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Tytuł:
Novel nociceptin analogues.
Autorzy:
Bartosz-Bechowski, Hubert
Międzybrodzki, Ryszard
Szymaniec, Stanisław
Powiązania:
https://bibliotekanauki.pl/articles/1044068.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
orphanin
nociceptin
neuropeptide
antiopioid
Opis:
A series of new nociceptin analogues containing cysteine was tested for their nociceptive effects in tail-flick test on mice after icv injection. The cysteines were introduced in order to get irreversibly binding analogues based on the assumption that the cysteines in the ligand can interact with the cysteines from the receptor to form an S-S bridge. In vivo tests revealed that Cys1-nociceptin (1-13)-NH2 (Cys1-NC) is an antagonist, whereas Cys7-NC is an agonist. Gly1,[Phe(p-NO2)]4-NC was less active indicating that the antagonist properties of Cys1-NC are associated with the presence of the sulfhydryl group of cysteine. The analogues D-Cys2 and Cys3 were also almost inactive.
Źródło:
Acta Biochimica Polonica; 2001, 48, 4; 1155-1158
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Antinociceptive effect of MAS MT in rats
Autorzy:
Rykaczewska-Czerwinska, M.
Radosz, A.
Szymanowska-Dziubasik, K.
Konopinska, D.
Plech, A.
Powiązania:
https://bibliotekanauki.pl/articles/55342.pdf
Data publikacji:
2008
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
Tematy:
Tenebrio molitor
antinociceptive effect
rat
larva
brain
neuropeptide
insect neuropeptide
Manduca sexta
proctolin
myotropin
biological activity
peptide chain
peptide
Opis:
MAS MT is a myotropic decapeptide isolated from Manduca sexta. This peptide exerts stimulatory effect on insects heart-beat frequency. The present study was undertaken in order to determine a probable antinociceptive effect in rats of native synthetic decapeptide, MAS MT-I and its two analogs, heptapeptides MAS MT-II and MAS MT-III. All these peptides were applied directly into the lateral brain ventricle (icv) at three doses: 10, 25 and 50 nmol. The analgesic (antinociceptive) effect was evaluated by a tail immersion test. It was found that two doses of MAS MT-I: 25 and 50 nmol induced significant antinociceptive effect, while MAS MT-II and MAS MT-III exert a less antinociceptive effect in comparison with native MAS MT-I. Prior icv administration of naloxone, an opioid antagonist weakly blocked MAS MT-I effect. We conclude that antinociceptive effect of MAS MT-I in rats is not mediated by central opioid system.
Źródło:
Pestycydy; 2008, 3-4; 139-146
0208-8703
Pojawia się w:
Pestycydy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
DIAGNOSTIC POTENTIAL OF SELECTED SALIVARY PROTEOMICS FOR AUTONOMIC NERVOUS SYSTEM ACTIVITY ASSESSMENT
Autorzy:
Dobrek, Lukasz
Powiązania:
https://bibliotekanauki.pl/articles/2137800.pdf
Data publikacji:
2020-05-14
Wydawca:
Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
Tematy:
saliva
vasoactive intestinal peptide
neuropeptide Y
chromogranin A
α-amylase
Opis:
The clinical assessment of autonomic nervous system (ANS) functioning, enabling the diagnosis of autonomic neuropathy present in the course of many diseases, is currently based on performing simple cardiovascular reflexes (Ewing tests), analyzing heart rate variability (HRV) or heart rate turbulence (HRT), examining skin sweating or recording neurophysiological tests (e.g. microneurography). Laboratory assessment of ANS function is very scarce and practically only includes the plasma assessment of noradrenaline as a surrogate for the biochemical indicator of sympathetic activity. Recently, the possibility of evaluation of selected compounds present in saliva as laboratory markers of not only oral diseases but also systemic diseases has been raised. This work focuses on a brief description of the anatomy and physiology of the salivary glands and describes the formation of saliva, its composition and the use of this bodily fluid in laboratory diagnostics. In addition, the paper specifically discusses the possibility of determining selected compounds that are considered to reflect autonomic activity. A review of the literature indicates primarily four proteomics: two neuropeptides (vasoactive intestinal peptide (VIP) and neuropeptide Y (NPY) that are co-transmitters in autonomic fibers, chromogranin A, a synaptic vesicle protein and α-amylase, a hydrolytic enzyme pre-digesting carbohydrates in the oral cavity. These are currently the most widely investigated agents for their usefulness as laboratory markers of ANS activity.
Źródło:
Acta Neuropsychologica; 2020, 18(2); 285-303
1730-7503
2084-4298
Pojawia się w:
Acta Neuropsychologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
trans-Pro isosteres in the development of non-selective and selective mimetic agonists of insect pyrokinin neuropeptides: A review
Autorzy:
Nachman, R.J.
Powiązania:
https://bibliotekanauki.pl/articles/55206.pdf
Data publikacji:
2009
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
Tematy:
diapause hormone
physiological process
melanization
pupariation
pheromonotropin
neuropeptide
pyrokinin family
pheromone
diapause break
pheromone biosynthesis activating neuropeptide
insect
reddish colouration hormone
peptide
Opis:
The pyrokinin (PK) family plays a multifunctional role in an array of important physiological processes in a variety of insects. A PK active core analog containing an (E)-alkene, transPro isosteric component was evaluated in five disparate PK bioassays and/or in a recombinant PK receptor cell line, representing six different insect species. The assays included pheromone biosynthesis in the moth Heliothis peltigera, melanization in the larval Spodoptera littoralis, pupariation acceleration in the larval fly Neobellieria bullata, diapause termination in the moth Heliothis zea, and hindgut contraction in the cockroach Leucophaea maderae. This constrained analog demonstrated unselective agonist activity that approached, matched, or exceeded the activity of parent PK peptides of equal length in all six PK assays. The results provide strong evidence for the orientation of Pro and the core conformation adopted by PK neuropeptides during interaction with disparate PK receptors. A PK active core analog incorporating a second transPro motif, the dihydroimidazoline moiety, was found to demonstrate pure, selective agonism in the melanotropic bioassay, with no significant activity in three other PK bioassays. Both types of transPro isosteric analogs feature modification adjacent to the primary tissue-bound peptidase hydrolysis site that is expected to enhance biostability over natural PK peptides. The research further identifies two novel scaffolds with which to design either selective or non-selective mimetic PK analogs as potential leads in the development of environmentally favorable pest management agents capable of disrupting PK-regulated systems.
Źródło:
Pestycydy; 2009, 1-4; 33-39
0208-8703
Pojawia się w:
Pestycydy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Involvement of central histaminergic system in cardiovascular effects of Y1 receptor antagonist BIBP 3226 in haemorrhagic shock in rats
Udział ośrodkowego układu histaminergicznego w efektach krążeniowych antagonisty receptorów Y1 we wstrząsie krwotocznym u szczurów
Autorzy:
Krawiec, Adam
Jasikowska, Karolina
Chojnacka, Katarzyna
Mitera, Agata
Jochem, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/1035908.pdf
Data publikacji:
2017
Wydawca:
Śląski Uniwersytet Medyczny w Katowicach
Tematy:
histamine
neuropeptide y
bibp 3226
haemorrhagic shock
histamina
neuropeptyd y
wstrząs krwotoczny
Opis:
INTRODUCTION: Activation of the central histaminergic system leads to the reversal of experimental haemorrhagic shock, whereas neuropeptide Y (NPY) administered intracerebroventricularly (icv) induces a depressor effect in haemorrhagic hypotension. Since histaminergic neurons of the tuberomammillary nucleus receive input from neurons producing NPY localized in the caudal magnocellular nucleus of the hypothalamus, the aim of the study was to examine (1) the cardiovascular effects of the NPY type 1 (Y1) receptor antagonist in haemorrhagic shock and (2) the possible involvement of the histaminergic system in this action. MATERIAL AND METHODS: Experiments were performed in ketamine/xylazine-anaesthetised male Wistar rats subjected to irreversible haemorrhagic hypotension, with mean arterial pressure (MAP) 20–25 mmHg and 0% survival at 2 h. Immediately after terminating bleeding, the animals were pre-treated icv with histamine H1 and H2 receptor antagonists chlorpheniramine (50 nmol) and ranitidine (50 nmol) as well as the H3/4 receptor antagonist/inverse agonist thioperamide (50 nmol), respectively, or saline. Five minutes later, the rats were injected icv with the Y1 receptor antagonist BIBP 3226 (64 nmol/kg). RESULTS: BIBP 3226 evoked rises in MAP, pulse pressure and renal blood flow (RBF) with an increase in survival to 100% at 2 h. Chlorpheniramine inhibited cardiovascular changes evoked by BIBP 3226 and decreased to 0% survival at 2 h. In contrast, ranitidine and thioperamide had no effect. CONCLUSIONS: We demonstrate for the first time (1) the pressor effect resulting from the blockage of central Y1 receptors in haemorrhage-shocked rats and (2) the involvement of the histaminergic system in this action.
WSTĘP: Pobudzenie ośrodkowego układu histaminergicznego wywołuje działanie resuscytacyjne w modelu wstrząsu krwotocznego, podczas gdy neuropeptyd Y (NPY) podawany do komory bocznej mózgu (icv) powoduje efekt depresyjny w stanie hipotensji krwotocznej. Mając na uwadze, iż na neurony histaminergiczne jądra guzowo-suteczko-watego mają wpływ neurony wytwarzające NPY zlokalizowane w jądrze olbrzymiokomórkowym tylnym podwzgórza, celem pracy było zbadanie (1) efektów krążeniowych antagonisty receptorów typu 1 dla NPY (Y1) we wstrząsie krwotocznym oraz (2) możliwego udziału układu histaminergicznego w tych efektach. MATERIAŁ I METODY: Badania przeprowadzono u szczurów samców szczepu Wistar w znieczuleniu ogólnym przy użyciu ketaminy i ksylazyny, u których wywoływano nieodwracalny wstrząs krwotoczny ze średnim ciśnieniem tętniczym (MAP) 20–25 mmHg oraz wskaźnikiem przeżycia 2 h 0%. Niezwłocznie po indukcji wstrząsu dokonywano pre-medykacji icv antagonistami receptorów histaminowych H1 i H2 chlorfenyraminą (50 nmol) i ranitydyną (50 nmol), antagonistą/odwrotnym agonistą receptorów H3/4 tioperamidem bądź 0,9% roztworem NaCl. Po pięciu minutach zwierzętom podawano icv antagonistę receptorów Y1 BIBP 3226 (64 nmol/kg). WYNIKI: BIBP 3226 wywoływał wzrosty MAP, ciśnienia tętna (PP) oraz nerkowego przepływu krwi (RBF), powodował także wzrost do 100% wskaźnika przeżycia 2 h. Chlorfenyramina hamowała zmiany MAP, PP i RBF wywoływane przez BIBP 3226 oraz zmniejszała do 0% wskaźnik przeżycia 2 h. W odróżnieniu do tego ranitydyna i tioperamid nie wykazywały wpływu na działanie BIBP 3226. WNIOSKI: Zablokowanie ośrodkowych receptorów Y1 wywołuje efekt presyjny u szczurów we wstrząsie krwotocznym. Działanie to odbywa się przy udziale układu histaminergicznego.
Źródło:
Annales Academiae Medicae Silesiensis; 2017, 71; 357-362
1734-025X
Pojawia się w:
Annales Academiae Medicae Silesiensis
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of haloperidol [HAL] on leucopyrokinin [LPK]-induced biphasic hyper- and hypothermic effect in rats
Autorzy:
Rykaczewska-Czerwinska, M.
Konopinska, D.
Plech, A.
Powiązania:
https://bibliotekanauki.pl/articles/55086.pdf
Data publikacji:
2008
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
Tematy:
haloperidol
rectal temperature
insect
hyperthermia effect
rat
leucopyrokinin
neuropeptide
hypothermia effect
Opis:
The aim of present study was to evaluate mechanisms involved in thermomodulatory effect LPK in rats.Experiments were performed on adult Wistar male rats. LPK was applied either intracerebroventricularly (icv), or intraperitoneally (ip) using the similar program and technique of experiments as in our previous study. We confirmed in this paper the results of our previous reports that icv administration LPK at the dose of 20 nmol induced evident significant rectal hypothermia, while lower dose LPK of 1 nmol icv exerted significant hyperthermic effect. Peripherally applied LPK at the range of doses 10-100 nmol/100 g ip displayed slight bimodal (hyperthermic and hypothermic) effect on rectal temperature. Prior administration of haloperidol, an antagonist of central dopamine receptors blocked both effects LPK applied either icv or ip. Obtained results indicate that both hypothermic and hyperthermic effects LPK are also modulated by central dopaminergic receptors.
Źródło:
Pestycydy; 2008, 1-2; 101-108
0208-8703
Pojawia się w:
Pestycydy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wpływ neuropeptydu Y na regulację czynności układu krążenia
The influence of neuropeptide Y on the cardiovascular regulation
Autorzy:
Swoboda, Ryszard
Jochem, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/1039561.pdf
Data publikacji:
2010
Wydawca:
Śląski Uniwersytet Medyczny w Katowicach
Tematy:
neuropeptyd y
podwzgórze
układ krążenia
hipotensja
neuropeptide y
hypothalamus
cardiovascular system
hypotension
Opis:
In this review we present influences of the neuropeptide Y (NPY), a 36-amino acid peptide which belongs to the pancreatic polypeptide family, on the central and peripheral cardiovascular regulation. NPY has been detected in many central nervous system areas, including arcuate and paraventricular nuclei of the hypothalamus, nucleus of the solitary tract (NTS) and rostral ventral-lateral medulla (RVLM). Moreover, it is released from postganglionic neurons of the sympathetic nervous system and platelets. Both at the central and peripheral level, NPY acts as a peptide neuromodulator secreted together with classical neurotransmitters. It influences the cardiovascular center function acting directly on RVLM and hypothalamic neurons and indirectly – via regulation of the baroreceptor reflex sensitivity at NTS level. Interestingly, the activation of different types of NPY receptors in different central nervous system areas can cause various, even opposite, effects in the cardiovascular regulation. There is an increase in NPY synthesis and release in conditions of disturbed circulatory homeostasis, for instance in haemorrhagic shock. In critical haemorrhagic hypotension, NPY probably activates compensatory mechanisms leading to maintenance of blood pressure values necessary to survive. Thus, we conclude that further studies are needed to clarify NPY functions in conditions of hyper- and hypotension.
W niniejszej pracy przedstawiono wpływ neuropeptydu Y (NPY), peptydu zbudowanego z 36 aminokwasów, należącego do rodziny polipeptydów trzustkowych, na ośrodkową oraz obwodową regulację układu krążenia. NPY jest obecny w wielu obszarach ośrodkowego układu nerwowego, takich jak jądra łukowate, przykomorowe podwzgórza, jądro pasma samotnego (NTS) czy też przednia brzuszno-boczna część rdzenia przedłużonego (RVLM). Ponadto jest on uwalniany z pozazwojowych neuronów układu współczulnego oraz z płytek krwi. NPY działa zarówno w ośrodkowym, jak i obwodowym układzie nerwowym jako neuromodulator uwalniany łącznie z klasycznymi neurotransmiterami. Wpływa on na funkcje ośrodka sercowo-naczynioruchowego w sposób bezpośredni, działając na RVLM oraz neurony podwzgórza, jak również pośrednio, poprzez wpływ na czułość odruchu z baroreceptorów tętniczych na poziomie NTS. Co ciekawe, aktywacja różnych typów receptorów NPY w ośrodkowym układzie nerwowym może powodować różne, a nawet przeciwstawne efekty w regulacji czynności układu krążenia. W stanie zaburzonej homeostazy krążeniowej, np. podczas wstrząsu krwotocznego, dochodzi do wzrostu syntezy i uwalniania NPY, który prawdopodobnie aktywuje mechanizmy kompensacyjne prowadzące do utrzymania niezbędnych do przeżycia wartości ciśnienia krwi. Przedstawiona analiza wskazuje na konieczność prowadzenia dalszych badań nad rolą NPY w stanie hiper- i hipotensji.
