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Tytuł:
Occupational allergy to Limonium sinuatum — a case report
Autorzy:
Wiszniewska, Marta
Pałczyński, Cezary
Krawczyk-Szulc, Patrycja
Wittczak, Tomasz
Cyran, Aleksandra
Walusiak-Skorupa, Jolanta
Powiązania:
https://bibliotekanauki.pl/articles/2185388.pdf
Data publikacji:
2011-09-01
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
Limonium sinuatum
occupational asthma
Rhinitis
Opis:
Decorative flowers are known to be a cause of occupational allergy in the floral industry. The allergic manifestations induced by flowers include asthma, rhinoconjunctivitis and urticaria. We present a case of a 55-year-old woman, who has been working for the last 30 years as a gardener with various kinds of flowers, e.g., Limonium sinuatum (LS), chrysanthemum, sweet William (Dianthus barbatus) and Lilium. During the last 10 years she has developed nasal and eyes symptoms, dry cough, dyspnoea, chest tightness and wheezing. Clinical examination, routine laboratory testing, chest radiography, skin prick tests (SPT) involving common allergens, native plants pollens and leaves by the prick-prick technique, rest spirometry, methacholine challenge test and specific inhalation challenge test (SICT) were conducted. SPT results to common allergens were positive for grass pollens. SPT with native plants pollens and leaves showed a positive reaction only for LS. SICT induced an isolated early asthmatic reaction and significant increase in the number of eosinophils in the nasal lavage fluid. Additionally, significant increase in non-specific bronchial hyperreactivity was observed after SICT. To our knowledge, the presently described report is the first one of Limonium sinuatum induced occupational asthma and rhinitis in a Polish gardener.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2011, 24, 3; 304-307
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Occupational allergy to horse allergens: More than exposure to horses!
Autorzy:
Liccardi, Gennaro
Calzetta, Luigino
Sapio, Carmine
Rogliani, Paola
Powiązania:
https://bibliotekanauki.pl/articles/2168363.pdf
Data publikacji:
2016-07-07
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
bronchial asthma
horse
horse allergy
hypersensitivity
occupational allergy
occupational asthma
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2016, 29, 5; 721-723
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Metal-induced asthma and chest X-ray changes in welders
Autorzy:
Wittczak, Tomasz
Dudek, Wojciech
Walusiak-Skorupa, Jolanta
Świerczyńska-Machura, Dominika
Cader, Wojciech
Kowalczyk, Monika
Pałczyński, Cezary
Powiązania:
https://bibliotekanauki.pl/articles/2180086.pdf
Data publikacji:
2012-06-01
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
welders
metals
occupational asthma
chest X-ray changes
Opis:
Objectives: The aim of this study was to evaluate the coexisting factors and usefulness of diagnostic methods in metal-induced asthma in Polish welders. Materials and Methods: Examination of 50 welders occupationally exposed to metals and with suspicion of metal-induced asthma (group A), 100 welders occupationally exposed to metals but without suspicion of metal-induced asthma (group B), and two control groups (10 patients with atopic asthma and 10 healthy subjects) was carried out. Questionnaire survey, clinical examination, skin prick tests to common aeroallergens and metal salts, rest spirometry tests, X-ray, metacholine challenge and a single-blind, placebo controlled specific inhalation challenge tests with metals (or work-like conditions challenge tests) were performed. Results: In group A – in 9 cases we obtained positive results of specific inhalation challenge tests with metals (in 3 cases with nickel, in 4 cases with chromium, in 1 case with cobalt and in 1 case with manganese). Nine cases of metal-induced occupational asthma were recognized. In group B – only in one case we obtained positive results of work-like conditions challenge test (clinical and spirometry changes, eosinophil influx in induced sputum), which confirmed the diagnosis of occupational asthma. In most of examined welders (62%), pulmonary changes in chest X-ray images were noted. The statistical analysis revealed that working as a welder for more than 10 years is the coexisting factor of presence of chest X-ray changes (p- or q-type nodular changes or interstitial changes). Positive results of skin prick tests with metal salts were the coexisting factors of occupational asthma due to metals among examined group of welders. Conclusions: Specific inhalation challenge plays the key role in diagnostics of metal-induced asthma in welders. Pulmonary changes in chest X-ray were found in a significant percentage of examined welders.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2012, 25, 3; 242-250
