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    Tytuł:
    The profile of ErbB/Her family genes copy number assessed by real-time PCR in parathyroid adenoma and hyperplasia associated with sporadic primary hyperparathyroidism
    Autorzy:
    Bednarz, Natalia
    Błaut, Krzysztof
    Sworczak, Krzysztof
    Osęka, Tomasz
    Bielawski, Krzysztof
    Powiązania:
    https://bibliotekanauki.pl/articles/1040637.pdf
    Data publikacji:
    2009
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    parathyroid hyperplasia
    hyperparathyroidism
    parathyroid adenoma
    ErbB/Her
    quantitative real-time PCR
    Opis:
    Hyperparathyroidism (pHPT) is a relatively frequent endocrinopathy, however, the molecular mechanisms of its etiology remain poorly understood. This disorder is mainly associated with benign tumours (adenoma) and hyperplasia of the parathyroid, hence, the focus is directed also to genes that are likely to be involved in carcinogenesis. Among such genes are ErbB/Her family genes already used in diagnosis of other tumours (e.g., breast carcinoma) and reported also to play a role in development of endocrine lesions. So far, ErbB-1/Her-1/EGFR expression has been detected in pHPT-associated adenomas and hyperplasia as opposed to no expression in normal parathyroid tissue. Moreover, losses or gains of the fragments of chromosomes where ErbB/Her genes are located have been reported. In this study, the gene dosage of ErbB/Her family genes were determined for the first time in parathyroid adenomas, hyperplasia and morphologically unchanged tissue in order to establish their putative role in the development of the disease. Genomic DNA was isolated from 33 patients with sporadic hyperparathyroidism and the gene copy numbers were assessed using real-time PCR. The ErbB/Her genes' profile was unaltered in most of the examined samples. Two low-level amplifications of ErbB-1/Her-1/EGFR gene, two deletions of ErbB-2/Her-2, and six deletions of ErbB-4/Her-4 were found. The ErbB-3/Her-3 gene remained unaffected. No correlation with clinical parameters was found for any gene. Both the low number of alterations and a lack of their associations with clinical parameters exclude the prognostic value of the ErbB/Her genes family in parathyroid tumourigenesis. Nevertheless, the ErbB-4/Her-4 deletions seem to be interesting for further investigations, especially in the context of PTH secretion.
    Źródło:
    Acta Biochimica Polonica; 2009, 56, 1; 83-88
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Oxidative stress in proliferative lesions of parathyroid gland
    Autorzy:
    Deska, Mariusz
    Romuk, Ewa
    Segiet, Oliwia
    Polczyk, Joanna
    Buła, Grzegorz
    Gawrychowski, Jacek
    Powiązania:
    https://bibliotekanauki.pl/articles/1392364.pdf
    Data publikacji:
    2019
    Wydawca:
    Index Copernicus International
    Tematy:
    oxidative stress
    primary hyperparathyroidism
    parathyroid hyperplasia
    parathyroid adenoma
    Opis:
    Background: Primary hyperparathyroidism (PHPT) is one of the most common endocrine disorders and defined as excessive secretion of parathormone. PHPT is a risk factor of several cardiovascular diseases, which could be caused by alterations in oxidant-antioxidant balance. Materials and methods: Blood serum collected from 52 consecutive patients with PHPT treated surgically constituted our study material, whereas 36 healthy volunteers were our control group. Oxidative stress was evaluated in both patients and control subjects by assessment of malondialdehyde (MDA) and lipid hydroperoxides (LHP). Antioxidants were evaluated by the measurement of superoxide dismutase (SOD), ceruloplasmin (CER), catalase (CAT), sulfhydryl (SH) groups, glutathione (GSH), glutathione peroxidase (GSH-Px), glutathione transferase activity (GST) and glutathione reductase (GR). Moreover, total antioxidant capacity (TAC) and total oxidative status (TOS) were measured and oxidative stress index (OSI) was calculated. Results: OSI was increased in patients with PHPT when compared to normal controls, whereas TAC was lower in PHPT. The levels of CER, MnSOD, GR, SH groups and MDA were significantly decreased in PHPT. The levels of serum LHP, catalase and SOD were significantly higher in patients with PHPT than in healthy patients. The erythrocyte CAT activity and GST were significantly increased in patients after parathyroidectomy. The erythrocyte GR and GPx were up-regulated postoperatively, whereas SOD activity decreased. Conclusions: In PHPT there are several alterations in the balance between the production of reactive oxygen species and antioxidant defense system.
