- Tytuł:
- Cytokine action and oxidative stress response in differentiated neuroblastoma SH-SY5Y cells.
- Autorzy:
-
Kania, Joanna
Barańska, Aleksandra
Guzdek, Amalia - Powiązania:
- https://bibliotekanauki.pl/articles/1043437.pdf
- Data publikacji:
- 2003
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
neuroblastoma cells
NFkB
cytokines
PDTC
MnSOD - Opis:
- In the retinoic acid-differentiated neuroblastoma SH-SY5Y cells, IL-1 induced binding activity of NFκB and up-regulated the expression and activity of MnSOD. The IL-1-elicited effects were partly reversed by IL-4 and IL-6. It is proposed that IL-4 and IL-6 may participate in the regulation of the imbalanced oxidant status induced by IL-1 in differentiated neuroblastoma cells. In the SH-SY5Y cell line, TNFα neither activated NFκ nor induced MnSOD expression and activity, but was capable of modulating the IL-1 effects. Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NFκB activation, down-regulated the expression and activity of MnSOD, which may suggest that the regulation of MnSOD by IL-1 in retinoic acid-differentiated neuroblastoma cells was mediated by the nuclear factor κB.
- Źródło:
-
Acta Biochimica Polonica; 2003, 50, 3; 659-666
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł