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Wyszukujesz frazę "pixantrone" wg kryterium: Temat

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    Wyświetlanie 1-4 z 4
    Tytuł:
    Complete response to pixantrone as a salvage therapy in a relapsed/refractory diffuse large B-cell lymphoma
    Autorzy:
    Pasternak, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/1035645.pdf
    Data publikacji:
    2020
    Wydawca:
    Medical Education
    Tematy:
    DLBCL lymphoma
    cardiotoxicity
    pixantrone
    Opis:
    Diffuse large B-cell lymphoma (DLBCL) is an aggressive form of non-Hodgkin lymphoma (NHL). It is one of the most common form of the disease. A combination of chemotherapy with anthracycline and a monoclonal antibody targeting CD20 is used as a I line therapy. About two out of three people with DLBCL achieve and maintain complete remission after this treatment. In case of relapse or refractory disease a salvage high‑dose chemotherapy followed by autologous stem cell transplantation (HD-ASCT) is the standard of care. Patientrs who relapse after HD-ASCT have a very poor prognosis. Pixantrone is a new anthracycline derivative registered to treat relapsed/refractory DLBCL in adult patients. It is a cytostatic agent with a reduced cardiotoxicity comparing to classic anthracyclines. Herein, we report two cases of relapsed/refractory DLBCL treated with pixantrone as a salvage therapy. The first case concernes a 58-year-old female patient with a diagnose of DLBCL, who relapsed after four prior lines of therapy (R-CHOP, ICE, HD-Mtx, CSN radiation) and achieved complete remission after pixantrone therapy, but died of acute myeloid leukemia 3 months after the end of treatment. Second case is a story of a 75-year-old female patient treated with two prior lines of treatment (R-CHOP, R-IVE), who achieved complete remission after a III line of therapy with pixantrone. Pixantrone monotherapy proves to be effective in relapsed/refractory DLBCL. This treatment is well tolerated in a group of elderly patients and can be also used in a group of patients with a limited cardiac function.
    Źródło:
    OncoReview; 2020, 10, 2; 62-68
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Pixantrone – anticancer drug in the monotherapy of aggressive lymphomas
    Autorzy:
    Hałka, Janusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1035635.pdf
    Data publikacji:
    2020-06-30
    Wydawca:
    Medical Education
    Tematy:
    aggressive non-Hodgkin lymphoma
    cardiotoxicity
    pixantrone
    Opis:
    Pixantrone is a first drug aza-anthracenedione approved as monotherapy of relapsed or refractory aggressive lymphomas. This drug has the unique chemical structure and mode of action properties distinguishing it from anthracyclines and anthracenediones. Pixantrone is one of the treatment option for heavily pretreated patients which to receive their living with doxorubicin and the further application from anthracyclines potentially can lead anthracycline-induced congestive heart failure. The benefit of pixantrone treatment has not been established in patients when used as V line or greater chemotherapy in patients who are refractory to last therapy. In general, pixantrone seems to be safe and manageable. In various trials, there were no unexpected side effects reported and no trials were closed prematurely because of side effects. In an evaluation of 12 clinical trials with pixantrone, the most common side effect (all grades) was hematological toxicity, mainly neutropenia (50% of patients; grade third/fourth: 41%), leukopenia (25%), anemia (31%), and thrombocytopenia (21%). Hematological toxicity was the main reason for a delayed start of subsequent cycles or for omitting the day-15 dose of pixantrone. In the outpatient setting, it is worth considering the use of hematopoietic growth factors. Other side effects included asthenia (23%), pyrexia (23%), and nausea, most patients experienced reversible skin discoloration
    Źródło:
    OncoReview; 2020, 10, 2; 48-51
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Application of pixantrone in a III line of treatment as a bridge therapy to allotransplantation of stem cells
    Autorzy:
    Kwiatkowska-Pamuła, Anna
    Janeczek, Aleksandra
    Giebel, Sebastian
    Powiązania:
    https://bibliotekanauki.pl/articles/1035647.pdf
    Data publikacji:
    2020-06-30
    Wydawca:
    Medical Education
    Tematy:
    DLBCL lymphoma
    allo-HSCT
    cardiotoxicity
    chemotherapy
    pixantrone
    Opis:
    Diffuse large B-cell lymphomas are the most common group among all lymphomas. Despite the effectiveness of the I line therapy in 10–40% of patients, the possibility of relapse should be taken into account. The anthracycline antibiotics used in the II line therapy carry a high risk of cardiac complications. In patients with refractory or recurrent disease, emergency treatment is used, aiming for the transplantation of hematopoietic cells. If the II line therapy fails, the prognosis is bad. A new chance for patients with refractory or recurrent B-cell lymphoma is pixantrone dimaleate, a drug structurally related to anthracyclines with a significantly lower cardiotoxic potential. The paper presents a case of a 65-year-old patient with relapsing DLBCL lymphoma, after two treatment lines: R-CHOP and R-DHAP, and after autologous transplantation of stem cells, in which the use of pixantrone in the treatment of recurrence allowed to achieve remission and prepare the patient for the allo-HSCT procedure.
    Źródło:
    OncoReview; 2020, 10, 2; 57-61
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Partial remission in patient with Richter syndrome: an „emergency” treatment with pixantrone
    Autorzy:
    Szwedyk, Paweł
    Powiązania:
    https://bibliotekanauki.pl/articles/1035640.pdf
    Data publikacji:
    2020-06-30
    Wydawca:
    Medical Education
    Tematy:
    Richter syndrome
    chemotherapy
    chronic lymphocytic leukemia
    immunotherapy
    pixantrone
    Opis:
    Chronic lymphocytic leukemia is the most commonly recognized type of leukemia in adults. The appearance of systemic symptoms such as weight loss, fever, or local symptoms in the form of rapidly growing organomegaly, lymphadenopathy in a patient with CLL raises the suspicion of transformation into a high-grade lymphoma – defined as Richter syndrome which is usually associated with very poor prognosis. The described case concerns a 71-year-old patient with this diagnosis, in whom due to the confirmed resistance to subsequent lines of immuno- and chemotherapy, an „emergency” treatment with a modern chemotherapy drug from the aza-anthracendion group – pixantrone was used. Treatment with pixantrone was associated with a relatively good response, translating into partial remission (also in the area of infiltrative changes in the head and neck structures), stabilization of the course of the disease and, consequently, allowed to extend the patient’s life.
    Źródło:
    OncoReview; 2020, 10, 2; 52-56
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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