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Latex sensitization and risk factors in female nurses in Thai governmental hospitals
Autorzy:
Supapvanich, Chompunuch
Povey, Andrew
Vocht, Frank
Powiązania:
https://bibliotekanauki.pl/articles/2178797.pdf
Data publikacji:
2014-03-22
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
sensitization
nursing
Latex allergy
developing world
occupational asthma
occupational dermatitis
Opis:
Objectives: Exposure to latex allergens in latex gloves can cause occupational health problems in nurses, yet latex gloves are still widely used in Thai hospitals. Therefore, we conducted a study to determine the prevalence of latex sensitization in nurses and identify risk factors associated with sensitization. Methods: A questionnaire, providing information on personal characteristics, ill-health, working conditions and symptoms related to latex product use, was administered to 363 female nurses working in two tertiary hospitals in southern Thailand. Latex sensitization was confirmed using a solid phase immunoassay to detect anti-latex IgE antibodies. Total glove protein levels were determined by using a modified Lowry method and latex aeroallergens by a competitive inhibition immunoassay. Results: The overall prevalence of latex sensitization was 4.4%. Respiratory symptoms related to latex glove use were significantly associated with latex sensitization (OR = 5.5, 95% CI: 1.57-19). Total glove protein levels ranged 87.8-250.8 μg protein/dm². The prevalence of latex sensiti- zation was higher (6.6% vs. 2.2%) in the hospital where gloves with higher protein levels (82-438 μg/g vs. 86-170 μg/g) were used. Furthermore, latex sensitization prevalence increased from 3% to 5% with increased average departmental aeroallergen concentrations. Conclusions: Latex sensitization prevalence in Thai nurses was higher than previously reported. Respiratory exposure seems to play an important role, in addition to dermal exposure. If latex gloves cannot be replaced by non-latex alternatives, replacement with gloves with lower protein content should be considered.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2014, 27, 1; 93-103
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Airborne contact dermatitis and asthma in a nail art operator
Autorzy:
Vaccaro, Mario
Guarneri, Fabrizio
Barbuzza, Olga
Cannavò, Serafinella P.
Powiązania:
https://bibliotekanauki.pl/articles/2178806.pdf
Data publikacji:
2014-01-01
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
occupational asthma
acrylates
airborne allergic contact dermatitis
nail art
Opis:
Nail art (creation and decoration of artificial nails) is a growing fashion trend. Proportionally to its popularity, the number of allergic reactions to the materials used has recently increased. We report the case of a nail art operator who developed occupational allergy to acrylates, manifested with the unusual simultaneous presence of asthma and dermatitis. Cutaneous lesions only affected areas not covered by individual protection devices or clothes, even if such areas were not in direct contact with acrylates, suggesting airborne allergic contact dermatitis. While respiratory problems were solved with the correct use of a mask at the workplace, facial dermatitis proved impossible to avoid or control and, for this reason, the patient had to change her work.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2014, 27, 1; 137-140
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Immunological determinants in a murine model of toluene diisocyanate-induced asthma
Autorzy:
Świerczyńska-Machura, Dominika
Walusiak-Skorupa, Jolanta
Nowakowska-Świrta, Ewa
Piasecka-Zelga, Joanna
Świercz, Radosław
Pałczyński, Cezary
Powiązania:
https://bibliotekanauki.pl/articles/2180077.pdf
Data publikacji:
