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Wyświetlanie 1-5 z 5
Tytuł:
Inhaled drug airflow patterns and particles deposition in the paediatric respiratory tract
Autorzy:
Tyfa, Zbigniew
Jóźwik, Paulina
Obidowski, Damian
Reorowicz, Piotr
Jodko, Daniel
Kapka, Krystyna
Makosiej, Ryszard
Czkwianianc, Elżbieta
Powiązania:
https://bibliotekanauki.pl/articles/27324137.pdf
Data publikacji:
2020
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
patient-specific model
particle tracking
inhaled drug
airflow CFD simulation
paediatric respiratory tract
śledzenie cząstek
lek wziewny
symulacja CFD przepływu powietrza
respirator dziecięcy
Opis:
: The effectiveness of inhaled drugs is strictly related to areas reachable by drug particles. Unless particles reach the desired part of the bronchial tree, their influence might not meet the expectations. Consequently, the disease progress might not be stopped or even slowed down. Therefore, the primary objective of this research was to analyze the airflow patterns and particle deposition of a standard inhaled drug using computational fluid dynamics. Methods: The study was devoted to the analysis of the particle diameter influence on their deposition areas within the entire respiratory tract. Two patient-specific respiratory tract models, for 6 and 12-year-old patients, were reconstructed based on the computed tomography examinations. Numerical analyses were carried out as stationary ones with the constant inflow of the particles of various diameters (within the range of 1–50 μm). It was proven that depending on the particle size, their deposition within the respiratory tract varies significantly. Results: The vast majority of the particles with diameters over 20 μm is gathered on the walls of the throat, whereas particles of diameters 5–15 μm are accumulated mainly on the trachea walls, leaving the alveoli insufficiently supplied with the drug particles. Conclusions: The inhaled drug size cannot be treated as negligible factor during the drug spraying. An improper distribution of the particles might not inhibit the symptoms of the asthma. Numerical simulations may improve drugs selection and visualize their distribution along the airways, which might accelerate asthma treatment personalization.
Źródło:
Acta of Bioengineering and Biomechanics; 2020, 22, 2; 101--110
1509-409X
2450-6303
Pojawia się w:
Acta of Bioengineering and Biomechanics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Numerical treatment of registration problem in generation of patient-specific anatomical models
Autorzy:
Chlebiej, M.
Król, Z.
Mikołajczak, P.
Powiązania:
https://bibliotekanauki.pl/articles/334013.pdf
Data publikacji:
2003
Wydawca:
Uniwersytet Śląski. Wydział Informatyki i Nauki o Materiałach. Instytut Informatyki. Zakład Systemów Komputerowych
Tematy:
rejestracja
metody optymalizacji
wizualizacja
wirtualne fantomy specyficzne dla pacjentów
registration
optimization methods
visualization
virtual patient-specific anatomical models
Visible Human Project dataset
Opis:
Registration is an important component of many medical data processing applications. Particularly significant is its role in the correlation of volumetric medical data aiming at generation of virtual patient-specific anatomical models. Such models enable optimization of various diagnostic and therapeutical procedures. The importance of the virtual patient models is becoming increasingly recognized in modern medicine. The advantages of using such biomedical virtual models are analogous to the advantages of real system behavior simulation in the engineering or material sciences. In this work some numerical issues associated with the registration problem and the visualization challenges arising in the context of virtual anatomical models have been presented and discussed.
Źródło:
Journal of Medical Informatics & Technologies; 2003, 6; IT13-20
1642-6037
Pojawia się w:
Journal of Medical Informatics & Technologies
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Optimal selection of dental implant for different bone conditions based on the mechanical response
Autorzy:
Roy, S.
Das, M.
Chakraborty, P.
Biswas, J. K.
Chatterjee, S.
Khutia, N.
Saha, S.
Roychowdhury, A.
Powiązania:
https://bibliotekanauki.pl/articles/307549.pdf
Data publikacji:
2017
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
wytrzymałość kości
implanty stomatologiczne
analiza FEM
pacjent
bone condition
porous dental implant
FE Analysis
patient specific
Opis:
Bone quality varies from one patient to another extensively; also, Young’s modulus may deviate up to 40% of normal bone quality, which results into alteration of bone stiffness immensely. The prime goal of this study is to design the optimum dental implant considering the mechanical response at bone implant interfaces for a patient with specific bone quality. Method. 3D model of mandible and natural molar tooth were prepared from CT scan data while, dental implants were modelled using different diameter, length and porosity and FE analysis was carried out. Based on the variation in bone density, five different bone qualities were considered. First, failure analysis of implants, under maximum biting force of 250N had been performed; next, the implants, those survived were selected for observing the mechanical response at bone implant interfaces under common chewing load of 120N. Result. Maximum Von Mises stress did not surpass the yield strength of the implant material (TiAl4V). However, factor of safety of 1.5 was considered and all but two dental implants survived the design stress or allowable stress. Under 120N load, distribution of Von Mises stress and strain at the bone-implant interface corresponding to the rest of the implants for five bone conditions were obtained and enlisted. Conclusion. Implants, exhibiting interface strain within 1500-3000 microstrain range show the best bone remodelling and osseointegration. So, implant models, having this range of interface strains were selected corresponding to the particular bone quality. A set of optimum dental implants for each of the bone qualities were predicted.
