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Wyszukujesz frazę "polymorphism" wg kryterium: Temat


Tytuł:
Polimorfizm języka naturalnego a twierdzenia Kurta Gödla
Autorzy:
Gomułka, Łukasz
Powiązania:
https://bibliotekanauki.pl/articles/2158817.pdf
Data publikacji:
2015
Wydawca:
Instytut Studiów Międzynarodowych i Edukacji Humanum
Tematy:
language
polymorphism
Opis:
The aim of this paper is to outline Stanisław Lem’s (1921-2006) original views on Kurt Gödl’s theorems. The project consists of five concise paragraphs in which such issues are discussed: the introduction with an explanation of selected terms: a natural language, polymorphism. The author of the article presents a short outline of certain mathematical problems, that is the problems of arithmetics and the history of trying to prove its absolute non-contradiction. The author also includes Gödl’s theorems into the greatest achievements of the scientific thought of 20th century (limitation theorems). After that, epistemological questions of Kurt Gödl’s theorems are introduced together with their original interpretation according to Stanisław Lem. The author of the paper emphasizes that this prominent philosopher and writer introduces cultural-linguistic interpretation of Gödl’s discoveries, thus suggesting that a natural language overcomes ‘Gödl-made abyss’ thanks to its characteristic polymorphism.
Źródło:
Prosopon. Europejskie Studia Społeczno-Humanistyczne; 2015, 3(12); 25-33
1730-0266
Pojawia się w:
Prosopon. Europejskie Studia Społeczno-Humanistyczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
An analysis of PPARGC1A gene polymorphism in relation to carcass quality in PIC hybrid fatteners
Analiza polimorfizmu genu PPARGC1A w odniesieniu do cech tuszy tuczników hybrydowych PIC
Autorzy:
Polasik, D.
Glodek, A.
Rybarczyk, A.
Powiązania:
https://bibliotekanauki.pl/articles/45231.pdf
Data publikacji:
2013
Wydawca:
Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Tematy:
PPARGC1A gene
gene polymorphism
polymorphism
carcass quality
hybrid
fattener
Opis:
The aim of this study was to determine the association between polymorphism located in exon 8 of PPARGC1A gene (Cys430Ser) and carcass quality in pigs. Experiment was carried out on 350 PIC hybrid fatteners. Polymorphism was analyzed using PCR-RFLP method. The frequency of genotypes was as follows: AA – 0.33, AT – 0.57, TT – 0.1, however alleles: A – 0.62, T – 0.38. In the analyzed population loss of Hardy-Weinberg equilibrium was observed (P ≤ 0.01). Statistical analysis showed that only one of the evaluated traits was associated with individual PPARGC1A genotypes. Cooling loss value for pig carcasses with TT genotype was statistically significant (P ≤ 0.05) higher than observed in those with AA and AT genotypes.
Celem niniejszych badań było wykazanie zależności pomiędzy polimorfizmem zlokalizowanym w 8 eksonie genu PPARGC1A (Cys430Ser) a cechami tuszy świń. Eksperyment został przeprowadzony na 350 tucznikach hybrydowych PIC. Polimorfizm analizowano z użyciem metody PCR-RFLP. Frekwencja genotypów była następująca: AA - 0.33, AT - 0.57, TT - 0.1, natomiast alleli: A - 0.62, T - 0.38. W analizowanej populacji zaobserwowano zachwianie równowagi genetycznej Hardy’ego-Weinberga (P ≤ 0,01). Analiza statystyczna wykazała, że tylko jedna z ocenianych cech była powiązana z poszczególnymi genotypami PPARGC1A. Wartość strat chłodzenia (%) dla świń z genotypem TT była statystycznie istotnie (P ≤ 0,05) wyższa niż obserwowana u osobników z genotypami AA i AT.
Źródło:
Acta Scientiarum Polonorum. Zootechnica; 2013, 12, 4
1644-0714
Pojawia się w:
Acta Scientiarum Polonorum. Zootechnica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Lack of correlation between X region spa polymorphism and virulence of methicillin resistant and methicillin sensitive Staphylococcus aureus strains
Autorzy:
Kurlenda, Julianna
Grinholc, Mariusz
Szweda, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1040442.pdf
Data publikacji:
2010
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
polymorphism
protein A
spa
virulence
Opis:
Staphylococcus aureus is an etiological factor of severe infections in both hospital and ambulatory environments. As methicillin resistant Staphylococcus aureus strains spread quickly across healthcare centers resulting in life-threatening infections with increased mortality, they are considered more virulent than MSSA strains. Protein A, encoded by the spa gene, is one of the virulence factors involved in the staphylococcal pathogenesis. It has been suggested that the number of 24-bp tandem repeat units along the X region of the spa gene correlates with the virulence level of the strains. The current work analyzed the relationships between the virulence of MRSA and MSSA strains with region X polymorphism. No obvious correlation was observed.
Źródło:
Acta Biochimica Polonica; 2010, 57, 1; 135-138
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Monadic Printing Revisited
Autorzy:
Grzanek, K.
Powiązania:
https://bibliotekanauki.pl/articles/108664.pdf
Data publikacji:
2016
Wydawca:
Społeczna Akademia Nauk w Łodzi
Tematy:
functional programming
monads
Haskell
polymorphism
Opis:
Expressive and clear implementation of monadic printing requires an amount of work to define and design proper abstractions to rely upon when performing the actual programming works. Our previous realization of tree printing library left us with a sense of lack with respect to these considerations. This is why we decided to re-design and re-implement the library with core algorithms based upon new, effective and expressive text printing and concatenation routines. This paper presents the results of our work.
Źródło:
Journal of Applied Computer Science Methods; 2016, 8 No. 1; 66-79
1689-9636
Pojawia się w:
Journal of Applied Computer Science Methods
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Rola wybranych polimorfizmów genu MGMT w rozwoju chorób nowotworowych
Role of selected MGMT polymorphisms in cancer development
Autorzy:
Kiczmer, Paweł
Szydło, Błażej
Strzelczyk, Joanna K.
Gołąbek, Karolina
Ostrowska, Zofia
Powiązania:
https://bibliotekanauki.pl/articles/1035896.pdf
Data publikacji:
2017
Wydawca:
Śląski Uniwersytet Medyczny w Katowicach
Tematy:
polimorfizm
nowotwory
mgmt
cancer
polymorphism
Opis:
Materiał genetyczny komórki jest nieustannie narażony na działanie czynników mutagennych. Odpowiednie mechanizmy chroniące przed szkodliwym wpływem mutagenów są niezwykle ważne dla prawidłowego funkcjonowania oraz kontroli proliferacji komórek. Jednym z mechanizmów naprawczych jest działanie enzymu MGMT, który odpowiada za ochronę DNA komórki przed czynnikami alkilującymi. Różnice w aktywności enzymu, wynikające z występowania wielu odmian polimorficznych jego genu, mogą prowadzić niekiedy do zwiększonego ryzyka zachorowania na nowotwory. Tematem pracy jest omówienie roli niektórych polimorfizmów genu MGMT w rozwoju oraz terapii chorób nowotworowych.
Cell DNA is constantly exposed to mutagenic factors. DNA repair mechanisms are very important to provide proper cell functioning and proliferation control. One of the DNA repair mechanisms is based on the O6-methylguanine-DNA methyltransferase enzyme, which provides protection against alkylating agents. Differences in MGMT enzyme activity may be caused by MGMT gene polymorphisms. MGMT polymorphisms may increase cancer risk, e.g. lung cancer or esophageal cancer. In this review we have described the role of some MGMT polymorphisms in cancer development and therapy.
Źródło:
Annales Academiae Medicae Silesiensis; 2017, 71; 378-382
1734-025X
Pojawia się w:
Annales Academiae Medicae Silesiensis
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
CTRC gene polymorphism may increase pancreatic cancer risk – preliminary study
Autorzy:
Głuszek, Stanisław
Kowalik, Artur
Kozieł, Dorota
Wawrzycka, Iwona
Głuszek-Osuch, Martyna
Matykiewicz, Jarosław
Powiązania:
https://bibliotekanauki.pl/articles/1393315.pdf
Data publikacji:
2017
Wydawca:
Index Copernicus International
Tematy:
pancreatic cancer
CTRC polymorphism
etiology
Opis:
Pancreatic cancer is often fatal due to delayed diagnosis and treatment difficulties. Objective: To analyze selected SPINK1, CTRC, CFTR, and PRSS1 gene mutations in cancer tissue and blood samples of patients with pancreatic tumors. Materials and method: We enrolled 16 consecutive patients diagnosed with pancreatic tumors. We collected cancer tissue, normal pancreatic tissue, and blood samples for genetic tests. The control group consisted of 419 healthy individuals. Peripheral blood samples were collected from all study participants in EDTA-coated tubes. Results: Out of 16 patients with pancreatic tumors, 12 had pancreatic cancer on microscopic examination (mean age, 60.2 years). The CTRC polymorphism Hetero p.G60=(c.180C>T) was found in 5 patients with pancreatic cancer (41.7% vs. 18.6% in the control group). One patient with pancreatic cancer and a positive family history had the SPINK1 (p.N34S) mutation [8.3% vs. 2.9% (12/419) in the control group]. One patient with pancreatic cancer had the CTRC (p.R254W) mutation [8.3% vs. 1% (4/419) in the control group]. Conclusions: Our preliminary results show that the CTRC polymorphism p.G60= (c.180C>T) is frequent in patients with pancreatic cancer. However, further research is needed to verify our findings.
Źródło:
Polish Journal of Surgery; 2017, 89, 5; 48-53
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Psychological factors and genetic characteristics of rural cannabis users
Autorzy:
Lachowicz, M.