2012-09-01
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
toluene diisocyanate
occupational asthma
murine model
allergic infl ammation
cytokines
Opis:
Objectives: Diisocyanates (DIC) are highly reactive, low-molecular-weight chemicals which are the leading cause of occupational asthma (OA). The aim of the study was to analyze certain aspects of the pathogenesis of allergic infl ammation in the airways induced by toluene diisocyanate (TDI) in an experimental model in mice. Materials and Methods: The experiment was carried out on 50 female BALB/cJ/Han/IMP mice, which were exposed by inhalation (intranasal and in the inhalation chamber) to toluene diisocyanate (2,4-TDI). After the experiment, the bronchoalveolar lavage fluid (BALF) was collected from the animals, and the composition of the induced infl ammatory cells, and the concentrations of certain cytokines (IL-4, IL-5, TNF-α) were evaluated. Results: The total number of cells in BALF of the examined group of mice was signifi cantly higher compared to the control mice. There was also a signifi cant increase in neutrophils and eosinophils in the study group compared to the controls. The number of lymphocytes and macrophages did not differ signifi cantly between the two groups. A statistically signifi cant increase in the level of TNF-α was shown to occur in the group exposed to toluene diisocyanate in comparison to the control group. The concentration of IL-4 increased in the study group, compared to the control one, but the differences did not reach the level of signifi cance, p > 0.05. Such difference was not observed for IL-5. Conclusions: We developed a murine model of TDI-induced asthma which caused the infl ux of infl ammatory cells like eosinophils and neutrophils in the bronchoalveolar lavage fl uid (BALF) in the TDI-treated mice. The increase of the concentration of some proinfl ammatory cytokines (TNF-α, IL-4) in BALF from the exposed mice was also observed.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2012, 25, 4; 492-498
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Occupational asthma caused by samba (Triplochiton scleroxylon) wood dust in a professional maker of wooden models of airplanes: A case study
Autorzy:
Krawczyk-Szulc, Patrycja
Wiszniewska, Marta
Pałczyński, Cezary
Nowakowska-Świrta, Ewa
Kozak, Anna
Walusiak-Skorupa, Jolanta
Powiązania:
https://bibliotekanauki.pl/articles/2178859.pdf
Data publikacji:
2014-06-21
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
occupational asthma
wood dusts
samba
triplochiton scleroxylon
specific inhalation challenge test
Opis:
Objectives: Wood dust is a known occupational allergen that may induce, in exposed workers, respiratory diseases including asthma and allergic rhinitis. Samba (obeche, Triplochiton scleroxylon) is a tropical tree, which grows in West Africa, therefore, Polish workers are rarely exposed to it. This paper describes a case of occupational asthma caused by samba wood dust. Material and Methods: The patient with suspicion of occupational asthma due to wood dust was examined at the Department of Occupational Diseases and Clinical Toxicology in the Nofer Institute of Occupational Medicine. Clinical evaluation included: analysis of occupational history, skin prick tests (SPT) to common and occupational allergens, determination of serum specific IgE to occupational allergens, serial spirometry measurements, metacholine challenge test and specific inhalation challenge test with samba dust. Results: SPT and specific serum IgE assessment revealed sensitization to common and occupational allergens including samba. Spirometry measurements showed mild obstruction. Metacholine challenge test revealed a high level of bronchial hyperactivity. Specific inhalation challenge test was positive and cellular changes in nasal lavage and induced sputum confirmed allergic reaction to samba. Conclusions: IgE mediated allergy to samba wood dust was confirmed. This case report presents the first documented occupational asthma and rhinitis due to samba wood dust in wooden airplanes model maker in Poland.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2014, 27, 3; 512-519
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Occupational asthma follow-up — Which markers are elevated in exhaled breath condensate and plasma?
Autorzy:
Pelclová, Daniela
Fenclová, Zdenka
Vlčková, Štěpánka
Klusáčková, Pavlína
Lebedová, Jindřiška
Syslová, Kamila
Běláček, Jaromír
Kuzma, Marek
Navrátil, Tomáš
Zakharov, Sergey
Kačer, Petr
Powiązania:
https://bibliotekanauki.pl/articles/2178829.pdf
Data publikacji:
2014-05-17
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
occupational asthma
exhaled breath condensate
eosinophilic cationic protein
8-isoprostane
leukotrienes
methacholine
Opis:
Objectives: To search for optimal markers in the exhaled breath condensate (EBC), plasma and urine that would reflect the activity/ severity of occupational asthma (OA) after the withdrawal from the exposure to the allergen. Material and Methods: Markers of oxidative stress: 8-iso-prostaglandin $ \text{F}_\text{2α}$ (8-isoprostane, 8-ISO), malondialdehyde (MDA), 4-hydroxy-trans-2-nonenale (HNE), cysteinyl leukotrienes (LT) and LTB₄ were determined using liquid chromatography and mass spectrometry in 43 subjects with immunological OA (49.3±11.8 years), removed from the exposure to the sensitizing agent 10.5±6.5 years ago; and in 20 healthy subjects (49.0±14.9 years). EBC was harvested both before and after the methacholine challenge test. In parallel, identical markers were collected in plasma and urine. The results were analyzed together with forced expiratory volume in one second (FEV1), blood eosinophils, immunoglobulin E (IgE) and eosinophilic cationic protein (ECP) and statistically evaluated (Spearman rank correlation $r_S$, two- or one-sample t tests and alternatively Kruskal Wallis or pair Wilcoxon tests). Results: Several parameters of lung functions were lower in the patients (FEV₁% predicted, MEF25% and MEF50%, Rtot%, p < 0.001). Shorter time interval since the removal from the allergen exposure correlated with higher ECP ($r_S$ = 0.375) and lower FEV1%, MEF25% and MEF50% after methacholine challenge ($r_S$ = -0.404, -0.425 and -0.532, respectively). In the patients, IgE (p < 0.001) and ECP (p = 0.009) was increased compared to controls. In EBC, 8-ISO and cysteinyl LTs were elevated in the asthmatics initially and after the challenge. Initial 8-ISO in plasma correlated negatively with FEV₁ ($r_S$ = -0.409) and with methacholine PD₂₀ ($r_S$ = -0.474). 8-ISO in plasma after the challenge correlated with IgE ($r_S$ = 0.396). Conclusions: The improvement in OA is very slow and objective impairments persist years after removal from the exposure. Cysteinyl LTs and 8-ISO in EBC and 8-ISO in plasma might enrich the spectrum of useful objective tests for the follow-up of OA.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2014, 27, 2; 206-215
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Mannitol vs. methacholine in the evaluation of airway responsiveness in bakers’ asthma
Autorzy:
Nowakowska-Świrta, Ewa
Wiszniewska, Marta
Lipińska-Ojrzanowska, Agnieszka
Walusiak-Skorupa, Jolanta
Powiązania:
https://bibliotekanauki.pl/articles/2116654.pdf
Data publikacji:
2020-03-13
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
mannitol
methacholine
nonspecific bronchial hyper-responsiveness
occupational asthma
specific inhalation challenge test
bakery workers
Opis:
ObjectivesVarious indirect or direct airway challenge tests are used to measure nonspecific bronchial hyper-responsiveness (NSBHR). The evaluation of NSBHR in diagnosing occupational asthma (OA) is performed, e.g., to monitor the specific inhalation challenge test (SICT). The aim of this study was to preliminarily compare the results of methacholine and mannitol inhalation challenge tests in SICT monitoring in bakers with work-related airway symptoms.Material and MethodsFour bakery workers with a suspicion of OA underwent single-blind placebo-controlled SICTs involving workplace allergens, accompanied by the evaluation of NSBHR with mannitol and methacholine, both before and after SICTs. Clinical examinations, spirometry tests, skin prick tests (SPTs) to common aeroallergens and occupational allergens, as well as tests to determine serum specific IgE antibodies to occupational aeroallergens were also performed.ResultsPositive SPTs results to occupational aeroallergens were found in all bakery workers, and specific IgE antibodies to flour were detected in 2 subjects. Three patients displayed positive SICT reactions. In all of these 3 patients, airway responsiveness to methacholine increased significantly. In 2 patients, airway reaction to mannitol was significant, whereas in 1 subject there was no increase in NSBHR after mannitol inhalation. The patient with a negative SICT result did not reveal any changes in NSBHR before and after the test, either to methacholine or mannitol.ConclusionsThe data obtained by the authors show that there is no clear correlation between the methacholine and mannitol inhalation challenge tests in SICT monitoring. Preliminary results indicate the need for further investigations to evaluate the usefulness of the mannitol challenge test in the diagnostics of OA.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2020, 33, 2; 235-239
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Non-malignant respiratory diseases and occupational exposure to wood dust. Part II. Dry wood industry
Autorzy:
Jacobsen, G
Schaumburg, I.
