Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

English (EN)·Polski (PL)·Yкраїнський (UK)
Przejdź do strony domowej biblioteki Centralna Biblioteka Wojskowa Link otwiera się w nowym oknie Logo biblioteki Prolib Integro - strona głównaCentralna Biblioteka Wojskowa

Wyszukujesz frazę "nitroaromatic compounds" wg kryterium: Temat

  Lista filtrów
Wyrównaj
    Wyświetlanie 1-6 z 6
    Tytuł:
    Reduction of nitroaromatic compounds by NAD(P)H:quinone oxidoreductase (NQO1): the role of electron-accepting potency and structural parameters in the substrate specificity
    Autorzy:
    Misevičienė, Lina
    Anusevičius, Žilvinas
    Šarlauskas, Jonas
    Čėnas, Narimantas
    Powiązania:
    https://bibliotekanauki.pl/articles/1041217.pdf
    Data publikacji:
    2006
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    reduction potential
    DT-diaphorase
    nitroaromatic compounds
    reduction mechanism
    explosives
    Opis:
    We aimed to elucidate the role of electronic and structural parameters of nitroaromatic compounds in their two-electron reduction by NAD(P)H:quinone oxidoreductase (NQO1, DT-diaphorase, EC 1.6.99.2). The multiparameter regression analysis shows that the reactivity of nitroaromatic compounds (n = 38) increases with an increase in their single-electron reduction potential and the torsion angle between nitrogroup(s) and the aromatic ring. The binding efficiency of nitroaromatics in the active center of NQO1 exerted a less evident role in their reactivity. The reduction of nitroaromatics is characterized by more positive entropies of activation than the reduction of quinones. This points to a less efficient electronic coupling of nitroaromatics with the reduced isoalloxazine ring of FAD, and may explain their lower reactivity as compared to quinones. Another important but poorly understood factor enhancing the reactivity of nitroaromatics is their ability to bind at the dicumarol/quinone binding site in the active center of NQO1.
    Źródło:
    Acta Biochimica Polonica; 2006, 53, 3; 569-576
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Single-electron reduction of quinone and nitroaromatic xenobiotics by recombinant rat neuronal nitric oxide synthase
    Autorzy:
    Anusevičius, Žilvinas
    Nivinskas, Henrikas
    Šarlauskas, Jonas
    Sari, Marie-Agnes
    Boucher, Jean-Luc
    Čėnas, Narimantas
    Powiązania:
    https://bibliotekanauki.pl/articles/1039577.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    antitumour agents
    nitroaromatic compounds
    electron transfer mechanism
    oxidative stress
    quinones
    Neuronal nitric oxide synthase (nNOS)
    Opis:
    We examined the kinetics of single-electron reduction of a large number of structurally diverse quinones and nitroaromatic compounds, including a number of antitumour and antiparasitic drugs, and nitroaromatic explosives by recombinant rat neuronal nitric oxide synthase (nNOS, EC 1.14.13.39), aiming to characterize the role of nNOS in the oxidative stress-type cytotoxicity of the above compounds. The steady-state second-order rate constants (kcat/Km) of reduction of the quinones and nitroaromatics varied from 102 M-1s-1 to 106 M-1s-1, and increased with an increase in their single-electron reduction potentials (E17). The presence of Ca2+/calmodulin enhanced the reactivity of nNOS. These reactions were consistent with an 'outer sphere' electron-transfer mechanism, considering the FMNH./FMNH2 couple of nNOS as the most reactive reduced enzyme form. An analysis of the reactions of nNOS within the 'outer sphere' electron-transfer mechanism gave the approximate values of the distance of electron transfer, 0.39-0.47 nm, which are consistent with the crystal structure of the reductase domain of nNOS. On the other hand, at low oxygen concentrations ([O2] = 40-50 μM), nNOS performs a net two-electron reduction of quinones and nitroaromatics. This implies that NOS may in part be responsible for the bioreductive alkylation by two-electron reduced forms of antitumour aziridinyl-substituted quinones under a modest hypoxia.
    Źródło:
    Acta Biochimica Polonica; 2013, 60, 2; 217-222
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Prediction of the Condensed Phase Enthalpy of Formation of Nitroaromatic Compounds Using the Estimated Gas Phase Enthalpies of Formation by the PM3 and B3LYP Methods
    Autorzy:
    Oftadeh, M.
    Keshavarz, M. H.
    Khodadadi, R.
    Powiązania:
    https://bibliotekanauki.pl/articles/951504.pdf
    Data publikacji:
    2014
    Wydawca:
    Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
    Tematy:
    condensed phase enthalpy formation
    gas phase enthalpy formation
    nitroaromatic compounds
    PM3
    B3LYP
    Opis:
    A new method is introduced to correlate the condensed phase enthalpies of formation of nitroaromatic compounds with their gas phase enthalpies of formation on the basis of the B3LYP/6-31G* and PM3 methods. For the B3LYP method, the condensed phase enthalpy of formation depends on the number of certain elements, nitro groups and aromatic rings. For the PM3 method the number of N=N or N≡N groups, and the presence or absence of three interconnected rings, in addition to some of the parameters mentioned above, are necessary in order to obtain a reliable correlation. For 72 nitroaromatic compounds, the calculated root mean square (rms) deviations of the condensed phase enthalpies of formation of nitroaromatic compounds using the B3LYP and PM3 methods are 63.63 and 32.17 kJ/mol, respectively. The results predicted on the basis of the PM3 method are compared with the best available experimental data.
    Źródło:
    Central European Journal of Energetic Materials; 2014, 11, 1; 143-156
    1733-7178
    Pojawia się w:
    Central European Journal of Energetic Materials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Quinone- and nitroreductase reactions of Thermotoga maritima thioredoxin reductase
    Autorzy:
    Valiauga, Benjaminas
    Rouhier, Nicolas
    Jacquot, Jean-Pierre
    Čėnas, Narimantas
    Powiązania:
    https://bibliotekanauki.pl/articles/1039108.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    thioredoxin reductase
    quinones
    nitroaromatic compounds
    oxidative stress
    Thermotoga
    Opis:
    The Thermotoga maritima NADH:thioredoxin reductase (TmTR) contains FAD and a catalytic disulfide in the active center, and uses a relatively poorly studied physiological oxidant Grx-1-type glutaredoxin. In order to further assess the redox properties of TmTR, we used series of quinoidal and nitroaromatic oxidants with a wide range of single-electron reduction potentials (E17, -0.49-0.09 V). We found that TmTR catalyzed the mixed single- and two-electron reduction of quinones and nitroaromatic compounds, which was much faster than the reduction of Grx-1. The reactivity of both groups of oxidants increased with an increase in their E17, thus pointing to the absence of their structural specificity. The maximal rates of quinone reduction in the steady-state reactions were lower than the maximal rates of reduction of FAD by NADH, obtained in presteady-state experiments. The mixed-type reaction inhibition by NAD+ was consistent with its competition for a NADH binding site in the oxidized enzyme form, and also with the reoxidation of the reduced enzyme form. The inhibition data yielded a value of the standard potential for TmTR of -0.31±0.03 V at pH 7.0, which may correspond to the FAD/FADH2 redox couple. Overall, the mechanism of quinone- and nitroreductase reactions of T. maritima TR was similar to the previously described mechanism of Arabidopsis thaliana TR, and points to their prooxidant and possibly cytotoxic role.
    Źródło:
    Acta Biochimica Polonica; 2015, 62, 2; 303-309
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The Relationship between Impact Sensitivity of Nitroaromatic Energetic Compounds and their Electrostatic Sensitivity
    Autorzy:
    Zohari, N.
    Seyed-Sadjadi, S. A.
    Marashi-Manesh, S.
    Powiązania:
    https://bibliotekanauki.pl/articles/358443.pdf
    Data publikacji:
    2016
    Wydawca:
    Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
    Tematy:
    energetic materials
    nitroaromatic compounds
    impact sensitivity
    electrostatic sensitivity
    safety
    Opis:
    This study presents a linear relationship between the impact sensitivity of nitroaromatic energetic compounds and their electric spark sensitivity. The methodology assumes that the impact sensitivity of a nitroaromatic energetic compound with the general formula CaHbNcOd can be expressed as a function of the electrostatic sensitivity, the number of NH2 group substitutions in the 2,4,6-trinitrophenyl ring and non-additive structural parameters. The root mean square and absolute standard deviation of a newly introduced correlation were respectively found to be 2.4 and 2.0 for 27 nitroaromatic energetic compounds. The proposed new correlation was also tested for 7 additional nitroaromatic energetic compounds, which have complex molecular structures such as 1-(2,4,6-trinitrophenyl)-5,7-dinitrobenzotriazole and 1,3,7,9-tetranitrophenoxazine.
    Źródło:
    Central European Journal of Energetic Materials; 2016, 13, 2; 427-443
    1733-7178
    Pojawia się w:
    Central European Journal of Energetic Materials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Biodegradation of 3,5-dinitrosalicylic acid by Phanerochaete chrysosporium
    Autorzy:
    Madaj, Rafał
    Kalinowska, Halina
    Sroczyński, Witold
    Szeląg, Jakub
    Sobiecka, Elżbieta
    Powiązania:
    https://bibliotekanauki.pl/articles/764850.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
    Tematy:
    nitroaromatic compounds
    white-rot fungi
    fungal biodegradation
    Opis:
    Związki nitrowe to szeroka grupa ksenobiotyków, które ze względu na swoją silną toksyczność, wyjątkową odporność na rozkład biologiczny oraz skłonność do bioakumulacji, stanowią bardzo poważny problem dla biosfery. Prowadzi się obecnie wiele badań nad mikroorganizmami, które zdołały wykształcić szlaki metaboliczne pozwalające na rozkład takich związków jak 2,4,6-trinitrotoluen, kwas pikrynowy czy kwas 3,5-dinitrosalicylowy. Jednym z takich mikroorganizmów jest podstawczak Phanerochaete chrysosporium, należący do grupy grzybów białej zgnilizny drewna. Artykuł ten poświęcony jest badaniom nad rozkładem kwasu 3,5-dinitrosalicylowego przez P. chrysosporium w warunkach hodowli stacjonarnej w pożywce zawierającej 0,05–0,5% masowego kwasu 3,5-dinitrosalicylowego. Uzyskane wyniki wskazują na zdolność wybranego mikroorganizmu do rozkładu substratu na drodze redukcji grup nitrowych.
    Despite intensive efforts put on prevention of environment pollution by nitroaromatic compounds, these xenobiotics have not been eliminated from the biosphere. The physicochemical properties make nitroaromatics extremely recalcitrant to biodegradation. Therefore, microbial degraders of these pollutants are sought after. This paper reports preliminary results of the study on degradation of 3,5-dinitrosalicylic acid (DNS) by a basidiomycetous fungus Phanerochaete chrysosporium under stationary conditions in a culture medium containing 0.05–0.5% v/v of DNS. The results obtained suggest that the fungus degrades DNS through the reductive pathway.
    Źródło:
    Acta Universitatis Lodziensis. Folia Biologica et Oecologica; 2018, 14; 14-22
    1730-2366
    2083-8484
    Pojawia się w:
    Acta Universitatis Lodziensis. Folia Biologica et Oecologica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

      Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies