- Tytuł:
- Are infinite dimensional models applicable in modelling and analysis of cancer chemotherapy?
- Autorzy:
-
Świerniak, A.
Kimmel, M.
Śmieja, J.
Rzeszowska-Wolny, J. - Powiązania:
- https://bibliotekanauki.pl/articles/333061.pdf
- Data publikacji:
- 2004
- Wydawca:
- Uniwersytet Śląski. Wydział Informatyki i Nauki o Materiałach. Instytut Informatyki. Zakład Systemów Komputerowych
- Tematy:
-
odporność na leki
nieskończenie wymiarowy system
przekształcenia Laplace'a
drug resistance
branching random walk
infinite-dimensional systems
Laplace transforms - Opis:
- Drug resistance and phase dependence have been regarded by many authors as the main obstacles against successful cancer chemotherapy. We propose a model which takes into account both these phenomena and give a tool to use phase specificity as an advantage rather than a fault and make it resistant of drug resistance. It combines models that so far have been studied separately, taking into account both the phenomenon of gene amplification and drug specificity in chemotherapy, in their different aspects. The mathematical description is given by an infinite dimensional state equation with a system matrix, the form of which enables decomposition of the model into two interacting subsystems. While the first one, of finite dimension, can have any form, the second one is infinite dimensional and tridiagonal.
- Źródło:
-
Journal of Medical Informatics & Technologies; 2004, 8; MM3-10
1642-6037 - Pojawia się w:
- Journal of Medical Informatics & Technologies
- Dostawca treści:
- Biblioteka Nauki
Artykuł