Sigsgaard, T.
Schlunssen, V.
Powiązania:
https://bibliotekanauki.pl/articles/51313.pdf
Data publikacji:
2010
Wydawca:
Instytut Medycyny Wsi
Tematy:
wood dust
dust
wood industry
dry wood industry
non-malignant respiratory disease
occupational exposure
epidemiology
lung function
asthma
occupational asthma
chronic bronchitis
bronchitis
rhinitis
occupational rhinitis
respiratory symptom
Denmark
Źródło:
Annals of Agricultural and Environmental Medicine; 2010, 17, 1; 29-44
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Non-malignant respiratory diseases and occupational exposure to wood dust. Part I. Fresh wood and mixed wood industry
Autorzy:
Jacobsen, G
Schaumburg, I.
Sigsgaard, T.
Schlunssen, V.
Powiązania:
https://bibliotekanauki.pl/articles/49513.pdf
Data publikacji:
2010
Wydawca:
Instytut Medycyny Wsi
Tematy:
non-malignant respiratory disease
occupational exposure
wood dust
dust
wood industry
epidemiology
lung function
occupational asthma
asthma
chronic bronchitis
rhinitis
occupational rhinitis
respiratory symptom
Denmark
fresh wood industry
mixed wood industry
Źródło:
Annals of Agricultural and Environmental Medicine; 2010, 17, 1; 15-28
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wytyczne do przeprowadzania swoistych wziewnych testów prowokacyjnych: stanowisko Europejskiego Towarzystwa Chorób Układu Oddechowego (ERS) w kontekście polskich doświadczeń
Recommendations for performing specific inhalation challenge tests: Polish experience in relation to the European Respiratory Society guideliness
Autorzy:
Walusiak-Skorupa, Jolanta
Lipinska-Ojrzanowska, Agnieszka
Wiszniewska, Marta
Powiązania:
https://bibliotekanauki.pl/articles/2085516.pdf
Data publikacji:
2020-05-15
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
swoisty wziewny test prowokacyjny
SIC
alergia zawodowa
orzecznictwo lekarskie
astma zawodowa
wytyczne orzecznicze
specific inhalation challenge tests
occupational allergy
medical certification
occupational asthma
recommendations
Opis:
W procesie diagnostyczno-orzeczniczym bardzo istotne jest zastosowanie metod obiektywnych o jak największej swoistości, ponieważ rozpoznanie choroby zawodowej implikuje konsekwencje natury medycznej i prawnej. Swoiste wziewne testy prowokacyjne (specific inhalation challenge – SIC) są niezastąpionym narzędziem diagnostycznym w rozpoznawaniu schorzeń alergicznych układu oddechowego (takich jak nieżyt nosa, astma) oraz alergicznego zapalenia spojówek i ostrych uogólnionych reakcji alergicznych, także o etiologii zawodowej. W 2014 r. zespół ekspertów Europejskiego Towarzystwa Chorób Układu Oddechowego (European Respiratory Society) opublikował wytyczne do przeprowadzania SIC stosowanych w diagnostyce chorób zawodowych układu oddechowego. Autorzy niniejszej publikacji omawiają europejskie wytyczne w kontekście polskich doświadczeń z ośrodka referencyjnego, tj. z Kliniki Chorób Zawodowych i Zdrowia Środowiskowego Instytutu Medycyny Pracy w Łodzi. W artykule szczegółowo opisano przebieg SIC oraz kryteria oceny otrzymanych wyników w diagnostyce astmy zawodowej.