    Źródło:
    Polish Journal of Surgery; 2019, 91, 1; 29-34
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Primary hyperparathyroidism on the example of a 33-year-old female patient with parathyroid adenoma
    Autorzy:
    Łach, Jarosław
    Dyaczyński, Michał
    Buczkowski, Krzysztof
    Powiązania:
    https://bibliotekanauki.pl/articles/1391700.pdf
    Data publikacji:
    2020
    Wydawca:
    Index Copernicus International
    Tematy:
    parathyroid hyperactivity
    parathyroid adenoma
    kidney stones
    Opis:
    Parathyroid hyperactivity is the state of over-production and PTH secretion [1]. The most common cause of primary hyperparathyroidism is parathyriod adenoma - about 80% of cases, the remaining are parathyroid hyperplasia around 15%cases [2] [3], and in 1-5% of cases, cancer [2] [3] [4] [5]. The disease is diagnosed inabout 40 people in 100,000 [5] [6] [3] [7]. The most common cause of adenoma is the mutation in gene MEN 1. Less than 5% of cases are chronichyperparathyroidism, which is a component of the MEN 1 MEN 2a endocrine adenocarcinoma syndrome [1]. Excess PTH in the body leads to increased mobilization of calcium from the bones, and henceincreased osteolysis, what also increases the absorption of calcium from thedigestive system, as well as an increased amount of phosphate excretion in the urine. Clinical picture of the disease is multiform and often runs in a latent form. Most often the diseaseoccurs in the form of osteoporosis, chronic recurrent kidney stones, and is also commonpyelonephritis on the basis of urolithiasis. The disease may be accompanied by: dysphagia, abdominal pain, metallic taste in the mouth, persistent constipation. In addition, from the systemnervous: dizziness and headaches, disturbances of consciousness. Arrhythmia the form of additional contractions and paroxysmal tachycardia. Osteolysis, osteoporosis and pathological fractures [1]. The purpose of this article is to bring closer to the reader case of 33 years old woman with primary hyperparathyroidism on the adenoma.
    Źródło:
    Polish Journal of Surgery; 2020, 92, 3; 55-61
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The comorbidity of papillary thyroid carcinoma and the primary hyperparathyroidism
    Autorzy:
    Podlasek, Robert
    Bednarczyk, Grzegorz
    Świder, Grzegorz
    Powiązania:
    https://bibliotekanauki.pl/articles/454749.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    thyroid carcinoma
    primary hyperparathyroidism parathyroid adenoma
    Opis:
    Introduction. The prevalence of papillary thyroid carcinoma (PTC) in patients with primary hyperparathyroidism (PHPT) is low, it can be estimated around 2 to 4%. For unknown reasons it is higher than the prevalence of PTC in the overall population. The authors analyse the comorbidity of PTC with PHPT on patients treated in their institution. Material and method. The analysis covered medical records of 885 patients subject to the thyroid resection procedure and 95 patients operated for PHPT, the procedures were performed in years 2005-2014. Results. In the above-mentioned period there were 121 patients operated due to a malignant thyroid tumour and there were 95 patients that had surgery for PHPT. There were 4 cases of comorbidity of PHPT with papillary thyroid cancer. Prevalence of PTC at the patients with PHPT was 4.2%. In two out of the four cases, both diseases were diagnosed prior to the procedure and the single appropriate surgery i.e. total thyroidectomy and excision of parathyroid adenoma was performed. In the other two cases false positive localisation of parathyroid adenoma occurred due to metastatic cancerous lesions in cervical lymph nodes. The diagnosis of PTC was made postoperatively based on surgical specimen examination. Second surgical procedure appropriate for this diagnosis was necessary in both cases. Conclusions. The comorbidity of PHPT and PTC is clinically important and should be taken into account in the case of patients with PHPT and thyroid tumours. There is the possibility of false positive localization of parathyroid adenoma in the case of metastatic cancerous lesions in cervical lymph nodes
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 2; 103-108
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Wpływ śródoperacyjnego radiomapowania nuklearnego na czas trwania zabiegu w paratyreoidektomii
    The influence of intraoperative nuclear radio-mapping on the duration of the surgical procedure in parathyroidectomy
    Autorzy:
    Sagan, D.
    Rejdak, K.
    Powiązania:
    https://bibliotekanauki.pl/articles/262042.pdf
    Data publikacji:
    2010
    Wydawca:
    Politechnika Wrocławska. Wydział Podstawowych Problemów Techniki. Katedra Inżynierii Biomedycznej
    Tematy:
    chirurgia
    gruczolak przytarczyc
    nadczynność przytarczyc
    przytarczyce
    paratyreoidektomia
    radiomapowanie nuklearne
    surgery
    parathyroid adenoma
    hyperparathyroidism
    parathyroid glands
    parathyroidectomy
    nuclear radio-mapping
    Opis:
    Śródoperacyjna identyfikacja nadczynnej tkanki przytarczyc stanowi jedno z największych wyzwań dla chirurgów wykonujących paratyreoidektomie. Przełomem w chirurgii przytarczyc może stać się nowa metoda śródoperacyjnego radiomapowania nuklearnego. Jest ona oparta na pomiarze emisji promieniowania gamma w czasie rzeczywistym przez tkanki w polu operacyjnym po uprzednim podaniu 99mTc MIBI (99mTc-methoxyisobutylisonitrile - 99mTc-metoksyizobutylizonitryl), wychwytywanego i akumulowanego wybiórczo przez tkankę przytarczyc. Celem artykułu była analiza wpływu zastosowania śródoperacyjnego radiomapowania nuklearnego na czas trwania zabiegu paratyreoidektomii. Badania przeprowadzono metodą analizy retrospektywnej jedno- i wieloczynnikowej w grupie 20 chorych poddanych zabiegom paratyreoidektomii, uwzględniając potencjalne czynniki kliniczne wpływające na czas zabiegu jako wejściowe zmienne niezależne. Jednoczynnikowa analiza statystyczna wykazała, że zastosowanie śródoperacyjnego radiomapowania nuklearnego skraca czas trwania zabiegu o średnio 60,38±7,47 min (p = 0,0459). Natomiast nadczynność wtórna, konieczność wykonania częściowej sternotomii oraz reoperacja przedłużały średni czas trwania zabiegu o odpowiednio: 88,44±40,21 min; 98,06±57,91 min oraz 74,33±33,92 min (p = 0,0112; p = 0,0409 oraz p = 0,0234; odpowiednio). Analiza wieloczynnikowa z zastosowaniem modelu regresji wielorakiej zidentyfikowała radiomapowanie nuklearne, sternotomię oraz reoperację jako zmienne niezależne istotnie statystycznie wpływające na czas trwania paratyreoidektomii. Uzyskane wyniki badań wykazały, że śródoperacyjne radiomapowanie nuklearne jest skuteczną metodą wspomagającą postępowanie chirurgiczne w zabiegach paratyreoidektomii. Dzięki ukierunkowaniu działania operacyjnego in vivo oraz zapewnieniu potwierdzenia tożsamości nadczynnej tkanki gruczolaka ex vivo natychmiast po jego resekcji metoda ta pozwala znacznie skrócić czas trwania paratyreoidektomii.
    Thorough localization and confirmation of hyperactive parathyroid tissue is one of the most difficult tasks for surgeons performing parathyroidectomies. Therefore, the need for an intraoperative aid during parathyroidectomy is currently widely accepted. An instant detection of radioactivity after 99mTc MIBI injection, which is accumulated in parathyroid glands, called nuclear radio-mapping, has become a novel technique applied in these operations. We aimed to assess the utility of this new technique as one of potential factors influencing the duration of parathyroidectomy. We retrospectively analyzed the influence of chosen clinical factors on the duration of the surgical procedure, using univariate and multivariate statistical methods in a group of 20 patients who underwent parathyroidectomy. The results of univariate analysis showed that using nuclear radio-mapping decreased the mean duration of parathyroidectomy by mean 60.38±7.47 min (p = 0.0459). However, in patients with secondary hyperparathyroidism, sternotomy and reoperation, the mean procedure duration increased by mean 88.44±40.21 min; 98.06±57.91 min and 74.33±33.92 min (p = 0.0112; p = 0.0409 and p = 0.0234) respectively. Multivariate analysis showed that nuclear radio-mapping, sternotomy and reoperation independently influenced the duration of parathyroidectomy. Concluding, nuclear radio-mapping not only guides the resection in vivo, but also allows to confirm the identity of removed parathyroid ex vivo and to decrease the duration of parathyroidectomy. This technique is a useful and efficient intraoperative adjunct in parathyroid surgery.
    Źródło:
    Acta Bio-Optica et Informatica Medica. Inżynieria Biomedyczna; 2010, 16, 3; 280-284
    1234-5563
    Pojawia się w:
    Acta Bio-Optica et Informatica Medica. Inżynieria Biomedyczna
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

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