Źródło:
Annales Academiae Medicae Silesiensis; 2010, 64, 5-6; 82-88
1734-025X
Pojawia się w:
Annales Academiae Medicae Silesiensis
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Antinociceptive effect of poneratoxin [PoTX] in rats
Autorzy:
Rykaczewska-Czerwinska, M.
Radosz, A.
Konopinska, D.
Wrobel, M.
Plech, A.
Powiązania:
https://bibliotekanauki.pl/articles/55195.pdf
Data publikacji:
2008
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
Tematy:
isolation
tail immersion test
analgetic effect
rat
ant
amino acid
poneratoxin
venom
neuropeptide
Opis:
Poneratoxin (molecular weight 2932) is a 25 amino acid neuropeptide, isolated from an ant venom. It affects excitability of nerve and muscle fibres by changing the kinetics of the voltage-dependent sodium channel. The aim of the study was to investigate the analgetic effect of synthetic poneratoxin (PoTX) in adult female Wistar rats. In the first part of the study the animals received PoTX intracerebroventricularly. The analgetic effect was evaluated by a tail immersion test. In the second part of the experiment the analgetic effect of PoTX was blocked with naloxone, an opioid receptors antagonist. The study showed that poneratoxin exerts the analgetic effect in rats and this effect is not mediated by central opioid system. Therefore it was concluded that other mechanism is resposible for the effect of PoTX.
Źródło:
Pestycydy; 2008, 1-2; 135-141
0208-8703
Pojawia się w:
Pestycydy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of resiniferatoxin on the chemical coding of neurons in dorsal root ganglia supplying the urinary bladder in the female pig
Autorzy:
Bossowska, A.
Majewski, M.
Powiązania:
https://bibliotekanauki.pl/articles/30452.pdf
Data publikacji:
2012
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
resiniferatoxin
chemical coding
neuron
dorsal root ganglion
urinary bladder
female
pig
sensory innervation
immunohistochemistry
neuropeptide
Opis:
Although resiniferatoxin (RTX) becomes more often used in experimental therapies of sensory system disorders, so far there is no data concerning the influence of RTX on the chemical coding of neurons in dorsal root ganglia (DRG) supplying the urinary bladder in the pig, an animal species considered as a reliable animal model for investigation dealing with human lower urinary tract disorders. Retrograde tracer Fast Blue (FB) was injected into the wall of the right half of the urinary bladder in six juvenile female pigs, and three weeks later, bladder instillation of RTX (500 nmol per animal) was carried out in all the animals. After a week, DRGs were harvested from all the pigs and the neurochemical characterization of FB+ neurons was performed using routine single-immunofluorescence labeling technique on 10-μm-thick cryostat sections. RTX instillation resulted in a distinct decrease in the numbers of FB+ cells containing calcitonin gene-related peptide (CGRP), nitric oxide synthase (NOS), somatostatin (SOM) and calbindin (CB) when compared with those found in the healthy animals (18% vs. 36%, 1% vs. 6%, 0.8% vs. 4% and 0.5% vs. 3%, respectively), and an increase in the number of pituitary adenylate cyclase-activating polypeptide (PACAP)- and galanin (GAL)-immunoreactive (IR) nerve cells (51% vs. 26% and 47% vs. 6.5%). The results obtained suggest that RTX could be taken into consideration when the neuroactive agents are planned to be used in experimental therapies of selected neurogenic bladder illnesses.
Źródło:
Polish Journal of Veterinary Sciences; 2012, 15, 1
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Conantokin G-induced changes in the chemical coding of dorsal root ganglion neurons supplying the porcine urinary bladder
Autorzy:
Bossowska, A.
Majewski, M.
Powiązania:
https://bibliotekanauki.pl/articles/31315.pdf
Data publikacji:
2012
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conantokin G
chemical coding
urinary bladder
dorsal root ganglion
neuron
sensory innervation
immunohistochemistry
neuropeptide
pig
Opis:
Conantokin G (CTG), isolated from the venom of the marine cone snail Conus geographus, is an antagonist of N-methyl-d-aspartate receptors (NMDARs), the activation of which, especially those located on the central afferent terminals and dorsal horn neurons, leads to hypersensitivity and pain. Thus, CTG blocking of NMDARs, has an antinociceptive effect, particularly in the case of neurogenic pain treatment. As many urinary bladder disorders are caused by hyperactivity of sensory bladder innervation, it seems useful to estimate the influence of CTG on the plasticity of sensory neurons supplying the organ. Retrograde tracer Fast Blue (FB) was injected into the urinary bladder wall of six juvenile female pigs. Three weeks later, intramural bladder injections of CTG (120 μg per animal) were carried out in all animals. After a week, dorsal root ganglia of interest were harvested from all animals and neurochemical characterization of FB+ neurons was performed using a routine double-immunofluorescence labeling technique on 10-μm-thick cryostat sections. CTG injections led to a significant decrease in the number of FB+ neurons containing substance P (SP), pituitary adenylate cyclase activating polypeptide (PACAP), somatostatin (SOM), calbindin (CB) and nitric oxide synthase (NOS) when compared with healthy animals (20% vs. 45%, 13% vs. 26%, 1.3% vs. 3%, 1.2 vs. 4% and 0.9% vs. 6% respectively) and to an increase in the number of cells immunolabelled for galanin (GAL, 39% vs. 6.5%). These data demonstrated that CTG changed the chemical coding of bladder sensory neurons, thus indicating that CTG could eventually be used in the therapy of selected neurogenic bladder illnesses.
Źródło:
Polish Journal of Veterinary Sciences; 2012, 15, 1
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Current concepts in clinical and laboratory assessments of autonomic nervous system activity
Autorzy:
Dobrek, L.
Thor, P.
Powiązania:
https://bibliotekanauki.pl/articles/3378.pdf
Data publikacji:
2015
Wydawca:
Instytut Medycyny Wsi
Tematy:
clinical assessment
laboratory assessment
autonomic nervous system
autonomic test
heart rate variability
noradrenaline
neuropeptide
Opis:
Introduction and objective. As the autonomic nervous system (ANS) dysfunction is present in course of many disorders, an objective assessment of the ANS function is very important. In practice, the assessment is difficult, and based rather on indirect analysis of autonomically-controlled cardiovascular reflexes, than on direct recording of activity of central or peripheral autonomic structures. The aim of our paper was to discuss briefly current, clinical and scientific ANS investigations, as well as possible future methods of autonomic activity evaluation. A brief description of the state of knowledge. The review presents a short outline of autonomic function assessments based on clinical autonomic tests (e.g. “Ewing’s battery”) and discusses the heart rate variability (HRV) study, as currently popular and widespread option of analysis of the ANS activity. Other, complementary methods, including the baroreceptor sensitivity testing, microneurography or plasma norepinephrine measurement were also mentioned. The article also provides premises related to the determination of selected neuropeptides in plasma or saliva as an innovative concept of autonomic activity assessment. Summary. The available, clinical, non-invasive methods used for assessment of the ANS function are still relatively sparse and, in fact, a surrogate for direct ANS assessment. New methods of autonomic tension determination are still needed that would allow a more complete and reliable assessment. Reports of potential new laboratory markers of the ANS activity (NPY and VIP assay) bring some hope.
Źródło:
Journal of Pre-Clinical and Clinical Research; 2015, 09, 1
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A beta-amino acid pyrokinin analog induces irregular pupariation behavior in larvae of the flesh fly Sarcophaga bullata
Autorzy:
Nachman, R.J.
Zubrzak, P.
Williams, H.
Strey, A.
Zdarek, J.
