Temat: phorbol myristate acetate - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Regulation of cyclooxygenase isoforms in the renal thick ascending limb: effects of extracellular calcium
Autorzy:: Wang, D.
McGiff, J.C.
Ferreri, N.R.
Powiązania:: https://bibliotekanauki.pl/articles/69248.pdf
Data publikacji:: 2000
Wydawca:: Polskie Towarzystwo Fizjologiczne
Tematy:: calcium-sensing receptor
arachidonic acid
limb
tumour necrosis factor-alpha
enzyme
kidney
cyclooxygenase
phorbol myristate acetate
extracellular calcium
Źródło:: Journal of Physiology and Pharmacology; 2000, 51, 4,1
0867-5910
Pojawia się w:: Journal of Physiology and Pharmacology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Sp1 mediates phorbol ester (PMA)-induced expression of membrane-bound guanylyl cyclase GC-A in human monocytic THP-1 cells
Autorzy:: Mitkiewicz, Małgorzata
Bac, Bernadeta
Kuropatwa, Marianna
Kurowska, Ewa
Matuszyk, Janusz
Siednienko, Jakub
Powiązania:: https://bibliotekanauki.pl/articles/1038369.pdf
Data publikacji:: 2018
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: membrane-bound guanylyl cyclase type A
phorbol 12-myristate 13-acetate
human monocytic cell line THP-1
protein kinases
Sp1 transcription factor
Opis:: Cyclic guanosine monophosphate (cGMP) is synthesized by two types of enzymes: particulate (membrane-bound) guanylyl cyclases (pGCs) and soluble (cytosolic) guanylyl cyclases (sGCs). sGCs are primarily activated by binding of nitric oxide to their prosthetic heme group while pGCs are activated by binding of peptide ligands to their extracellular domains. One of them, pGC type A (GC-A) is activated by atrial and brain natriuretic peptides (ANP and BNP, respectively). Human monocytes isolated from peripheral blood mononuclear cells have been found to display sGC expression without concomitant expression of GC-A. However, GC-A activity appears in monocytes under certain conditions but a molecular mechanism of GC-A expression is still poorly understood. In this report we show that phorbol ester (PMA) induces transcription of a gene encoding GC-A in human monocytic THP-1 cells. Moreover, we find that PMA-treated THP-1 cells raise cGMP content following treatment with ANP. Studies using pharmacological inhibitors of protein kinases suggest involvement of protein kinase C (PKC), mitogen extracellular kinases (MEK1/2), and extracellular signal-regulated kinases (ERK1/2) in PMA-induced expression of the GC-A encoding gene in THP-1 cells. Finally, we show that PMA stimulates binding of Sp1 transcription factor to GC-rich DNA sequences and mithramycin A (a selective Sp1 inhibitor) inhibits expression of the GC-A mRNA in PMA-treated THP-1 cells. Taken together, our findings suggest that the PMA-stimulated PKC and MEK/ERK signaling pathways induce Sp1-mediated transcription of the GC-A encoding gene in human monocytic THP-1 cells.
Źródło:: Acta Biochimica Polonica; 2018, 65, 3; 409-414
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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