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    Wyświetlanie 1-5 z 5
    Tytuł:
    Buffer composition affects rose bengal dialysis rate through cellulose membrane
    Autorzy:
    Sztandera, Krzysztof
    Powiązania:
    https://bibliotekanauki.pl/articles/1830657.pdf
    Data publikacji:
    2021-09-29
    Wydawca:
    Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
    Tematy:
    nanocarriers
    dialysis
    rose bengal
    photodynamic therapy
    Opis:
    Due to its fluorescent and phototoxic properties, rose bengal (RB) is used in photodynamic therapy. To improve the delivery of RB to its site of action, the application of nanocarrier systems has been proposed. The most promising approach includes the use of pH-responsive nanoparticles. To evaluate the pattern of drug release in different buffers, equilibrium dialysis is commonly used. Here, we used water and two buffers to determine the impact of solvent composition on the aggregation and dialysis rate of RB through a cellulose membrane. The results show that buffer composition does not influence the fluorescent properties of RB. However, the presence of additional ions causes a change in diffusion rate that is most probably linked to the size of RB aggregates.
    Źródło:
    Acta Universitatis Lodziensis. Folia Biologica et Oecologica; 2021, 17; 32-36
    1730-2366
    2083-8484
    Pojawia się w:
    Acta Universitatis Lodziensis. Folia Biologica et Oecologica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Preparation and characterization of drug delivery carriers for local administration of sodium alendronate
    Autorzy:
    Posadowska, U.
    Moreira, A.
    Martins, R.
    Pamuła, E.
    Powiązania:
    https://bibliotekanauki.pl/articles/284303.pdf
    Data publikacji:
    2013
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    nanocarriers
    microcarriers
    poly(lactide-co-glycolide) (PLGA)
    osteoporosis
    controlled drug delivery
    sodium alendronate
    Opis:
    Osteoporosis is often treated with the use of sodium alendronate - a drug that inhibits osteoclast-mediated bone resorption and regulates rate of bone turnover. However the disadvantage of oral administration of sodium alendronate is poor drug absorption from the gastrointestinal track and severe adverse effects. Therefore we propose local sustained drug delivery systems based on poly(lactide-co-glycolide) (PLGA) micro- and nanocarriers, which can be administered directly by simple injections to the required place in the body. In this study we encapsulated sodium alendronate into PLGA micro- and nanospheres via a double-emulsification technique. Emulsion formation in different shear rate conditions was used to optimize the size of the carriers. The prepared microspheres were observed under an inverted optical microscope which confirmed their micrometric size. The nanospheres were analyzed by atomic force microscopy, which allowed visualization of their shape and measurement of their size. Moreover the hydrodynamic diameter of the nanospheres, polydispersity index as well as zeta potential were examined by dynamic light scattering. The experiments show that drug release does not depend on the size of the carriers. Analyzed carriers do not cause cytotoxicity upon contact with osteoblast like-cells.
    Źródło:
    Engineering of Biomaterials; 2013, 16, 119; 8-12
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Chemiczne aspekty celowanej terapii przeciwnowotworowej II. Połączenia nośnik -lek
    Chemical aspects of targeted anticancer therapy II . Bond of carrier to drug
    Autorzy:
    Werengowska, K. M.
    Wiśniewski, M.
    Terzyk, A.P.
    Gurtowska, N.
    Drewa, T. A.
    Olkowska, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/172570.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    nanonośniki leków
    leki przeciwnowotworowe
    wiązania kowalencyjne
    adsorpcja
    nanocarriers of drugs
    anticancer drugs
    covalent bonds
    adsorption
    Opis:
    Traditional anticancer therapy is usually low effective. Popular and common drugs applied in anticancer therapy are characterized by low solubility and nonspecific biodistribution in an organism. The chemotherapy kills not only cancer but also healthy cells [4]. Building of modern drug delivery systems based on nanocarriers is a new method of anticancer treatment. The present study is directed towards nanomaterials (as carbon nanotubes, liposomes, polymeric micelles) as modern drug carriers. Thus, we characterized mechanisms of actions of traditional chemotherapeutics: paclitaxel, cisplatin and doxorubicin (Figs. 3–5) [1, 15, 21]. The purpose of this study is a description of the bioconjugation of drug-nanocarrier. Chemotherapeutics can be connected to external or internal surfaces of nanocarriers (Fig. 6) [6]. We described two main methods of drug delivery from internal space of nanocarriers: nanoextraction and nanocondensation (Fig. 7) [32]. The type of drug-carrier bonding can be covalent or noncovalent. We report recent advances in the field showing the formation of esters (Figs. 10–11) [28, 29, 53, 54], acethylhydrazone (Fig. 12) [55–61], amides [62–64], and disulfides groups [12, 65]. These reactions depend on functional groups in structures of drugs and require suitable modification of nanocarrier surfaces. In practice, the functionalization of nanocarrier surface is associated with the covering with polymers including PE G, HPMA, PG and PL GA [3]. Adsorption is the most popular process of bonding chemotherapeutic and nanomaterials (Fig. 13) [66]. Special attention is paid to electrostatic interaction between drugs: paclitaxel [74], cisplatin [59, 76, 77], doxorubicin [67–73] and nanocarriers: carbon nanotubes and/or polymeric micells. By application of modern anticancer therapy, drugs are preserved from lysosomal degradation and to fast reaction in biological environment. Finally, nanocarriers improve adsorption of drug and increase concentration of drug only in cancer tissues [6, 7].
