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    Wyświetlanie 1-14 z 14
    Tytuł:
    PET and SPECT imaging as a solid guide to detect and discriminate atypical phenotypes of neurodegenerative disorders
    Autorzy:
    Ruffini, Livia
    Zilioli, Alessandro
    Cervati, Veronica
    Lauretani, Fulvio
    Misirocchi, Francesco
    Maggio, Marcello
    Migliari, Silvia
    Graziani, Tiziano
    Cidda, Carla
    Baldari, Giorgio
    Spallazzi, Marco
    Scarlattei, Maura
    Powiązania:
    https://bibliotekanauki.pl/articles/40521373.pdf
    Data publikacji:
    2024-03-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    atypical phenotypes
    neurodegenerative diseases
    positron emission tomography
    single photon emission computed tomography
    Opis:
    Introduction and aim. Atypical or mixed presentations of neurodegenerative disorders may postpone or confound the final diagnosis. Molecular imaging with positron emission tomography (PET) and single photon emission computed tomography (SPECT) radioligands provide target-specific information and may anticipate the diagnosis by “in vivo” detection of the neuropathological substrate, as Aβ deposition, nigrostriatal dopaminergic depletion or tau inclusions. This concise review will discuss the potential of PET and SPECT imaging as a solid guide to better characterize atypical phenotypes of neurodegeneration in the clinical routine, with the potential to drive personalized interventions, improve cohort uniformity for clinical trials, and serve as biomarkers for targeted molecular therapies. Material and methods. Literature search was performed focusing on the role of PET and SPECT imaging in assessing atypical phenotypes of neurodegeneration, using the electronic source of database PubMed/MEDLINE and the web-based search engines Google, Google Scholar. Analysis of the literature. New disease-modifying drugs may increase their effect with early initiation, which is especially important in working persons and younger subjects presenting atypical symptoms. In older individuals, the coexistence of neurodegeneration, age-related changes, cerebrovascular lesions, or depression makes challenging a definitive diagnosis. Quantitative tools able to measure tracer distribution increase the accuracy of molecular neuroimaging creating topographic maps that compare subject’s data with healthy controls databases. Conclusion. Atypical phenotypes may be associated with quantitative key-pattern allowing a more precise and early diagnosis of the neurodegenerative disorder. Finally, quantitative assessment of the pathological substrates allows us to track the disease process and measure treatment response.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2024, 22, 1; 201-221
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Application of the compress sensing theory for improvement of the TOF resolution in a novel J-PET instrument
    Autorzy:
    Raczyński, L.
    Moskal, P.
    Kowalski, P.
    Wiślicki, W.
    Bednarski, T.
    Białas, P.
    Czerwiński, E.
    Gajos, A.
    Kapłon, Ł.
    Kochanowski, A.
    Korcyl, G.
    Kowal, J.
    Kozik, T.
    Krzemień, W.
    Kubicz, E.
    Niedźwiecki, S.
    Pałka, M.
    Rudy, Z.
    Salabura, P.
    Gupta-Sharma, N.
    Silarski, M.
    Słomski, A.
    Smyrski, J.
    Strzelecki, A.
    Wieczorek, A.
    Zieliński, M.
    Zoń, N.
    Powiązania:
    https://bibliotekanauki.pl/articles/146280.pdf
    Data publikacji:
    2016
    Wydawca:
    Instytut Chemii i Techniki Jądrowej
    Tematy:
    compressed sensing
    positron emission tomography
    time-of-flight
    Opis:
    Nowadays, in positron emission tomography (PET) systems, a time of fl ight (TOF) information is used to improve the image reconstruction process. In TOF-PET, fast detectors are able to measure the difference in the arrival time of the two gamma rays, with the precision enabling to shorten signifi cantly a range along the line-of-response (LOR) where the annihilation occurred. In the new concept, called J-PET scanner, gamma rays are detected in plastic scintillators. In a single strip of J-PET system, time values are obtained by probing signals in the amplitude domain. Owing to compressive sensing (CS) theory, information about the shape and amplitude of the signals is recovered. In this paper, we demonstrate that based on the acquired signals parameters, a better signal normalization may be provided in order to improve the TOF resolution. The procedure was tested using large sample of data registered by a dedicated detection setup enabling sampling of signals with 50-ps intervals. Experimental setup provided irradiation of a chosen position in the plastic scintillator strip with annihilation gamma quanta.
