Temat: noradrenergic neuron - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Distribution and pharmacology of alpha 2-adrenoceptors in the central nervous system
Autorzy:: MacDonald, E
Scheinin, M.
Powiązania:: https://bibliotekanauki.pl/articles/69473.pdf
Data publikacji:: 1995
Wydawca:: Polskie Towarzystwo Fizjologiczne
Tematy:: brain
alpha 2-adrenoceptor
idazoxan
atipamezole
dexmedetomidine
noradrenergic neuron
pharmacology
central nervous system
Źródło:: Journal of Physiology and Pharmacology; 1995, 46, 3
0867-5910
Pojawia się w:: Journal of Physiology and Pharmacology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: The influence of botulinum toxin type A (BTX) on the immunohistochemical characteristics of noradrenergic and cholinergic nerve fibres supplying the porcine urinary bladder wall
Autorzy:: Lepiarczyk, E.
Bossowska, A.
Kaleczyc, J.
Majewski, M.
Powiązania:: https://bibliotekanauki.pl/articles/32489.pdf
Data publikacji:: 2011
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: botulinic toxin type A
immunohistochemistry
noradrenergic nerve fibre
cholinergic nerve fibre
nerve fibre
pig
urinary bladder
bladder wall
botulinum toxin
neurotoxin
autonomic neuron
Opis:: Botulinum toxin (BTX) belongs to a family of neurotoxins which strongly influence the function of autonomic neurons supplying the urinary bladder. Accordingly, BTX has been used as an effective drug in experimental therapies of a range of neurogenic bladder disorders. However, there is no detailed information dealing with the influence of BTX on the morphological and chemical properties of nerve fibres supplying the urinary bladder wall. Therefore, the present study investigated, using double-labeling immunohistochemistry, the distribution, relative frequency and chemical coding of cholinergic and noradrenergic nerve fibers supplying the wall of the urinary bladder in normal female pigs (n=6) and in the pigs (n=6) after intravesical BTX injections. In the pigs injected with BTX, the number of adrenergic (DβH-positive) nerve fibers distributed in the bladder wall (urothelium, submucosa and muscle coat) was distinctly higher while the number of cholinergic (VAChT-positive) nerve terminals was lower than that found in the control animals. Moreover, the injections of BTX resulted in some changes dealing with the chemical coding of the adrenergic nerve fibers. In contrast to the normal pigs, in BTX injected animals the number of DβH/NPY- or DβH/CGRP-positive axons was higher in the muscle coat, and some fibres distributed in the urothelium and submucosa expressed immunoreactivity to CGRP. The results obtained suggest that the therapeutic effects of BTX on the urinary bladder might be dependent on changes in the distribution and chemical coding of nerve fibers supplying this organ.
Źródło:: Polish Journal of Veterinary Sciences; 2011, 14, 2
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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