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Tytuł:
What can a mathematician do in neuroscience?
Autorzy:
Karbowski, Jan
Powiązania:
https://bibliotekanauki.pl/articles/748768.pdf
Data publikacji:
2012
Wydawca:
Polskie Towarzystwo Matematyczne
Tematy:
mózg, modelowanie systemu nerwowego, neurobiologia obliczeniowa, neurony, procesy mózgowe
Computational Neuroscience
Brain, Modeling, Neurons
Opis:
Mózg ssaków jest jednym z najbardziej złozonych obiektów we wszechswiecie. Jest odpowiedzialny za sterowanie wszystkimi aspektami zachowan zwierzecia i człowieka. Obecnie usprawiedliwione wydaje sie stwierdzenie, ze nasza wiedza na temat pracy mózgu i jego funkcjach jest dosc ograniczona. Neurobiologia obliczeniowa jest dyscyplina naukowa, która próbuje zrozumiec i opisac mózg w kategoriach modelowania matematycznego. W tej pracy zawarto przyjazny dla czytelnika przeglad zagadnien, który ma na celu wprowadzenie w ten stosunkowo nowy dla matematyków i fizyków obszar badawczy, pokazujac przykłady najnowszych trendów w tej dziedzinie. Artykuł omawia takze krótko przyszłe perspektywy dla budowy zintegrowanej teorii funkcji mózgu.
Mammalian brain is one of the most complex objects in the known universe, as it governs every aspect of animal’s and human behavior. It is fair to say that we have a very limited knowledge of how the brain operates and functions. Computational Neuroscience is a scientific discipline that attempts to understand and describe the brain in terms of mathematical modeling. This user-friendly review tries to introduce this relatively new field to mathematicians and physicists by showing examples of recent trends. It also discusses briefly future prospects for constructing an integrated theory of brain function.
Źródło:
Mathematica Applicanda; 2012, 40, 1
1730-2668
2299-4009
Pojawia się w:
Mathematica Applicanda
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
W poszukiwaniu korzeni języka naturalnego – intencjonalna komunikacja u naczelnych różnych od człowieka
Searching for the roots of natural language: intentional communication among non-human primates
Autorzy:
Kwiatek, Łukasz
Powiązania:
https://bibliotekanauki.pl/articles/690826.pdf
Data publikacji:
2014
Wydawca:
Copernicus Center Press
Tematy:
Michael Tomasello
Michael Arbib
language
communication
intentionality
mirror neurons
vocalizations
gestures
cultural evolution
biological evolution
Opis:
Where should we seek the roots of natural language? Common sense suggests that human language should have somehow evolved from primitive vocal communication, which is also, to some extent, present among other animals, especially since primary humans mean of communication is speech. Some biological and psychological evidences, however, both from observation and experiments, indicate that for the missing evolutionary link between human language and animal (apes) communication one should take chimpanzee gestural communication, the only undoubtedly intentional non-human mean of communication. In this paper, I present the evidences for the aforementioned theory and draw some conclusions regarding the issue of two “sources” of language – biological and cultural evolution.
Źródło:
Zagadnienia Filozoficzne w Nauce; 2014, 55; 43-73
0867-8286
2451-0602
Pojawia się w:
Zagadnienia Filozoficzne w Nauce
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Użyteczność modeli parametrycznych i sztucznych sieci neuronowych w prognozowaniu kosztów produkcji
The usefulness of parametric models and artificial neural networks in the estimation of production costs
Autorzy:
Leszczyński, Zbigniew
Jasiński, Tomasz
Powiązania:
https://bibliotekanauki.pl/articles/953077.pdf
Data publikacji:
2017
Wydawca:
Stowarzyszenie Księgowych w Polsce
Tematy:
model prognozowania kosztów
prognozowanie parametryczne
sztuczne sieci neuronowe
koszty prognozowane
model of cost estimation
parametric estimation
artificial neural neurons
estimated costs
Opis:
Celem artykułu jest analiza użyteczności modeli parametrycznych i sztucznych sieci neuronowych w prognozowaniu kosztów produkcji. Prognozowane koszty produkcji stanowią fundamentalną determinantę dla podejmowanych przez inżynierów decyzji technicznych i biznesowych związanych z zarządzaniem produkcją i kosztami produkcyjnymi. W pierwszej części artykułu przedstawiono ramy konceptualne budowy modelu prognozowania parametrycznego kosztów produkcji, wielowymiarowego o zależnościach liniowych i nieliniowych. Następnie omówiono istotę i zastosowanie sztucznych sieci neuronowych jako modelu – nieparametrycznego prognozowania kosztów produkcji. W obu częściach artykułu przeprowadzono badanie empiryczne z wykorzystaniem analizy regresji oraz sztucznych neuronów połączonych w sieci. Badanie empiryczne prezentuje procedury budowy modeli – parametrycznego i nieparametrycznego prognozowania kosztów produkcji oraz ich wady i zalety. W toku procedury badawczej przedstawiono zastosowanie analizowanych modeli prognozowania kosztów produkcji w określonym środowisku przemysłowym.
The aim of the paper is to analyze parametric models and artificial neural networks in terms of their suitability as estimation tools of the production costs. Estimated production costs are a fundamental determinant of the decision-making process by costs engineers relating to design and management costs of new products, infrastructure projects and production lines. The first part of the paper presents a conceptual framework for the construction of a model of production costs parametric estimation, multi-dimensional with linear and nonlinear dependency. It then discusses the nature and use of artificial neural networks as nonparametric estimates of production costs. In both parts of the article, an empirical study is conducted with the use of adequate statistical methods and artificial neurons. This study presents procedures for construction of models of parametric and nonparametric estimation of production costs and discusses their advantages and disadvantages. It also presents the application and usefulness of both models for estimating production costs in production environment.
Źródło:
Zeszyty Teoretyczne Rachunkowości; 2017, 91(147); 87-112
1641-4381
2391-677X
Pojawia się w:
Zeszyty Teoretyczne Rachunkowości
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The expression of androgen receptor in neurons of the anterior pelvic ganglion and celiac-superior mesenteric ganglion in the male pig
Autorzy:
Kaleczyc, J.
Kasica-Jarosz, N.
Pidsudko, Z.
Przyborowska, A.
Sienkiewicz, W.
Powiązania:
https://bibliotekanauki.pl/articles/2087598.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
androgen receptor
neurons
anterior pelvic ganglion
celiac-superior mesenteric ganglion
quantitative real-time PCR
immunohistochemistry
male pig
Źródło:
Polish Journal of Veterinary Sciences; 2019, 1; 151-155
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Przeciw empatii – Sartre i Gombrowicz, czyli jak filozofia i literatura wyprzedzają koncepcje naukowe
Autorzy:
Cieliczko, Małgorzata
Powiązania:
https://bibliotekanauki.pl/articles/437580.pdf
Data publikacji:
2014
Wydawca:
Uniwersytet Pedagogiczny im. Komisji Edukacji Narodowej w Krakowie. Instytut Filozofii i Socjologii
Tematy:
body
corporeality
being
empathy
compassion
identification
interpersonal relations
mirror neurons
Jean Paul Sartre
Witold Gombrowicz
Opis:
The article presents Jean Paul Sartre’s idea of the human body and the bodiliness described in his book Being and nothingness (1943). In this book, Sartre argued that every human relation is based on the objectification of one human by another, and entering into empathic contactis basically impossible. The author of the article has confronted this thesis with contemporary psychological and neuropsychological thought (mirror neuron theory) and has investigated how the category of empathy functions in literary studies. A very important part of this article is the reflection on the presence and topicality of Sartre’s beliefs in the literature. The author has conducted an interpretation of Witold Gombrowicz’s story Tancerz mecenasa Kraykowskiego (1926) from the collection Bakakaj (1957), and has shown that the ideas presented by Sartre are reflected there in a very interesting way. Sartre’s philosophy turns out to be absolutely up‑to‑date right now, more than many psychological theories — it not only supplies a philosophical base for the analysis of human relations (those also presented in literature), but also gives a certain tool for describing them in the form of specific language and terminology.
