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Wyświetlanie 1-15 z 16
Tytuł:
Helicobacter pylori cytotoxin-associated gene A impairs the filtration barrier function of podocytes via p38 MAPK signaling pathway
Autorzy:
Yang, Man
Wang, Ling
Gu, Li-jie
Yuan, Wei-jie
Powiązania:
https://bibliotekanauki.pl/articles/1038590.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
CagA
ZO-1
p38 MAPK
podocyte
proteinuria
Opis:
Helicobacter pylori (Hp) specific antigens were found deposited in the glomeruli in some kidney diseases. However, the underlying molecular mechanisms remain to be elucidated. The aim of this study was to investigate the effect of cytotoxin associated gene A protein (CagA), a key virulence factor of Hp, on mouse podocytes. Cells were cultured and treated with recombinant CagA protein. The expression of the tight junction protein ZO-1 and p38 MAPK signaling pathway activation were measured with real-time RT-PCR and western blotting. The filtration barrier function of podocytes was evaluated with albumin influx assay. CagA decreased the expression and membrane distribution of ZO-1, impaired the filtration barrier function of podocytes, while activating p38 MAPK signaling pathway in these cells. Selective p38 MAPK inhibition partly prevented CagA-induced filtration barrier dysfunction of podocytes through ameliorating ZO-1 downregulation. Taken together, the results suggested that CagA, at least via p38 MAPK signaling pathway, may induce podocyte injury. Anti-Hp therapy may be beneficial for the treatment of kidney diseases related to Hp antigen deposition.
Źródło:
Acta Biochimica Polonica; 2017, 64, 3; 471-475
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Role of p38 mitogen-activated protein kinase in the healing of gastric ulcers in rats
Autorzy:
Kabayashi, N.
Kataoka, T.
Ono, A.
Tsukimi, Y.
Okabe, S.
Powiązania:
https://bibliotekanauki.pl/articles/69658.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
ulcer
gastric ulcer
p38 kinase
cytokine
nitric oxide
angiogenesis
p38 mitogen-activated protein kinase
acetic acid
healing
rat
Źródło:
Journal of Physiology and Pharmacology; 2001, 52, 2
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Induction of hemolysis and eryptosis by occupational pollutant nickel chloride is mediated through calcium influx and p38 MAP kinase signaling
Autorzy:
Alfhili, Mohammad A.
Alamri, Hassan S.
Alsughayyir, Jawaher
Basudan, Ahmed M.
Powiązania:
https://bibliotekanauki.pl/articles/2085691.pdf
Data publikacji:
2022-02-15
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
calcium
p38 MAPK
oxidative stress
hemolysis
nickel
eryptosis
Opis:
ObjectivesNickel (Ni) is an abundant environmental hazard and an occupational pollutant. Exposure to Ni compounds is prevalent in electroplating workers and in the printing industry, among others. The toxicity of Ni manifests as dermatological, gastrointestinal, respiratory, allergic, and cardiovascular symptoms. In particular, hyperbilirubinemia and reticulocytosis have been detected in intoxicated subjects; an observation possibly implicating selective red blood cell (RBC) toxicity. Herein, the interaction of nickel chloride (NiCl2) with human RBCs and associated molecular mechanisms are described.Material and MethodsCells from healthy donors were incubated for 24 h at 37°C in the presence or absence of 0.5‒10 mM of NiCl2, and cytotoxicity was determined through hemoglobin leakage by colorimetry under different experimental conditions. Eryptotic markers were also identified by flow cytofluorometry using Annexin-V-FITC tagging for phosphatidylserine (PS) exposure, light scatter properties for cellular dimensions, Fluo4/AM labeling for intracellular calcium, and H2DCFDA staining for reactive oxygen species (ROS). Additionally, small molecule inhibitors were used to probe the signaling pathways involved.ResultsIt was found that NiCl2 at 10 mM caused profound intracellular calcium overload and significant calcium-dependent hemolysis. Also, NiCl2 reduced forward scatter and increased side scatter, Annexin-positive cells, and ROS levels. Importantly, NiCl2-induced hemolysis was significantly attenuated by the exclusion of extracellular calcium, and in the presence of p38 MAP kinase (MAPK) inhibitor SB203580.ConclusionsIt is concluded that NiCl2 induces p38 MAPK-dependent hemolysis, and stimulates the canonical features of premature eryptosis. This report presents the first description of the molecular mechanisms underlying the hemolytic and eryptotic potential of NiCl2 and, thus, may explain changes in hematological parameters observed in poisoning victims.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2022, 35, 1; 1-11
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Delay in oral mucosal ulcer healing by aspirin is linked to the disturbances in p38 mitogen-activated protein kinase activation
Autorzy:
Slomiany, B.L.