Powiązania:
https://bibliotekanauki.pl/articles/54984.pdf
Data publikacji:
2008
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
Tematy:
pyrokinin analogue
Sarcophaga bullata
insect
pyrokinin class
beta-amino acid
flesh fly
larva
pupariation process
neuropeptide
Opis:
The developmental process of pupariation is accelerated by members of the pyrokinin class of neuropeptides in larvae of the flesh fly Sarcophaga bullata. A pyrokinin analog (Ac-Y[β3Phe]TPRLamide), in which a Phe residue is replaced with a β-amino acid, accelerates pupariation in this fly at a potency (0.2 pmol/larva) that matches that of the native pyrokinin factor. At higher concentrations, this β-amino acid pyrokinin analog induces irregular pupariation behavior patterns that are suggestive of neurotoxic properties. Biostable analogs based on this structure may in future provide analog leads with the potential to disrupt the important pupariation process in flies.
Źródło:
Pestycydy; 2008, 1-2; 95-100
0208-8703
Pojawia się w:
Pestycydy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effects of arginine substitutions on the cardioinhibitory activity of the Led-NPF-I neuropeptide
Autorzy:
Marciniak, P.
Slocinska, M.
Bednarz, P.
Grodecki, S.
Konopinska, D.
Rosinski, G.
Powiązania:
https://bibliotekanauki.pl/articles/55015.pdf
Data publikacji:
2009
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
Tematy:
cardioinhibitory activity
arginine substitution
mealworm beetle
Zophobas atratus
giant mealworm beetle
Led-NPF-I-peptide
insect
beetle
neuropeptide
Opis:
Effects of structural changes on the cardioinhibitory activity of the Led-NPF-I peptide (Ala-Arg-Gly-Pro-Gln-Leu-Arg-Leu-Arg-Phe-amide) were examined by replacing Arg residues in positions 2, 7 and 9. Replacement of L-Arg2 with another basic amino acid, such as Lys, His or D-Arg, did not abolish but rather promoted cardioinhibitory activity in giant mealworm beetle Zophobas atratus Fab. Agonistic peptides were also obtained by substitution of Arg residue in position 7 with Lys or D-Arg, and Arg in position 9 with His or D-Arg, respectively. All these analogues showed stronger cardioinhibitory effects than the native peptide at low concentration (10-9 M), and [Lys7]-, [D-Arg7]- and [D-Arg9]-Led-NPF-I also at the higher concentration (10-6 M). However, substitutions of the Arg residues in position 7 with His or in position 9 with Lys caused a loss of the cardioinhibitory activity. In addition, the replacement of Arg residues in all three positions with Lys or Orn caused a reduction of cardioinhibitory activity, although a single substitution of Arg in positions 2 or 7 with Lys yielded agonistic peptides. We conclude that the Arg2 position in the N-terminal region is more tolerant to structural modification than the other two Arg positions located in the C-terminal region.
Źródło:
Pestycydy; 2009, 1-4; 71-78
0208-8703
Pojawia się w:
Pestycydy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The endocrine control of Malpighian tubule secretion: past, present and future
Autorzy:
Coast, G.M.
Powiązania:
https://bibliotekanauki.pl/articles/55107.pdf
Data publikacji:
2008
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
Tematy:
diuretic hormone
ion transport
Malpighian tubule secretion
insect
biogenic amine
endocrine control
diuresis control
neuropeptide
primary urine formation
Opis:
Work by Ramsay in the 1950’s established the foundations for our current understanding of primary urine production by Malpighian tubules and we now have detailed knowledge of the epithelial transport processes underlying fluid secretion. Identified neuropeptides and biogenic amines have been shown to stimulate fluid secretion and, for some, detailed information is available on the second messenger pathways and transport processes they activate. There are significant gaps in our knowledge, however, particularly concerning the role of identified diuretics in vivo. The hormonal status of many has yet to be established and it is also unclear whether they are used to control different types of diuresis.
Źródło:
Pestycydy; 2008, 1-2; 87-94
0208-8703
Pojawia się w:
Pestycydy
Dostawca treści:
Biblioteka Nauki
Artykuł
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