Temat: positron emission tomography - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Modern radiation techniques for treatment of head and neck cancers
Autorzy:: Kiprian, Dorota
Powiązania:: https://bibliotekanauki.pl/articles/1401820.pdf
Data publikacji:: 2015
Wydawca:: Index Copernicus International
Tematy:: positron emission tomography
radiotherapy
throat
apoptosis
Opis:: Alongside surgery, radiation therapy remains the mainstay of treatment for head and neck cancers. Because the head and neck contain a number of critically important structures, it is crucial to try to curtail the adverse effects of radiation therapy by increasing its precision. Such precise radiation techniques include the three-dimensional conformal as well as highly conformal radiotherapy. The latter includes, for instance, intensity modulated radiation therapy (IMRT), stereotactic radiation, and proton-beam therapy. All of the above-mentioned techniques are available in Poland and give the opportunity of a more aggressive treatment that lead to improved outcomes, curtailment of adverse effects, and by that, a better quality of life.
Źródło:: Polski Przegląd Otorynolaryngologiczny; 2015, 4, 4; 1-10
2084-5308
2300-7338
Pojawia się w:: Polski Przegląd Otorynolaryngologiczny
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Spectacular efficacy of neoadjuvant chemotherapy in a patient with cervical cancer of IB2 grade according to FIGO 2009
Spektakularna skuteczność chemioterapii neoadiuwantowej u pacjentki z rozpoznaniem raka szyjki macicy w stopniu IB2 według FIGO 2009 r.
Autorzy:: Kaźmierczak, Kamila
Nowakowski, Błażej
Kufel-Grabowska, Joanna
Cholewiński, Witold
Powiązania:: https://bibliotekanauki.pl/articles/1035650.pdf
Data publikacji:: 2020
Wydawca:: Medical Education
Tematy:: cervical cancer
neoadjuvant chemotherapy
positron emission tomography
Opis:: The presented case report is an example of a spectacular effect of induction systemic treatment in a patient with locally advanced cervical cancer of IB2 grade according to FIGO 2009 (International Federation of Gynecologist and Obstetrician). The effect of induction chemotherapy (three series in paclitaxel/24 h + cisplatin regimen at an interval of three weeks) was the total metabolic response of the primary tumor and nodal lesions found in FDG-PET/CT (18F-fluorodeoxyglucose – positron emission tomography combined with computed tomography) as well as an image of total regression of the tumor in the obtained postoperative histopathological examination.
Przedstawiony opis przypadku jest przykładem spektakularnego efektu zastosowania chemioterapii neoadiuwantowej (NACT, neoadjuvant chemotherapy) u pacjentki z miejscowo zaawansowanym rakiem szyjki macicy w stopniu IB2 według FIGO 2009 r. (International Federation of Gynecologist and Obstetrician). Efektem zastosowanej chemioterapii indukcyjnej (trzech serii w schemacie paklitaksel/24 h + cisplatyna w odstępie 3-tygodniowym) była całkowita odpowiedź metaboliczna guza pierwotnego i zmian węzłowych stwierdzona w badaniu FDG-PET/CT (18F-fluorodeoksyglukoza – pozytonowa tomografia emisyjna połączona z tomografią komputerową), a także obraz całkowitej odpowiedzi patologicznej w otrzymanym pooperacyjnym badaniu histopatologicznym.
Źródło:: OncoReview; 2020, 10, 2; 69-76
2450-6125
Pojawia się w:: OncoReview
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Compact cyclotrons for the production of tracers and radiopharmaceuticals
Autorzy:: Paans, A.
Powiązania:: https://bibliotekanauki.pl/articles/146155.pdf
Data publikacji:: 2003
Wydawca:: Instytut Chemii i Techniki Jądrowej
Tematy:: positron emission tomography (PET)
cyclotron
radionuclide production
Opis:: Positron Emission Tomography (PET) is a method for determining biochemical and physiological processes in vivo in a quantitative manner. The most commonly used radionuclides are 11C, 13N, 15O and 18F, with respective half-lives of approximately 20 min, 10 min, 2 min, and 110 min. 18F labeled FDG (fluoro-2-deoxy-D-glucose) is now the most frequently used radiopharmaceutical and finds its application prominently in the field of oncology. Originally, the production of these radionuclides was performed with the existing accelerators, designed for nuclear physics, but with increasing interest in the PET methodology specially designed PET-production cyclotrons became available. The nuclear reactions involved are (p,n), (d,n), (p,a) and (d,a) and the thresholds for the nuclear reactions involved are 5 to 6 MeV. Based on these values and on other parameters, a proton 15 to 20 MeV cyclotron is often chosen. Since the half-life of a radionuclide limits the production time, the maximum beam current is an important parameter, together with the target construction, for the ultimate yield obtainable. In the development of special PET production cyclotrons, attention has also been paid to improve the extraction efficiency and the possibility of multiple extractions by designing negative ion cyclotrons. Commercial cyclotrons can often be acquired as an easy to operate integrated radionuclide production unit including targetry and some units. Regional FDG factories are nowadays being created to fulfil the demand for PET radiopharmaceutics. The possible choices in commercially available cyclotrons for the production of PET radionuclides will be discussed.
Źródło:: Nukleonika; 2003, 48,suppl.2; 169-172
0029-5922
1508-5791
Pojawia się w:: Nukleonika
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Preparation, quality control and biodistribution studies of [61Cu]-oxinate for PET tumor imaging
Autorzy:: Jalilian, A. R.
Zolghadri, S.
Faghihi, R.
Yousefnia, H.
Garousi, J.
Shafaii, K.
Bolourinovin, F.
Powiązania:: https://bibliotekanauki.pl/articles/148094.pdf
Data publikacji:: 2009
Wydawca:: Instytut Chemii i Techniki Jądrowej
Tematy:: copper-61
8-hydroxyquinoline
positron emission tomography
fibrosarcoma
Opis:: Targeting apoptosis is an interesting issue in molecular imaging and various modalities have been presented. However, recent experiences in nuclear pharmacy demonstrated the application of small tracer molecules is more desired. This work was conducted for production of a radiolabeled copper complex, i.e. 61Cu-oxinate as a potential PET tracer for apoptosis imaging in oncology. Cu-61 was prepared by natural zinc target irradiation with 22 MeV protons (150 miA) via the natZn(p, xn)61Cu nuclear reaction with a yield of 3.33 mCi/miAh. In order to obtain the best labeling method, optimization reactions were performed for pH, temperature and concentration followed by solid phase extraction. Biodistribution of the tracer was studied in wild-type and fibrosarcoma bearing mice. Under the optimized conditions, radio-thin-layer chromatography (RTLC) and HPLC showed radiochemical purities of 99.99% and 97% respectively (with a minimum specific activity of 16 Ci/mM). Biodistribution of the tracer in fibrosarcoma bearing mice demonstrated a significant tumor uptake after 3 h. Tumor:blood and tumor:muscle ratios were 2.0 and 6.0 after 3 h, respectively.
Źródło:: Nukleonika; 2009, 54, 3; 175-179
0029-5922
1508-5791
Pojawia się w:: Nukleonika
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Application of the compress sensing theory for improvement of the TOF resolution in a novel J-PET instrument
Autorzy:: Raczyński, L.
Moskal, P.
Kowalski, P.
Wiślicki, W.
Bednarski, T.
Białas, P.
Czerwiński, E.
Gajos, A.
Kapłon, Ł.
Kochanowski, A.
Korcyl, G.
Kowal, J.
Kozik, T.
Krzemień, W.
Kubicz, E.
Niedźwiecki, S.
Pałka, M.
Rudy, Z.
Salabura, P.
Gupta-Sharma, N.
Silarski, M.
Słomski, A.
Smyrski, J.
Strzelecki, A.
Wieczorek, A.
Zieliński, M.
Zoń, N.
Powiązania:: https://bibliotekanauki.pl/articles/146280.pdf
Data publikacji:: 2016
Wydawca:: Instytut Chemii i Techniki Jądrowej
Tematy:: compressed sensing
positron emission tomography
time-of-flight
Opis:: Nowadays, in positron emission tomography (PET) systems, a time of fl ight (TOF) information is used to improve the image reconstruction process. In TOF-PET, fast detectors are able to measure the difference in the arrival time of the two gamma rays, with the precision enabling to shorten signifi cantly a range along the line-of-response (LOR) where the annihilation occurred. In the new concept, called J-PET scanner, gamma rays are detected in plastic scintillators. In a single strip of J-PET system, time values are obtained by probing signals in the amplitude domain. Owing to compressive sensing (CS) theory, information about the shape and amplitude of the signals is recovered. In this paper, we demonstrate that based on the acquired signals parameters, a better signal normalization may be provided in order to improve the TOF resolution. The procedure was tested using large sample of data registered by a dedicated detection setup enabling sampling of signals with 50-ps intervals. Experimental setup provided irradiation of a chosen position in the plastic scintillator strip with annihilation gamma quanta.
Źródło:: Nukleonika; 2016, 61, 1; 35-39
0029-5922
1508-5791
Pojawia się w:: Nukleonika
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: Preparation and biological evaluation of [61Cu]bleomycin complex as a possible PET radiopharmaceutical in normal and fibrosarcoma-bearing animals
Autorzy:: Jalilian, A. R.
Zandi, H.
Sardari, D.
Akhlaghi, M.
Kamali-Dehghan, M.
Shafaei, K.
Majdabadi, A.
Powiązania:: https://bibliotekanauki.pl/articles/148090.pdf
Data publikacji:: 2009
Wydawca:: Instytut Chemii i Techniki Jądrowej
Tematy:: radiopharmaceutical
copper-61
bleomycin
positron emission tomography
fibrosarcoma
Opis:: [61Cu]bleomycin ([61Cu]BLM) was prepared using [61Cu]CuCl2 produced via natZn(p,x)61Cu. [61Cu]BLM was prepared under optimized conditions (room temperature, 45 min, 0.1 mg bleomycin for 92.5–370 MBq 61CuCl2) with radiochemical purity over 98% shown by HPLC and RTLC. [61Cu]BLM was administered into normal and tumor bearing rodents up to 210 min followed by biodistribution and co-incidence imaging studies. A significant tumor/non tumor accumulation was observed either by animal sacrification or an imaging method. [61Cu]BLM can be a potential PET radiotracer for tumor imaging.
Źródło:: Nukleonika; 2009, 54, 2; 135-141
0029-5922
1508-5791
Pojawia się w:: Nukleonika
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: PET and SPECT imaging as a solid guide to detect and discriminate atypical phenotypes of neurodegenerative disorders
Autorzy:: Ruffini, Livia
Zilioli, Alessandro
Cervati, Veronica
Lauretani, Fulvio
Misirocchi, Francesco
Maggio, Marcello
Migliari, Silvia
Graziani, Tiziano
Cidda, Carla
Baldari, Giorgio
Spallazzi, Marco
Scarlattei, Maura
Powiązania:: https://bibliotekanauki.pl/articles/40521373.pdf
Data publikacji:: 2024-03-30
Wydawca:: Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:: atypical phenotypes
neurodegenerative diseases
positron emission tomography
single photon emission computed tomography
Opis:: Introduction and aim. Atypical or mixed presentations of neurodegenerative disorders may postpone or confound the final diagnosis. Molecular imaging with positron emission tomography (PET) and single photon emission computed tomography (SPECT) radioligands provide target-specific information and may anticipate the diagnosis by “in vivo” detection of the neuropathological substrate, as Aβ deposition, nigrostriatal dopaminergic depletion or tau inclusions. This concise review will discuss the potential of PET and SPECT imaging as a solid guide to better characterize atypical phenotypes of neurodegeneration in the clinical routine, with the potential to drive personalized interventions, improve cohort uniformity for clinical trials, and serve as biomarkers for targeted molecular therapies. Material and methods. Literature search was performed focusing on the role of PET and SPECT imaging in assessing atypical phenotypes of neurodegeneration, using the electronic source of database PubMed/MEDLINE and the web-based search engines Google, Google Scholar. Analysis of the literature. New disease-modifying drugs may increase their effect with early initiation, which is especially important in working persons and younger subjects presenting atypical symptoms. In older individuals, the coexistence of neurodegeneration, age-related changes, cerebrovascular lesions, or depression makes challenging a definitive diagnosis. Quantitative tools able to measure tracer distribution increase the accuracy of molecular neuroimaging creating topographic maps that compare subject’s data with healthy controls databases. Conclusion. Atypical phenotypes may be associated with quantitative key-pattern allowing a more precise and early diagnosis of the neurodegenerative disorder. Finally, quantitative assessment of the pathological substrates allows us to track the disease process and measure treatment response.
Źródło:: European Journal of Clinical and Experimental Medicine; 2024, 22, 1; 201-221
2544-2406
2544-1361
Pojawia się w:: European Journal of Clinical and Experimental Medicine
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 8.

Tytuł:: New Porosimetric Method Based on the 3γ Annihilation Rate. Applications to Materials Science and Medical Imaging
Autorzy:: Jasińska, B.
Zgardzińska, B.
Powiązania:: https://bibliotekanauki.pl/articles/1033228.pdf
Data publikacji:: 2017-11
Wydawca:: Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:: positron annihilation
positronium
3γ annihilation
porosity
positron emission tomography
medical imaging
Opis:: A new parameter δ based on 3γ annihilation is proposed. It describes the porosity of the materials containing small intermolecular voids below 1 nm. It can be applied to material investigation to compare changes in the material porosity depending on temperature or pressure as well as to study of ageing or manufacturing processes. Particularly it is dedicated to prepare the new imaging method and can be used during positron emission tomography diagnosis allowing determination the kind or stage of pathogenic alteration.
Źródło:: Acta Physica Polonica A; 2017, 132, 5; 1616-1619
0587-4246
1898-794X
Pojawia się w:: Acta Physica Polonica A
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 9.

Tytuł:: Development of [66Ga]oxine complex; a possible PET tracer
Autorzy:: Jalilian, A.
Rowshanfarzad, P.
Sabet, M.
Rahiminejad-Kisomi, A.
Rajamand, A.
Powiązania:: https://bibliotekanauki.pl/articles/146276.pdf
Data publikacji:: 2006
Wydawca:: Instytut Chemii i Techniki Jądrowej
Tematy:: gallium-66
oxine
positron emission tomography
blood cell labeling
stability
Opis:: The aim of this work is development of a possible blood cell labeling agent for ultimate use in PET. Gallium-66 (T1/2 = 9.49 h) is an interesting radionuclide that has a potential for positron emission tomography (PET) imaging of biological processes with intermediate to slow target tissue uptake. Oxine has been labeled with this radionuclide in the form of [66Ga]gallium chloride for its possible diagnostic properties. In this study, 66Ga was produced at a 30 MeV cyclotron (IBA-Cyclone 30) via the 66Zn(p,n)66Ga reaction. The production yield was 445.5 MBq/mAh. The [66Ga]oxine complex was obtained at pH = 5 in phosphate buffer medium at 37°C in 10 min. Radio-TLC showed a radiochemical purity of more than 98 š 2%. The chemical stability of the complex was checked in vitro with a specific activity of 1113 GBq/mmol. The serum stability and log P of the complex were calculated. The produced [66Ga]oxine can be used for diagnostic studies, due to its desirable physico-chemical properties both in vitro and in vivo according to internationally accepted limits.
Źródło:: Nukleonika; 2006, 51, 3; 155-159
0029-5922
1508-5791
Pojawia się w:: Nukleonika
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 10.

Tytuł:: Preliminary design and simulation of a spherical brain PET system (SBPET) with liquid xenon as scintillator
Autorzy:: Moghaddam, N. M.
Karimian, A.
Mostajaboddavati, S. M.
Vondervoort, E.
Sossi, V.
Powiązania:: https://bibliotekanauki.pl/articles/146444.pdf
Data publikacji:: 2009
Wydawca:: Instytut Chemii i Techniki Jądrowej
Tematy:: positron emission tomography (PET)
Monte Carlo simulation
GATE
liquid xenon
brain imaging
Opis:: Preliminary design of a spherical brain PET (SBPET) using liquid xenon (LXe) as detector is considered in this research work. The major advantage of a spherical design is the large solid angle of acceptance which improves the sensitivity and increases signal-to-noise ratio (SNR) of the image. The use of a liquid active medium enabled us to design a spherical detector. LXe, due to the intrinsic physical properties, is an excellent liquid medium for accurate tracking of gamma rays in the relevant energy range. The performance of SBPET was evaluated by Monte Carlo simulation tools (GATE) and compared to ECAT HRRT. The numerical results showed the SBPET has a sensitivity of 1.14% and spatial resolution of ~2.7 mm FWHM which is superior to ECAT HRRT especially at high-count rates.
Źródło:: Nukleonika; 2009, 54, 1; 33-38
0029-5922
1508-5791
Pojawia się w:: Nukleonika
Dostawca treści:: Biblioteka Nauki

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