Temat: neutrophil-to-lymphocyte ratio - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Prognostic value of lymphocyte-related systemic inflammatory biomarkers in triple negative breast cancer
Wartość prognostyczna biomarkerów stanu zapalnego powiązanych z limfocytami w potrójnie ujemnym raku piersi
Autorzy:: Oraczewski, Rafał Karol
Czerniawska-Meler, Małgorzata
Korzeniewicz, Martyna
Kade, Grzegorz
Kozielec, Zygmunt
Michalak, Maciej
Król, Magdalena
Zdaniukiewicz, Adam
Bodnar, Lubomir
Powiązania:: https://bibliotekanauki.pl/articles/2159007.pdf
Data publikacji:: 2022-06-29
Wydawca:: Medical Education
Tematy:: triple negative breast cancer
neutrophil-to-lymphocyte ratio
platelet-to-lymphocyte ratio
the systemic immune inflammation index
prognostic factor
potrójnie ujemny rak piersi
czynnik prognostyczny
stosunek neutrofilów do limfocytów
stosunek płytek do limfocytów
wskaźnik ogólnoustrojowej reakcji immunologiczno-zapalnej
Opis:: The aim was to evaluate inflammatory biomarkers as prognostic factors in patients with triple negativbreast cancer. We have collected data from 143 patients and evaluated using Chi-Squared test, Wilcoxon–Mann–Whitney test and Cox regression. We found a relationship between high neutrophil- to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immune inflammation index and local advancement features: tumor (T3/T4) (P = 0.0001, P = 0.0198, P = 0.0001), positive regional lymph nodes (P = 0.0014, P = 0.0075, P = 0.0206). In the multivariate analysis metastatic disease, worse performance status and high NLR (Hazard ratio: 4.48 [2.05–9.80], P=0.0002; 2.23 [1.24–4.03], P=0.0010; 2.23 [1.24–4.03], P=0.0075) were adverse prognostic factors. High neutrophil-to-lymphocyte ratio with worse performance status turned out an adverse independent prognostic factors.
Celem pracy było określenie wartości prognostycznej markerów stanu zapalnego u pacjentów z potrójnie ujemnym rakiem piersi. Zebrano dane dotyczące 143 chorych i oceniono używając testu chi-kwadrat, testu Wilcoxon–Mann–Whitney oraz regresji Coxa. Stwierdzono związek między wysokim poziomem stosunku neutrofilów do limfocytów, płytek do limfocytów, wskaźnikiem ogólnoustrojowej reakcji immunologiczno-zapalnej a miejscowym stopniem zaawansowania: guz (T3/T4) (P=0.0001, P=0.0198, P=0.0001), dodatnie regionalne węzły chłonne (P=0.0014, P=0.0075, P=0.0206). Wielowymiarowa analiza wykazała, że choroba rozsiana, gorszy stan sprawności oraz wysoki stosunek neutrofilów do limfocytów (Hazard ratio: 4.48 [2.05-9.80], P=0.0002; 2.23 [1.24-4.03], P=0.0010; 2.23 [1.24-4.03], P=0.0075) stanowią negatywne czynniki prognostyczne. Wysoki stosunek neutrofilów do limfocytów oraz gorszy stan sprawności stanowią niezależne negatywne czynniki prognostyczne.
Źródło:: OncoReview; 2022, 12, 2; 25-34
2450-6125
Pojawia się w:: OncoReview
Dostawca treści:: Biblioteka Nauki

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Tytuł:: Evaluation of Outcomes and Treatment Safety of Patients with Metastatic Colorectal Cancer to the Liver with Estimation of Prognostic Factors
Autorzy:: Zeman, Marcin
Maciejewski, Adam
Półtorak, Stanisław
Kryj, Mariusz
Powiązania:: https://bibliotekanauki.pl/articles/1396271.pdf
Data publikacji:: 2013-06-01
Wydawca:: Index Copernicus International
Tematy:: colorectal cancer liver metastases
liver resection
neutrophil to lymphocyte ratio
fibrinogen
Opis:: Liver resection is essential part of colorectal cancer liver metastases (CLM) treatment. Mean 5-year overall survival after resection achieves 30-45%. There are many factors influencing long-term outcomes, and among them the inflammatory response to tumor plays an important role. The aim of the study was evaluation of outcomes and treatment safety of patients with metastatic colorectal cancer to the liver with estimation of prognostic factors. Material and methods. 130 consecutive patients (70 men and 60 women) operated in MSC Institute and Cancer Center in Gliwice from 2001 to 2009 due to colorectal liver metastases were analysed. Age of the patients ranged from 33 to 82 years (median 60 years). 96 (74%) patients underwent potentially radical resection, and in remaining 34 (26%) was performed radiofrequency ablation (RFA) alone or combined with the resection. In the resection group 37 right hepatectomies, 11 left hepatectomies, 28 segmentectomies and 20 metastasectomies were performed. Disease-free survival (DFS) and overall survival (OS) were statistically analysed using the Kaplan-Meier method. Factors determining DFS and OS were analysed using Cox regression model. Results. In the resection group the 3- and 5-years OS was 64,5% and 46,6% respectively, and the 3- and 5-years DFS was 32% and 30,5% respectively. In the RFA group the 3- and 5-years OS was 33% and 9,5%. Statistically significant prognostic factors in the resection group in uni- and multivariate analysis were: grade and nodal involvement of the primary tumor, diameter of metastatic focus, positive and narrow (<1 mm) resection margins, preoperative fibrinogen level, preoperative neutrophil to lymphocyte ratio and leukocyte amount of the peripheral blood. The perioperative mortality rate was 3%. Conclusions. Liver resection due to colorectal liver metastases is a safe and effective method resulting in high survival rates. We confirmed some generally accepted prognostic factors influencing longterm outcomes and shown the impact of inflammatory response. We also confirmed the hypothesis that preoperative plasma fibrinogen level influences outcomes after liver resection due to CLM.
Źródło:: Polish Journal of Surgery; 2013, 85, 6; 333-339
0032-373X
2299-2847
Pojawia się w:: Polish Journal of Surgery
Dostawca treści:: Biblioteka Nauki

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