Źródło:
ARGUMENT: Biannual Philosophical Journal; 2014, 4, 2; 359-374
2083-6635
2084-1043
Pojawia się w:
ARGUMENT: Biannual Philosophical Journal
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Poeta zmysłów
A poet of the sence
Autorzy:
Łapiński, Zdzisław
Powiązania:
https://bibliotekanauki.pl/articles/16729485.pdf
Data publikacji:
2020-05-05
Wydawca:
Katolicki Uniwersytet Lubelski Jana Pawła II. Towarzystwo Naukowe KUL
Tematy:
ucieleśnienie
zmysły
neurony lustrzane
symulacja
alegoria
incarnation
senses
mirror neurons
simulation
allegory
Opis:
The article is an attempt to explain sensual depictions that are constantly present in Norwid’s works – albeit they are sometimes hidden – by means of cognitivistic categories. On the example of two texts two different ways are shown, in which these depictions are used by the poet. A fragment from the drama Cleopatra and Caesar illustrates Norwid’s technique of realistic description, and the poem Fate – the technique of allegory.
Źródło:
Studia Norwidiana; 2013, 31; 5-15
0860-0562
Pojawia się w:
Studia Norwidiana
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Perception-based reasoning: evaluation systems
Autorzy:
Rutkowska, D.
Powiązania:
https://bibliotekanauki.pl/articles/1931577.pdf
Data publikacji:
2003
Wydawca:
Politechnika Gdańska
Tematy:
fuzzy sets
perception-based systems
fuzzy neurons
neural networks
artificial intelligence
Opis:
A perception-based interpretation of evaluation systems is proposed in this paper. Thus, a perception-based approach to create intelligent systems is considered. The evaluation systems can be employed eg. in order to assess student exams, as well as to other applications. Evaluation marks used in these systems are given as perceptions expressed by words. The words play the role of labels of perceptions, and are represented by fuzzy sets. This means that the idea of perception-based systems, introduced by Zadeh, is applied. Various algorithms of overall assessment are suggested in this paper. Overall evaluation is produced as an aggregation of component evaluation marks. Systems of this kind can be obtained using fuzzy neurons, so fuzzy neural networks are also mentioned as a method of perception-based reasoning. The usefulness in artificial intelligence of both fuzzy sets and neural networks, and especially a combination of these, is shown.
Źródło:
TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk; 2003, 7, 1; 131-145
1428-6394
Pojawia się w:
TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Neuroplasticity and Microglia Functions Applied in Dense Wireless Networks
Autorzy:
Kułacz, Łukasz
Kliks, Adrian
Powiązania:
https://bibliotekanauki.pl/articles/308840.pdf
Data publikacji:
2019
Wydawca:
Instytut Łączności - Państwowy Instytut Badawczy
Tematy:
ad-hoc network
brain inspired communication
glial cells
neurons
Opis:
This paper presents developments in the area of brain-inspired wireless communications relied upon in dense wireless networks. Classic approaches to network design are complemented, firstly, by the neuroplasticity feature enabling to add the learning ability to the network. Secondly, the microglia ability enabling to repair a network with damaged neurons is considered. When combined, these two functionalities guarantee a certain level of fault-tolerance and self-repair of the network. This work is inspired primarily by observations of extremely energy efficient functions of the brain, and of the role that microglia cells play in the active immune defense system. The concept is verified by computer simulations, where messages are transferred through a dense wireless network based on the assumption of minimized energy consumption. Simulation encompasses three different network topologies which show the impact that the location of microglia nodes and their quantity exerts on network performance. Based on the results achieved, some algorithm improvements and potential future work directions have been identified.
