Temat: platelet. - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Evaluation of platelet indexes as potential biomarkers of suspected pulmonary embolism
Autorzy:: Wójcik, Mariusz
Daszyk-Wójcik, Joanna
Skoczyński, Kamil
Powiązania:: https://bibliotekanauki.pl/articles/454999.pdf
Data publikacji:: 2019
Wydawca:: Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:: mean platelet volume
platelet count
platelet distribution width
pulmonary embolism
Opis:: Introduction. Pulmonary embolism is one of the most frequent cardiovascular diseases, potentially leading to death. There is no validated biomarker with both high specificity and sensitivity. Aim. The aim of the study was to define the diagnostic importance of platelet count (PLT), mean platelet volume (MPV) and platelet distribution width (PDW) on acute pulmonary embolism. Material and methods. We retrospectively reviewed the medical records of 145 patients with clinically suspected acute pulmonary embolism admitted to the Emergency Department. Demographic data and laboratory tests were collected on admission. All patients underwent computed tomography (CT) angiography. Results. The total data of 145 patients were analyzed, including 65 patients (67±17 years; 30 men/35 women) with acute pulmonary embolism confirmed with CT and 80 patients (67±19 years; 26 men/54 women) with negative CT. The MPV did not differ between the patients with acute PE and the control group (8.0 fL [IQR: 7.6-8.4] vs. 7.9 fL [IQR: 7.4-8.7], p=0.45). There were no significant differences in PLT (220x10³/mm³ [IQR: 172-274] vs. 243x10³/mm³ [IQR: 186-286], p=0.12) and PDW (59.0 ± 6.9% vs. 57.2 ± 7.3%, p=0.12). Conclusions. Our results suggest that platelet indexes (at a single time point) are not a reliable diagnostic biomarkers of acute pulmonary embolism.
Źródło:: European Journal of Clinical and Experimental Medicine; 2019, 2; 113-117
2544-2406
2544-1361
Pojawia się w:: European Journal of Clinical and Experimental Medicine
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: The effect of some ε-aminocaproic acid derivatives on platelet responses.
Autorzy:: Bruzgo, Irena
Tomasiak, Marian
Stelmach, Halina
Midura-Nowaczek, Krystyna
Powiązania:: https://bibliotekanauki.pl/articles/1043320.pdf
Data publikacji:: 2004
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: platelet aggregation
ε-aminocaproic acid derivatives
platelet adhesion
LDH release
Opis:: ε-Aminocaproic acid (EACA) is a synthetic low molecular drug with antifibrinolytic activity. However, treatment with this drug can be incidentally associated with an increased thrombotic tendency. The aim of the present work was to test synthetic EACA derivatives for their antiplatelet activities. We investigated the effect of three EACA derivatives with antifibrinolytic activity: I. ε-aminocaproyl-L-leucine hydrochloride (HClH-EACA-L-Leu-OH), II. ε-aminocaproyl-L-(S-benzyl)-cysteine hydrochloride (HClH-EACA-L-Cys(S-Bzl)-OH) and III. ε-aminocaproyl-L-norleucine (H-EACA-L-Nle-OH) on platelet responses (aggregation and adhesion) and on their integrity. It was found that: 1. as judged by LDH release test, none of the tested compounds, up to 20 mM, was toxic to platelets, 2. in comparison with EACA, all the synthetic derivatives inhibited much stronger the ADP- and collagen-induced aggregation of platelets suspended in plasma (platelet rich plasma) and aggregation of these cells in whole blood, 3. EACA and its derivatives exerted a similar inhibitory effect on the thrombin-induced adhesion of platelets to fibrinogen-coated surfaces. Since platelet activation and blood coagulation are tightly associated processes, the antiplatelet properties of EACA derivatives are expected to indicate reduced thrombotic properties of these derivatives compared to EACA.
Źródło:: Acta Biochimica Polonica; 2004, 51, 1; 73-80
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: The role of Na+/H+ exchanger in serotonin secretion from porcine blood platelets
Autorzy:: Tomasiak, Marian
Ciborowski, Michal
Stelmach, Halina
Powiązania:: https://bibliotekanauki.pl/articles/1041323.pdf
Data publikacji:: 2005
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: platelet swelling
platelet secretion
serotonin release
Na+/H+ exchanger
platelets
Opis:: This study was undertaken to evaluate whether a link exists between the activation of protein kinase C (PKC), operation of Na+/H+ exchanger (NHE), cell swelling and serotonin (5-HT) secretion in porcine platelets. Activation of platelets by thrombin or phorbol 12-myristate 13-acetate (PMA), a PKC activator, initiated a rapid rise in the activity of Na+/H+ exchanger and secretion of 5-HT. Both thrombin- and PMA-evoked activation of Na+/H+ exchanger was less pronounced in the presence of ethyl-isopropyl-amiloride (EIPA), an NHE inhibitor, and by GF 109203X, a PKC inhibitor. Monensin (simulating the action of NHE) caused a dose-dependent release of 5-HT that was not abolished by GF 109203X or EGTA. Lack of Na+ in the suspending medium reduced thrombin-, PMA-, and monensin-evoked 5-HT secretion. GF 109203X nearly completely inhibited 5-HT release induced by PMA-, partly that induced by thrombin, and had no effect on 5-HT release induced by monensin. EIPA partly inhibited 5-HT release induced by thrombin and nearly totally that evoked by PMA. Electronic cell sizing measurements showed an increase in mean platelet volume upon treatment of cells with monensin, PMA or thrombin. The PMA- and thrombin-evoked rise in mean platelet volume was strongly reduced in the presence of EIPA. As judged by optical swelling assay monensin and PMA produced a rapid rise in platelet volume. The swelling elicited by PMA was inhibited by EIPA and its kinetics was similar to that observed in the presence of monensin. Hypoosmotically evoked platelet swelling did not affect platelet aggregation but significantly potentiated thrombin-evoked release of 5-HT and ATP. Taken together, these results show that in porcine platelets PKC may promote 5-HT secretion through the activation of NHE. It is hypothesized that enhanced Na+/H+ antiport may result in a rise in cell membrane tension (due to cell swelling) which in turn facilitates fusion of secretory granules with the plasma membrane leading to 5-HT secretion.
Źródło:: Acta Biochimica Polonica; 2005, 52, 4; 811-822
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Effects of cisplatin and selenite on the level of thiols in pig blood platelets
Autorzy:: Wachowicz, B
Krajewski, T.
Olas, B.
Zbikowska, H.M.
Powiązania:: https://bibliotekanauki.pl/articles/70215.pdf
Data publikacji:: 1995
Wydawca:: Polskie Towarzystwo Fizjologiczne
Tematy:: pig
sulphydryl group
platelet lipid
platelet fraction
sodium selenite
protein
thiol
glutathione
DNA
in vitro
platelet
selenite
Źródło:: Journal of Physiology and Pharmacology; 1995, 46, 1
0867-5910
Pojawia się w:: Journal of Physiology and Pharmacology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Inhibition of collagen-induced platelet reactivity by DGEA peptide.
Autorzy:: Luzak, Boguslawa
Golanski, Jacek
Rozalski, Marcin
Boncler, Magdalena
Watala, Cezary
Powiązania:: https://bibliotekanauki.pl/articles/1043398.pdf
Data publikacji:: 2003
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: collagen
platelet receptor antagonists
collagen receptors
GPIaIIa
DGEA
platelet reactivity
Opis:: Direct interactions between collagen, the most thrombogenic component of the extracellular matrix, and platelet surface membrane receptors mediate platelet adhesion and induce platelet activation and aggregation. In this process two glycoproteins are crucial: integrin α2β1, an adhesive receptor, and GPVI, which is especially responsible for signal transduction. Specific antagonists of the collagen receptors are useful tools for investigating the complexity of platelet-collagen interactions. In this work we assessed the usefulness of DGEA peptide (Asp-Gly-Glu-Ala), the shortest collagen type I-derived motif recognised by the collagen-binding integrin α2β1, as a potential antagonist of collagen receptors. We examined platelet function using several methods including platelet adhesion under static conditions, platelet function analyser PFA-100TM, whole blood electric impedance aggregometry (WBEA) and flow cytometry. We found that DGEA significantly inhibited adhesion, aggregation and release reaction of collagen activated blood platelets. The inhibitory effect of DGEA on static platelet adhesion reached sub-maximal values at millimolar inhibitor concentrations, whereas the specific blocker of α2β1 - monoclonal antibodies Gi9, when used at saturating concentrations, had only a moderate inhibitory effect on platelet adhesion. Considering that 25-30% of total collagen binding to α2β1 is specific, we conclude that DGEA is a strong antagonist interfering with a variety of collagen-platelet interactions, and it can be recognised not only by the primary platelet adhesion receptor α2β1 but also by other collagen receptors.