A diagnosis of occupational diseases implicates some medical and legal consequences; therefore, the most specific and objective methods are needed in the diagnostic process. Specific inhalation challenge (SIC) tests currently play an irreplaceable role in diagnosing allergic airway diseases (e.g., allergic rhinitis, asthma) as well as allergic conjunctivitis and systemic reactions, also the occupational ones. In 2014, a team of the European Respiratory Society experts published a statement that provides practical recommendations for performing SIC tests in diagnosing occupational asthma. In the current publication, the authors discuss the European guidelines in the context of Polish experience of the reference center – the Department of Occupational Diseases and Environmental Health, the Nofer Institute of Occupational Medicine in Łódź. The article describes the procedures and diagnostic criteria employed during SIC tests in diagnosing occupational asthma.
Źródło:
Medycyna Pracy; 2020, 71, 3; 381-397
0465-5893
2353-1339
Pojawia się w:
Medycyna Pracy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The prevalence of asthma work relatedness: Preliminary data
Autorzy:
Dudek, Wojciech
Kupryś-Lipińska, Izabela
Wittczak, Tomasz
Świerczyńska-Machura, Dominika
Kupczyk, Maciej
Walusiak-Skorupa, Jolanta
Kuna, Piotr
Pałczyński, Cezary
Powiązania:
https://bibliotekanauki.pl/articles/2177104.pdf
Data publikacji:
2015-08-06
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
asthma
occupational diseases
epidemiology
Opis:
Objectives About 5–10% of asthmatics do not respond well to standard treatment plan. Occupational exposure may be one of the factors that can be linked with treatment failure. The aim of the study was to assess the prevalence of work-related asthma (WRA) among adult asthmatics under follow up in an outpatient allergy clinic and to create a useful tool for detecting individuals with possible WRA. Material and Methods Preliminary 5-question questionnaire designed to recognize WRA was presented to 300 asthmatics. All patients with positive preliminary verification along with 50 subjects from control group were asked to fill up a detailed questionnaire. The WRA was diagnosed by positive match for asthma symptoms in combination with workplace exposure indicated in the detailed WRA questionnaire followed by confirmation of each WRA case by detailed exposure analysis. Results Work-related asthma was recognized in 63 subjects (21% of study group). The preliminary questionnaire has 76.9% sensitivity and 94% specificity in recognition of WRA. Occupational exposure to irritants is a risk factor of WRA recognition (relative risk (RR) = 2.09 (1.44:3.03)). Working in exposure-free environment is a factor against WRA recognition (RR = 0.38 (0.24:0.61)). Among subjects with work-related asthma, the uncontrolled course of the disease is significantly more frequent (p = 0.012). Subjects with WRA more often report sickness absenteeism due to asthma than those without WRA (9.6% vs. 3.2%, respectively), but the observed differences did not reach the statistical significance. Conclusions Short 5-question questionnaire seems to be a promising tool to detect individuals with possible work-related asthma in the outpatient setting for further evaluation and additional attention.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2015, 28, 6; 1025-1029
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Occupational exposure to diisocyanates in polyurethane foam factory workers
Autorzy:
Świerczyńska-Machura, Dominika
Brzeźnicki, Sławomir
Nowakowska-Świrta, Ewa
Walusiak-Skorupa, Jolanta
Wittczak, Tomasz
Dudek, Wojciech
Bonczarowska, Marzena
Wesolowski, Wiktor
Czerczak, Sławomir
Pałczyński, Cezary
Powiązania:
https://bibliotekanauki.pl/articles/2177097.pdf
Data publikacji:
2015-08-10
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
biomarkers
diisocyanates
asthma
polyurethanes
biological monitoring
occupational exposure
occupational diseases
Opis:
Objectives The aim of the study was to evaluate health effects of occupational exposure to diisocyanates (DIC) among polyurethane foam products factory workers. Material and Methods Thirty workers had a physical examination, skin prick tests with common allergens, allergen-specific immunoglobulin E (IgE) antibodies to diisocyanates and pulmonary function tests. Concentrations of selected isocyanates in the workplace air samples as well as concentration of their metabolites in the urine samples collected from the workers of the plant were determined. Results The most frequent work-related symptoms reported by the examined subjects were rhinitis and skin symptoms. Sensitization to at least 1 common allergen was noted in 26.7% of the subjects. Spirometry changes of bronchial obstruction of a mild degree was observed in 5 workers. The specific IgE antibodies to toluene diisocyanate (TDI) and 4,4’-methylenebis(phenyl isocyanate) (MDI) were not detected in any of the patients’ serum. Cellular profiles of the collected induced sputum (ISP) did not reveal any abnormalities. Air concentrations of TDI isomers ranged 0.2–58.9 μg/m³ and in 7 cases they exceeded the Combined Exposure Index (CEI) value for those compounds. Concentrations of TDI metabolites in post-shift urine samples were significantly higher than in the case of pre-shift urine samples and in 6 cases they exceeded the British Biological Monitoring Guidance Value (BMGV – 1 μmol amine/mol creatinine). We didn’t find a correlation between urinary concentrations of TDI, concentrations in the air and concentrations of toluenediamine (TDA) in the post shift urine samples. Lack of such a correlation may be an effect of the respiratory protective equipment use. Conclusions Determination of specific IgE in serum is not sensitive enough to serve as a biomarker. Estimation of concentrations of diisocyanate metabolites in urine samples and the presence of work-related allergic symptoms seem to be an adequate method for occupational exposure monitoring of DIC, which may help to determine workers at risk as well as to recognize hazardous workplaces.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2015, 28, 6; 985-998
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Occupational diseases in Poland — An overview of current trends
Autorzy:
Szeszenia-Dąbrowska, Neonila
Wilczyńska, Urszula
Powiązania:
https://bibliotekanauki.pl/articles/2179140.pdf
Data publikacji:
2013-06-01
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
occupational poisoning
asbestosis
cancer
viral hepatitis
asthma
Opis:
Introduction: The number of occupational diseases (OD) recorded in Poland in the 1990's rapidly increased, and the numer of recognized cases has steadily decreased until now. Hence, it was decided to demonstrate the trends of selected pathologies which in Poland are "underestimated" in comparison to other countries. The presented data may constitute a basis for further research into the dependence of OD on socio-economic factors. Materials and Methods: Occupational Disease Reporting Forms, completed and sent obligatorily by the state health inspectors to the Central Register of Occupational Diseases were used as source documents for analysis. This work analyzes changes in the incidence of chronic poisonings, asbestosis, voice organ diseases, cancers, viral hepatitis, asthma and the musculoskeletal disorders over the years 1998-2011. Results: In 1998, the total number of registered diseases reached the maximum - 12,017 cases, which fell in the subsequent years to 2,562 cases in 2011. During that period, the incidence rate decreased by 6 cases per year per 100,000 employees. A considerable decrease, exceeding 90% of cases, was observed in voice organ disorders, hearing loss, chronic poisonings and viral hepatitis. The abovementioned changes, as well as improved detection of asbestos-related diseases through implementing a medical examination program of former asbestos processing plant workers, are advantages of the current situation in the epidemiology of OD. However, the disadvantages include underestimation, in comparison to other countries, of asthma, cancer and pathologies of the musculoskeletal system. Conclusion: The reported data indicates the need to assess the occupational fraction of the underestimated pathologies present in the work environment in Poland, as well as the need for studies aimed at clarifying the effect of systemic factors on identifying their occupational background.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2013, 26, 3; 457-470
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
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