    Źródło:
    Wiadomości Chemiczne; 2012, 66, 7-8; 637-670
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Nanonośniki jako nowoczesne transportery w kontrolowanym dostarczaniu leków
    Nanocarriers as modern transport media in drug delivery systems
    Autorzy:
    Niemirowicz, K.
    Car, H.
    Powiązania:
    https://bibliotekanauki.pl/articles/1218473.pdf
    Data publikacji:
    2012
    Wydawca:
    Stowarzyszenie Inżynierów i Techników Przemysłu Chemicznego. Zakład Wydawniczy CHEMPRESS-SITPChem
    Tematy:
    nanonośniki
    nanocząstki
    kontrolowane dostarczanie leków (DDS)
    struktury core-shell
    nanocarriers
    nanoparticles
    targeted therapy
    drug delivery system (DDS)
    core-shell structures
    Opis:
    W systemie kontrolowanego dostarczania leków na poziomie nanocząstek (NP) wykorzystuje się różne ugrupowania, w tym polimery, materiały węglowe oraz nanocząstki magnetyczne. Wymienione związki, występują w postaci prostego nośnika lub stanowią otoczkę typu core - shell, np. na rdzeniu magnetycznym. Taka modyfikacja pozwala na kontrolowany transport w miejsce docelowe, a także obrazowanie zachodzących w tkance procesów desorpcji leku. W niniejszym artykule zostanie przedstawiona synteza nośników leków, funkcjonalizacja ich powierzchni oraz sposoby immobilizacji związków aktywnych na ich powierzchni ze szczególnym uwzględnieniem materiałów magnetycznych.
    In drug delivery systems there are many different groups used at the level of nanoparticles (NP), including polymers, carbon materials and magnetic nanoparticles. The above-mentioned compounds occur in the form of a simple carrier or make a complex core - shell system, e.g. on a magnetic core. This modification allows for a controlled drug delivery to a target site as well as imaging the celllevel drug desorption processes. This paper presents the process of synthesising the drug carriers, functionalising their surfaces and the methods for immobilising active substances on their surface with special emphasis given to magnetic materials.
    Źródło:
    Chemik; 2012, 66, 8; 868-881
    0009-2886
    Pojawia się w:
    Chemik
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Chemiczne aspekty celowanej terapii przeciwnowotworowej I. Kowalencyjne połączenia ligand-nośnik
    Chemical as pects of targeted anticancer therapy I. Covalent bond of ligand to carier
    Autorzy:
    Werengowska, K. M.
    Wiśniewski, M.
    Terzyk, A.P.
    Gurtowska, N.
    Drewa, T. A.
    Powiązania:
    https://bibliotekanauki.pl/articles/171972.pdf
    Data publikacji:
    2011
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    nanonośniki leków
    terapia celowana
    ligandy
    wiązania kowalencyjne
    system dostarczania leków przeciwnowotworowych
    nanocarriers of drugs
    targeted therapy
    ligands
    covalent bond
    anticancer drug delivery system
    Opis:
    In this study we describe the most popular biomedical engineering nanoparticles including carbon nanotubes [17-20], liposomes [4-7], polymeric micells [11-13], quantum dots [3, 21-23], hydrogels [24-27], dendrimers [14-16] which are recently considered as modern drug carriers. These nanomaterials are applied for cancer diagnostic and targeted delivery of active compounds as chemotherapeutics in so called targeted therapy. Thus, we characterized the ideas of targeted therapy for which compositions of carriers with antibody are constructed (Figs. 3, 4). We also compared the traditional and targeted mechanisms [1, 3, 28-29] of drug delivery (Fig. 2). During targeted therapy only the essential dose of drug (less than during conventional chemotherapy) is delivering to the cancer cell. In additional, the application of targeted therapy reduces side effects, being very characteristic for the traditional treatment. The anticancer compound can selectively hits the target only, due to the presence of the ligands attached to the surface of nanocarirer. We characterized ligands which are often use in nanomedicine: antibodies [33-37], folic acid [30-33], peptides [33, 38, 39], aptamers [33, 40, 41] and transferrin [33, 42-44]. The purpose of this study is description of the bioconjugation of ligand-nanocarrier. This step is necessary and very important in synthesis of the novel drug delivery systems in targeted anticancer therapy. We report recent advances in the field showing the formation of amides (Figs. 6-8) [51-57], thioethers (Figs. 9-11) [52, 60-66], disulfides (Fig. 12) [69], and acethyl-hydrazone groups (Fig. 13) [73]. Special attention is paid to the process such as Diels-Alder (Figs. 14, 15) [74, 75] and "click chemistry" through the cycloaddition of Huisgen (Figs. 16, 17) [79-82]. We describe also the reaction of Staudinger [83] and the process of formation Schiff 's base [84]. The processes enable very mild and selective modification of the carriers through formation of amide bound. These methods ware less popular but allow the fictionalization of nanocarriers in biomedical application. Each reaction or process needs special and individual environment and conditions, which are summarized in Table 1.
    Źródło:
    Wiadomości Chemiczne; 2011, 65, 9-10; 887-915
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

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