Źródło:
Journal of Telecommunications and Information Technology; 2019, 1; 39-46
1509-4553
1899-8852
Pojawia się w:
Journal of Telecommunications and Information Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Neurophysiological changes in the afferent somatosensory system indices in the case of vertebrogenic spine pathology in miners
Autorzy:
Battakova, Sharbanu
Shraimanov, Bekkair
Powiązania:
https://bibliotekanauki.pl/articles/2179775.pdf
Data publikacji:
2013-04-01
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
miners
vertebral pathology
pain syndrome
Somatosensory Stimulated Potential (SSP)
pain reception
afferent neurons
Opis:
Objectives: The aim of the paper was to prove that job conditions impact the state of the afferent part of the somatosensory system in miners. Materials and Methods: Data analysis of the electrophysiological examination of the syndrome in 148 patients, aged from 28 to 55 years, with a mild, moderate and severe degree of the pain syndrome was performed. The control group included 28 people without any pain symptoms. The method used was that of somatosensory stimulated potential (SSP) with the potentials amplitude and latency main components taken into consideration. Results: It was proven that the true decrease of the somatosensory stimulated potential SSP N22 (p < 0.05) component amplitudes by 41%; N30 component amplitude tend to decrease by 26%. This proves that the true N22 (p < 0.01) component latency increase by 63.8% corresponds to afferent excitation wave conductibility under the pain syndrome of vertebral pathology through sensitivity pathways mainly in the posterior spinal cord columns and then, through the parts of the brain stem, involving the cerebral cortex, which is confirmed by the fact that the P38 and P46 components amplitudes tend to decrease. In addition to this, the proven N10–N13 (p < 0.05), N13–N20 (p < 0.05), N10–N20 (p < 0.05) intervals increases by 43.5–41.8–38.7%, respectively, correspond to the nervous impulse conductibility through the peripheral nervous system structures and allow to reveal the subclinical slowdown of impulse conductibility, which indicates that the conducting system is changed even under a mild pain syndrome. Conclusions: It was found that the data obtained allow for the better understanding of how the neuropathological pain syndrome under vertebral spine pathology is formed.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2013, 26, 2; 230-234
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Koncepcja ucieleśnionego poznania w kognitywnej teorii filmu
The Concept of Embodied Cognition in Cognitive Film Theory
Autorzy:
Ostaszewski, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/26850481.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Instytut Sztuki PAN
Tematy:
kognitywna teoria filmu
przetwarzanie informacji
ucieleśnione poznanie
neurony lustrzane
reakcje autonomiczne
empatia
cognitive film theory
information processing
embodied cognition
mirror neurons
autonomic reactions
empathy
Opis:
Autor artykułu wyjaśnia źródła rozwoju kognitywnej teorii filmu. Przedstawia także dwie podstawowe orientacje w ramach nauki o procesach poznawczych – model poznania obliczeniowego i model poznania ucieleśnionego – które w teorii filmu funkcjonują jako dwie kolejne fazy. Model poznania ucieleśnionego jest wyjaśniany w kontekście zarówno tradycji myśli fenomenologicznej, jak i dokonań neuronauki, w tym odkrycia neuronów lustrzanych, które mimo kontrowersji stało się podstawą dla wielokierunkowej refleksji nad odbiorem filmów. Artykuł zawiera omówienie implementacji hipotezy o systemie lustrzanym do wyjaśniania przedpojęciowego odbioru filmu, z uwzględnieniem roli symulacji ucieleśnionej i empatii jako mechanizmów uczestnictwa w poznawczym i estetycznym doświadczaniu filmu. Przedstawione zostało także zagadnienie metodologiczne projektu estetyki naturalistycznej oraz możliwości syntezy podejścia kognitywnego i fenomenologicznego do wyjaśniania estetycznego doświadczania filmu.
The article explains the origins of the development of cognitive film theory. It also presents two basic orientations within cognitive science - the computational model of cognition and the embodied model of cognition – which function in film theory as two consecutive phases. The embodied model of cognition is explained in the context of both the tradition of phenomenological thought and the achievements of neuroscience, including the discovery of mirror neurons, which, despite the surrounding controversy, became the basis for multidirectional reflection on the reception of films. The article discusses the implementation of the mirror system hypothesis in the explication of the pre-conceptual film perception, including the role of embodied simulation and empathy as mechanisms of participation in cognitive and aesthetic film experience. The methodological issue of the naturalized aesthetics project as well as the possibilities of synthesizing the cognitive and phenomenological approach in the elucidation of the aesthetic reception of film are also presented.
Źródło:
Kwartalnik Filmowy; 2022, 119; 6-29
0452-9502
2719-2725
Pojawia się w:
Kwartalnik Filmowy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Interactions between art, architecture and CNS functions
Interakcje pomiędzy sztuką i architekturą, a funkcjonowaniem OUN (ośrodkowego układu nerwowego)
Autorzy:
Bil, J. S.
Łabuz-Roszak, B.
Gorczyca, P. W.
Powiązania:
https://bibliotekanauki.pl/articles/370564.pdf
Data publikacji:
2017
Wydawca:
Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Tematy:
architecture
mirror neurons
neuroscience
physiology
Theory of Mind
architektura
fizjologia neuronauka
neurony lustrzane
teoria umysłu
Opis:
The theories, which help to understand a connection between neuroscience and architecture, are the theory of mirror neurons and the Theory of Mind (ToM). They attempt to explain how, the built environment influences human emotions, behavioural and physiological reactions, and also social relations. It helps to understand the origins of empathy and emotions with both social and anthropomorphic environment.
