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Tytuł:
Genetic variants of the glucagon-like receptor-1 in obesity
Autorzy:
Nikulina, Anna
Powiązania:
https://bibliotekanauki.pl/articles/29519596.pdf
Data publikacji:
2023-12-31
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
analysis of single nucleotide gene variants
children
glucagon-like peptide-1 receptor
metabolically healthy obesity
metabolically unhealthy obesity
Opis:
Introduction and aim. Dysfunction of the glucagon-like peptide 1 (GLP-1)/GLP-1 receptor (GLP-1R) axis promotes obesity and metabolic disorders. The aim was to study the associations of the single nucleotide variants (SNV) GLP1R gene with proinflammatory cytokines and metabolic disorders in children with various obesity phenotypes. Material and methods. 252 children with obesity aged 6-18 years were examined. The first group (n=152) was represented by children with metabolically unhealthy obesity (MUO). The second group (n=100) consolidated of children with metabolically healthy obesity (MHO). Whole genome sequencing (CeGat, Germany) was performed in 52 children. Results. An association with the development of obesity was noted for T alleles rs61754624 (t=3.33) and rs10305457 (t=2.06); with MUO – for C alleles rs1042044 (t=2.23), rs1126476 (t=2.63), rs2235868 (t=2.82); T alleles rs61754624 (t=3.33), rs10305457 (t=2.06) GLP1R, p<0.05. In the MHO group, a correlation was found with the levels of pro-inflammatory markers IL-1β, IL-6 in the presence of the GA genotype SNV rs3765468; with hyperglycemia - GA genotype SNV rs6923761, CC genotype SNV rs1042044, AA rs6918287; hyperinsulinemia - GA genotype SNV rs3765468, GG rs10305421; triglyceridemia - AA rs6918287 of GLP1R. Conclusion. SNV rs1042044, rs3765468, rs6923761, s6918287, and rs rs10305421 GLP1R are associated with the development of MUO in individuals with MHO.
Źródło:
European Journal of Clinical and Experimental Medicine; 2023, 4; 682-691
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Aminokwasy, glikany, peptydy i białka w ścieżkach diagnostycznych i terapeutycznych chorób cywilizacyjnych XXI wieku : projektowanie i charakterystyka fizykochemiczna oraz strukturalna
Amino acids, glycans, peptides and proteins in the diagnostic and therapeutic pathways of the 21st century civilization diseases : design, physicochemical and structural characterisation
Autorzy:
Bylińska, Irena
Dzierżyńska, Maria
Giżyńska, Małgorzata
Guzow, Katarzyna
Jankowska, Elżbieta
Jurczak, Przemysław
Kaczyński, Zbigniew
Karska, Natalia
Kowalczyk, Agnieszka
Kuncewicz, Katarzyna
Orlikowska, Marta
Sawicka, Justyna
Spodzieja, Marta
Szpakowska, Nikola
Szymańska, Aneta
Wieczerzak, Ewa
Witkowska, Julia
Rodziewicz-Motowidło, Sylwia
Powiązania:
https://bibliotekanauki.pl/articles/2200549.pdf
Data publikacji:
2022
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
fluorophores
fluorescence spectroscopy
antimicrobial activity
anticancer activity
Cystapep
Stahylococcus aureus
antimicrobial compounds
amyloidogenic protein
mutagenesis
fibrilization
proteasome
aging
neurodegeneration
self-assembling peptides
tissue engineering
biomaterials
immune checkpoints
peptide inhibitors
immunotherapy
ligands of TAP protein
viral diseases
NMR structure of the UL49.5 protein
glycans
glycoconjugates
fluorofory
spektroskopia fluorescencyjna
aktywność przeciwdrobnoustrojowa
aktywność antynowotworowa
Staphylococcus aureus
związki przeciwbakteryjne
białko amyloidogenne
mutageneza
fibrylizacja
proteasom
procesy starzeniowe
neurodegeneracja
peptydy samoorganizujące
inżynieria tkankowa
biomateriały
punkty kontrolne układu immunologicznego
inhibitory peptydowe
immunoterapia
ligandy białka TAP
choroby wirusowe,
struktura NMR białka UL49.5
glikany
glikokoniugaty
Opis:
The civilization diseases of the 21st century are non-infectious disorders, affecting a large part of modern society. They are associated with the significant development of industry and technology, and hence with environmental pollution and an unhealthy lifestyle. These factors have led to the development of many civilization diseases, which currently include: cardiovascular diseases, respiratory diseases, diabetes, obesity, malignant tumors, gastrointestinal diseases, mental disorders and allergic diseases. The development of technologies, including modern therapies and new drugs, resulted in increase in life expectancy. This creates a global problem of an aging population with an increasing number of diseases of the old age, i.e. dementias. In addition, sedentary lifestyles and changing diets are the reasons why more and more people develop metabolic diseases, as well as neurological and cognitive disorders characterized by progressive damage to nerve cells and dementia. Currently, problem on a global scale is also the growing resistance to existing antimicrobial drugs. Therefore, the scientists face many challenges related to searching for the causes of these diseases, their diagnosis and treatment. Scientific research conducted at the Department of Biomedical Chemistry at the Faculty of Chemistry of the University of Gdańsk is part of this research trend. In this publication, we discuss various research topics with the long-term aim of solving the problems associated with the diseases mentioned above. The following chapters are dedicated to (i) looking for new effective fluorophores with diagnostic and anti-cancer activity; (ii) designing of new compounds with antibacterial and antiviral activity and their synthesis; (iii) investigating the mechanisms of amyloid deposit formation by human cystatin C and possibilities of inhibition of this process; (iv) designing and studies of compounds activating the proteasome with the potential to suppress the development of neurodegenerative diseases; (v) designing peptide fibrils and hydrogels as drug carriers; (vi) searching for peptide inhibitors of immune checkpoint as potential drugs for immunotherapy; (vii) studying the mechanism of action of selected herpesviruses by determining the structure of viral proteins and (viii) studying the composition of natural glycans and glycoconjugates in order to better understand the mechanisms of interaction of bacteria with the environment or with the host.
Źródło:
Wiadomości Chemiczne; 2022, 76, 5-6; 393--431
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Antioxidant Activity of Hybrid Sturgeon (Huso dauricus × Acipenser schrenckii) Protein Hydrolysate Prepared Using Bromelain, Its Fractions and Purified Peptides
Autorzy:
Noman, Anwar
Wang, Yuxia
Zhang, Chao
Abed, Sherif M.
Powiązania:
https://bibliotekanauki.pl/articles/2019350.pdf
Data publikacji:
2022-03-01
Wydawca:
Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk w Olsztynie
Tematy:
hybrid sturgeon
enzymatic hydrolysis
hydrolysis optimization
bromelain
degree of hydrolysis
radical scavenging activity
peptide purification
Opis:
Protein hydrolysates could be a natural and safer source of antioxidant peptides. The purpose of this study was to optimize the hydrolysis of Huso dauricus × Acipenser schrenckii sturgeon proteins using bromelain and purify antioxidant peptides from hydrolysate. The degree of hydrolysis of 18.69% was obtained under the optimal conditions and hydrolysate had 94.76% solubility, 902 nm particle size and high antioxidant activity. The IC50 for DPPH• and ABTS•+ scavenging activity were 3.14 and 3.81 mg/mL, respectively. The fraction of hydrolysate with a molecular weight of <1 kDa exhibited the highest antiradical activity against DPPH• with IC50 of 2.10 mg/mL. In turn, the IC50 of the most active fraction after the Sephadex G-15 separation was 1.77 mg/mL. The reverse phase high performance liquid chromatography (RP-HPLC) was used to purify the peptides from this fraction. The peptide with histidine, leucine and glycine (MW of 0.2955 kDa) exhibited the highest antioxidant activity (IC50 of 1.33 mg/mL). The obtained fractions and peptides with antioxidant activity could be used as natural substitutes for synthetic antioxidants, especially in food and pharmaceuticals.
Źródło:
Polish Journal of Food and Nutrition Sciences; 2022, 72, 1; 79-89
1230-0322
2083-6007
Pojawia się w:
Polish Journal of Food and Nutrition Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Modele eksperymentalne w badaniach zewnątrzkomórkowego transportu miedzi
Experimental models in studies of extracellular copper transport
Autorzy:
Bal, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/2200581.pdf
Data publikacji:
2022
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
copper(II)
peptide
complexation
reaction kinetics
biological mechanisms
miedź(II)
peptyd
kompleksowanie
kinetyka reakcji
mechanizmy biologiczne
Opis:
The biological relevance of proteins and peptides for Cu(II) biology, including the extracellular transport of this element, is commonly estimated by studying stabilities and structures of their complexes. However, our experimental studies on the kinetics of formation of Cu(II) complexes of ATCUN/NTS and Xaa-His-R peptides, considered to be key actors in extracellular copper biology, revealed novel long-lived reaction intermediates. These intermediates, rather than the final reaction products fulfil the chemical criteria for actual biocomplexes derived from biological studies. Our research clearly demonstrated that understanding of the kinetic aspect of interactions is indispensable for realistic modeling of biological interactions of metal ions.
Źródło:
Wiadomości Chemiczne; 2022, 76, 5-6; 456-466
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Identification of CD4plus T cell epitopes from Staphylococcus aureus secretome using immunoinformatic prediction and molecular docking
Autorzy:
Francis, D.
Kumar, A.
Chittalakkottu, S.
Powiązania:
https://bibliotekanauki.pl/articles/2096359.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
CD4+
T cell
epitope prediction
secretory proteins
Staphylococcus aureus
peptide vaccine
molecular docking
Opis:
One major reason for the lack of clinical success of Staphylococcus aureus vaccine candidates is the inability of the antigens to develop a CD4+ T cell-mediated immune response. Hence, it is important to identify CD4+ T cell antigens from S. aureus. CD4+ T cells are activated following the presentation of epitopes derived from exogenous proteins on HLA class II molecules. Fifty-nine secretory proteins of S. aureus were analyzed computationally for the presence of HLA class II binding peptides. Fifteen-mer peptides were generated, and their binding to 26 HLA class II alleles was predicted. The structural feasibility of the peptides binding to HLA-II was studied using molecular docking. Of the 16,724 peptides generated, 6991 (41.8%) were predicted to bind to any one of the alleles with an IC50 value below 50 nM. Comparative sequence analysis revealed that only 545 of the strong binding peptides are non-self in the human system. Approximately 50% of the binding peptides were monoallele-specific. Moreover, approximately 95% of the predicted strong binding non-self peptides interacted with the binding groove of at least one HLA class II molecule with a glide score better than !10 kcal/mol. On the basis of the analysis of the strength of binding, non-self presentation in the human host, propensity to bind to a higher number of alleles, and energetically favorable interactions with HLA molecules, a set of 11 CD4+ T cell epitopes that can be used as vaccine candidates was identified.
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2021, 102, 1; 43-54
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The role of binary and ternary systems in protein studies
Rola systemów binarnych I ternarnych w badaniu białek
Autorzy:
Ławrynowicz, Julian
Nowak-Kępczyk, Małgorzata
Suzuki, Osamu
Powiązania:
https://bibliotekanauki.pl/articles/1837641.pdf
Data publikacji:
2021-08-12
Wydawca:
Łódzkie Towarzystwo Naukowe
Tematy:
binary physical structure
ternary physical structure
quaternary physical structure
quinary physical structure
senary physical structure
alloy
pentacene
polymer
protein
peptide
amino acid
Galois extension
Riemann surface
binarna struktura fizyczna
ternarna struktura fizyczna
kwaternarna struktura fizyczna
kwinarna struktura fizyczna
sennarna struktura fizyczna
stop
pentacen
polimer
białko
peptyd
aminokwas
rozszerzenie Galois
powierzchnia Riemanna
Opis:
Various aspects of binary, ternary, quaternary, quinary, and senary structures for alloys, polymers and, in particular, proteins are studied. We refer to quinary and senary structures in some polymers indicating the role of total energy maxima in the infrared and Raman activity energy spectra. Decomposition of quinary structures to ternary structures is discussed. A complex analytical method of binary and ternary Galois extension is proposed as well as its realization in terms of Riemann surfaces. Slightly wavy behaviour of the system of hexagons in a polymer leaf is investigated