    Źródło:
    Nukleonika; 2016, 61, 1; 35-39
    0029-5922
    1508-5791
    Pojawia się w:
    Nukleonika
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Compact cyclotrons for the production of tracers and radiopharmaceuticals
    Autorzy:
    Paans, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/146155.pdf
    Data publikacji:
    2003
    Wydawca:
    Instytut Chemii i Techniki Jądrowej
    Tematy:
    positron emission tomography (PET)
    cyclotron
    radionuclide production
    Opis:
    Positron Emission Tomography (PET) is a method for determining biochemical and physiological processes in vivo in a quantitative manner. The most commonly used radionuclides are 11C, 13N, 15O and 18F, with respective half-lives of approximately 20 min, 10 min, 2 min, and 110 min. 18F labeled FDG (fluoro-2-deoxy-D-glucose) is now the most frequently used radiopharmaceutical and finds its application prominently in the field of oncology. Originally, the production of these radionuclides was performed with the existing accelerators, designed for nuclear physics, but with increasing interest in the PET methodology specially designed PET-production cyclotrons became available. The nuclear reactions involved are (p,n), (d,n), (p,a) and (d,a) and the thresholds for the nuclear reactions involved are 5 to 6 MeV. Based on these values and on other parameters, a proton 15 to 20 MeV cyclotron is often chosen. Since the half-life of a radionuclide limits the production time, the maximum beam current is an important parameter, together with the target construction, for the ultimate yield obtainable. In the development of special PET production cyclotrons, attention has also been paid to improve the extraction efficiency and the possibility of multiple extractions by designing negative ion cyclotrons. Commercial cyclotrons can often be acquired as an easy to operate integrated radionuclide production unit including targetry and some units. Regional FDG factories are nowadays being created to fulfil the demand for PET radiopharmaceutics. The possible choices in commercially available cyclotrons for the production of PET radionuclides will be discussed.
    Źródło:
    Nukleonika; 2003, 48,suppl.2; 169-172
    0029-5922
    1508-5791
    Pojawia się w:
    Nukleonika
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Preliminary design and simulation of a spherical brain PET system (SBPET) with liquid xenon as scintillator
    Autorzy:
    Moghaddam, N. M.
    Karimian, A.
    Mostajaboddavati, S. M.
    Vondervoort, E.
    Sossi, V.
    Powiązania:
    https://bibliotekanauki.pl/articles/146444.pdf
    Data publikacji:
    2009
    Wydawca:
    Instytut Chemii i Techniki Jądrowej
    Tematy:
    positron emission tomography (PET)
    Monte Carlo simulation
    GATE
    liquid xenon
    brain imaging
    Opis:
    Preliminary design of a spherical brain PET (SBPET) using liquid xenon (LXe) as detector is considered in this research work. The major advantage of a spherical design is the large solid angle of acceptance which improves the sensitivity and increases signal-to-noise ratio (SNR) of the image. The use of a liquid active medium enabled us to design a spherical detector. LXe, due to the intrinsic physical properties, is an excellent liquid medium for accurate tracking of gamma rays in the relevant energy range. The performance of SBPET was evaluated by Monte Carlo simulation tools (GATE) and compared to ECAT HRRT. The numerical results showed the SBPET has a sensitivity of 1.14% and spatial resolution of ~2.7 mm FWHM which is superior to ECAT HRRT especially at high-count rates.
    Źródło:
    Nukleonika; 2009, 54, 1; 33-38
    0029-5922
    1508-5791
    Pojawia się w:
    Nukleonika
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Interpolation-based reconstruction methods for tomographic imaging in 3D positron emission tomography
    Autorzy:
    Li, Y.
    Kummert, A.
    Boschen, F.
    Herzog, H.