Slomiany, A.
Powiązania:
https://bibliotekanauki.pl/articles/68979.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
oral tissue
nonsteroidal antiinflammatory drug
ulcer healing
oral mucosa
aspirin
p38 mitogen-activated protein kinase
Źródło:
Journal of Physiology and Pharmacology; 2001, 52, 2
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Crosstalk between the TGF-β and WNT signalling pathways during cardiac fibrogenesis
Autorzy:
Działo, Edyta
Tkacz, Karolina
Błyszczuk, Przemysław
Powiązania:
https://bibliotekanauki.pl/articles/1038355.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
TGF-beta
Smad
WNT
beta-catenin
RhoA-ROCK
p38
JNK
Erk1/2
MAPK
cardiac fibrosis
tissue remodelling
cardiac fibroblasts
heart
Opis:
Cardiac fibrosis is referred to as an excessive accumulation of stromal cells and extracellular matrix proteins in the myocardium. Progressive fibrosis causes stiffening of the cardiac tissue and affects conduction of electrical impulses, leading to heart failures in a broad range of cardiac conditions. At the cellular level, activation of the cardiac stromal cells and myofibroblast formation are considered as hallmarks of fibrogenesis. At the molecular level, transforming growth factor β (TGF-β) is traditionally considered as a master regulator of the profibrotic processes. More recently, the WNT signalling pathway has also been found to be implicated in the development of myocardial fibrosis. In this review, we summarize current knowledge on the involvement of TGF-β and WNT downstream molecular pathways to cardiac fibrogenesis and describe a crosstalk between these two profibrotic pathways. TGF-β and WNT ligands bind to different receptors and trigger various outputs. However, a growing body of evidence points to cross-regulation between these two pathways. It has been recognized that in cardiac pathologies TGF-β activates WNT/β-catenin signalling, which in turn stabilizes the TGF-β/Smad response. Furthermore both, the non-canonical TGF-β and non-canonical WNT signalling pathways, activate the same mitogen-activated protein kinases (MAPKs): the extracellular signal-regulated kinase (Erk), the c-Jun N-terminal kinases (JNKs) and p38. The crosstalk between TGF-β and WNT pathways seems to play an essential role in switching on the genetic machinery initiating profibrotic changes in the heart. Better understanding of these mechanisms will open new opportunities for development of targeted therapeutic approaches against cardiac fibrosis in the future.
Źródło:
Acta Biochimica Polonica; 2018, 65, 3; 341-349
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
P-38 J-L Lightning
Autorzy:
Pęczkowski, Robert.
Współwytwórcy:
Juszczak, Artur. Ilustracje
Matusiak, Wojciech. Tłumaczenie
Data publikacji:
2003
Wydawca:
Sandomierz : "Stratus"
Tematy:
Lockheed P-38 Lightning (samolot) Stany Zjednoczone 1939-1945 r. wydawnictwa popularne
Samoloty myśliwskie Stany Zjednoczone 1939-1945 r. wydawnictwa popularne
Fighters
Opis:
Tyt. okł.: Lookheed P-38 J-L Lightning. --- Tekst tł. z pol.
Bibliogr. s. 111.
Dostawca treści:
Bibliografia CBW
Książka
Tytuł:
Piezoceramic Transducers Selection Method for High Power Ultrasonic Devices
Autorzy:
Kluk, P.
Milewski, A.
Powiązania:
https://bibliotekanauki.pl/articles/1398757.pdf
Data publikacji:
2015-03
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
43.35.+d
43.35.-c
43.35.Zc
43.38.Fx
43.38.+n
43.38.-p
Opis:
A universal method for selecting piezoceramic transducers used in high power ultrasonic devices such as ultrasonic welding and cutting systems has been presented. The key element of such systems is a high power ultrasonic sandwich transducer consisting of a stack of piezoceramic transducers mounted between two masses. Because of relatively large dispersion of piezoceramic transducer parameters between production lots, they must be selected in order to obtain a high quality and long-life sandwich transducer. Presented selection method consists of three stages. First, the parametric identification of the Butterworth-Van Dyke equivalent circuit model is performed based on piezoceramic transducer electrical impedance measurements. Next, the electrical impedance frequency samples are estimated using the identified Butterworth-Van Dyke model. Finally, the k-means clustering algorithm is used to select the best fitted piezoceramic transducer sets.
Źródło:
Acta Physica Polonica A; 2015, 127, 3; 719-722
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
New Multimode Sonotrodes Models Designed for Rotary Ultrasonic Welding Systems
Autorzy:
Kogut, P.
Milewski, A.
Kardyś, W.
Kluk, P.
Gawryś, P.
Powiązania:
https://bibliotekanauki.pl/articles/1399374.pdf
Data publikacji:
2013-09
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
43.40.-r
43.40.+s
43.35.+d
43.38.+n
43.38.-p
46.40.-f
Opis:
The paper presents methods of designing sonotrodes, working in varied mechanical vibration modes in high power application regime such as rotary ultrasonic welding systems. The aim of the sonotrode design process is to optimize its shape to achieve the best energy efficiency for a given welding process. Sonotrode geometry influences the power transferred to the welded element because it determines the vibration amplitude distribution in the sonotrode. The most popular applications use sonotrodes designed for axial vibration. Conducted research have shown that the optimal displacement and strain distribution is achieved for sonotrodes working in various vibration modes such as axial, transverse, radial or their compositions. In the paper examples of multimode sonotrode models for various rotary ultrasonic welding technologies have been presented.
Źródło:
Acta Physica Polonica A; 2013, 124, 3; 474-478
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Measurement System for Parameter Estimation and Diagnostic of Ultrasonic Transducers
Autorzy:
Kluk, P.
Milewski, A.
Kardyś, W.
Kogut, P.
Michalski, P.
Powiązania:
https://bibliotekanauki.pl/articles/1399367.pdf
Data publikacji:
2013-09
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
43.35.-c
43.35.+d
43.38.+n
43.38.-p
84.37.+q
07.10.-h
46.40.-f
07.20.Dt
Opis:
The paper presents an architecture and design of measurement system and methods for parameter estimation and diagnostic of ultrasonic transducers used in ultrasonic welding and cutting systems manufactured by Tele and Radio Research Institute. The key element of the ultrasonic welding and cutting system is a high power ultrasonic transducer implemented as a sandwich transducer consisting of a stack of piezoelectric ceramic rings mounted between two masses. High quality welding and cutting demand predetermined frequency characteristic of transducer impedance. Also important are: high energy efficiency, high coupling coefficient, low dielectric loss, and the optimal radiation pattern. In order to manufacture high quality and long-life transducers the piezoelectric rings must be selected and the sandwich transducers diagnosed on the basis of their measured parameters. Presented measurement system takes advantage of the virtual instrument technique in the NI LabVIEW environment. It uses Agilent U2761A Function Generator, U2531A Data Acquisition Unit, and the linear amplifier to measure impedance frequency characteristic in the frequency range of 10 kHz to 100 kHz. Moreover, the system can measure the vibration amplitude in the range of 1 μm up to 100 μm, using an optical sensor, and the temperature of the transducer using a pyrometer sensor.
Źródło:
Acta Physica Polonica A; 2013, 124, 3; 468-470
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 16

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