Temat: pentylenetetrazol - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Нейромедіаторні механізми когнітивних порушень в щурів при довготривалому пентиленететразоловому кіндлінзі
Neurotransmitter mechanisms of rats cognitive impairments in prolonged pentylenetetrazol-induced kindling
Autorzy:: Vastyanov, R. S.
Prishchepa, Ye. A.
Powiązania:: https://bibliotekanauki.pl/articles/1032246.pdf
Data publikacji:: 2014
Wydawca:: Uniwersytet Kazimierza Wielkiego w Bydgoszczy
Tematy:: pentylenetetrazol
kindling
noradrenergic and serotoninergic neurotransmitter systems
conditioned reflex
cognitive impairments
Opis:: The data of experimental trials devoted to prolonged pentylenetetrazol (PTZ) kindling neurotransmitter mechanisms investigation are given. The authors studied the peculiarities of the conditioned reflex (CR) formation, its both preservation and inhibition in kindled rats in conditions of adrenergic and serotoninergic neurotransmitter systems activity modulation. The data obtained showed that kindled rats develop cognitive impairment as CR formation repression, inability of its saving and rapid inhibition. These impairments expression progresses in the chronic seizure activity model dynamics. Revealed mnestic disorders were found in kindling rats in case of both adrenergic and serotoninergic neurotransmitter systems activation that shows their pathogenetic importance in the context of prolonged PTZ-induced kindling.
Źródło:: Journal of Health Sciences; 2014, 4, 6; 147-156
1429-9623
Pojawia się w:: Journal of Health Sciences
Dostawca treści:: Biblioteka Nauki

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Tytuł:: Evaluation of antiepileptic activity of methanolic leaves extract of Tragia involucrata Linn. in mice
Autorzy:: Varma, G.G.
Mathai, B.K.
Das, K.
Gowda, G.
Rammohan, S.
Einstein, J.W.
Powiązania:: https://bibliotekanauki.pl/articles/11927.pdf
Data publikacji:: 2014
Wydawca:: Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:: antiepileptic drug
antiepileptic activity
methanolic extract
leaf
plant extract
Tragia involucrata
Indian stinging nettle
mice
mouse
anticonvulsant action
pentylenetetrazol
picrotoxin
Opis:: The present investigation was aimed to study an antiepileptic activity of methanolic extract of Tragia involucrata Linn in mice. In vivo screening models like maximal electroshock-induced convulsion (MES), pentylenetetrazole (PTZ) and picrotoxin (PTX) induced models are used to evaluate the antiepileptic effects of the extracts. The biochemical estimation was done by measuring the lipid peroxidation and reduced glutathione (GSH). In the MES induced convulsion, methanolic extract of Tragia involucrata (METI) at high dose (800 mg/kg body weight), showed high significant inhibition on tonic hind limb extension (THLE, 6.83 ±0.30***) and decrease in duration of stupor period (108.7 ±6.53***). In PTZ and PTX induced model METI (400 mg/kg and 800 mg/kg) showed significant delay on the onset of convulsions, decreased duration of convulsion and reduced mortality significantly. It also showed significant decrease in brain MDA level in lipid peroxidation profile, and increase in the brain glutathione levels in mice against PTZ induced convulsion. The results confirmed that Tragia involucrata Linn possesses dose dependent antiepileptic activity.
Źródło:: International Letters of Natural Sciences; 2014, 12, 2
2300-9675
Pojawia się w:: International Letters of Natural Sciences
Dostawca treści:: Biblioteka Nauki

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