Źródło:
Acta of Bioengineering and Biomechanics; 2017, 19, 2; 11-20
1509-409X
2450-6303
Pojawia się w:
Acta of Bioengineering and Biomechanics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Photobiomodulation with cluster does not present superior results to placebo in young people with chronic non-specific lumbar pain
Autorzy:
Bohnenberger Escanes, I.B.
Cordeiro Baierle, I.
de Assis, T.
Neves, M.
Flores, L.J.F.
Bertolini, G.R.F.
Powiązania:
https://bibliotekanauki.pl/articles/2098208.pdf
Data publikacji:
2020
Wydawca:
Instytut Medycyny Wsi
Tematy:
lumbar section
non-specific dysfunction
human morbidity
photobiomodulation
laser therapy
young patient
Opis:
Introduction and objective. Since the characteristic of chronic non-specific lumbar dysfunction presents a high prevalence and morbidity, and that there are still conflicting results with the use of photobiomodulation, the aim of this study was to analyze the effect of photobiomodulation application in patients with chronic non-specific lombalgy. Materials and method. A quantitative, experimental, randomized study composed of 21 volunteers randomly separated into two groups: 1) the intervention group (IG), who were given an application of photobiomodulation (LED (617nm ±10%, 1,500 mW) and low-level laser therapy (830nm, 150 mW, beam area 12.57mm), combined energy of 8.4 J per area for one minute in four different locations: in regions of greatest pain referred to palpation, on a bilateral basis, area of the applicator – 23,8 cm2). 2) the control group (CG), in which the device remained switched-off during therapy. All subjects were evaluated by McGill and Roland Morris questionnaires before and at the end of 6 interventions (3 weeks). Results. For both McGill and Roland Morris total pain rates, there was no inter-group interaction or interaction between evaluation and group (p>0.05). In the comparison between evaluations (before and after), there was a significant difference (p<0.001). Conclusions. The use of photobiomodulation in these parameters in young patients with chronic non-specific lombalgy, was not more effective than the placebo for the relief of painful symptoms. Nor did it promote a decrease in the repercussion of lombalgy in the performance of daily activities.
Źródło:
Journal of Pre-Clinical and Clinical Research; 2020, 14, 4; 107-110
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Visible Human Projects - a step towards the virtual patient: models and simulations
Autorzy:
Król, Z.
Chlebiej, M.
Mikołajczak, P.
Hoffmann, K.-H.
Powiązania:
https://bibliotekanauki.pl/articles/333562.pdf
Data publikacji:
2004
Wydawca:
Uniwersytet Śląski. Wydział Informatyki i Nauki o Materiałach. Instytut Informatyki. Zakład Systemów Komputerowych
Tematy:
segmentacja
rejestracja
modele funkcyjne
symulacja biomechaniczna
wirtualne fantomy specyficzne dla pacjentów
segmentation
registration
Visible Human Project
functional models
biomechanical simulation
virtual patient-specific anatomical models
Opis:
This paper reports on our experiences using datasets from the Visible Human Project in different biomedical applications. Introduced 1994 by the US National Library of Medicine the digitized multimodal anatomical datasets of the Visible Man have challenged the worldwide scientific community. A significant response to this challenge from several interdisciplinary research teams has emerged as a new area of research. This area requires close interaction and collaboration among anatomists, radiologists, computer scientists, mathematicians, engineers and physicians. The digitized volumetric images of the human body have been applied not only for the computer-aided exploration of the human gross anatomy, but also as structural input for the therapy planning and simulation systems. The importance of such virtual patient model is becoming increasingly recognized in modern medicine. To effectively use these specific datasets a sophisticated framework consisting of image processing, computer graphics and mathematical modelling methods is required. In this work various aspects of the developed framework are presented and discussed. Some preliminary results of our biomedical simulations are presented.
Źródło:
Journal of Medical Informatics & Technologies; 2004, 7; MIP51-58
1642-6037
Pojawia się w:
Journal of Medical Informatics & Technologies
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-5 z 5

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