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Wyszukujesz frazę "potassium channels" wg kryterium: Temat


Wyświetlanie 1-3 z 3
Tytuł:
Mitochondrial potassium and chloride channels.
Autorzy:
Kicińska, Anna
Dębska, Grażyna
Kunz, Wolfram
Szewczyk, Adam
Powiązania:
https://bibliotekanauki.pl/articles/1044286.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
ATP
ion channels
mitochondria
chloride channel
potassium channel
channel openers
sulfonylurea
Opis:
Channels selective for potassium or chloride ions are present in inner mitochondrial membranes. They probably play an important role in mitochondrial events such as the formation of ΔpH and regulation of mitochondrial volume changes. Mitochondrial potassium and chloride channels could also be the targets for pharmacologically active compounds such as potassium channel openers and antidiabetic sulfonylureas. This review describes the properties, pharmacology, and current observations concerning the functional role of mitochondrial potassium and chloride channels.
Źródło:
Acta Biochimica Polonica; 2000, 47, 3; 541-551
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Intracellular potassium and chloride channels: An update.
Autorzy:
Dębska, Grażyna
Kicińska, Anna
Skalska, Jolanta
Szewczyk, Adam
Powiązania:
https://bibliotekanauki.pl/articles/1044174.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
ATP
ion channels
chromaffin granules
mitochondria
chloride channel
potassium channel openers
sulfonylurea
Opis:
Channels selective for potassium or chloride ions are present in all intracellular membranes such as mitochondrial membranes, sarcoplasmic/endoplasmic reticulum, nuclear membrane and chromaffin granule membranes. They probably play an important role in events such as acidification of intracellular compartments and regulation of organelle volume. Additionally, intracellular ion channels are targets for pharmacologically active compounds, e.g. mitochondrial potassium channels interact with potassium channel openers such as diazoxide. This review describes current observations concerning the properties and functional roles of intracellular potassium and chloride channels.
Źródło:
Acta Biochimica Polonica; 2001, 48, 1; 137-144
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Endothelium as target for large-conductance calcium-activated potassium channel openers
Autorzy:
Wrzosek, Antoni
Powiązania:
https://bibliotekanauki.pl/articles/1040527.pdf
Data publikacji:
2009
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
endothelium-derived hyperpolarising factor
potassium channels
endothelium
Opis:
The endothelium is a highly active organ responsible for vasculatory tone and structure, angiogenesis, as well as hemodynamic, humoral, and inflammatory responses. The endothelium is constantly exposed to blood flow, sheer stress and tension. Endothelial cells are present as a vasculature in every tissue of the body and react to and control its microenvironment. A variety of ion channels are present in the plasma membranes of endothelial cells. These include potassium channels such as inwardly rectifying potassium (Kir) channels, voltage-dependent (Kv) channels, ATP-regulated potassium (KATP) channels and three types of calcium-activated potassium channels (KCa), the large (BKCa), intermediate (IKCa), and small (SKCa) -conductance potassium channels. Potassium current plays a critical role in action potentials in excitable cells, in setting the resting membrane potential, and in regulating neurotransmitter release. Mitochondrial isoforms of potassium channel contribute to the cytoprotection of endothelial cells. Prominent among potassium channels are families of calcium-activated potassium channels, and especially large-conductance calcium-activated potassium channels. The modulation of BKCa channels, which are voltage- and calcium-dependent, has been intensively studied. The BKCa channels show large expression dynamics in endothelial cells and tissue-specific expression of large numbers of alternatively spliced isoforms. In this review, a few examples of the modulatory mechanisms and physiological consequences of the expression of BKCa channels are discussed in relation to potential targets for pharmacological intervention.
Źródło:
Acta Biochimica Polonica; 2009, 56, 3; 393-404
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-3 z 3

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