Powiązania:
https://bibliotekanauki.pl/articles/394678.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Instytut Gospodarki Surowcami Mineralnymi i Energią PAN
Tematy:
zużycie gazu
model prognostyczny
random forest
gas consumption
prognostic model
Opis:
Działania mające na celu poprawę efektywności energetycznej systemów zaopatrzenia w ciepło wymagają korzystania z coraz bardziej złożonych metod. Podstawowe sposoby zmniejszenia zużycia ciepła poprzez stosowanie lepszej izolacji cieplnej mają coraz bardziej ograniczone możliwości iwymagają stosunkowo dużych nakładów finansowych. Dobre efekty mogą być osiągane przez coraz lepsze dopasowanie rozwiązań technicznych, sposobów regulacji czy zasad eksploatacji źródła ciepła do warunków konkretnego obiektu zasilanego wciepło. Wymaga to jednak zarówno badań identyfikujących skuteczność takich metod, jak inarzędzi służących do opisu wybranych elementów systemu czy jego całości. Artykuł przedstawia wyniki badań przeprowadzonych dla kotłowni gazowej zasilającej w ciepło grupę budynków mieszkalnych. Celem było zbudowanie modelu, który prognozowałby dla konkretnego dnia przedział czasowy, w którym występuje maksymalne zużycie gazu. Dysponując pomiarami zużycia gazu wkolejnych godzinach doby, zdecydowano się zbudować model prognostyczny wyznaczający tę część doby, w której takie maksimum wystąpi. W opracowanym modelu zdecydowano się zastosować procedurę lasów losowych (random forest). Do utworzenia modelu zastosowano pakiet mlr (Kassambara), w którym przeprowadzono również strojenie hiperparametrów modelu na bazie danych historycznych. W oparciu o odrębne dane dla innego okresu działania kotłowni przedstawiono wyniki oceny jego jakości. Uzyskano skuteczność niemal 44%. Strojenie modelu wpłynęło na poprawę jego zdolności predykcyjnych.
The heat supply systems energy efficiency improvement requires the use of increasingly complex methods. The basic ways to reduce heat consumption is by using better thermal insulation, although they have more and more limited possibilities and need relatively large financial outlays. Good effects can be achieved by the better heat source adaptation to the conditions of aspecific facility supplied with heat. However, this requires research that identifies the effectiveness of such solutions as well as the tools used to describe selected elements of the system or its entirety. The article presents the results of tests carried out for agas boiler room supplying heat to agroup of residential buildings. The goal was to build amodel that would forecast the day range in which the maximum gas consumption occurs for agiven day. Having measurements of gas consumption in subsequent hours of the day, it was decided to build aforecasting model determining the part of the day in which such amaximum would occur. To create the model the random forest procedure was used along with the mlr (Kassambara) package. The model’s hyperparameters were tuned based on historical data. Based on data for another period of boilerroom operation, the results of the model’s quality assessment were presented. Close to 44% efficiency was achieved. Tuning the model improved its predictive ability.
Źródło:
Zeszyty Naukowe Instytutu Gospodarki Surowcami Mineralnymi i Energią PAN; 2019, 109; 93-109
2080-0819
Pojawia się w:
Zeszyty Naukowe Instytutu Gospodarki Surowcami Mineralnymi i Energią PAN
Dostawca treści:
Biblioteka Nauki
Artykuł
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