- Tytuł:
- Elevation of plasma fibrinogen in silent myocardial ischaemia
- Autorzy:
-
Grzywacz, Alina
Psuja, Piotr
Zozulińska, Maria
Elikowski, Waldemar
Zawilska, Krystyna - Powiązania:
- https://bibliotekanauki.pl/articles/1044459.pdf
- Data publikacji:
- 1999
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
silent myocardial ischaemia
fibrinogen
plasminogen activator inhibitor-1 - Opis:
- High plasma levels of fibrinogen and plasminogen activator inhibitor (PAI-1) are reported to be correlated with coronary heart disease. Therefore the level of fibrinogen concentration in plasma was examined and verified for the possible correlation with the previously explored PAI-1 antigen and PAI-1 activity in the pathogenesis of premature atherosclerosis (Grzywaczet al., 1998,Blood Coagul Fibrinol. 9, 245-249). Examination included only men, aged 33-46 years, who were in a stable condition for at least six months after the acute event. They were divided into two subgroups: group A (n = 14) with and group B (n = 15) without ischaemic changes in 24 h Holter electrocardiogram. The number of involved vessels visible on the coronarography picture was similar in both groups. In the patients of group A the mean level of fibrinogen (3.92 vs 3.23 g/l, P < 0.05) was higher than in the controls (n = 15). No statistically differences were found between group B and control healthy subjects in any of the parameters measured. There were no correlation between fibrinogen concentration and PAI-1 antigen and activity levels, which were elevated in both groups of patients according to our previous study. Our results indicate that elevated levels of plasma fibrinogen and PAI-1 appeared in the group of patients with more severe disease, as revealed by silent myocardial ischaemia.
- Źródło:
-
Acta Biochimica Polonica; 1999, 46, 4; 985-989
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł