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    Wyświetlanie 1-5 z 5
    Tytuł:
    Porcine model in the laparoscopic liver surgery training
    Autorzy:
    Komorowski, Andrzej
    Mituś, Jerzy
    Sanchez Hurtado, Miguel Angel
    Sanchez Margallo, Francisco Miguel
    Powiązania:
    https://bibliotekanauki.pl/articles/1394344.pdf
    Data publikacji:
    2015
    Wydawca:
    Index Copernicus International
    Tematy:
    laparoscopic liver resection
    porcine model
    laparoscopic training
    Opis:
    The aim of the study was to evaluate the possibility to use live anesthetized pigs as a model for laparoscopic liver resection. During two days laparoscopy course two trainees were operating on two live animals performing exposure of the liver, Pringle manoeuver, division of liver ligaments, dissecting of the structures inside the hepatoduodenal ligament, dissection of the hepatic veins and left lateral liver sectionectomy. Exposure of the liver and Pringle manoeuver were performed correctly within 50 and 35 minutes. Left lateral sectionectomy has been performed correctly within 2 hours. The full dissection of the hepatoduodenal ligament and exposure of the hepatic veins were judged as insufficient by experienced laparoscopic tutors. There was one injury to the suprahepatic vena cava that was managed laparoscopically. The porcine model can be used as an advanced training for laparoscopic liver surgery.
    Źródło:
    Polish Journal of Surgery; 2015, 87, 8; 425-428
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Novel potential of pancreatic-like enzymes of microbial origin in exocrine pancreatic insufficiency - study on a pig model
    Autorzy:
    Szwiec, K.
    Goncharova, K.
    Velverde-Piedra, J.L.
    Ushakova, G.
    Kovalenko, T.
    Osadchenko, I.
    Kardas, M.
    Swieboda, P.
    Podgurniak, P.
    Winiarczyk, M.
    Grochowska-Niedworok, E.
    Lozinska, L.
    Filip, R.
    Pierzynowski, S.G.
    Powiązania:
    https://bibliotekanauki.pl/articles/3181.pdf
    Data publikacji:
    2015
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    pancreatic-like enzyme
    microbial enzyme
    exocrine pancreatic insufficiency
    porcine model
    pig
    animal model
    enzyme activity
    Opis:
    Introduction. The standard porcine-derived pancreatic enzyme replacement therapy (PERT) is a lifesaving treatment for patients with diseases causing exocrine pancreatic insufficiency (EPI). An attempt to replace PERT with microbial enzymes were undertaken. The aim was to highlight whether the mode of application, mixed with food or applied directly to the stomach, of pancreatic-like enzymes of microbial origin (PLEM) can affect their activity along the gastrointestinal tract. Materials and method. The activity of amylase, lipase and proteinase in the stomach, duodenum and ileum were tested in EPI pigs (n=6) after supplementation of PLEM, either orally – before and during feed consumption – or via the stomach – before and during feed consumption. Healthy pigs not treated with PLEM (n=3) served as controls. Activity of the enzymes measured in the chyme were obtained together with the digesta pH. Activity of the enzymatic residues in the stool samples was also checked. Results. The highest pancreatic enzyme activities were found in the duodenum of the healthy pigs (amylase 162,68 kU/ mL, lipase 507,34 kU/mL and protolitic (trypsin) activity 357,60 kU/mL). Nevertheless, the microbial enzymes remained also active along the entire length of the GIT – including stomach in EPI pigs, regardless of their route of administration. However, activity level was significantly lower. Discussion. Results indicate that the activity pattern of PLEM in the small intestine mimics the activity of the natural endogenous pancreatic enzymes in healthy pigs. The most physiological features of PLEM were observed when enzymes were offered orally. The magnitude of PLEM activity in the stomach of EPI pigs was essential and significantly higher than that measured in healthy pigs, thus being somewhat not physiological, and for health reasons of the patients should be further explored. Interestingly, specific trypsin-like activity was measured in all parts of the GIT after PLEM application. However, proteolytic activity of the experimental proteaze in in vitro studies did not exhibit trypsin-like activity.