Źródło:: Acta Biochimica Polonica; 2003, 50, 4; 1119-1128
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: PDGF-BB homodimer serum level – a good indicator of the severity of alcoholic liver cirrhosis
Autorzy:: Kurys-Denis, E.
Prystupa, A.
Luchowska-Kocot, D.
Krupski, W.
Bis-Wencel, H.
Panasiuk, L.
Powiązania:: https://bibliotekanauki.pl/articles/2085441.pdf
Data publikacji:: 2020
Wydawca:: Instytut Medycyny Wsi
Tematy:: alcohol
liver cirrhosis
Child-Pugh score
platelet derived growth factor AA
platelet growth factor AB
platelet derived
growth factor BB
Opis:: Introduction. Liver cirrhosis is a chronic disease in which progressive fibrosis is noted. This process leads to changed architectonics of the liver parenchyma and the appearance of regenerative nodules, all of which are caused by pathological activation of the hepatic stellate cells. This process is enhanced on a molecular level by many cytokines, with platelet-derived growth factors (PDGFs) playing the key role. Objective. The aim of the study was to assess serum concentrations of PDGFs active biodymers (PDGF-AA, PDGF-BB and PDGF-AB) in patients with alcoholic liver cirrhosis, and to correlate them with the stage of disease. Materials and method. 64 patients with alcoholic cirrhosis and a control group of 16 healthy individuals were analysed. Liver cirrhosis was determined based on clinical image, history of the patients’ alcohol consumption, laboratory findings and abdominal ultrasonography. The serum PDGF-AA, PDGF-BB and PDGF-AB concentrations were determined using ELISA kits. Results. Serum concentration of PDGF-AA and PDGF-BB homodimers increases in patients with alcoholic liver cirrhosis (p=0.034 and p<0.0001, respectively), unlike the serum concentration of PDGF-AB heterodimer (p>0.05). When the stage of the disease increases, the concentrations of PDGF-AA and PGFD-BB in blood also oncrease. Furthermore, the serum level of both PDGF-AA and PDGF-BB correlates significantly with the severity of alcoholic liver cirrhosis (measured by Pugh-Child’s scale), the correlation being stronger in the case of PDGF-BB levels than PDGF-AA (R=0.28; p=0.027 and R=0.26; p=0.038, respectively). Conclusions. The plasma levels of PDGF-AA and -BB may be indicators of alcohol-induced liver fibrosis process, and might be considered as future possible treatment targets, with PDGF-BB levels being an even better indicator than PDGF-AA levels.
Źródło:: Annals of Agricultural and Environmental Medicine; 2020, 27, 1; 80-85
1232-1966
Pojawia się w:: Annals of Agricultural and Environmental Medicine
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: Platelet-rich plasma, platelet-rich fibrin, and enamel matrix derivative for oral mucosal wound healing
Autorzy:: Vokurka, J.
Hromcik, F.
Faldyna, M.
Gopfert, E.
Vicenova, M.
Pozarova, L.
Izakovicova Holla, L.
Powiązania:: https://bibliotekanauki.pl/articles/2087323.pdf
Data publikacji:: 2020
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: platelet-rich plasma
platelet-rich fibrin
wound healing
dental enamel proteins
artificial membranes
Źródło:: Polish Journal of Veterinary Sciences; 2020, 23, 2; 169-176
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 8.