Rozważamy rozmaite aspekty struktur binarnych, ternarnych, kwaternarnych i senarnych dla stopów, polimerów i protein. W szczególności odnosimy się do struktur kwinarnych i senarnych w niektórych polimerach wskazując na rolę maksimów energii w spektrach podczerwieni i aktywności Ramana. Dyskutujemy rozkład struktur kwinarnych do ternarnych. Proponujemy zespoloną metodę analityczną dla binarnych i ternarnych rozszerzeń Galois, jak również ich realizację na powierzchniach Riemanna. Omawiamy lekko falujące zachowanie układu sześciokątów w liściu polimeru
Źródło:
Bulletin de la Société des Sciences et des Lettres de Łódź, Série: Recherches sur les déformations; 2020, 70, 1; 169-187
1895-7838
2450-9329
Pojawia się w:
Bulletin de la Société des Sciences et des Lettres de Łódź, Série: Recherches sur les déformations
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Właściwości koordynacyjne wybranych cyklicznych hormonów peptydowych oraz ich pochodnych
Coordination properties of selected cyclic peptide hormones and their analogues
Autorzy:
Witak, Weronika
Marciniak, Aleksandra
Powiązania:
https://bibliotekanauki.pl/articles/1409943.pdf
Data publikacji:
2021
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
hormony peptydowe
peptydy
wiązanie disulfidowe
jony metali
peptide hormones
cyclic peptides
disulfide bridge
metal ions
Opis:
Hormones are a heterogeneous, significant compounds, responsible for proper functioning of living organisms, produced by specialized cells, tissues and glands. Theirs main role is signals transmission to target tissues, responsible for the right working of the whole organism. Dysfunctions of the hormones homeostasis balance lead to disease states [1-3]. Recently, scientists have paid attention to role of the metal ions in the proper synthesis of these compounds and functioning of human body [4]. More and more scientific works explain the complicated roles of metals as beneficial factors that stimulate the conformation of peptides. Metal ions are responsible for biological properties and influence of hormones binding to appropriate receptors, but also adverse factors [4,5]. The search for an answer to the question about the metal - hormone relationship has led to the development of a new, interdisciplinary studies: metalloendocrinology, linking inorganic chemistry with endocrinology [4]. In this work, we present the literature data that relate to metal - peptide hormone interactions. We focused on cyclic hormones with a disulfide bridge and their analogues. In our review we have focused on selected natural cyclic peptide hormones: oxytocin, vasopressin, somatostatin, hepcidin and amylin. The studies on the coordination abilities showed that transition metal ions, such as copper(II), zinc(II) or nickel(II), form stable complexes with described peptides. Metal ions actively participate in many phenomena. They have played role in the formation of amylin aggregates in patients with type 2 diabetes [6]. The high ability to copper(II) by hepcidin may have an effect on its homeostasis [7]. Stable complexes of oxytocin and vasopressin facilitate binding with appropriate receptors for these peptides [8].
Źródło:
Wiadomości Chemiczne; 2021, 75, 5-6; 799-821
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
DIAGNOSTIC POTENTIAL OF SELECTED SALIVARY PROTEOMICS FOR AUTONOMIC NERVOUS SYSTEM ACTIVITY ASSESSMENT
Autorzy:
Dobrek, Lukasz
Powiązania:
https://bibliotekanauki.pl/articles/2137800.pdf
Data publikacji:
2020-05-14
Wydawca:
Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
Tematy:
saliva
vasoactive intestinal peptide
neuropeptide Y
chromogranin A
α-amylase
Opis:
The clinical assessment of autonomic nervous system (ANS) functioning, enabling the diagnosis of autonomic neuropathy present in the course of many diseases, is currently based on performing simple cardiovascular reflexes (Ewing tests), analyzing heart rate variability (HRV) or heart rate turbulence (HRT), examining skin sweating or recording neurophysiological tests (e.g. microneurography). Laboratory assessment of ANS function is very scarce and practically only includes the plasma assessment of noradrenaline as a surrogate for the biochemical indicator of sympathetic activity. Recently, the possibility of evaluation of selected compounds present in saliva as laboratory markers of not only oral diseases but also systemic diseases has been raised. This work focuses on a brief description of the anatomy and physiology of the salivary glands and describes the formation of saliva, its composition and the use of this bodily fluid in laboratory diagnostics. In addition, the paper specifically discusses the possibility of determining selected compounds that are considered to reflect autonomic activity. A review of the literature indicates primarily four proteomics: two neuropeptides (vasoactive intestinal peptide (VIP) and neuropeptide Y (NPY) that are co-transmitters in autonomic fibers, chromogranin A, a synaptic vesicle protein and α-amylase, a hydrolytic enzyme pre-digesting carbohydrates in the oral cavity. These are currently the most widely investigated agents for their usefulness as laboratory markers of ANS activity.
Źródło:
Acta Neuropsychologica; 2020, 18(2); 285-303
1730-7503
2084-4298
Pojawia się w:
Acta Neuropsychologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Immunohistochemical study on the expression of biologically active substances in the endocrine pancreas of the European bison
Autorzy:
Mozel, S.
Szymańczyk, S.
Krzysiak, M.
Puzio, I.
Zacharko-Siembida, A.
Arciszewski, M.B.
Powiązania:
https://bibliotekanauki.pl/articles/2087293.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
glucagon-like peptide-1
glucagon
insulin
somatostatin
immunohistochemistry
pancreas
European bison
Źródło:
Polish Journal of Veterinary Sciences; 2020, 23, 3; 333-340
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wpływ różnych reszt β-aminokwasowych na zdolności koordynacyjne peptydów wobec jonów metali przejściowych
The influence of different β-amino acid residues on coordinating abilities of peptides toward transition metal ions
Autorzy:
Krzciuk-Gula, Joanna
Ledwoń, Patrycja
Staśkiewicz, Agnieszka
Latajkа, Rafał
Powiązania:
https://bibliotekanauki.pl/articles/972289.pdf
Data publikacji:
2020
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
β-peptyd
koordynacja
jon metalu przejściowego
β-peptide
coordination
transition metal ion
Opis:
Peptidomimetics are different groups of compounds which are the modifications of natural occurring peptides - mostly in the sense of the structure. Due to these kind of changes, the new, modified systems are more stable and could act as a tool dedicated in specific biological activity. One of the most important and developed group of peptidomimetics are β-peptides. This review discusses the coordination ability of peptides containing β-amino acid residues incorporated into their sequence. Special attention is given to the importance of βAla residue and metal binding affinity of transition metal ions, especially Cu2+ ion. The coordination process occurs analogously to peptides composed of a-amino acids. The complexes are usually formed initially by coordination of N-terminal amine group and subsequently, with increasing pH value, by deprotonation of amide bonds. The main difference can be observed in the stability and geometry of complexes. Namely, the stability constants of β-peptides are usually slightly lower than in the case of natural analogues. Furthermore, the review presents data according to coordination ability of peptides containing β-amino acids, such as: βAsp, βHis, βCys and βLys. In spite of differences between standard peptides and their analogues, containing β-amino acid residues, there are no very important differences in the model of their coordination with the transition metal ions. However, the comparison of β-peptides and their natural counterparts reveals interesting features, which can be useful for more effective designing of new compounds possessing expected properties.
Źródło:
Wiadomości Chemiczne; 2020, 74, 3-4; 285-310
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Fengycin or plipastatin? A confusing question in Bacilli
Autorzy:
Hussein, W.
Powiązania:
https://bibliotekanauki.pl/articles/79895.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
fengycin
plipastatin
L-tyrosine
Bacillus subtilis
Bacillus amyloliquefaciens
Bacillus atrophaeus
epimerization
nonribosomal peptide system
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2019, 100, 1
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Polymorphic analysis of peptide binding domain of major histocompatibility complex class I in domestic ducks
Autorzy:
Yu, S.
Wu, J.
Bai, J.
Ding, Y.
Qiu, W.
Zhang, L.
Powiązania:
https://bibliotekanauki.pl/articles/2087551.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
domestic duck
highly variably sites
MHC class I
peptide binding domain
phylogenetic tree
polymorphism
Źródło:
Polish Journal of Veterinary Sciences; 2019, 2; 415-422
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthetic extracellular matrix as a substrate for regenerative medicine
Autorzy:
Stodolak-Zych, Ewa
Menaszek, Elżbieta
Twardy, Aleksandra
Ścisłowska-Czarnecka, Anna
Boguń, Maciej
Kolesińska, Beata
Powiązania:
https://bibliotekanauki.pl/articles/285740.pdf
Data publikacji:
2019
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
synthetic extracellular matrix
biomimetic
peptide
polysaccharides
laboratory model
Opis:
The work presents materials characteristics of fibrous polysaccharide substrates (calcium alginate, CA) modified with short peptides. Three types of synthesized peptides (hexapeptides) were composed of: cysteine (C) and tryptophan (W) named - (WWC)2or cysteine (C) and tyrosine (Y) named (YYC)2 or phenyloalanine (F) named 6F. The peptides size distribution (DLS method) showed that they agglomerated in an alcohol medium. These results were used to select a modification method of the fibrous substrates i.e. the peptides were deposited on the fibrous alginate substrate by the electrospraying technique. Using this method three kinds of polysaccharide- peptides systems were obtained i.e.: CA/(WWC)2, CA/(YYC)2CA/6F. As a reference material, the pure calcium alginate fibrous substrate was used. The results of modification with short peptides were evaluated via scanning electron microscopy (SEM): small aggregates were observed (40-100 nm) on the surface of fibers, and the fibers size remained the same after modification (11-12 μm). The size of aggregates depended on the kind of short peptide; the smaller (40 nm) aggregates were observed when the peptide had only aromatic chain (6F), the bigger (<100 nm) ones were observed when the peptide had heterocyclic rings in the chain (WWC and YYC). All materials were contacted with osteoblast-like cells (MG-63) to test biocompatibility (cells viability after 3 and 7 days) and the results proved showed higher viability in the polysaccharide-peptide system which increased with the time of observation. The durability of polysaccharide-peptide systems was tested using the enzymatic assay: collagenase confirmed the stability of materials. The progress of degradation rate was observed using infrared spectroscopy (FTIR-ATR) - the ratio on bands with C-O and C-OH increased after degradation under in vitro conditions.Results of the investigations on the fibrous substrates have confirmed that the system is a good model of an extracellular matrix (ECM) due to its chemical composition and microstructure which both have biomimetic characteristics. Thus, it may be used as a filling of bone defects supporting the regeneration of the damaged tissue. Additionally, it may also serve as the model research system of ECM.
Źródło:
Engineering of Biomaterials; 2019, 22, 152; 10-15
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wettability of chitosan-modified and lipid/polypeptide-coated peek surfaces
Autorzy:
Przykaza, Kacper
Woźniak, Klaudia
Jurak, Małgorzata
Wiącek, Agnieszka Ewa
Powiązania:
https://bibliotekanauki.pl/articles/1034248.pdf
Data publikacji:
2019
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
cyclosporine drug delivery
lipid-peptide films
plasma-activated PEEK
surface free energy
Opis:
In the present paper, cold plasma-activated and chitosan-coated polyetheretherketone (PEEK) was covered with thin films of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine, cholesterol, cyclosporine A, and their mixtures using the Langmuir-Blodgett technique. The thermodynamic function, i.e., surface free energy, of those systems was determined based on the contact angle hysteresis (CAH) approach. This parameter seems to be essential in determination of cell adhesion to polymeric materials and molecular interactions with living tissues. The obtained results show that the wettability and surface free energy of PEEK can be changed depending on the composition of the coating
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2019, 24; 172-182
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
1,3-OXAZOLIDIN-5-ONES DERIVED FROM PROLINE AS CHIRAL COMPONENTS IN THE SYNTHESIS OF PREDICTIVE ENANTIOSELECTIVE COUPLING REAGENTS
Autorzy:
Kasperowicz-Frankowska, Katarzyna
Kolesińska, Beata
Gzik, Anna
Jastrząbek, Konrad
Kaminski, Zbigniew J.
Powiązania:
https://bibliotekanauki.pl/articles/895643.pdf
Data publikacji:
2018-08-31
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
enantioselective condensation
peptide synthesis
chirality transfer on nitrogen
chiral nitrogen atom
triazine coupling reagent
Opis:
1,3-Oxazolidin-5-ones derived from both enantiomers of proline and trichloroacetaldehyde were prepared and applied as amine component in the synthesis of chiral predictive triazine based coupling reagents. The usefulness of these reagents in the condensations yielding enantiomerically enriched products from racemic substrates was presented.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 4; 921-927
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 92

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