    Źródło:
    Journal of Pre-Clinical and Clinical Research; 2015, 09, 1
    1898-2395
    Pojawia się w:
    Journal of Pre-Clinical and Clinical Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Determination of Uniaxial Tensile Behavior of Hypodermis in Porcine Skin Based on Rule of Mixtures
    Autorzy:
    Choi, Junsuk
    Kim, Sanghoon
    Rhim, Sungsoo
    Rhee, Kyong-Yop
    Powiązania:
    https://bibliotekanauki.pl/articles/353406.pdf
    Data publikacji:
    2019
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    porcine skin
    skin layers
    visco-hyperelastic
    constitutive model
    Opis:
    In this study, we investigate the mechanical behavior of each skin layer, in terms of the nominal stress-strain curve by uniaxial tensile tests using specimens of porcine skin in two forms: dermis containing epidermis, and all three layers. All tests were performed under cyclic loading at the constant strain rate of 10-3 s-1 at ambient temperature. To measure the precise initial crosssectional areas of each layer, the thickness of each skin layer was quantified by counting the number of pixels on the photo-image using image-processing software. In the tensile test, force-strain curves of the total skin and dermis with epidermis were obtained. Subsequently, a rule of mixtures was applied to determine the nonlinear mechanical properties of the hypodermis layer. In conclusion, we could define the uniaxial tensile behavior of the hypodermis, and additionally predict the weight effect of the dermis and hypodermis layers in the tensile test.
    Źródło:
    Archives of Metallurgy and Materials; 2019, 64, 2; 491-494
    1733-3490
    Pojawia się w:
    Archives of Metallurgy and Materials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Calibration of Visco-Hyperelastic Model for Tensile Behavior of Porcine Skin
    Autorzy:
    Shin, Heonseop
    Han, Doyeon
    Kim, Sanghoon
    Rhim, Sungsoo
    Powiązania:
    https://bibliotekanauki.pl/articles/354427.pdf
    Data publikacji:
    2019
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    porcine skin
    skin layers
    visco-hyperelastic
    constitutive model
    Opis:
    Uniaxial tensile tests were performed on porcine skin to investigate the tensile stress-strain constitutive characteristic at qua-sistatic deformations using uniaxial tensile tests. Experimental results were then used to determine the parameters of the various constitutive model types for rubber, including the Mooney-Rivlin, Yeoh, Ogden, and others. The Prony series viscoelastic model was also calibrated based on the stress relaxation test. To investigate the calibrated constitutive equations (visco-hyperelastic), the falling impact test was conducted. From the viewpoint of the maximum impact load, the error was approximately 15.87%. Overall, the Ogden model predicted the experimental measurements most reasonably. The calibrated constitutive model is expected to be of practical use in describing the mechanical properties of porcine skin.
    Źródło:
    Archives of Metallurgy and Materials; 2019, 64, 3; 819-822
    1733-3490
    Pojawia się w:
    Archives of Metallurgy and Materials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Protective effect of lithium chloride on pulmonary injury caused by Actinobacillus pleuropneumoniae via inhibition of GSK-3β-NF-κB-dependent pathway
    Autorzy:
    Zhang, Y.
    Xu, W.
    Tang, Y.
    Huang, F.
    Powiązania:
    https://bibliotekanauki.pl/articles/16539075.pdf
    Data publikacji:
    2022
    Wydawca:
    Polska Akademia Nauk. Czasopisma i Monografie PAN
    Tematy:
    porcine contagious pleuropneumonia
    mouse model
    lithium chloride
    toll-likereceptor 4
    GSK-3β-NF-κB-dependent pathways
    Opis:
    Porcine contagious pleuropneumonia (PCP) is a very serious respiratory disease which is difficult to prevent and treat. In this study, the therapeutic effects of lithium chloride (LiCl) on PCP were examined using a mouse model. A mouse model of PCP was established by intranasal infections with Actinobacillus pleuropneumoniae (App). Histopathological analysis was performed by routine paraffin sections and an H-E staining method. The inflammatory factors, TLR4 and CCL2 were analyzed by qPCR. The expression levels of p-p65 and pGSK-3ß were detected using the Western Blot Method. The death rates, clinical symptoms, lung injuries, and levels of TLR-4, IL-1ß, IL-6, TNF-α, and CCL2 were observed to decrease in the App-infected mice treated with LiCl. It was determined that the LiCl treatments had significantly reduced the mortality of the App-infected cells, as well as the expressions of p-p65 and pGSK-3ß. The results of this study indicated that LiCl could improve the pulmonary injuries of mice caused by App via the inhibition of the GSK-3β-NF-κB-dependent pathways, and may potentially become an effective drug for improving pulmonary injuries caused by PCP.
    Źródło:
    Polish Journal of Veterinary Sciences; 2022, 25, 1; 35-44
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

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