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    Wyświetlanie 1-5 z 5
    Tytuł:
    Activity of paraoxonase 1 (PON1) and its relationship to markers of lipoprotein oxidation in healthy Slovaks
    Autorzy:
    Sumegová, Katarína
    Blažíček, Pavel
    Waczulíková, Iveta
    Žitňanová, Ingrid
    Ďuračková, Zdeňka
    Powiązania:
    https://bibliotekanauki.pl/articles/1041175.pdf
    Data publikacji:
    2006
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    paraoxonase 1
    atherosclerosis
    ox-LDL
    HDL
    Opis:
    Low-density lipoproteins (LDLs), when modified by free radicals derived from artery wall cells, induce atherosclerosis. In contrast to oxidized LDL (ox-LDL), high-density lipoproteins (HDLs) are able to prevent atherosclerosis through a protein with antioxidant properties, paraoxonase 1 (PON1). The purpose of this study was to explore the association between the activity of HDL-associated PON1 and circulating ox-LDL as well as to investigate the relationship between ox-LDL and parameters of lipid profile in thirty Slovaks aged 21-73 years because recent studies have presented controversial results concerning PON1 and its role in LDL oxidation. For determination of circulating ox-LDL sandwich ELISA was used and other lipid parameters were determined by routine laboratory analyses. PON1 activities were assayed by two synthetic substrates - paraoxon and phenyl acetate. Lipid peroxides were determined spectrophotometrically. Of the lipid parameters examined, ox-LDL level correlated positively with total (P < 0.0001) and LDL-cholesterol (P < 0.001). Triacylglycerols (TAG) (P < 0.001), lipid peroxides (P < 0.01) and atherogenic index (AI = total cholesterol/HDL) (P < 0.0001) were also strongly correlated with ox-LDL. No inverse relationships were observed between ox-LDL and HDL-cholesterol or arylesterase/paraoxonase activities of PON1. Furthermore, it was found that ox-LDL (P < 0.01) and lipid peroxides (P < 0.05) were significantly higher in men than in women. PON1 arylesterase activity was marginally affected by sex. The results of this study suggest that the anti-atherogenic properties of HDLs are not directly related to their total concentration and that PON1 activity determined towards synthetic compounds (paraoxon and phenyl acetate) reflects no association with markers of oxidative stress. Furthermore, it follows from our results that men are more susceptible to developing atherosclerosis compared to women.
    Źródło:
    Acta Biochimica Polonica; 2006, 53, 4; 783-787
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Inference of oxidative stress in patients with hypothyroidism
    Autorzy:
    Rada, Feryal
    Powiązania:
    https://bibliotekanauki.pl/articles/40555549.pdf
    Data publikacji:
    2024-06-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    glutathione
    hypothyroidism
    malondialdehyde
    oxidative stress
    paraoxonase-1
    Opis:
    Introduction and aim. Oxidative stress is one of the complications that accompany defects in thyroid hormone levels. This study was designed to evaluate oxidative stress markers in patients with hypothyroidism. Material and methods. This case control study was comprised of forty-two hypothyroid patients aged 36–46 years and forty age matched (35–43 years) healthy control participants randomly selected from the Endocrine Clinic of Al-Yarmook Hospital in Iraq. Blood levels of thyroid hormones malondialdehyde, glutathione, and paraoxonase-1 were assessed. Body mass index was calculated for each patient and control participant. Results. Regarding the data of oxidative stress markers in hypothyroid patients compared to controls, a significant elevation was reported in blood levels of malondialdehyde and a significant reduction was found in blood levels of glutathione (p=0.031). On the other hand, the blood levels of paraoxonase-1 were significantly different in hypothyroid patients compared with the control. Conclusion. Elevated blood levels of malondialdehyde and declined blood levels of glutathione in hypothyroid patients are a signal of oxidative stress and consequently increase the risk of cardiovascular complications.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2024, 22, 2; 270-274
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Antyoksydacyjne właściwości i przeciwmiażdżycowe działanie paraoksonazy 1
    Antioxidant and antiatherosclerotic properties of paraoxonase 1
    Autorzy:
    Kupczyk, D.
    Karczmarska-Wódzka, A.
    Studzińska, R.