Chmielowiec, J.
Chmielowiec, K.
Suchanecka, A.
Michałowska-Sawczyn, M.
Mierzecki, A.
Mroczek, B.
Grzywacz, A.
Powiązania:
https://bibliotekanauki.pl/articles/2085700.pdf
Data publikacji:
2020
Wydawca:
Instytut Medycyny Wsi
Tematy:
addiction
polymorphism
personality traits
cannabis
Opis:
Introduction. Marijuana is one of the most widely used psychoactive substance. There is evidence of genetic predisposition for addiction. Objective. The aim of the study is to evaluate personality traits measured by the NEO Five-Factor Inventory and State-Trait Anxiety Inventory, combined with analysis of Tag1B rs1079597 and Tag1D rs1800498 located in the DRD2 gene. Materials and method. The study group consisted of 214 rural cannabinoid users and 301 controls. The same psychometric test and real-time PCR genotyping were performed in both studied groups. Results. The values of Anxiety state, Anxiety trait, NEO FFI: Neuroticism and Openness in the rural cannabis using group were significantly higher than in the control group. On the other hand, lower values were observed among rural people using cannabis compared to the control group for NEO FFI: Extraversion, Agreeability and Conscientiousness. In the Anxiety trait subscale, a 2% association with the polymorphism DRD2 Tag1B rs1079597 was detected in subjects using cannabis. However, for the DRD2 Tag1D rs1800498, there was no effect on the differences in personality traits between rural cannabis users and the control group. Conclusions. The study shows differences in personality traits between the cannabis using group and controls. Interaction between genetic factors and personality traits was also detected. The association showing the combination of psychological characteristics and genetic variants can bring us closer to the overall picture of the issue of marijuana addiction.
Źródło:
Annals of Agricultural and Environmental Medicine; 2020, 27, 2; 260-268
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Association and polymorphism study of seven candidate genes with reproductive traits in three pig breeds in Hungary
Autorzy:
Hunyadi-Bagi, Ágnes
Balogh, Péter
Nagy, Krisztina
Kusza, Szilvia
Powiązania:
https://bibliotekanauki.pl/articles/1038827.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
reproduction traits
pig
polymorphism
genes
Hungary
Opis:
Seven genes (BF, EGF, ESR, FSHB, H2AFZ, LEP and PRLP) were studied as candidate gene influencing eleven reproduction traits (interval between litters (IBL), percent of litter (PL), number of litters (NL), number of piglets born dead (NBD), number of piglet born alive (NBA), total number born (TNB), mean of born alive (MBA), mean of born dead (MBD), mean of born total (MBT), mean of piglets at 21 days of age (M21D) and growth rate (GR) in three pig breeds (Hungarian Large White (HLW), Duroc and Pietrain) by PCR-RFLP. Based on the observed vs. expected genotypes frequencies populations across loci were in Hardy-Weinberg equilibrium (P>0.05). In case HLW breed ESR and FSHβ genes were in disequilibrium. Association study suggested that only EGF gene showed significant influence on the trait NBA and TNB. The AA genotype are preferable for sows, associated with higher NBA and TNB. The longest IBL, and the highest NL is associated with AB and AA genotype of EGF gene. IBL is significantly shorter in case of pigs with AB and AA alleles than BB alleles of PRLP genes. Selection for these SNPs could improve the reproductivity in the studied breeds.
Źródło:
Acta Biochimica Polonica; 2016, 63, 2; 359-364
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Induced isozyme polymorphism in spring barley mutants
Autorzy:
Kucharska, M
Maluszynski, M
Powiązania:
https://bibliotekanauki.pl/articles/2047711.pdf
Data publikacji:
1996
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
polymorphism
isoenzyme
barley
induced mutant
mutant
Opis:
The usefulness of mutagenic treatment to enlarge isozymic variability of barley and the use of induced mutants for genetic analysis were evaluated. N-methyl-N-nitroso urea, sodium azide and gamma rays were employed as mutagenic agents. Electrophoretic assays of 3848 M₂ seedlings obtained by chemical mutagenic treatment of the spring barley cultivars Dema, Aramir, Bielik and 3100 M₂ seedlings obtained by physical mutagenic treatment of the cv. Dema revealed 70 isozymic mutants, which represent 30 separate mutants in 25 M₁ plants. Most of mutations (27) were induced by chemical mutagen at polymorphic esterase loci. The occurrence of induced mutants at monomorphic loci, Got2 and Lap2, made it possible to perform genetic analysis of those loci in barley including mapping respective genes within chromosomes.
Źródło:
Journal of Applied Genetics; 1996, 37, 1; 1-9
1234-1983
Pojawia się w:
Journal of Applied Genetics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Genetic diversity of winter wheat cultivars and strains determined by electrophoregrams of gliadin and glutenin proteins
Autorzy:
Węgrzyn, Stanisław
Waga, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/2198933.pdf
Data publikacji:
2004-06-20
Wydawca:
Instytut Hodowli i Aklimatyzacji Roślin
Tematy:
cluster analysis
electrophoresis
gliadins
glutenins
polymorphism
Opis:
Based on the polymorphism of gliadin and glutenin proteins relationships of 45 cultivars and strains of winter wheat were evaluated. The cluster analysis showed a considerable variation of the investigated genotypes. The similarity indices were calculated using the Nei and Li formula. The genetic distances between the cultivars ranged from 1.00 to 0.12. The highest similarity index - SI=1.00- being proof of the identical physicochemical composition of storage proteins, was found for the pair Farmer and Elena. The groups of similar and genetically distant cultivars have been presented in the form of a dendrogram. The possibility of using the results obtained from the cluster analysis in breeding programmes has been discussed.
Źródło:
Plant Breeding and Seed Science; 2004, 49; 51-61
1429-3862
2083-599X
Pojawia się w:
Plant Breeding and Seed Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of splicing mutation within the lysophosphatidic acid receptor 1 gene (LPAR1) on semen quality in Holstein-Friesian bulls
Autorzy:
Kamiński, S.
Hering, D.M.
Kordan, W.
Lecewicz, M.
Sazanov, A.
Powiązania:
https://bibliotekanauki.pl/articles/2087732.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
bull
sperm
quality
LPAR1
polymorphism
Źródło:
Polish Journal of Veterinary Sciences; 2018, 21, 2; 419-421
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Expression and polymorphism of defensins in farm animals
Autorzy:
Bagnicka, Emilia
Strzałkowska, Nina
Jóźwik, Artur
Krzyżewski, Józef
Horbańczuk, Jarosław
Zwierzchowski, Lech
Powiązania:
https://bibliotekanauki.pl/articles/1040309.pdf
Data publikacji:
2010
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
farm animals
expression
defensins
polymorphism
Opis:
Due to their activity against bacteria, viruses, and fungi, antimicrobial peptides are important factors in the innate resistance system of humans and animals. They are called "new generation antibiotics" for their potential use in preventive and therapeutic medicine. The most numerous group of antimicrobial peptides is a family of cationic peptides which include defensins and cathelicidins. Among them the most common are peptides with a beta-sheet structure containing three intra-molecular disulphide bonds, called defensins, comprising three classes: alpha, beta, and theta. The class of beta-defensins is the largest one. Their transcripts have been found in many tissues of humans and animals. The aim of this paper is to present the current knowledge about antimicrobial peptides from the defensin family in farm animals, their expression, polymorphism, as well as the potential of their use as genetic markers of health and production traits.
Źródło:
Acta Biochimica Polonica; 2010, 57, 4; 487-497
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Association between a nucleotide polymorphism in the calpain 10 gene and carbohydrate metabolism disturbances in patients with polycystic ovary syndrome
Autorzy:
Szydlarska, Dorota
Machaj, Małgorzata
Powiązania:
https://bibliotekanauki.pl/articles/552368.pdf
Data publikacji:
2016
Wydawca:
Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych
Tematy:
diabetes
hyperandrogenism
single nucleotide polymorphism.
Źródło:
Family Medicine & Primary Care Review; 2016, 4; 497-500
1734-3402
Pojawia się w:
Family Medicine & Primary Care Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The importance of platelet phosphofructokinase (PFKP) rs6602024 polymorphism in pathogenesis of obesity
Znaczenie polimorfizmu rs6602024 genu fosfofruktokinazy płytkowej (PFKP) w patogenezie otyłości
Autorzy:
Woźny, Łukasz
Danikiewicz, Marta
Stefanowicz, Magdalena
Wojtas, Elżbieta
Gola, Mateusz
Śnit, Mirosław
Grzeszczak, Władysław
Powiązania:
https://bibliotekanauki.pl/articles/1035900.pdf
Data publikacji:
2017
Wydawca:
Śląski Uniwersytet Medyczny w Katowicach
Tematy:
obesity
polymorphism
pfkp
otyłość
polimorfizm
Opis:
OBJECTIVE: The aim of the study was to demonstrate the potential relationship between overweight and obesity and the platelet phosphofructokinase (PFKP) rs6602024 polymorphism in patients reporting to a general practitioner at a primary care outpatient clinic. MATERIAL AND METHODS: The study included a total of 438 patients from Southern Poland who reported to the general primary care outpatient clinic. PFKP rs6602024 polymorphism genotyping was conducted using fluorescence-labelled probes. The Statistica 8.0 program was used to calculate individual parameters. RESULTS: Certain metabolic disorders were shown in overweight and obese people, as well as in the whole group of overweight or obese subjects. The results were compared with the outcomes obtained from people who were not overweight or obese. There were no statistically significant differences in the distribution of PFKP rs6602024 polymorphism genotypes and alleles between the study and control group. The control group showed a statistically significant difference in allele distribution between men and women. Among women, a statistically significant difference was found in the distribution of G/A alleles between the controls and overweight people as well as those overweight and obese altogether. CONCLUSIONS: 1. Overweight and obesity are very common in people reporting to the primary care outpatient clinic. 2. The presence of PFKP rs6602024 polymorphism allele A in women is associated with an increased risk of being overweight and obese.
CEL PRACY: Celem pracy było wykazanie potencjalnego związku między występowaniem nadwagi i otyłości a polimorfizmem rs6602024 genu fosfofruktokinazy płytkowej (PFKP) u kolejnych pacjentów zgłaszających się do lekarza pierwszego kontaktu w POZ. MATERIAŁ I METODY: Badaniem objęto łącznie kolejnych 438 pacjentów z rejonu Polski południowej, którzy zgłaszali się do poradni ogólnej POZ. Genotypowanie polimorfizmu genu PFKP rs6602024 prowadzono z wykorzystaniem znakowanych fluorescencyjnie sond. Do obliczeń poszczególnych parametrów w ujęciu statystycznym zastosowano program Statistica 8,0. WYNIKI: U osób z nadwagą oraz otyłością, a także w całej badanej grupie osób z nadwagą lub otyłością wykazano występowanie określonych zaburzeń metabolicznych. Wyniki porównano z rezultatami osób bez nadwagi i otyłości. U badanych osób nie stwierdzono istotnych statystycznie różnic w rozkładzie genotypów i alleli polimorfizmu rs6602024 PFKP w porównaniu z kontrolą. W grupie kontrolnej wykazano znamienną statystycznie różnicę pomiędzy kobietami i mężczyznami w rozkładzie alleli. Wśród kobiet stwierdzono znamienną statystycznie różnicę w rozkładzie alleli G/A między osobami z grupy kontrolnej a osobami z nadwagą oraz nadwagą i otyłością razem wziętych. WNIOSKI: 1. Nadwaga i otyłość bardzo często występują u osób zgłaszających się do lekarza POZ. 2. Występowaniu allelu A polimorfizmu rs6602024 genu PFKP u kobiet towarzyszy zwiększone ryzyko nadwagi i otyłości.
Źródło:
Annales Academiae Medicae Silesiensis; 2017, 71; 173-182
1734-025X
Pojawia się w:
Annales Academiae Medicae Silesiensis
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Joint effect of N-acetyltransferase 2 gene and smoking status on bladder carcinogenesis in Algerian population
Autorzy:
Ribouh-Arras, A.
Chaoui-Kherouatou, N.
Hireche, A.
Abadi, N.
Satta, D.
Powiązania:
https://bibliotekanauki.pl/articles/80202.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
N-acetyltransferase 2 gene
genetic polymorphism
malignancy
bladder cancer
single nucleotide polymorphism
phenotype
smoking
Algerian population
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2019, 100, 2
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Human AGT-p.Met268Thr and coronary heart disease risk: a case-control study and meta-analysis
Autorzy:
Hanieh, Mohammadi
Narges, Razavi
Abbasi, Ali
Babaei, Faezeh
Seyedrezazadeh, Ensiyeh
Hosseinzade, Abasalt
Powiązania:
https://bibliotekanauki.pl/articles/551649.pdf
Data publikacji:
2018
Wydawca:
Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych
Tematy:
coronary disease
angiotensinogen
genetic polymorphism
meta-analysis.
Źródło:
Family Medicine & Primary Care Review; 2018, 1; 17-24
1734-3402
Pojawia się w:
Family Medicine & Primary Care Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Genetic research in modern sport
Autorzy:
Leońska-Duniec, Agata
Powiązania:
https://bibliotekanauki.pl/articles/1054958.pdf
Data publikacji:
2013
Wydawca:
Uniwersytet Szczeciński. Wydawnictwo Naukowe Uniwersytetu Szczecińskiego
Tematy:
athlete status
physical activity
polymorphism
sport genetics
Opis:
Sport genomics is a comparatively new scientific discipline concentrating on the organization and functioning of the genome of elite athletes. It seems to be the most promising tool for sport selection, individualization of the training process, sport traumatology, and also in illegal ‘gene doping’. With genotyping more available, research of gene variants’ influence on several phenotype traits related to physical performance have been widely carried out worldwide. This review not only summarizes the current findings of sport genomics study of molecular markers, their association with athlete status and training responses, but it also explores future trends and possibilities. The importance of genetics in modern sport increases every year. However, the recent studies still represent only the first steps towards a better understanding of the genetic factors that influence human physical abilities, and therefore continuing studies are necessary.
Źródło:
Central European Journal of Sport Sciences and Medicine; 2013, 3, 3; 19-26
2300-9705
2353-2807
Pojawia się w:
Central European Journal of Sport Sciences and Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Polimorficzność motywacji osób twórczych. Implikacje pedagogiczne
Autorzy:
Aneta, Bartnicka-Michalska,
Powiązania:
https://bibliotekanauki.pl/articles/892405.pdf
Data publikacji:
2015
Wydawca:
Uniwersytet Warszawski. Wydawnictwa Uniwersytetu Warszawskiego
Tematy:
interpreting artist
efficient personality
polymorphism of motivation
Opis:
In the article the hypothesis of motivational polymorphism in creativity is formulated and confirmed. The hypothesis assumes that activation of creative behaviour needs many different types of motivation, which are variations of one main motivation. The theoretical basis of this article rests on Józef Kozielecki’s concept of psychotransgressionism, which assumes that creative behaviour can be activated by three motivations: self-esteem motivation (hubristic), motivation of the meaning of life and motivation of self-efficiency. In this study on a sample of interpreting artists (N = 133), creative behaviour was measured using the STZ questionnaire (Strzałecki 2003). The motivational orientations were measured using the Polish adaptation of Power Motivation Scale (PMS) by Tokarz and Trzebińska (2011), the Polish adaptation of Life Attitude Profile questionnaire (LAP-R) by Klamut (2010) and the Polish adaptation of General Self- Efficacy Scale questionnaire (GSES) by Juczyński (2001). The results confirmed the hypothesis of a polymorphic nature of motivation in creative people. Educational implications of results are discussed.
Źródło:
Kwartalnik Pedagogiczny; 2015, 60(3 (237)); 34-52
0023-5938
Pojawia się w:
Kwartalnik Pedagogiczny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Morphological diversity and dna polymorphism of common oat (Avena sativa L.) landraces cultivated in Poland.
Autorzy:
Nowosielska, Dorota
Nowosielski, Jarosław
Powiązania:
https://bibliotekanauki.pl/articles/2199164.pdf
Data publikacji:
2008-12-21
Wydawca:
Instytut Hodowli i Aklimatyzacji Roślin
Tematy:
common oat
DNA polymorphism
landraces
morphological traits
Opis:
The aim of the work was characterization of morphological diversity and DNA polymorphism of common oat landraces. 25 Morphological traits and DNA polymorphism have been examined using AFLP methods. It has been found, that identification of oat landraces is possible based on the examined morphological traits. The examined accessions were differentiated by traits important for intraspecific taxonomy of oat: type of panicle, presence of awns, colour of grain, as well as other morphological traits, such as shape of panicle, rigidity of stem leaves, and type of awns. Relationships of morphological traits of leaves, grains, and stem with some DNA fragments suggesting presence of molecular markers of these morphological traits have been found. Morphological similarity of landraces doesn’t correspond to affinity complied with DNA similarity of these objects...
Źródło:
Plant Breeding and Seed Science; 2008, 58; 11-22
1429-3862
2083-599X
Pojawia się w:
Plant Breeding and Seed Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The relation of PON1-L55M gene polymorphism and clinical manifestation of Behcets disease
Autorzy:
Dursun, Ahmet
Cicek, Salih
Keni, Fatih
Karakas-Celik, Sevim
Sezer, Tuna
Altinyazar, Cevdet
Powiązania:
https://bibliotekanauki.pl/articles/1039286.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
PON1 gene
Polymorphism
Behçet's disease
Opis:
Purpose: Behçet's disease is a multisystem disease characterized by recurrent oral and genital ulcers, relapsing uveitis, mucocutaneous, articular, gastrointestinal, neurologic, and vascular manifestations. Paraoxonase is believed to play an important role in protection of LDL and HDL particles from oxidation, in antioxidant effect against lipid peroxidation on cellular membranes, and in anti-inflammatory process. Lipid peroxidation and free oxygen radicals have been thought to play a role in pathogenesis of BD. The association of paraoxonase gene polymorphisms with Behçet's Disease in a group of Turkish patients with clinical manifestations and healthy controls has been investigated. Patients and Methods: Paraoxonase (PON-1-L55M) gene polymorphism was investigated in 50 Behcet patients and 50 healthy individuals with a PCR/RFLP method. Results: There were significant differences between patients and the control group in allele frequencies of the PON1 L55M polymorphism (p=0.04). Also, when patients were compared with the control group according to clinical manifestations, this statistical significance was getting sharper. Compared with the PON55 L allele, the M allele was associated with greater than 3.5 fold (OR 3.5, 95% CI 1.3-8.9) increased risk of ocular (OR 2.4, 95% CI 1.1-5.3), 2.4 fold joint and 3.1 fold (OR 3.1, 95% CI 1.1-8.4) central nervous system manifestations of BD. Conclusion The PON L55M gene polymorphism seemed to play a role in the pathogenesis of BD.
Źródło:
Acta Biochimica Polonica; 2014, 61, 2; 271-274
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Genetic diversity in Vernonia amygdalina Delile accessions revealed by random amplified polymorphic DNAs (RAPDs)
Autorzy:
Aikpokpodion, P.
Abebe, J.
Igwe, D.
Powiązania:
https://bibliotekanauki.pl/articles/79809.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
genetic diversity
Vernonia amygdalina
random amplified polymorphic DNA
polymorphism
molecular characteristics
single-nucleotide polymorphism
geographic differentiation
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2018, 99, 2
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The mRNA sequence polymorphisms of flowering key genes in bolting sensitive or tolerant sugar beet genotypes
Autorzy:
Alimirzaee, M.
Mirzaie-Asl, A.
Abdollahi, M.R.
Kolaei, H.E.
Fasahat, P.
Powiązania:
https://bibliotekanauki.pl/articles/79841.pdf
Data publikacji:
2017
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
sugar-beet
Beta vulgaris ssp.maritima
mRNA
polymorphism
flowering
single nucleotide polymorphism
genetic control
RNA extraction
protein structure prediction
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2017, 98, 3
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Genetic polymorphisms of leptin and leptin receptor genes in relation with production and reproduction traits in cattle
Autorzy:
Trakovická, Anna
Moravčíková, Nina
Kasarda, Radovan
Powiązania:
https://bibliotekanauki.pl/articles/1039486.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
cattle
leptin
leptin receptor
milk production
polymorphism
reproduction
Opis:
Leptin and leptin receptor genes are considered as production traits markers in dairy or beef cattle. The aim of this study was to verify the associations of polymorphisms in bovine LEP and LEPR genes with production and reproduction traits in Slovak Spotted and Pinzgau cows. Long-life production was evaluated: milk, protein, and fat yield and reproduction traits: age at first calving, calving interval, days open, and insemination interval. In total, 296 blood samples of Slovak Spotted and 85 hair roots samples of Pinzgau cows were analyzed. In order to detect LEP/Sau3AI (BTA 4, inron 2) and LEPR/T945M (BTA 3, exon 20) genotypes PCR-RFLP method was used. In Slovak Spotted and Pinzgau cows allele frequencies were 0.838/0.162 and 0.694/0.306 for A and B LEP variants, and 0.954/0.046 and 0.912/0.088 for C and T LEPR variants, respectively. For testing the associations between SNPs LEP/Sau3AI and LEPR/T945M and evaluated traits, the General Linear Model procedure in SAS Software was used. Statistical analysis showed that SNP LEP/Sau3AI significantly affected milk, protein and fat yield (P<0.05), and age at first calving (P<0.01) in analyzed population of cows. Statistically, SNP LEPR/T945M affected significantly calving interval (P<0.01) only. Results of our study suggest that especially leptin is a candidate gene, which influences mainly milk production traits and might be implemented in breeding strategies to improve the production performance of both analyzed cattle breeds.
Źródło:
Acta Biochimica Polonica; 2013, 60, 4; 783-787
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Preliminary report on β-casein gene Met183QVal183 polymorphism in Romanian indigenous Zackel sheep breeds
Autorzy:
Kusza, Szilvia
Ilie, Daniela
Sauer, Maria
Sauer, Ioan-Walter
Gavojdian, Dinu
Powiązania:
https://bibliotekanauki.pl/articles/1038660.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
β-casein
gene polymorphism
ovine milk
Racka
Turcana
Opis:
Genetic polymorphisms of the milk protein genes are important because of their effects on quantitative traits and technological properties of milk manufacturing. In the present study we identified the polymorphism of the beta-casein gene in two local sheep breeds (Racka n=98 and Turcana n=111) in Romania. The most studied variants at the ovine beta-casein (CSN2) locus are: A and G variants. Genomic DNA was extracted from hair follicles and beta-casein genotypes were determined by the rapid TaqMan (Applied Biosystems, USA) genotyping assay. Homozygote genotypes GG were not detected in any of the studied breeds. In both, the Racka and Turcana breeds, the A variant had a much higher frequency, 0.98% and 0.97%, respectively. In the current study, the fast DNA tests for genotyping ovine CSN2 were successfully optimized, however, further samples and correlations of genomic results with milk characteristics and production data are needed for the development of future selection schemes of the Romanian indigenous sheep breeds, with the ultimate purpose to produce low allergen level sheep milk and derived dairy products.
Źródło:
Acta Biochimica Polonica; 2017, 64, 2; 339-341
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Association between uridin diphosphate glucuronosylotransferase 1A1 (UGT1A1) gene polymorphism and neonatal hyperbilirubinemia
Autorzy:
Mazur-Kominek, Katarzyna
Romanowski, Tomasz
Bielawski, Krzysztof
Kiełbratowska, Bogumiła
Preis, Krzysztof
Domżalska-Popadiuk, Iwona
Słomińska-Frączek, Magdalena
Sznurkowska, Katarzyna
Renke, Joanna
Plata-Nazar, Katarzyna
Śledzińska, Karolina
Sikorska-Wiśniewska, Grażyna
Góra-Gębka, Magdalena
Liberek, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1038662.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
UGT1A1 gene
polymorphism
hyperbilirubinemia
neonates
Opis:
Objective: To assess the prevalence of UGT1A1*28 and UGT1A1*60 polymorphisms of UGT1A1 gene and their association with hyperbilirubinemia. Study design: The study was performed at a single centre - at the Department of Obstetrics of the Medical University of Gdansk in Poland. DNA was isolated from Guthrie cards of 171 infants. Only full term newborns (gestational age 38-42 weeks) were included in the study. Fluorescent molecular probes were used for UGT1A1 promoter variation analysis. The presence of UGT1A1*28 polymorphism was detected with a dual-probe system, and UGT1A1*60 with a SimpleProbe™. Result: Homozygous UGT1A1*28 and UGT1A1*60 genotypes were detected in 14.6% and 20.5% of the newborns, respectively. Homozygous (G/G) genotypes of UGT1A1*60 polymorphism were found in all of the UGT1A1*28 (i.e. (TA)7/(TA)7) homozygotes. More than 80% (55/66) of the children with "wild" type UGT1A1*28 genotype (where no polymorphism was detected) (i.e. (TA)6/(TA)6) carried the "wild" (T/T) genotype of UGT1A1*60 as well. The UGT1A1*28 polymorphism was detected more often among neonates with elevated bilirubin. Hyperbilirubinemia was diagnosed more frequently in boys. Conclusion: Polymorphisms of the UGT1A1 gene frequently co-exist in neonates. The presence of UGT1A1*28 polymorphism and male gender seem to predispose to neonatal hyperbilirubinemia.
Źródło:
Acta Biochimica Polonica; 2017, 64, 2; 351-356
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Intra-strains diversity of expression of polymorphic PKS4 gene in comparison in zearalenone production by Fusarium graminearum during in vitro cultivation
Autorzy:
Misiewicz, Anna
Goncerzewicz, Anna
Jędrzejczak, Renata
Zdziennicki, Filip
Powiązania:
https://bibliotekanauki.pl/articles/1038847.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Fusarium sp. PKS4
ZEA
gene expression
polymorphism
Opis:
Filamentous fungi belonging to the Fusarium genus are responsible for large economic losses due to their high pathogenicity and toxigenicity. Fusarium sp. may produce variety of mycotoxins, one of them is zearalenone (ZEA). The presence of the PKS4 gene shows the possibility of zearalenone biosynthesis by Fusarium sp. In this study, in four Fusarium graminearum and one Fusarium poae strains the presence of PKS4 genes and ZEA concentrations were determined. The presence of the PKS4 gene was confirmed by classical polymerase chain reaction (PCR) in three of four strains of F. graminearum. One strain with no PKS4 gene detected was found while still producing ZEA. In the present study, a real-time PCR assay has been successfully performed for the relative expression of Fusarium strains based on new designed primers targeting the PKS4 gene involved in ZEA biosynthesis. Result shows that P56/4 strain of F. graminearum has the highest mRNA level, in the range of 12, what correlates to the high production of this mycotoxin. In this study, a real-time PCR assay has been successfully developed for the prediction of the production of ZEA by F. graminearum strains by PCR real-time techniques based on primers targeting the gene, PKS4, involved in ZEA biosynthesis. The special significance was pointed to occurring genes polymorphism.
Źródło:
Acta Biochimica Polonica; 2016, 63, 1; 97-102
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Association of the DIO2 gene single nucleotide polymorphisms with recurrent depressive disorder
Autorzy:
Gałecka, Elżbieta
Talarowska, Monika
Orzechowska, Agata
Górski, Paweł
Bieńkiewicz, Małgorzata
Szemraj, Janusz
Powiązania:
https://bibliotekanauki.pl/articles/1039107.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
depressive disorder
iodothyronine deiodinase type II
polymorphism
haplotype
Opis:
Genetic factors may play a role in the etiology of depressive disorder. The type 2 iodothyronine deiodinase gene (DIO2) encoding the enzyme catalyzing the conversion of T4 to T3 is suggested to play a role in the recurrent depressive disorder (rDD). The current study investigates whether a specific single nucleotide polymorphism (SNP) of the DIO2 gene, Thr92Ala (T/C); rs 225014 or ORFa-Gly3Asp (C/T); rs 12885300, correlate with the risk for recurrent depression. Genotypes for these two single nucleotide polymorphisms (SNPs) were determined in 179 patients meeting the ICD-10 criteria for rDD group and in 152 healthy individuals (control group) using a polymerase chain reaction (PCR) based method. The specific variant of the DIO2 gene, namely the CC genotype of the Thr92Ala polymorphism, was more frequently found in healthy subjects than in patients with depression, what suggests that it could potentially serve as a marker of a lower risk for recurrent depressive disorder. The distribution of four haplotypes was also significantly different between the two study groups with the TC (Thr-Gly) haplotype more frequently detected in patients with depression. In conclusion, data generated from this study suggest for the first time that DIO2 gene may play a role in the etiology of the disease, and thus should be further investigated.
Źródło:
Acta Biochimica Polonica; 2015, 62, 2; 297-302
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Chenophila nanseni sp. n. (Acari: Syringophilidae) parasitising the barnacle goose in Svalbard
Autorzy:
Skoracki, Maciej
Zawierucha, Krzysztof
Powiązania:
https://bibliotekanauki.pl/articles/2046855.pdf
Data publikacji:
2016
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
Arctic
barnacle goose
parasites
quill mites
female polymorphism
Źródło:
Polish Polar Research; 2016, 37, 1; 121-130
0138-0338
2081-8262
Pojawia się w:
Polish Polar Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Polymorphism in Syringa rDNA regions assessed by PCR technique
Autorzy:
Smolik, M.
Andrys, D.
Franas, A.
Krupa-Malkiewicz, M.
Malinowska, K.
Powiązania:
https://bibliotekanauki.pl/articles/41641.pdf
Data publikacji:
2010
Wydawca:
Polska Akademia Nauk. Instytut Dendrologii PAN
Tematy:
polymorphism
lilac
Syringa
rDNA region
polymerase chain reaction
Opis:
The Syringa genus is characterizedby a multiplicity of forms. Its chief asset is the ornamental value of thousands of accessions, species or hybrids. From a phylogenetic point of view the genus is difficult in an explicit classification due to its frequently complex genome. The aim of this study was to determine the possibility for the identification of genotypic diversity and genetic relationships in the nrDNA sequence of some selected Syringa accessions – part of a collection of the Dendrological Garden in Przelewice (Poland). For this purpose, the PCR technique together with a combination of various ‘universal’ primers designed for the nrDNA sequence analysis were employed. Fourteen Syringa accessions: Syringa × chinensis Willd., S. × prestoniae Mc Kelv., S. × prestoniae ‘Telimena’, S. × prestoniae ‘Jaga’, S. × prestoniae ‘Basia’, S. meyeri ‘Palibin’, S. vulgaris ‘Miss Ellen Willmott’, S. vulgaris, S. vulgaris ‘Jules Simon’, S. vulgaris ‘Katherine Havemeyer’, S. vulgaris ‘Krasawica Moskvy’, S. vulgaris ‘Mirabeau’, S. vulgaris ‘Madame Lemoine’ and S. vulgaris ‘Niebo Moskvy’ made up the research material. In the conducted amplifications, genetic profiles were obtained for 14 combinations among the 25 combinations of different pairs of primers used. The nrDNA templates coding the small subunit (SSU), 5.8S subunit andITS1, ITS2 andIGS sequences were amplified. In PCR reactions a total of 33 PCR products were generated, of which 21 (64%) products were polymorphic, 6 (18%) monomorphic and6 (18%) were genotype-specific. For the lilac accessions examined246 amplicons were generated from ~230 to ~1100 bp in length. The analysis of both the dendrogram and the genetic similarity matrix revealedlow diversity between the examinedaccessions. For most they rangedfrom 70 to 80%, andthe greatest diversity (87%) was foundbetween the S. × prestoniae: ‘Basia’ and‘Telimena’ accessions, while the lowest (57%) was observed between S. vulgaris ‘Katherine Havermeyer’ and S. × chinensis.
Źródło:
Dendrobiology; 2010, 64
1641-1307
Pojawia się w:
Dendrobiology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Morphological Diversity and Dna Polymorphism of Common Oat (Avena Sativa L.) Breeding Varieties Cultivated in Poland
Autorzy:
Nowosielska, Dorota
Nowosielski, Jarosław
Powiązania:
https://bibliotekanauki.pl/articles/2199038.pdf
Data publikacji:
2009-12-20
Wydawca:
Instytut Hodowli i Aklimatyzacji Roślin
Tematy:
breeding varieties
common oat
DNA polymorphism
morphological traits
Opis:
The aim of the work was characterization of morphological diversity and DNA polymorphism of common oat breeding varieties. 25 morphological traits and DNA polymorphism have been examined using AFLP and RAPD methods. It has been found, that identification of oat breeding varieties is possible based on the examined morphological traits...
Źródło:
Plant Breeding and Seed Science; 2009, 60; 31-44
1429-3862
2083-599X
Pojawia się w:
Plant Breeding and Seed Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Determination of polymorphism of IS-1311 sequence in Mycobacterium avium subspecies paratuberculosis strains isolated from milk samples
Autorzy:
Szteyn, J.
Bednarko-Młynarczyk, E.
K. Liedke
Wiszniewska-Łaszczych, A.
Wojtacka, J.
Powiązania:
https://bibliotekanauki.pl/articles/2087864.pdf
Data publikacji:
2017
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
Mycobacterium avium subsp. paratuberculosis
milk
IS-1311 polymorphism
Źródło:
Polish Journal of Veterinary Sciences; 2017, 4; 827-829
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Silver nanoparticles in isotactic polypropylene. Part II. Molecular modelling of polypropylene chains arrangement on the surface of silver nanoparticles
Nanocząstki srebra w izotaktycznym polipropylenie. Cz. II. Modelowanie ułożenia łańcuchów polipropylenu na powierzchni nanocząstek srebra
Autorzy:
Hybiak, D.
Chmielewska, S.
Garbarczyk, J.
Powiązania:
https://bibliotekanauki.pl/articles/947446.pdf
Data publikacji:
2015
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Chemii Przemysłowej
Tematy:
polymorphism
epitaxy
molecular modelling
polimorfizm
epitaksja
modelowanie molekularne
Opis:
Molecular modelling (MM) was used to explain the mechanism of formation of polymorphic form of isotactic polypropylene (iPP) at the surface of the silver nanoparticles (nAg). Geometrical optimization of iPP chains and unit cell of Ag systems was made with the use of MM+force field in vacuum. According to the results, the arrangement of methyl groups in the (110) contact plane implies a lateral packing of helices with a periodicity α ≈ 19 Å, which is a characteristic feature of the complicated packing of helices in β iPP. Partial charges calculated on the basis of the hybrid potential BLYP revealed the possibility of electrostatic interactions between hydrogens from methyl groups and silver atoms at the edge of unit cell. Analysis of the optimized iPP/Ag system confirmed that the formation of the polymorphic β iPP can be explained by the epitaxial mechanism.
W celu wyjaśnienia mechanizmu tworzenia się formy β izotaktycznego polipropylenu (iPP) na powierzchni nanocząstek srebra (nAg) wykorzystano modelowanie molekularne (MM). Wykonano optymalizacje geometryczne układów iPP z nAg przy użyciu pola siłowego MM+ w próżni. Stwierdzono, że ustawienie grup metylowych w płaszczyźnie kontaktu (110) ujawnia boczne upakowanie helis z okresowością α ≈ 19 Å. Jest to cecha charakterystyczna dla upakowania helis w formie β iPP. Wyniki obliczeń ładunków cząstkowych przy użyciu potencjału hybrydowego BLYP wskazują na możliwość występowania oddziaływań elektrostatycznych między wodorami z grup metylowych łańcuchów iPP i atomami srebra leżącymi na krawędziach komórki elementarnej. Analiza optymalizowanych układów potwierdziła, że oddziaływanie atomów srebra z makrocząsteczką iPP może się przyczyniać do tworzenia polimorficznej formy β na drodze mechanizmu epitaksjalnego.
Źródło:
Polimery; 2015, 60, 11-12; 700-704
0032-2725
Pojawia się w:
Polimery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Genetic diversity in populations of Slovak Spotted cattle based on single nucleotide polymorphisms analyses
Autorzy:
Moravčíková, Nina
Trakovická, Anna
Navrátilová, Alica
Powiązania:
https://bibliotekanauki.pl/articles/1039494.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
cattle
growth hormone
leptin
leptin receptor
polymorphism
Opis:
The aim of this study was to identify SNPs in leptin (LEP), leptin receptor (LEPR) and growth hormone (GH) genes in order to analyze genetic diversity of Slovak Spotted cattle. The total numbers of blood samples were taken from 353 Slovak Spotted cows originating from four farms. Genomic DNA was isolated by phenol-chloroform extraction method and analyzed by PCR-RFLP method. After digestion with restriction, enzymes were detected in whole population of cow's alleles with frequency: LEP/Sau3AI A 0.84 and B 0.16 (±0.0152); LEPR/BseGI C 0.95 and T 0.05 (±0.0089) and GH/AluI L 0.70 and V 0.30 (±0.0188). Based on the observed vs. expected genotypes frequencies populations across loci were in Hardy-Weinberg equilibrium (P\>0.05). Predominant for SNP LEP/Sau3AI was AA genotype (0.70), for SNP LEPR/T945M CC genotype (0.91), and LL genotype (0.48) was most frequent for SNP GH/AluI. The observed heterozygosity of SNPs across populations was also transferred to the low or median polymorphic information content 0.24 (He 0.28), 0.08 (He 0.09) and 0.33 (He 0.47) for LEP, LEPR and GH genes, respectively. Within genetic variability estimating negative values of fixation indexes FIS (-0.09-0.05) and FIT (-0.07-0.03) indicating heterozygote excess were observed. The value of FST indexes (0.018-0.023) shows very low levels of genetic differentiation in allele frequencies of loci among evaluated subpopulations. The low values of genetic distances (0.0018-0.0159) indicated high genetic relatedness among animals in subpopulations caused probably by common ancestry used in breeding program at farms.
Źródło:
Acta Biochimica Polonica; 2013, 60, 4; 807-810
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Sequence analysis of human cytomegalovirus US28 gene in low-passage clinical isolates from children and AIDS patients
Autorzy:
He, Rong
Xia, Chang
Ruan, Qiang
Qi, Ying
Ma, Yan-Ping
Ji, Yao-Hua
Guo, Jin-Jin
Powiązania:
https://bibliotekanauki.pl/articles/1039923.pdf
Data publikacji:
2011
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
chemokine receptors
cytomegalovirus
genetic polymorphism
US28
Opis:
Human cytomegalovirus (HCMV) is often a dangerous opportunistic pathogen that causes significant morbidity and mortality in newborn children and immunocompromised patients. The different symptoms and tissue tropisms of HCMV infection may result from genetic polymorphism. This study investigated the sequence variability of the HCMV US28 ORF, which shows sequence homology to the G protein-coupled receptor. HCMV isolated from suspected pediatric cases and isolates from AIDS patients were compared in order to examine the possible associations between polymorphisms and pathogenesis. Seventy children with suspected congenital HCMV infection, who suffered from jaundice (47), megacolon (10), and microcephaly (13), and 17 AIDS patients, were studied. Mutation was prevalent among the sequences of US28, with a focus on the two ends of US28. The important functional groups of US28 are highly conserved. An unrooted tree showed that all sequences from suspected congenitally infected infants and AIDS patients were divided into three groups. Comparison showed that most of the sequences (12/17) from pediatric patients were included in the first group (G1), whereas most of the sequences (11/17) from AIDS patients were included in the third group (G3). The specific high mutation sites in US28 from children were located at the C terminus of the protein, whereas those from AIDS patients were located at the N terminus. We demonstrated the existence of polymorphisms among the US28 genes of clinical isolates of HCMV from infants with suspected congenital infection. Comparison of US28 sequences from AIDS patients with those from children showed that both sequences have their own specific high mutation points.
Źródło:
Acta Biochimica Polonica; 2011, 58, 2; 231-236
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Development of microsatellite markers for horse-chestnut (Aesculus hippocastanum), their polymorphism in natural Greek populations, and cross-amplification in related species
Autorzy:
Walas, L.
Iszkulo, G.
Barina, Z.
Dering, M.
Powiązania:
https://bibliotekanauki.pl/articles/2078223.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Instytut Dendrologii PAN
Tematy:
Tertiary relict
endemic species
cross-amplification
polymorphism
Opis:
New nuclear microsatellite markers (SSRs) were developed for Aesculus hippocastanum, a relict tree species from the Balkan Peninsula. The development of microsatellites was done using the Illumina MiSeq PE300 platform. Out of a set of 500 SSRs designed, a subset of 13 loci was tested using 290 individuals from seven natural populations. Twelve species-specific loci were polymorphic. The number of alleles per locus ranged from 2 to 17 and expected heterozygosity from 0.089 to 0.800 with a mean value of 0.484. The population of Kalampaka had the lowest value of allelic richness (2.63) and gene diversity in comparison to the remaining populations. STRUCTURE analysis confirmed isolation of population Mariolata from the southern edge of the species range and genetic similarity among populations from the Pindos Mts. Additionally, the utility of new SSRs in 29 individuals from nine other Aesculus taxa was tested. Eleven markers gave polymorphic products for all tested species. For 24 individuals, a high-quality product was obtained for each marker. Results confirmed the utility of specific markers for future population genetics studies.
Źródło:
Dendrobiology; 2021, 85; 105-116
1641-1307
Pojawia się w:
Dendrobiology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
THE POSSIBILITY OF USING X-RAY POWDER DIFFRACTION, INFRARED AND RAMAN SPECTROSCOPY IN THE STUDY OF THE IDENTIFICATION OF STRUCTURAL POLYMORPHS OF ACETAMINOPHEN
Autorzy:
Stasiłowicz, Anna
Mizera, Mikołaj
Tykarska, Ewa
Lewandowska, Kornelia
Miklaszewski, Andrzej
Cielecka-Piontek, Judyta
Powiązania:
https://bibliotekanauki.pl/articles/895486.pdf
Data publikacji:
2019-12-29
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
acetaminophen
PXRD
Raman
FT-IR
structural polymorphism
Opis:
Paracetamol (acetaminophen), a pain-killer with antipyretic properties, shows structural polymorphism. It occurs in three polymorphic forms: monoclinic, orthorhombic, and unstable form III. In the study, the commercially available samples of paracetamol (P1 and P2) were examined using X-ray powder diffraction, infrared, and Raman spectroscopy. Results demonstrated that all of the methods defined polymorphic forms of paracetamol in the samples. However, only Raman spectroscopy and PXRD methods detected impurities in the sample P1. These methods transpired to be more sensitive than the FT-IR method, which identified samples of paracetamol as one structural form (monoclinic polymorph). Moreover, the Raman spectroscopy identified impurities in the form P1 as changes in the crystalline form.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 6; 997-1004
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Polimorficzność motywacji osób twórczych. Implikacje pedagogiczne
Autorzy:
Bartnicka-Michalska, Aneta
Powiązania:
https://bibliotekanauki.pl/articles/1789867.pdf
Data publikacji:
2015
Wydawca:
Uniwersytet Warszawski. Wydawnictwa Uniwersytetu Warszawskiego
Tematy:
interpreting artist
efficient personality
polymorphism of motivation
Opis:
In the article the hypothesis of motivational polymorphism in creativity is formulated and confirmed. The hypothesis assumes that activation of creative behaviour needs many different types of motivation, which are variations of one main motivation. The theoretical basis of this article rests on Józef Kozielecki’s concept of psychotransgressionism, which assumes that creative behaviour can be activated by three motivations: self-esteem motivation (hubristic), motivation of the meaning of life and motivation of self-efficiency. In this study on a sample of interpreting artists (N = 133), creative behaviour was measured using the STZ questionnaire (Strzałecki 2003). The motivational orientations were measured using the Polish adaptation of Power Motivation Scale (PMS) by Tokarz and Trzebińska (2011), the Polish adaptation of Life Attitude Profile questionnaire (LAP-R) by Klamut (2010) and the Polish adaptation of General Self- Efficacy Scale questionnaire (GSES) by Juczyński (2001). The results confirmed the hypothesis of a polymorphic nature of motivation in creative people. Educational implications of results are discussed.
Źródło:
Kwartalnik Pedagogiczny; 2015, 60(3 (237)); 34-52
0023-5938
Pojawia się w:
Kwartalnik Pedagogiczny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Revision of reciprocal action of mercury and selenium
Autorzy:
Kuraś, Renata
Janasik, Beata
Wąsowicz, Wojciech
Stanisławska, Magdalena
Powiązania:
https://bibliotekanauki.pl/articles/2162011.pdf
Data publikacji:
2018-10-23
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
gene expression
polymorphism
mercury
selenium
antagonism
interaction
Opis:
Diverse forms of mercury (Hg) have various effects on animals and humans because of a variety of routes of administration. Inorganic mercury (iHg) binds to thiol groups of proteins and enzymes in one’s body or is methylated by microorganisms. Organic form of Hg, contrary to the iHg, is more stable but may be demethylated to Hg2+ in the tissue of intestinal flora. Selenium (Se) also occurs in a variety of chemical forms in one’s body but both of these elements behave very differently from one another. Mercury binding to selenide or Se-containing ligands is a primary molecular mechanism that reduces toxicity of Hg. Complexes formed in such a way are irreversible, and thus, biologically inactive. Se deficiency in a human body may impair normal synthesis of selenoproteins and its expression because expression of mRNA may be potentially regulated by the Se status. This paper provides a comprehensive review concerning Hg–Se reciprocal action as a potential mechanism of protective action of Se against Hg toxicity as well as a potential detoxification mechanism. Although interactions between Hg–Se have been presented in numerous studies concerning animals and humans, we have focused mainly on animal models so as to understand molecular mechanisms responsible for antagonism better. The review also investigates what conclusions have been drawn by researchers with respect to the chemical species of Se and Hg (and their relationship) in biological systems as well as genetic variations and expression and/or activity of selenoproteins related to the thioredoxin (thioredoxin Trx/TrxR) system and glutathione metabolism. Int J Occup Med Environ Health 2018;31(5):575–592
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2018, 31, 5; 575-592
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of effect CAT -262C/T, SOD + 35A/C, GPx1 Pro197Leu polymorphisms in patients with ibd in the polish population
Autorzy:
Mrowicki, Jerzy
Mrowicka, Małgorzata
Majsterek, Ireneusz
Mik, Michał
Dziki, Adam
Dziki, Łukasz
Powiązania:
https://bibliotekanauki.pl/articles/1393718.pdf
Data publikacji:
2016
Wydawca:
Index Copernicus International
Tematy:
genetic polymorphism
antioxidant enzyme
inflammatory bowel disease
Opis:
Inflammatory bowel disease (IBD) are a heterogeneous group of disorders in the course dominated by chronic, recurrent gastrointestinal inflammation. It is believed that the activation of IBD occurs in patients with a genetic predisposition to their development. Chronic inflammation develops as a result of an excessive reaction of the immune system principally under the influence of environmental risk factors. Among them, it has been shown that the mechanism of oxidative stress is associated with the pathophysiology of inflammatory bowel disease, responsible for the commencement and progress of these diseases. The aim of the study was the relationship between single nucleotide polymorphisms (SNPs) of individual antioxidant enzymes, and the prevalence of inflammatory bowel disease that may be associated with increased levels of oxidative stress. Material and methods. A total of 111 IBD patients, including 65 patients with ulcerative colitis (UC) and 46 with Crohn’s disease (CD) and 125 healthy controls recruited from the Polish population, were genotyped for CAT -262C / T (rs1001179), SOD + 35A / C (rs2234694), GPx Pro 197 Leu polymorphisms. Genotyping of CAT, SOD, GPx gene polymorphism was performed by a RFLP-PCR. Results. The performed analysis of genetic polymorphisms of antioxidant enzymes showed that polymorphic variant of the CAT -262 C / T may have protective effects in patients with ulcerative colitis in the range of genotype C / T; OR = 0.49 (0.25-0.99), p = 0.044. Trend protective, but statistically unrelated, it was also observed for genotype T / T and T allele of the same polymorphism and genotypes and alleles + 35A / C SOD1 in UC as well as polymorphic variants CAT -262 C / T, Pro197Leu of GPx1, + 35A / C SOD1 in CD. The results were compared with a control group of potentially healthy individuals without such diseases. Conclusions. It has been shown that the polymorphism of antioxidant enzymes CAT gene -262 C / T may have protective effects in patients who are carriers of a genotype C / T at the UC. The potential protective effect without statistical relationships were also observed for other genotypes and alleles studied polymorphic variants of antioxidant enzymes in CD and CAT- 262C / T and + 35 A / C SOD1 in UC. Conducted our audit should be extended to more group of patients in order to assess whether or not to confirm the observed during analysis, the protective effect of CAT-262 C / T in ulcerative colitis and other trends observed for other polymorphic variants tested genes.
Źródło:
Polish Journal of Surgery; 2016, 88, 6; 565-575
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
DNA polymorphism in locus D1S80 in Poland. DNA profiling and detection of new alleles by heteroduplex formation between alleles of the same size
Autorzy:
Kwiatkowska, J
Dziechciowska, K
Lisiecka, D
Slomski, R
Powiązania:
https://bibliotekanauki.pl/articles/2046677.pdf
Data publikacji:
1997
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
DNA sequence
polymorphism
Polska
hybridization
Polish population
heteroduplex formation
DNA polymorphism
same size
polymerase chain reaction
allele
distribution
Opis:
We have analysed allele distribution at the highly polymorphic variable number of tandem repeats (VNTR) locus D1S80 (pMCT118) in the Polish population using the, polymerase chain reaction (PCR) technique. Characteristics of the D1S80 locus makes it a very useful marker for population genetic research, genetic linkage studies and forensic identification of individuals. During our routine application of the D1S80 marker to paternity testing in several cases of homozygosity detected by polyacrylamide gel electrophoresis, heteroduplex formation for alleles 18 and 24 was also observed. Direct sequencing of PCR products revealed that alleles 18 and 24 of locus D1S80 actually represent a mixture composed of different sequences. Our observations indicate that identification of some 18 and 24 VNTR alleles based only on size estimated in electrophoretic analyses could lead to errors in paternity testing and DNA profiling.
Źródło:
Journal of Applied Genetics; 1997, 38, 3; 335-341
1234-1983
Pojawia się w:
Journal of Applied Genetics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Doubled haploids as a material for biotechnological manipulation and as a modern tool for breeding oilseed rape (Brassica napus L.)
Autorzy:
Cegielska-Taras, T.
Szala, L.
Matuszczak, M.
Babula-Skowronska, D.
Mikolajczyk, K.
Poplawska, W.
Sosnowska, K.
Hernacki, B.
Olejnik, A.
Bartkowiak-Broda, I.
Powiązania:
https://bibliotekanauki.pl/articles/80477.pdf
Data publikacji:
2015
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
Brassica napus
oilseed rape
doubled haploid
marker-assisted selection
gene mapping
transformation
breeding
amplified fragment length polymorphism
random amplified polymorphic DNA
restriction fragment length polymorphism
recombinant inbred line
single nucleotide polymorphism
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2015, 96, 1
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The angiotensin converting enzyme gene i/d polymorphism in Polish rowers
Autorzy:
Jastrzębski, Zbigniew
Leońska-Duniec, Agata
Kolbowicz, Marek
Tomiak, Tomasz
Powiązania:
https://bibliotekanauki.pl/articles/1055139.pdf
Data publikacji:
2014
Wydawca:
Uniwersytet Szczeciński. Wydawnictwo Naukowe Uniwersytetu Szczecińskiego
Tematy:
ACE I/D polymorphism
athlete status
rowers
sport genetics
Opis:
Angiotensin converting enzyme gene (ACE) is the most frequently investigated genetic marker in the context of genetic conditioning of athletic predispositions. The product of the gene is a key component of the renin-angiotensin system (RAS) and the kallikrein-kinin system (KKS), mainly responsible for the regulation of blood pressure. The main aim of the study was to determine the possible interaction between the ACE I/D polymorphism and endurance athlete status in a group of Polish rowers in comparison with sedentary individuals. 121 male Polish rowers, members of academic sports clubs, and 115 unrelated volunteers, were recruited for the study. The PCR amplification of the insertion (I) or deletion (D) fragment of the ACE gene was performed. Compared with control group, the frequency of the I allele differ significantly from that found in rowers (57.4% vs. 44.3%; P=0.013) and the ACE genotype frequency amongst the whole cohort of rowers (30.6% II, 53.7% ID, 15.7% DD) was also different from expected values (control group 19.1% II, 50.4% ID, 30.4% DD; P=0.017). Our investigation confirms a positive association of the I allele of the ACE gene with endurance athlete status in a group of Polish rowers.
Źródło:
Central European Journal of Sport Sciences and Medicine; 2014, 5, 1; 77-82
2300-9705
2353-2807
Pojawia się w:
Central European Journal of Sport Sciences and Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of the G/C polymorphism in the 5-untranslated region of the RAD51 gene in breast cancer.
Autorzy:
Blasiak, Janusz
Przybyłowska, Karolina
Czechowska, Agnieszka
Zadrożny, Marek
Pertyński, Tomasz
Rykała, Jan
Kołacińska, Agnieszka
Morawiec, Zbigniew
Drzewoski, Józef
Powiązania:
https://bibliotekanauki.pl/articles/1043672.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
genetic polymorphism
RAD51 gene
RFLP-PCR
breast cancer
Opis:
The breast cancer suppressor proteins BRCA1 and BRCA2 interact with RAD51, a protein essential for maintaining genomic stability by playing a central role in homology-dependent recombinational repair of the DNA double-strand breaks. Therefore, genetic variability in the RAD51 gene may contribute to the appearance and/or progression of breast cancer. A single nucleotide polymorphism in the 5'- untranslated region of RAD51 (a G to C substitution at position 135, the G/C polymorphism) is reported to modulate breast cancer risk. We investigated the distribution of genotypes and frequency of alleles of the G/C polymorphism in breast cancer. Tumor tissues were obtained from postmenopausal women with node-negative and node-positive breast carcinoma with uniform tumor size. Blood samples from age matched healthy women served as control. The G/C polymorphism was determined by PCR-based MvaI restriction fragment length polymorphism. The distribution of the genotypes of the G/C polymorphism did not differ significantly (P >0.05) from those predicted by the Hardy-Weinberg distribution. There were no differences in the genotype distribution and allele frequencies between node-positive and node-negative patients. There were no significant differences between distributions of the genotypes in subgroups assigned to histological grades according to Scarf-Bloom-Richardson criteria and the distribution predicted by Hardy-Weinberg equilibrium (P >0.05). Our study implies that the G/C polymorphism of the RAD51 gene may not be directly involved in the development and/or progression of breast cancer and so it may not be useful as an independent marker in this disease.
Źródło:
Acta Biochimica Polonica; 2003, 50, 1; 249-253
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Transferrin receptor levels and polymorphism of its gene in age-related macular degeneration
Autorzy:
Wysokinski, Daniel
Danisz, Katarzyna
Pawlowska, Elzbieta
Dorecka, Mariola
Romaniuk, Dorota
Robaszkiewicz, Jacek
Szaflik, Marta
Szaflik, Jerzy
Blasiak, Janusz
Szaflik, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/1039085.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
AMD
gene polymorphism
iron
oxidative stress
TFRC
transferrin receptor
Opis:
The aim of the present study was to investigate the association of age related macular degeneration (AMD) risk with some aspects of iron homeostasis: iron concentration in serum, level of soluble transferrin receptor (sTfR), and transferrin receptor (TFRC) genetic variability. Four hundred and ninety one AMD patients and 171 controls were enrolled in the study. Restriction fragment length polymorphism PCR was employed to genotype polymorphisms of the TFRC gene, and colorimetric assays were used to determine the level of iron and sTfR. Multiple logistic regression was applied for all genotype/allele-related analyses and the ANOVA test for iron and sTfR serum level comparison. We found that the genotypes and alleles of the c.-253G > A polymorphism of the TFRC gene were associated with AMD risk and this association was modulated by smoking status, AMD family history, living environment (rural/urban), body mass index and age. The levels of sTfR was higher in AMD patients than controls, whereas concentrations of iron did not differ in these two groups. No association was found between AMD occurrence and the p.Gly142Ser polymorphism of the TRFC gene. The results obtained suggest that transferrin receptor and variability of its gene may influence AMD risk.
Źródło:
Acta Biochimica Polonica; 2015, 62, 2; 177-184
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Polymorphism of the porcine growth hormone gene and its linkage to microsatellites S0083 and S0090
Autorzy:
Korwin-Kossakowska, A
Pierzchala, M.
Kuryl, J.
Zwierzchowski, L.
Cymerowska-Prokopczyk, I.
Siadkowska, E.