    Powiązania:
    https://bibliotekanauki.pl/articles/908045.pdf
    Data publikacji:
    2008
    Wydawca:
    Uniwersytet Zielonogórski. Oficyna Wydawnicza
    Tematy:
    rekonstrukcja tomograficzna
    interpolacja dwuwymiarowa
    twierdzenie o przekroju Fouriera
    szereg rozdzielczy
    tomographic reconstruction
    three-dimensional positron emission tomography
    Fourier slice theorem
    frequency sample distribution
    two-dimensional interpolation
    inverse distance weighting
    gridding method
    Opis:
    Positron Emission Tomography (PET) is considered a key diagnostic tool in neuroscience, by means of which valuable insight into the metabolism function in vivo may be gained. Due to the underlying physical nature of PET, 3D imaging techniques in terms of a 3D measuring mode are intrinsically demanded to assure satisfying resolutions of the reconstructed images. However, incorporating additional cross-plane measurements, which are specific for the 3D measuring mode, usually imposes an excessive amount of projection data and significantly complicates the reconstruction procedure. For this reason, interpolation-based reconstruction methods deserve a thorough investigation, whose crucial parts are the interpolating processes in the 3D frequency domain. The benefit of such approaches is apparently short reconstruction duration, which can, however, only be achieved at the expense of accepting the inaccuracies associated with the interpolating process. In the present paper, two distinct approaches to the realization of the interpolating procedure are proposed and analyzed. The first one refers to a direct approach based on linear averaging (inverse distance weighting), and the second one refers to an indirect approach based on two-dimensional convolution (gridding method). In particular, attention is paid to two aspects of the gridding method. The first aspect is the choice of the two-dimensional convolution function applied, and the second one is the correct discretization of the underlying continuous convolution. In this respect, the geometrical structure named the Voronoi diagram and its computational construction are considered. At the end, results of performed simulation studies are presented and discussed.
    Źródło:
    International Journal of Applied Mathematics and Computer Science; 2008, 18, 1; 63-73
    1641-876X
    2083-8492
    Pojawia się w:
    International Journal of Applied Mathematics and Computer Science
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Modern radiation techniques for treatment of head and neck cancers
    Autorzy:
    Kiprian, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/1401820.pdf
    Data publikacji:
    2015
    Wydawca:
    Index Copernicus International
    Tematy:
    positron emission tomography
    radiotherapy
    throat
    apoptosis
    Opis:
    Alongside surgery, radiation therapy remains the mainstay of treatment for head and neck cancers.  Because the head and neck contain a number of critically important structures, it is crucial to try to curtail the adverse effects of radiation therapy by increasing its precision. Such precise radiation techniques include the three-dimensional conformal as well as highly conformal radiotherapy. The latter includes, for instance, intensity modulated radiation therapy (IMRT), stereotactic radiation, and proton-beam therapy. All of the above-mentioned techniques are available in Poland and give the opportunity of a more aggressive treatment that lead to improved outcomes, curtailment of adverse effects, and by that, a better quality of life.
    Źródło:
    Polski Przegląd Otorynolaryngologiczny; 2015, 4, 4; 1-10
    2084-5308
    2300-7338
    Pojawia się w:
    Polski Przegląd Otorynolaryngologiczny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Spectacular efficacy of neoadjuvant chemotherapy in a patient with cervical cancer of IB2 grade according to FIGO 2009
    Spektakularna skuteczność chemioterapii neoadiuwantowej u pacjentki z rozpoznaniem raka szyjki macicy w stopniu IB2 według FIGO 2009 r.
    Autorzy:
    Kaźmierczak, Kamila
    Nowakowski, Błażej
    Kufel-Grabowska, Joanna
    Cholewiński, Witold
    Powiązania:
    https://bibliotekanauki.pl/articles/1035650.pdf
    Data publikacji:
    2020
    Wydawca:
    Medical Education
    Tematy:
    cervical cancer
    neoadjuvant chemotherapy
    positron emission tomography
    Opis:
    The presented case report is an example of a spectacular effect of induction systemic treatment in a patient with locally advanced cervical cancer of IB2 grade according to FIGO 2009 (International Federation of Gynecologist and Obstetrician). The effect of induction chemotherapy (three series in paclitaxel/24 h + cisplatin regimen at an interval of three weeks) was the total metabolic response of the primary tumor and nodal lesions found in FDG-PET/CT (18F-fluorodeoxyglucose – positron emission tomography combined with computed tomography) as well as an image of total regression of the tumor in the obtained postoperative histopathological examination.
    Przedstawiony opis przypadku jest przykładem spektakularnego efektu zastosowania chemioterapii neoadiuwantowej (NACT, neoadjuvant chemotherapy) u pacjentki z miejscowo zaawansowanym rakiem szyjki macicy w stopniu IB2 według FIGO 2009 r. (International Federation of Gynecologist and Obstetrician). Efektem zastosowanej chemioterapii indukcyjnej (trzech serii w schemacie paklitaksel/24 h + cisplatyna w odstępie 3-tygodniowym) była całkowita odpowiedź metaboliczna guza pierwotnego i zmian węzłowych stwierdzona w badaniu FDG-PET/CT (18F-fluorodeoksyglukoza – pozytonowa tomografia emisyjna połączona z tomografią komputerową), a także obraz całkowitej odpowiedzi patologicznej w otrzymanym pooperacyjnym badaniu histopatologicznym.
    Źródło:
    OncoReview; 2020, 10, 2; 69-76
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    New Porosimetric Method Based on the 3γ Annihilation Rate. Applications to Materials Science and Medical Imaging
    Autorzy:
    Jasińska, B.
    Zgardzińska, B.
    Powiązania:
    https://bibliotekanauki.pl/articles/1033228.pdf
    Data publikacji:
    2017-11
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    positron annihilation
    positronium
    3γ annihilation
    porosity
    positron emission tomography
    medical imaging
    Opis:
    A new parameter δ based on 3γ annihilation is proposed. It describes the porosity of the materials containing small intermolecular voids below 1 nm. It can be applied to material investigation to compare changes in the material porosity depending on temperature or pressure as well as to study of ageing or manufacturing processes. Particularly it is dedicated to prepare the new imaging method and can be used during positron emission tomography diagnosis allowing determination the kind or stage of pathogenic alteration.
    Źródło:
    Acta Physica Polonica A; 2017, 132, 5; 1616-1619
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Preparation and biological evaluation of [61Cu]bleomycin complex as a possible PET radiopharmaceutical in normal and fibrosarcoma-bearing animals
    Autorzy:
    Jalilian, A. R.
    Zandi, H.
    Sardari, D.
    Akhlaghi, M.
    Kamali-Dehghan, M.
    Shafaei, K.
    Majdabadi, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/148090.pdf
    Data publikacji:
    2009
    Wydawca:
    Instytut Chemii i Techniki Jądrowej
    Tematy:
    radiopharmaceutical
    copper-61
    bleomycin
    positron emission tomography
    fibrosarcoma
    Opis:
    [61Cu]bleomycin ([61Cu]BLM) was prepared using [61Cu]CuCl2 produced via natZn(p,x)61Cu. [61Cu]BLM was prepared under optimized conditions (room temperature, 45 min, 0.1 mg bleomycin for 92.5–370 MBq 61CuCl2) with radiochemical purity over 98% shown by HPLC and RTLC. [61Cu]BLM was administered into normal and tumor bearing rodents up to 210 min followed by biodistribution and co-incidence imaging studies. A significant tumor/non tumor accumulation was observed either by animal sacrification or an imaging method. [61Cu]BLM can be a potential PET radiotracer for tumor imaging.
    Źródło:
    Nukleonika; 2009, 54, 2; 135-141
    0029-5922
    1508-5791
    Pojawia się w:
    Nukleonika
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Preparation, quality control and biodistribution studies of [61Cu]-oxinate for PET tumor imaging
    Autorzy:
    Jalilian, A. R.
    Zolghadri, S.
    Faghihi, R.
    Yousefnia, H.
    Garousi, J.
    Shafaii, K.
    Bolourinovin, F.