Teorie, które pomagają zrozumieć związek pomiędzy neurobiologią a architekturą, to teorie neuronów lustrzanych i teoria umysłu (ToM). Próbują wytłumaczyć, jak zbudowane środowisko wpływa na ludzkie emocje, reakcje behawioralne i fizjologiczne, a także na stosunki społeczne. Definiują podstawę empatii i emocji oraz relacje z otoczeniem.
Źródło:
Przestrzeń i Forma; 2017, 30; 75-86
1895-3247
2391-7725
Pojawia się w:
Przestrzeń i Forma
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Increased neurogenesis after ACEA and levetiracetam treatment in mouse pilocarpine model of epilepsy
Autorzy:
Zagaja, Mirosław
Szewczyk, Aleksandra
Haratym-Maj, Agnieszka
Rola, Radosław
Maj, Maciej
Łuszczki, Jarogniew J.
Anders-Mach, Marta
Powiązania:
https://bibliotekanauki.pl/articles/972512.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
neurogenesis
neurons
astrocytes
pilocarpine
ACEA
Levetiracetam
Opis:
Introduction and objectives. The aim of the study was to asses the impact of long-term therapy with the second generation antiepileptic drug levetiracetam (LEV) with arachidonyl-2’-chloroethylamide (ACEA), a highly selective cannabinoid CB1 receptor agoniston the process of neurogenesis in a mouse pilocarpine model of epilepsy (PILO). Additionally, a relationship was established between the treatment with ACEA in combination with LEV, and hippocampal neurogenesis in mouse PILO brain. Materials and method. All experiments were performed on adolescent male CB57/BL mice injected i.p. with LEV (10 mg/kg), ACEA (10 mg/kg) and PMSF (30 mg/kg) (phenylmethylsulfonyl fluoride — a substance protecting ACEA against degradation by the fatty-acid amidohydrolase), pilocarpine (PILO, a single dose 290 mg/kg) and methylscopolamine (30 min before PILO to stop the peripheral cholinergic effects of the pilocarpine, 1 mg/kg). The process of neurogenesis was evaluated after10 days treatment with LEV and ACEA. Results. Obtained results indicated that the combinations of ACEA+PMSF+LEV and ACEA +PMSF increased the total number of total newborn cells compared to the control. Moreover, ACEA+PMSF administered alone and in combination with LEV had a significant impact on neurogenesis increasing the total number of newborn neurons compared to the control group. Neither LEV nor PMSF had a significant impact on the number of proliferating cells and newborn neurons when compared to the control PILO group. In turn, LEV administered alone decreased significantly the number of astrocytes. However, ACEA+PMSF has demonstrated significant increase of astrocytes compare to control mice. Conclusions. These data provide substantial evidence that the combination of LEV+ACEA significantly increases the level of newborn neurons in the PILO dentate subgranular zone.
Źródło:
Journal of Pre-Clinical and Clinical Research; 2017, 11, 2; 136-141
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Immunohistochemical characterization of nerve elements in porcine intrinsic laryngeal ganglia
Autorzy:
Sienkiewicz, W.
Klimczuk, M.
Gulbinowicz-Gowkielewicz, M.
Lepiarczyk, E.
Kaleczyc, J.
Powiązania:
https://bibliotekanauki.pl/articles/16539221.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
larynx
intrinsic neurons
pig
immunohistochemistry
biologically active substances
Opis:
The present study investigated the chemical coding of neurons and nerve fibres in local laryngeal ganglia in pigs (n=5) using double-labelling immunohistochemistry. Virtually all the neurons were cholinergic in nature (ChAT- or VAChT-positive). Only very solitary, small nerve cells (presumably representing interneurons) stained intensely for adrenergic marker, DβH. Many neurons also contained immunoreactivity for NOS (91%), VIP (62.7%), NPY (24.7%), galanin (10%), SP (1.3%) and CGRP (5.3%). No neurons expressing somatostatin or Leu-enkephalin were observed. Nearly all the neuronal somata were densely supplied with varicose cholinergic nerve terminals, which presumably represented preganglionic axons, and some of them were also closely apposed with CGRP- and/or SP-positive varicose nerve endings, which were putative collaterals of extrinsic primary sensory fibres. In conclusion, this study has revealed that intrinsic neurons in the porcine larynx, like in many other mammalian species studied, should be classified as parasympathetic cholinergic neurons expressing biologically active substances, predominantly NOS and VIP. Furthermore, they are likely to receive inputs from not only preganglionic neurons but also primary sensory nerve cells. Finally, it appears that the information on the occurrence of the local laryngeal ganglia should be regularly included in textbooks dealing with the cranial portion of the parasympathetic nervous system in mammals.
Źródło:
Polish Journal of Veterinary Sciences; 2022, 25, 2; 325-334
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Identification of proteins associated with amyloidosis by polarity index method
Autorzy:
Polanco, Carlos
Samaniego, José
Uversky, Vladimir
Castañón-González, Jorge
Buhse, Thomas
Leopold-Sordo, Marili
Madero-Arteaga, Alejandro
Morales-Reyes, Alicia
Tavera-Sierra, Lourdes
González-Bernal, Jesus
Arias-Estrada, Miguel
Powiązania:
https://bibliotekanauki.pl/articles/1039130.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Polarity index method
natively unfolded proteins
intrinsically disordered proteins
natively folded proteins
neurons
amyloidosis
amyloid
amyloidogenic protein
Opis:
There is a natural protein form, insoluble and resistant to proteolysis, adopted by many proteins independently of their amino acid sequences via specific misfolding-aggregation process. This dynamic process occurs in parallel with or as an alternative to physiologic folding, generating toxic protein aggregates that are deposited and accumulated in various organs and tissues. These proteinaceous deposits typically represent bundles of β-sheet-enriched fibrillar species known as the amyloid fibrils that are responsible for serious pathological conditions, including but not limited to neurodegenerative diseases, grouped under the term amyloidoses. The proteins that might adopt this fibrillar conformation are some globular proteins and natively unfolded (or intrinsically disordered) proteins. Our work shows that intrinsically disordered and intrinsically ordered proteins can be reliably identified, discriminated, and differentiated by analyzing their polarity profiles generated using a computational tool known as the polarity index method (Polanco & Samaniego, 2009; Polanco et al., 2012; 2013; 2013a; 2014; 2014a; 2014b; 2014c; 2014d). We also show that proteins expressed in neurons can be differentiated from proteins in these two groups based on their polarity profiles, and also that this computational tool can be used to identify proteins associated with amyloidoses. The efficiency of the proposed method is high (i.e. 70%) as evidenced by the analysis of peptides and proteins in the APD2 database (2012), AVPpred database (2013), and CPPsite database (2013), the set of selective antibacterial peptides from del Rio et al. (2001), the sets of natively unfolded and natively folded proteins from Oldfield et al. (2005), the set of human revised proteins expressed in neurons, and non-human revised proteins expressed in neurons, from the Uniprot database (2014), and also the set of amyloidogenic proteins from the AmyPDB database (2014).
Źródło:
Acta Biochimica Polonica; 2015, 62, 1; 41-55
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Historia sztuki i medycyna
Art history and medicine
Autorzy:
Kędziora, Łukasz
Powiązania:
https://bibliotekanauki.pl/articles/1041322.pdf
Data publikacji:
2019-01-11
Wydawca:
Uniwersytet im. Adama Mickiewicza w Poznaniu
Tematy:
neuroesthetics
embodied simulation
mirror neurons
Zoe Leonard
Wilhelm Sasnal
art
medicine
art history
empathy
Opis:
The article Art history and medicine concerns selected aspects of the Medicine in art exhibition, taking place at the Museum of Contemporary Art in Kraków (MOCAK) between 22nd April and 22nd October 2016. The author discusses the issue of medicine with regard to its mechanisms that let us create and perceive art. This reflection includes a historical overview of the “medically-oriented” art research. Another significant aspect constitutes the attempt to explain by the tools associated with neuroaesthetics, why the viewers are likely to look at some drastic images created by artists with such willingness and involvement. The analysis refers to texts by D. Freedberg, V. Gallese, A. Damasio, P. Przybysz, and others. It also includes interpretations of the photohraph Seated anatomical model by Zoe Leonard, as well as the Medical Kit installation by Wilhelm Sasnal.
Źródło:
Poznańskie Studia Polonistyczne. Seria Literacka; 2018, 34; 341-356
1233-8680
2450-4947
Pojawia się w:
Poznańskie Studia Polonistyczne. Seria Literacka
Dostawca treści:
Biblioteka Nauki
Artykuł

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