Tytuł:: Inhibitory effect of resveratrol on free radical generation in blood platelets
Autorzy:: Olas, Beata
Żbikowska, Halina
Wachowicz, Barbara
Krajewski, Tadeusz
Buczyński, Andrzej
Magnuszewska, Arleta
Powiązania:: https://bibliotekanauki.pl/articles/1044455.pdf
Data publikacji:: 1999
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: resveratrol
blood platelet
free radicals
Opis:: Resveratrol (3,4',5-trihydroxystilbene), a compound found in many plants, has been shown to prevent coronary heart diseases and to exert a variety of antiinflammatory and anticancerogenic effects. It is effective in lowering the level of serum lipids and in inhibiting platelet aggregation. We evaluated the effect of trans-resveratrol on the production of free radicals in pig blood platelets and showed that resveratrol inhibited the production of different reactive oxygen species (O^·_2H^2O^2, singlet oxygen and organic radicals) measured by the luminol-dependent chemiluminescence in resting platelets (P < 0.05). Resveratrol inhibited also the generation of radicals in platelets activated by thrombin (P < 0.05). Treatment of platelets with resveratrol at concentrations of 6.25 and 12.5 μg/ml caused a statistically insignificant increase in the production of O^·-_2 in these cells, as measured by reduction of cytochrome c; however, at higher doses (25, 50 and 100 μg/ml) resveratrol distinctly reduced the generation of O^·-_2 in platelets (P < 0.05). We suggest that free radicals play an important role in the reduced reactivity of blood platelets induced by resveratrol.
Źródło:: Acta Biochimica Polonica; 1999, 46, 4; 961-966
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 9.

Tytuł:: Comparing prevalence and characteristic of anemia in children with simple versus complex febrile seizures
Autorzy:: Momen, Ali Akbar
Asnafi, Ali Amin
Nikkhah, Ali
Reza Khalilian, Mohammad
Mahmudi, Mohammad
Da voodzadeh, Hannaneh
Powiązania:: https://bibliotekanauki.pl/articles/552868.pdf
Data publikacji:: 2018
Wydawca:: Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych
Tematy:: seizures
febrile
anemia
hemoglobin
platelet.
Źródło:: Family Medicine & Primary Care Review; 2018, 1; 25-28
1734-3402
Pojawia się w:: Family Medicine & Primary Care Review
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 10.

Tytuł:: The use of platelet-rich plasma in anti-aging therapy (overview)
Autorzy:: Chorążewska, Małgorzata
Piech, Piotr
Pietrak, Justyna
Kozioł, Maciej
Obierzyński, Paweł
Maślanko, Monika
Wilczyńska, Karolina
Tulwin, Tytus
Łuczyk, Robert
Powiązania:: https://bibliotekanauki.pl/articles/765465.pdf
Data publikacji:: 2017
Wydawca:: Uniwersytet Mikołaja Kopernika w Toruniu. Wydział Nauk o Ziemi i Gospodarki Przestrzennej. Katedra Kultury Fizycznej
Tematy:: platelet-rich plasma, anti-aging therapy
Opis:: IntroductionAging stands for the changes in the human body, which are recognized as natural processes that concern every person and are related to the passage of time. Despite ‘normalness’ of the process, a tendency is emerging to treat aging as a pathology requiring proper diagnostics. Consequently, an ‘anti-aging’ medicine has been established - defined as study of preventing and slowing down the process of aging.Aim of the studyThe aim of this study is to summarize and present the current knowledge, based on the overview of writing on the properties and effectiveness of the use of PRP in anti-aging therapy. Description of knowledge Autologous platelet-rich plasma is a concentrate of human blood platelets suspended in a small amount of plasma, wherein concentration of thrombocytes is higher than initial concentration. For autologous plasma to have high healing properties, platelet levels should be at least 1 million in 5 ml of plasma.The basic condition for initiating repair and regenerative processes in vivo is the formation of a blood clot. Also, by degranulating, platelets release many growth factors, such as PDGF, TGF-β, EGF, FGF, VEGF and others, which are involved not only in blood coagulation, but also in immune response and tissue healing.The large variety of PRP-obtaining methods and the range of concentration levels of growth factors in PRP may lead to ambiguity in the literature, as to the extent to which formulation was actually used in a variety of preclinical and clinical studies. Some of those studies are presented in this article. Summary Platelet-rich treatments are part of the growing popularity of regenerative medicine, which is beginning to be recognized as the medicine of the future. However, without proper control methods or optimization of numerous variables (e.g. concentration or ratio of growth factors) during PRP preparation, it is not known which ingredients are needed and preferred, and which are harmful for tissue regeneration.However, numerous studies show PRP injection as a promising method of rejuvenating the skin, therefore platelet-rich treatments are an important part of the growing popularity of regenerative medicine.
Źródło:: Journal of Education, Health and Sport; 2017, 7, 11
2391-8306
Pojawia się w:: Journal of Education, Health and Sport
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 11.

Tytuł:: The effect of nitric oxide donors on the release of plasminogen activator inhibitor [PAI] from rabbit platelets in vitro
Autorzy:: Korbut, R
Marcinkiewicz, E.
Cieslik, K.
Gryglewski, R.J.
Powiązania:: https://bibliotekanauki.pl/articles/68948.pdf
Data publikacji:: 1995
Wydawca:: Polskie Towarzystwo Fizjologiczne
Tematy:: donor
nitrovasodilator
sodium nitroprusside
fibrinolysis
rabbit platelet
nitric oxide
plasminogen activator
prostacyclin
in vitro
inhibitor
platelet
Źródło:: Journal of Physiology and Pharmacology; 1995, 46, 1
0867-5910
Pojawia się w:: Journal of Physiology and Pharmacology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 12.

Tytuł:: The role of platelet-activating factor (PAF) antagonists and nitric oxide in cardiac actions of PAF. Electrophysiological and morphological study
Autorzy:: Kecskemeti, V.
Balogh, I.
Powiązania:: https://bibliotekanauki.pl/articles/69829.pdf
Data publikacji:: 2000
Wydawca:: Polskie Towarzystwo Fizjologiczne
Tematy:: platelet-activating factor
cardiac ultrastructure
cardiac action
nitric oxide
glibenclamide
atrial fibre
cardiovascular disease
platelet
ventricular fibre
Źródło:: Journal of Physiology and Pharmacology; 2000, 51, 4,1
0867-5910
Pojawia się w:: Journal of Physiology and Pharmacology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 13.

Tytuł:: Theoretical study of stress transfer in platelet reinforced composites
Autorzy:: Fattahi, A. M.
Mondali, M.
Powiązania:: https://bibliotekanauki.pl/articles/281969.pdf
Data publikacji:: 2014
Wydawca:: Polskie Towarzystwo Mechaniki Teoretycznej i Stosowanej
Tematy:: analytical modeling
platelet reinforced composites
stress transfer
Opis:: An analytical approach was developed for rectangular platelet reinforced composites which could be used for a 3D elastic stress field distribution subjected to an applied axial load. The ends of the platelet could be bonded to the matrix. Exact displacement solutions were derived for the matrix/platelet fromtheory of elasticity. These displacement solutions were then superposed for achieving analytical expressions for the matrix/platelet 3D stress field components over the entire composite system including the platelet end region, using the adding imaginary fiber technique. The platelet/matrix components could exactly satisfy the equilibrium and compatibility conditions and satisfy the equilibrium requirements and the overall boundary conditions. The obtained analytical results were then validated by FEM and Shear-lag modeling, and some of discrepancies among the shear-lag models were resolved. Good agreements were observed between the analytical and numerical predictions.
Źródło:: Journal of Theoretical and Applied Mechanics; 2014, 52, 1; 3-14
1429-2955
Pojawia się w:: Journal of Theoretical and Applied Mechanics
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 14.

Tytuł:: Platelet count in elderly patients with unipolar depression – case control analysis
Liczba płytek krwi u pacjentów w podeszłym wieku z depresją jednobiegunową – analiza typu case control
Autorzy:: Wysokiński, Adam
Socha, Krzysztof
Sołtysik, Bartłomiej Konrad
Kłoszewska, Iwona
Sobów, Tomasz
Kostka, Tomasz
Powiązania:: https://bibliotekanauki.pl/articles/941700.pdf
Data publikacji:: 2018
Wydawca:: Medical Communications
Tematy:: depression
elderly
old age psychiatry
platelet count
Opis:: Aim: While the effect of antidepressants on platelet functions is relatively well studied, there are few studies comparing platelet parameters, such as platelet count, between elderly patients with unipolar depression and non-depressed elderly subjects. Therefore, the aim of the study was to determine if there are differences in platelet count in elderly patients with unipolar depression (DEP) compared with non-depressed elderly patients (nonDEP) using case-control analysis. Methods: We measured platelet count in 582 (DEP: n = 291, nonDEP: n = 291) Caucasian in-patients aged ≥60. The mean age of the study subjects was 77.2 years, there were 243 (83.5%) women in both study groups. Results: The mean platelet count was significantly (p = 0.02) lower in the DEP group (241.6 ± 82.0) compared with the nonDEP group (263.6 ± 107.2). We also found that platelet count was not correlated with age. Conclusions: Compared with non-depressed controls, elderly patients with depression have decreased number of platelet cells. This, combined with the known effect of antidepressants on platelet agreeability, may translate into an increased risk of bleeding complications in the course of antidepressive treatment in elderly patients. Careful monitoring of platelet parameters is therefore recommended in the clinical population of elderly depressed patients.
Cel: O ile wpływ leków przeciwdepresyjnych na funkcje płytek krwi jest stosunkowo dobrze zbadany, o tyle niewiele jest badań porównujących parametry płytek krwi (takie jak liczba płytek krwi) u osób w podeszłym wieku z depresją jednobiegunową i bez depresji. Celem badania było określenie, czy istnieją różnice w liczbie płytek u pacjentów w podeszłym wieku z depresją jednobiegunową (DEP) w porównaniu z pacjentami w podeszłym wieku (nonDEP), za pomocą metody analizy case control. Metody: Oceniono liczbę płytek krwi u 582 (DEP: n = 291, nonDEP: n = 291) pacjentów rasy kaukaskiej w wieku ≥60 lat. Średni wiek badanych wynosił 77,2 roku, w obu grupach było 243 (83,5%) kobiet. Wyniki: Średnia liczba płytek krwi była istotnie statystycznie mniejsza (p = 0,02) w grupie DEP (241,6 ± 82,0) w porównaniu z grupą nonDEP (263,6 ± 107,2). Stwierdzono ponadto, że liczba płytek krwi nie korelowała z wiekiem. Wnioski: W porównaniu z grupą kontrolną u pacjentów w podeszłym wieku z depresją liczba płytek krwi była mniejsza. Fakt ten, w połączeniu ze znanym wpływem leków przeciwdepresyjnych na agregację płytek krwi, może przełożyć się na zwiększone ryzyko wystąpienia powikłań krwotocznych w trakcie leczenia przeciwdepresyjnego u pacjentów w podeszłym wieku. Zaleca się ostrożne monitorowanie parametrów płytek w populacji klinicznej u pacjentów w podeszłym wieku.
Źródło:: Psychiatria i Psychologia Kliniczna; 2018, 18, 1; 19-24
1644-6313
2451-0645
Pojawia się w:: Psychiatria i Psychologia Kliniczna
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 15.

Tytuł:: Assessment of hemocompatibility of materials with arterial blood flow by platelet functional tests
Autorzy:: Sanak, M.
Jakieła, B.
Węgrzyn, W.
Powiązania:: https://bibliotekanauki.pl/articles/200067.pdf
Data publikacji:: 2010
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: hemocompatibility tests
blood shear stress
platelet microparticles
Opis:: Hemocompatibility test of medical materials aims to detect adverse interaction between artificial surface and blood, which can activate or destruct blood components. In arterial flow conditions, due to a high shear stress, platelet is the cell critical for the hemocompatibility compliance. A classical instrumentation for the dynamic test of hemocompatibility involves a flow chamber with a contact surface between blood stream and tested plate. In the current study we investigated a simplified model of the whole blood shear stress, based on a cone and plate rotational viscometer. Several indices of platelet activation were analyzed, including platelet- and granulocyte-platelet aggregates, platelet activation markers and platelet-derived microparticles. This model allowed to estimate platelet destruction, however no adhesion could be measured directly. In following tests of several polymer and metallic layer coated materials, the test revealed comparable performance to more laborious hemocompatibility experiments. We suggest, that thrombogenic potential of platelet-derived microparticles, which can be accurately measured in blood plasma, offers very useful estimate of hemocompatibility. Moreover, this parameter has already been validated in clinics and could be used for monitoring of implanted cardiovascular materials.
Źródło:: Bulletin of the Polish Academy of Sciences. Technical Sciences; 2010, 58, 2; 317-322
0239-7528
Pojawia się w:: Bulletin of the Polish Academy of Sciences. Technical Sciences
Dostawca treści:: Biblioteka Nauki

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