    Sikora, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/172751.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    paraoksonaza 1
    stres oksydacyjny
    miażdżyca
    paraoxonase 1
    oxidative stress
    atherosclerosis
    Opis:
    This overview will discuss the Paraoxonase 1 (PON1) in arteriosclerosis diseases. Atherosclerosis is one of lifestyle diseases and affects greater number of people. Ischemic heart disease, acute coronary syndromes or stroke are the clinical symptoms of atherosclerosis and are the most common cause of morbidity especially in middle and old age people. In atherosclerosis, in the space between the endothelium and the muscular layer in the wall of a blood vessel, accumulates deposits consisting of macrophages, lipoprotein, low density foam cells and extracellular concentrations of cholesterol. In this way fatty streaks are formed which are early stage atherosclerotic lesions. With the passage of time they are joined by elements of fibrous connective tissue that undergo hypertrophy. They begin to surround primarily created the fireplace of inflammation and separate them from the rest of the blood vessel [1]. Further research if needed to better understanding the mechanisms related to atherosclerosis development and plaque instability because it may have important clinical implications for the identification of high-risk patients. The present review tries to summarize the current knowledge on the role of PON1 in the formation of atherosclerotic plaque is the goal of current research [2].
    Źródło:
    Wiadomości Chemiczne; 2017, 71, 1-2; 3-36
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Paraoxonase-1 activities in children and adolescents with type 1 diabetes mellitus
    Autorzy:
    Craciun, Elena
    Leucuta, Daniel
    Rusu, Razvan
    David, Bianca
    Cret, Victoria
    Dronca, Eleonora
    Powiązania:
    https://bibliotekanauki.pl/articles/1038772.pdf
    Data publikacji:
    2016
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    paraoxonase-1
    lactonase
    arylesterase
    children
    type 1 diabetes mellitus
    Opis:
    Background: Paraoxonase-1 is an HDL-associated esterase that acts as an anti-atherogenic agent by protecting LDL from oxidation. This study investigates paraoxonase-1 activities in children and adolescents with type 1 diabetes mellitus and possible associations with other biochemical markers. Patients and methods: The study enrolled 82 children and adolescents with type 1 diabetes mellitus and 41 controls with similar age and gender distribution. Serum paraoxonase-1 arylesterase and salt-stimulated paraoxonase activities were assessed by measuring the rates of phenyl acetate and paraoxon hydrolysis, respectively; paraoxonase-1 lactonase activity and oxidized LDL were assessed by a pH-sensitive colorimetric assay and ELISA, respectively. Glycated haemoglobin HbA1c and lipid profile were assayed with an immunoturbidimetric method and commercially available kits, respectively. Results: We found lower paraoxonase-1 activities in diabetics when compared to controls. The decrease was statistically significant only for the lactonase activity, the difference being higher when referring to the subgroup with poor glycaemic control. The lactonase activity/HDL ratio was also lower in diabetics vs. controls, but without statistical significance. Both lactonase and arylesterase activities were negatively correlated with HbA1c in diabetics, but only the latter was statistically significant (ρ = -0.21, P = 0.055; ρ = -0.24, P = 0.03, respectively). A correlation coefficient of ρ = 0.196 (P = 0.078) was found between oxidized LDL and HbA1c. Conclusion: All paraoxonase-1 activities were lower in diabetic children and adolescents, but only the decrease in the lactonase activity was statistically significant. Although lipid profile and glycaemic control were altered in diabetics, no differences were observed between groups regarding oxidized LDL level.
    Źródło:
    Acta Biochimica Polonica; 2016, 63, 3; 511-515
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    High density lipoprotein subfractions and paraoxonase 1 in children
    Autorzy:
    Muchová, Jana
    Andrezálová, Lucia
    Oravec, Stanislav
    Nagyová, Zuzana
    Garaiova, Iveta
    Ďuračková, Zdeňka
    Powiązania:
    https://bibliotekanauki.pl/articles/1038781.pdf
    Data publikacji:
    2016
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    lipoproteins
    LDL-lipoproteins
    HDL-lipoproteins
    children
    paraoxonase 1
    Opis:
    The Lipoprint system (Quantimetrix Corp., CA, USA), enables the determination of 10 high density lipoprotein (HDL) subfractions in contrast to the 5 HDL subfractions that can be determined by ultracentrifuge analysis. HDL subfractions, and their relationships to the arylesterase (PON1-A) and lactonase (PON1-L) activities of paraoxonase 1 (PON1), together with total-, very low density lipoprotein- and low density lipoprotein (LDL)-cholesterol and LDL subfractions were investigated in the serum of 27 mildly hypercholesterolemic children and 21 healthy controls. Our results suggest the antiatherogenity of large HDL (L-HDL) subfractions and the atherogenity of small HDL (S-HDL) subfractions in the study groups. However, the relationship between the intermediate HDL (I-HDL) subfractions with the LDL subfractions and other lipoproteins did not suggest that I-HDL subfractions are antiatherogenic. No significant association between PON1-A and the HDL subfractions was found. In contrast, PON1-L activity positively correlated with the antiatherogenic large HDL1 subfraction and negatively with intermediate HDL subfractions 4, 5 and 6. Our results contribute to the knowledge of the roles of total HDL and ten individual HDL subfractions in children and adolescents.
    Źródło:
    Acta Biochimica Polonica; 2016, 63, 3; 555-563
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

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