    Powiązania:
    https://bibliotekanauki.pl/articles/148094.pdf
    Data publikacji:
    2009
    Wydawca:
    Instytut Chemii i Techniki Jądrowej
    Tematy:
    copper-61
    8-hydroxyquinoline
    positron emission tomography
    fibrosarcoma
    Opis:
    Targeting apoptosis is an interesting issue in molecular imaging and various modalities have been presented. However, recent experiences in nuclear pharmacy demonstrated the application of small tracer molecules is more desired. This work was conducted for production of a radiolabeled copper complex, i.e. 61Cu-oxinate as a potential PET tracer for apoptosis imaging in oncology. Cu-61 was prepared by natural zinc target irradiation with 22 MeV protons (150 miA) via the natZn(p, xn)61Cu nuclear reaction with a yield of 3.33 mCi/miAh. In order to obtain the best labeling method, optimization reactions were performed for pH, temperature and concentration followed by solid phase extraction. Biodistribution of the tracer was studied in wild-type and fibrosarcoma bearing mice. Under the optimized conditions, radio-thin-layer chromatography (RTLC) and HPLC showed radiochemical purities of 99.99% and 97% respectively (with a minimum specific activity of 16 Ci/mM). Biodistribution of the tracer in fibrosarcoma bearing mice demonstrated a significant tumor uptake after 3 h. Tumor:blood and tumor:muscle ratios were 2.0 and 6.0 after 3 h, respectively.
    Źródło:
    Nukleonika; 2009, 54, 3; 175-179
    0029-5922
    1508-5791
    Pojawia się w:
    Nukleonika
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Development of [66Ga]oxine complex; a possible PET tracer
    Autorzy:
    Jalilian, A.
    Rowshanfarzad, P.
    Sabet, M.
    Rahiminejad-Kisomi, A.
    Rajamand, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/146276.pdf
    Data publikacji:
    2006
    Wydawca:
    Instytut Chemii i Techniki Jądrowej
    Tematy:
    gallium-66
    oxine
    positron emission tomography
    blood cell labeling
    stability
    Opis:
    The aim of this work is development of a possible blood cell labeling agent for ultimate use in PET. Gallium-66 (T1/2 = 9.49 h) is an interesting radionuclide that has a potential for positron emission tomography (PET) imaging of biological processes with intermediate to slow target tissue uptake. Oxine has been labeled with this radionuclide in the form of [66Ga]gallium chloride for its possible diagnostic properties. In this study, 66Ga was produced at a 30 MeV cyclotron (IBA-Cyclone 30) via the 66Zn(p,n)66Ga reaction. The production yield was 445.5 MBq/mAh. The [66Ga]oxine complex was obtained at pH = 5 in phosphate buffer medium at 37°C in 10 min. Radio-TLC showed a radiochemical purity of more than 98 š 2%. The chemical stability of the complex was checked in vitro with a specific activity of 1113 GBq/mmol. The serum stability and log P of the complex were calculated. The produced [66Ga]oxine can be used for diagnostic studies, due to its desirable physico-chemical properties both in vitro and in vivo according to internationally accepted limits.
    Źródło:
    Nukleonika; 2006, 51, 3; 155-159
    0029-5922
    1508-5791
    Pojawia się w:
    Nukleonika
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    PF-6 an effective plasma focus as a source of ionizing radiation and plasma streams for application in material technology, biology and medicine
    Autorzy:
    Gribkov, V.
    Dubrovsky, A.
    Scholz, M.
    Jednorog, S.
    Karpiński, L.
    Tomaszewski, K.
    Paduch, M.
    Miklaszewski, R.
    Pimenov, V.
    Ivanov, L. I.
    Dyomina, E. V.
    Maslyaev, S. A.
    Orlova, M. A.
    Powiązania:
    https://bibliotekanauki.pl/articles/147424.pdf
    Data publikacji:
    2006
    Wydawca:
    Instytut Chemii i Techniki Jądrowej
    Tematy:
    dense plasma focus (DPF)
    ion beam
    plasma beam
    X-ray beams
    surface damage
    microlithography
    radioenzymology
    positron emission tomography (PET)
    Opis:
    A review of results on the design and operation of the new efficient Dense Plasma Focus device PF-6 of medium size (transportable) having bank energy of ca. 7 kJ and possessing a long lifetime is presented. New data on the interaction of the pulsed fast ion beams and dense plasma streams generated at this apparatus with various materials are given. These results are compared with the analogous information received at the biggest facility PF-1000. It is shown that it is possible to have about the same power flux density (in the range of 105 109 W/cm2) in both devices however in different areas. Doses of soft X-rays produced by the device within the resists for the goals of microlithography and micromachining appear to be several times less that it is with the conventional X-ray tube. In biological application of this device, medium- and hard-energy X-rays are exploited in the field of radioenzymology. It was found that the necessary dose producing activation/inactivation of enzymes can be by several orders of magnitude lower if used at a high-power flux density in comparison with those received with isotope sources. In medicine, short-life isotope production for the goals of the positron emission tomography (medicine diagnostics) is possible by means of the fast ions generated within DPF. All these experiments are discussed in the framework of pulsed radiation physics and chemistry in its perfect sense thereto the criteria are formulated.
    Źródło:
    Nukleonika; 2006, 51, 1; 55-62
    0029-5922
    1508-5791
    Pojawia się w:
    Nukleonika
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Choroba Bourneville'a-Pringle'a - opis przypadku
    Morbus Bourneville-pringle – case report
    Autorzy:
    Dryla, Przemysław
    Wojtuń, Stanisław
    Gil, Jerzy
    Jałocha, Łukasz
    Wojtkowiak, Marek
    Błaszak, Antoni
    Powiązania:
    https://bibliotekanauki.pl/articles/1031081.pdf
    Data publikacji:
    2008
    Wydawca:
    Medical Communications
    Tematy:
    tuberous sclerosis complex
    bourneville-pringle syndrome
    computer tomography
    positron emission tomography
    endoscopy
    stwardnienie guzowate
    choroba bourneville’a-pringle’a
    tomografia komputerowa
    pozytronowa tomografia emisyjna
    endoskopia
    Opis:
    Tuberous sclerosis complex (TSC), known as Bourneville-Pringle syndrome, is a genetically conditioned multiple organ disease associated with mental retardation and epilepsy. It could be found in any ethnic groups and races in both sexes. It is estimated that about 2 million people suffer from the disease in the world. Clinical manifestations in the disease could be various. Many signs appear along with the natural development of a child. Lesions that could be found in the disease are associated with skin, nervous system, eye bulbs, heart, kidneys, liver and intestines. These could take form of cysts as well as tumours that could become malignant. Histologically these are fibromas, lipomas, myomas or vasolipomyomas. Specific organ lesions do not require histological confirmation. TSC diagnosis could be established on Gomez criteria established on TSC Consensus in Annapolis in 1998. TSC diagnosis could be assumed as final, when two major criteria are met or one major and two minor. There are no pathognomonic signs of TSC. That means many signs should be taken into account, sometimes hard to find in not highly specialized assessment. Many specialists and specific tests should take part in diagnosis establishment (dermatologic, neurologic, oculistic, cardiologic, endoscopic and imaging procedures – USG, CT, MRI, PET-CT). Family background and often assessment of family members is essential for diagnosis establishment. Therapeutic indications for specific organ lesions need individual approach. Treatment of the illness could be only palliative. It is based on surgical procedures of malignant tumours resection and antiepileptic treatment. In the paper authors discuss case of woman with liver lesions. Those weren’t assessed histologically because of the high risk of hemorrhagic complications. Follow-up was planned with use of imaging procedures. Discussed case shows that during decision making process risk assessment of imaging procedures should be taken into account.
