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Wyszukujesz frazę "occupational intoxication" wg kryterium: Temat


Wyświetlanie 1-2 z 2
Tytuł:
HSP70 (HSPA1) polymorphisms in former workers with chronic mercury vapor exposure
Autorzy:
Chernyak, Yury I.
Merinova, Alla P.
Powiązania:
https://bibliotekanauki.pl/articles/2161928.pdf
Data publikacji:
2017-02-21
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
chronic mercury vapor exposure
chronic mercury intoxication
heat shock protein 70
HSPA1 polymorphisms
genetics in occupational health
association with chronic mercury intoxication
Opis:
Objectives To investigate 4 loci of 3 HSP70 genes in caustic soda production plant former workers, who have been exposed to metallic mercury vapors for a long time, and including numerous cases of chronic mercury intoxication (CMI). Material and Methods Polymorphisms in HSP70 gene family members (HSP1A1 (+190G/C, rs1043618), HSPA1B (+1267A/G and +2074G/C, rs1061581) and HSP1AL (+2437T/C, rs2227956)) genes were studied among 120 male workers involved in caustic soda production by mercury electrolysis at 2 plants in Eastern Siberia. These subjects had been chronically exposed to metallic mercury vapors for > 5 years and divided into 3 groups based on the occurrence and time of the CMI diagnosis, or absence of this disease. The Group 1 consisted of individuals (N = 46), who had had contact with mercury but were not diagnosed with the CMI. The Group 2 included workers (N = 56), who were diagnosed with the CMI longer than 14 years ago. The Group 3 consisted of the subjects (N = 18), who had been diagnosed with the CMI 3–5 years ago. The logistic regression analysis was used for 3 genetic models with and without adjustment for age and duration of mercury vapor exposure. Results We found that genotypes СС-HSPA1A (+190G/C) and GG-HSPA1B (+1267A/G) had a high predictive risk of the CMI development (adjusted odds ratio ($\text{OR}_\text{adj}$) = 5.58, p = 0.026 and $\text{OR}_\text{adj}$ = 14.7, p = 0.0015, respectively). Twelve individuals with the CMI had a specific combination of СС-HSPA1A (+190G/C) and GG-HSPA1B (+1267A/G) genotypes, which strongly associated with the diagnosis ($\text{OR}_\text{adj}$ = 12.3, p = 0.0285). Moreover, significant association with the CMI was also obtained for the haplotype G-C of 1267A/G and 190G/C polymorphisms (OR = 2.1, p = 0.018). Conclusions The association of СС-HSPA1A (+190G/C) and GG-HSPA1B (+1267A/G) genotypes and their combination for the CMI individuals suggests the role for HSPA1 genes in mercury-dependent mechanisms of the CMI development and progression. Int J Occup Med Environ Health 2017;30(1):77–85
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2017, 30, 1; 77-85
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The relationship between manganism and the workplace environment in China
Autorzy:
Wang, Yongyi
Xue, Jian
Cheng, Shuqun
Ding, Yubin
He, Junlin
Liu, Xueqing
Chen, Xuemei
Wang, Yingxiong
Feng, Xiangyu
Xia, Yinyin
Powiązania:
https://bibliotekanauki.pl/articles/2180079.pdf
Data publikacji:
2012-09-01
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
manganese
occupational exposure
welding
mining
occupational intoxication
chronic manganism
Opis:
Manganese is a trace element and a cofactor of many enzymes, so it is essential for physiologic functioning, but it is also a neurotoxin at high doses. Manganism is most often caused by occupational exposure. It is manifested by a myriad of signs and symptoms ranging from the neurasthenia syndrome, such as headache and dizziness, to the Parkinson-like syndrome, depending on the blood manganese levels as well as the duration of exposure. We are reporting a case of manganism using both clinical and occupational hygiene investigation methods. The patient presented the neurasthenia syndrome accompanied by hypertonicity of arm muscles and was diagnosed to have mild chronic manganism. Finally, the patient was discharged from the hospital after the treatment had improved her condition. In China, there are many chronic manga nese cases, partly due to a rapid industrial development with great use of Mn and the low self-protection awareness among the workers and the factories management that cannot catch up with the speed of the economical development. Therefore, factories are responsible for improving the conditions at the workplace.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2012, 25, 4; 501-505
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-2 z 2

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