Powiązania:
https://bibliotekanauki.pl/articles/2043894.pdf
Data publikacji:
1999
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
pig
gene
polymorphism
microsatellite
Sus scrofa
linkage
growth hormone
Źródło:
Journal of Applied Genetics; 1999, 40, 2; 85-91
1234-1983
Pojawia się w:
Journal of Applied Genetics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Fixing Design Inconsistencies of Polymorphic Methods Using Swarm Intelligence
Autorzy:
George, Renu
Samuel, Philip
Powiązania:
https://bibliotekanauki.pl/articles/1818478.pdf
Data publikacji:
2021
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
UML models
software design inconsistency
polymorphism
particle swarm optimization
Opis:
Background: Modern industry is heavily dependent on software. The complexity of designing and developing software is a serious engineering issue. With the growing size of software systems and increase in complexity, inconsistencies arise in software design and intelligent techniques are required to detect and fix inconsistencies. Aim: Current industrial practice of manually detecting inconsistencies is time consuming, error prone and incomplete. Inconsistencies arising as a result of polymorphic object interactions are hard to trace. We propose an approach to detect and fix inconsistencies in polymorphic method invocations in sequence models. Method: A novel intelligent approach based on self regulating particle swarm optimization to solve the inconsistency during software system design is presented. Inconsistency handling is modelled as an optimization problem that uses a maximizing fitness function. The proposed approach also identifies the changes required in the design diagrams to fix the inconsistencies. Result: The method is evaluated on different software design models involving static and dynamic polymorphism and inconsistencies are detected and resolved. Conclusion: Ensuring consistency of design is highly essential to develop quality software and solves a major design issue for practitioners. In addition, our approach helps to reduce the time and cost of developing software.
Źródło:
e-Informatica Software Engineering Journal; 2021, 15, 1; 7--27
1897-7979
Pojawia się w:
e-Informatica Software Engineering Journal
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Polimorfizm 575C/T genu RANK i jego związek z osteoporozą u kobiet po menopauzie
575C/T polymorphism of RANK gene and its association with osteoporosis in postmenopausal women
Autorzy:
Boroń, Dariusz
Plewka, Ariel
Jędrusik, Przemysław
Powiązania:
https://bibliotekanauki.pl/articles/1037782.pdf
Data publikacji:
2014
Wydawca:
Śląski Uniwersytet Medyczny w Katowicach
Tematy:
rank
polimorfizm
osteoporoza
kobieta
wiek
polymorphism
osteoporosis
women
age
Opis:
INTRODUCTION Osteoporosis is a skeletal disturbance in which bone strength is at increased risk of fracture. It was demonstrated that genetic variations in RANK are associated with skeletal diseases. AIM OF STUDY The aim of the study is to examine the frequency of RANK gene polymorphism and evaluate its relation with clinical parameters concerning bone turnover and the degree of postmenopausal osteoporosis progress. MATERIAL AND METHODS The study was conducted among a group of 570 women at postmenopausal age (404) and reproductive age (166). The group at postmenopausal age included women with osteoporosis, osteopenia and healthy individuals. The women at reproductive age were healthy. The polymorphism incidence of the examined gene in a group of patients with a determined bone mineral density (BMD) and in the control group was studied. The study was performed by means of the RFLP-PCR method. RESULTS The obtained results did not show a correlation of RANK C575T polymorphism with decreased bone density or increased risk of postemopausal osteoporosis incidence. CONCLUSIONS The TT polymorphism homozygote of the RANK receptor gene is not an increased risk factor of osteoporosis development and is associated with lower values describing bone density in women with osteoporosis and osteopenia.
W S T Ę P Osteoporoza jest szkieletowym zaburzeniem charakteryzującym się obniżeniem wytrzymałości kości, zwiększającym ryzyko złamania. Wykazano, że genetyczne wariacje w RANK mają związek z chorobami szkieletu kostnego. Celem pracy było zbadanie częstości występowania polimorfizmu genu RANK oraz ocena jego związku z parametrami klinicznymi dotyczącymi obrotu kostnego i stopnia zaawansowania osteoporozy pomenopauzalnej. M A T E R I A Ł Y I M E T O D Y Badania przeprowadzono w grupie 570 kobiet w wieku postmenopauzalnym (404) i rozrodczym (166). Grupa w wieku postmenopauzalnym obejmowała kobiety z osteoporozą, osteopenią i zdrowe. Kobiety w wieku rozrodczym były zdrowe. Zbadano częstość występowania polimorfizmu badanego genu w grupie pacjentek z oznaczoną gęstością mineralną kości (bone mineral density – BMD) oraz w grupie kontrolnej. Badanie przeprowadzono metodą RFLP-PCR. WYNIKI Uzyskane wyniki badań nie wykazały korelacji polimorfizmu RANK C575T ze zmniejszoną gęstością kości oraz zwiększonym ryzykiem występowania osteoporozy pomenopauzalnej. WNIOSKI Homozygota TT polimorfizmu genu receptora RANK nie jest czynnikiem zwiększonego ryzyka wystąpienia osteoporozy i jest powiązana z niższymi wartościami opisującymi BMD u kobiet z osteoporozą i osteopenią.
Źródło:
Annales Academiae Medicae Silesiensis; 2014, 68, 4; 192-199
1734-025X
Pojawia się w:
Annales Academiae Medicae Silesiensis
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Lack of Association Between the 135G/C Rad51 Gene Polymorphism and the Risk of Colorectal Cancer Among Polish Population
Autorzy:
Mucha, Bartosz
Przybyłowska-Sygut, Karolina
Dziki, Łukasz
Dziki, Adam
Sygut, Andrzej
Majsterek, Ireneusz
Powiązania:
https://bibliotekanauki.pl/articles/1396683.pdf
Data publikacji:
2012-07-01
Wydawca:
Index Copernicus International
Tematy:
polymorphism
135G/C RAD51 gene
colorectal cancer
Opis:
One of the major causes of carcinogenesis is loss of genome stability. RAD51 in process of homologous recombination (HR) played crucial role in maintenance integrity of genome through initiate of DNA double strand breaks repair. Presence of single nucleotide polymorphism (SNP) in RAD51 gene could change the capacity of DNA repair and altered the response to damaging agents. Research on potential impact of genetic variability on development and progression CRC may contribute to setting new genetic markers or/and determined individual susceptibility to CRC.The aim of the study. This study was designed to evaluate the effect of 135 G/C (rs1801320) RAD51 polymorphism located in the 5' untraslated region on the risk and progression of CRC.Material and methods. The subjects consisted of histologically confirmed colorectal cancer (n = 200) and controls (n = 200) with lack of previous history of cancer. The distribution of genotypes was determined by restriction fragment length polymorphism PCR (RFLP - PCR). Statistical analysis was based on multivariate regression model.Results and conclusion. Our study reveal no significance association of 135 G/C RAD51 polymorphism with occurrence and progression of colorectal cancer.
Źródło:
Polish Journal of Surgery; 2012, 84, 7; 358-362
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Polymorphisms in the p53 pathway genes and micronucleus occurrence in Chinese vinyl chloride-exposed workers
Autorzy:
Li, Yong
Feng, Nan-Nan
Zhang, Guang-Hui
Wang, Qi
Hao, Yan-Hui
Nanzhang, Ya
Long, Changxu
Li, Yongliang
Brandt-Rauf, Paul W.
Xia, Zhao-Lin
Powiązania:
https://bibliotekanauki.pl/articles/2179059.pdf
Data publikacji:
2013-12-01
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
VC
occupational exposure
p53 pathway genes
genetic polymorphism
Opis:
Objectives: To investigate the association between polymorphisms in the p53 pathway genes and chromosomal damage in vinyl chloride (VC)-exposed workers. Materials and Methods: Cytokinesis block micronucleus test was performed in 310 VC-exposed workers and 149 non-exposed workers to determine chromosomal damage. The polymerase chain reaction and restriction fragment length polymorphism technique were used to detect six SNPs in the p53 pathway genes involved in the cell cycle. Results: There was a highly significant dose-response relationship between VC exposure and chromosomal damage. Individuals carrying the variant genotypes were at higher risk for chromosomal damage compared with their wild type genotype: p53rs1042522, MDM2 Del1518rs3730485, MDM2rs2279744 and GADD45Ars532446. On the other hand, individuals possessing the variant genotype of CDKN2A rs3088440 had significantly decreased risk compared with the corresponding wild-type. Conclusions: Genetic polymorphisms in P53 pathway genes may have an impact on VC-induced chromosomal damage.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2013, 26, 6; 825-836
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Population genetic structure of Iris pumila L. in Ukraine: effects of habitat fragmentation
Autorzy:
Bublyk, O.
Andreev, I.
Parnikoza, I.
Kunakh, V.
Powiązania:
https://bibliotekanauki.pl/articles/2117815.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
conservation
genetic polymorphism
habitat fragmentation
ISSR markers
population
genetics
Opis:
Habitat fragmentation is one of serious threats to biodiversity of nature in today's world. The present study of a typical steppe species Iris pumila L. (Iridaceae) has analyzed the impacts of geographical isolation and population size on genetic diversity and population structure in conditions of habitat fragmentation. The key indices of population genetic variability calculated from the ISSR markers data were on average as follows: Shannon diversity index (S) – 0.188; unbiased Nei’s gene diversity (He ) – 0.123; and the average measure of Jaccard’s genetic distances between individuals within populations – 58.4%. Although the largest population had significantly higher values of S and He, the small and marginal populations also showed a comparable level of variation. Most of the genetic variation of I. pumila was distributed within the populations. A strong correlation was found between Nei’s genetic distances and geographic distances between the populations. According to the Bayesian analysis, genetic structure of the populations was highly homogeneous; however, the presence of admixed genotypes indicated the possibility of gene flow between the populations at present.
Źródło:
Acta Biologica Cracoviensia. Series Botanica; 2020, 62, 1; 51-61
0001-5296
Pojawia się w:
Acta Biologica Cracoviensia. Series Botanica
Dostawca treści:
Biblioteka Nauki
Artykuł

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