    Stwardnienie guzowate (tuberous sclerosis complex, TSC), nazywane chorobą Bourneville’a-Pringle’a to wielo-narządowa choroba uwarunkowana genetycznie, związana z upośledzeniem umysłowym i padaczką. Spotykane jest we wszystkich grupach etnicznych i rasowych, jednakowo często u obojga płci. Szacuje się, że występuje u około 2 milionów osób na świecie. Zmienność obrazu klinicznego w stwardnieniu guzowatym jest bardzo duża. Wiele objawów pojawia się wraz z rozwojem dziecka. Zmiany dotyczą głównie skóry oraz układu nerwowego, a także gałek ocznych, serca, nerek, wątroby i jelit. Mogą przyjmować postać torbieli i guzów wykazujących nierzadko tendencję do transformacji w nowotwory złośliwe. Pod względem histopatologicznym są to włókniaki, tłuszczaki, mięśniaki, naczyniakotłuszczakomięśniaki. Poszczególne zmiany narządowe z reguły nie wymagają potwierdzenia histopatologicznego. Diagnoza TSC standardowo stawiana jest na podstawie zmienionych kryteriów Gomeza ustalonych na TSC Consensus Conference w Annapolis w 1998 roku. Rozpoznanie TSC uważa się za ostateczne, gdy spełnione są dwa większe kryteria albo jedno większe i dwa mniejsze. Nie ma patognomonicznych dla TSC objawów, co oznacza, że diagnoza musi uwzględniać liczne objawy, często nieuchwytne w niespecjalistycznym badaniu lekarskim. W rozpoznaniu konieczne są współpraca wielu specjalistów oraz wykonanie badań wielokierunkowych (badanie dermatologiczne, neurologiczne, okulistyczne, kardiologiczne, badania endoskopowe, badania obrazowe - USG, TK, MRI, PET-CT). Kluczowe jest dokładne zebranie wywiadu rodzinnego i nierzadko przebadanie pozostałych członków rodziny. Leczenie chorych ze stwardnieniem guzowatym jest objawowe i polega na chirurgicznym usuwaniu guzów złośliwych i podawaniu leków przeciwpadaczkowych. Zalecenia terapeutyczne dla poszczególnych zmian narządowych wymagają indywidualnego rozpatrzenia. W pracy omówiono przypadek chorej kobiety, u której stwierdzono zmiany ogniskowe wątroby. Chociaż istniało podejrzenie ich złośliwego charakteru, nie zostało ono zweryfikowane histopatologicznie z powodu wysokiego ryzyka powikłań krwotocznych. U pacjentki zaplanowano badania kontrolne z wykorzystaniem badań obrazowych. Omawiany przypadek pokazuje, że czasami w podejmowaniu decyzji trzeba uwzględnić ryzyko stosowanych metod diagnostycznych.
    Źródło:
    Pediatria i Medycyna Rodzinna; 2008, 4, 3; 189-194
    1734-1531
    2451-0742
    Pojawia się w:
    Pediatria i Medycyna Rodzinna
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Zastosowanie PET/CT w neurologii
    PET/CT in neurology
    Autorzy:
    Cegła, Paulina
    Chrapko, Beata
    Pietrasz, Katarzyna
    Cholewiński, Witold
    Powiązania:
    https://bibliotekanauki.pl/articles/986633.pdf
    Data publikacji:
    2019
    Wydawca:
    Indygo Zahir Media
    Tematy:
    pozytonowa tomografia emisyjna
    neurologia
    obrazowanie molekularne
    positron emission tomography
    neurology
    molecular imaging
    Opis:
    Pozytonowa tomografia emisyjna w połączeniu z tomografią komputerową (positron emission tomography/computed tomography, PET/CT) jest techniką dostarczającą informacji na temat różnych procesów zachodzących w ośrodkowym układzie nerwowym (OUN). Pozwala na ocenę metabolizmu glukozy (18F-fluorodeoksyglukoza, 18F-FDG), układu dopaminergicznego (18F-DOPA) czy wychwytu aminokwasów (18F-fluoroetylotyrozyna, 18F-FET). Celem niniejszej pracy jest omówienie zastosowania techniki PET/CT w zaburzeniach neurologicznych w oparciu o analizę piśmiennictwa.
    Positron emission tomography/computed tomography (PET/ CT) is an imaging technique used for assessment of different metabolic processes of central nervous system (CNS). Allows to evaluate glucose metabolism (18F-Fluorodeoxyglucose, 18F-FDG), dopaminergic pathway integrity (18F-dihydroxyphenylalanine, 18F-DOPA) and amino acid uptake (18F-fluoroethylo-thyrosine, 18F-FET). The aim of this review is to discuss the usefulness of the PET/CT method in the neurological disorders based on literature review.
    Źródło:
    Inżynier i Fizyk Medyczny; 2019, 8, 2; 79-83
    2300-1410
    Pojawia się w:
    Inżynier i Fizyk Medyczny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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