Temat: mutant - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Dynamics of excitation energy transfer in PSII particles of Arabidopsis thaliana mutant clpC1
Autorzy:: Adamiec, M.
Lucinski, R.
Gibasiewicz, K.
Giera, W.
Sipinska, W.
Jackowski, G.
Powiązania:: https://bibliotekanauki.pl/articles/80441.pdf
Data publikacji:: 2013
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: conference
excitation energy transfer
Arabidopsis thaliana
clpC1 mutant
polypeptide
time-resolved fluorescence
regulatory protein
chloroplast
apoprotein
Źródło:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 3
0860-7796
Pojawia się w:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Comparative stability analysis of D23N mutated Aβ
Autorzy:: Alred, E. J.
Scheele, E. G.
Berhanu, W. M.
Hansmann, U. H. E.
Powiązania:: https://bibliotekanauki.pl/articles/1935815.pdf
Data publikacji:: 2014
Wydawca:: Politechnika Gdańska
Tematy:: Aβ
structural polymorphism
molecular dynamics
parallel and anti-parallel β sheets
Iowa mutant
Opis:: Amyloid β (Aβ) is the subject of numerous studies due to its link to the devastating Alzheimer’s disease and it exists in a parallel structure in fibril aggregate. The Iowa mutant (D 23 N) Aβ posses a unique antiparallel fibril aggregate structure and can also form parallel structure. This structural difference, coupled with the fact that occurrence of the Iowa mutant is correlated with early onset Alzheimer’s, suggests to use these peptides as candidates for computational studies of the structural determinants of the toxicity of Alzheimer’s disease. In order to compare the two observed Aβ structural motifs, we designed a computational study to probe the factors that affect the stability of parallel and antiparallel aggregates. Since the structural changes may occur on a timescale beyond that sampled in traditional molecular dynamics (MD), we employed a techniques of scaling the mass to reduce the solution ’s viscosity and compared the results to regular molecular dynamics. The knowledge gained from this study could provide insight into the mechanism of selection for antiparallel and parallel two fold structures.
Źródło:: TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk; 2014, 18, 4; 365--371
1428-6394
Pojawia się w:: TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Role of Sinorhizobium meliloti glutaredoxins in nitrogen-fixing symbiosis
Autorzy:: Benyamina, S.
Alloing, G.
Rouhier, N.
Jacquot, J.
Puppo, A.
Frendo, P.
Powiązania:: https://bibliotekanauki.pl/articles/80782.pdf
Data publikacji:: 2013
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: conference
Sinorhizobium meliloti
glutaredoxin
nitrogen-fixing symbiosis
bacteroid
Smgrx2 mutant strain
iron metabolism
Źródło:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
0860-7796
Pojawia się w:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Analysis of selected grasspea mutants by generalized linear model
Analiza wybranych mutantów lędźwianu siewnego przy zastosowaniu uogólnionego modelu liniowego
Autorzy:: Bocianowski, J.
Bakinowska, E.
Rybinski, W.
Powiązania:: https://bibliotekanauki.pl/articles/9591.pdf
Data publikacji:: 2008
Wydawca:: Uniwersytet Przyrodniczy w Lublinie. Katedra Zastosowań Matematyki i Informatyki
Tematy:: grass pea
Lathyrus sativus
mutant
fatty acid
seed
generalized linear model
logistic model
Źródło:: Colloquium Biometricum; 2008, 38
1896-7701
Pojawia się w:: Colloquium Biometricum
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Two Gln187 mutants of human soluble APRIL inhibit proliferation of lung carcinoma A549 cells
Autorzy:: Dai, Shuangshuang
Zheng, Yingru
Chen, Bin
Gao, Min
Zhang, Yan
Zhang, Li
Gong, Wei
He, Fengtain
Powiązania:: https://bibliotekanauki.pl/articles/1040492.pdf
Data publikacji:: 2009
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: APRIL
Gln187 mutant of sAPRIL
anti-tumor activity
Opis:: Soluble APRIL (sAPRIL), the active form of a proliferation-inducing ligand (APRIL), is implicated in the proliferation of tumor cells. Suppressing APRIL function has been considered as a potential strategy for the therapy of APRIL-associated tumors. In the present study, we generated human sAPRIL and its two mutants, Gln187-D-sAPRIL (Gln187 deleted) and Gly187-sAPRIL (Gln187 replaced by Gly). In vitro experiments showed that the two mutants had similar specific binding capacity to lung carcinoma A549 cells compared to the wild-type sAPRIL, and both, especially Gly187-sAPRIL, exhibited significant antagonistic effect on sAPRIL-induced tumor cell proliferation in a dose-dependent manner, which might be predominantly mediated by blocking sAPRIL-induced MEK and ERK phosphorylation but not p38MAPK or JNK signaling. In vivo experiments with nude mice bearing A549 cell-derived xenograft tumor showed that only the Gly187-sAPRIL mutant could significantly suppress the tumor growth. These results suggest that Gln187 may be a crucial amino acid in APRIL-mediated tumor cell proliferation via the MEK-ERK signaling pathway and that the sAPRIL mutants may serve as novel potential antagonists of APRIL for the therapy of APRIL-associated cancers.
Źródło:: Acta Biochimica Polonica; 2009, 56, 4; 703-710
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: Effect of gamma irradiation on plants in interaction with arbuscular mycorrhizae
Autorzy:: Ene, M.
Trandafir, L.
Alexandru, M.
Powiązania:: https://bibliotekanauki.pl/articles/148043.pdf
Data publikacji:: 2009
Wydawca:: Instytut Chemii i Techniki Jądrowej
Tematy:: tomato
mutant
gamma irradiation
mycorrhiza defective
Opis:: Arbuscular mycorrhizae are endogenous fungi that form symbiotic association with the vast majority of vascular plants. They help to increase the nutrient uptake, especially phosphorus and to exploit a larger area of soil. Also, they improve soil aggregation, contribute to nutrient cycling processes in plants and improve their tolerance of heavy metal contamination or drought, as well as their susceptibility to root pathogens or herbivores. These fungi colonize the root epidermis and outer cortical layers and release bioactive molecules. The transcriptome and the proteome of plants are substantially altered. They have evolved multiple mechanisms that result in improvements in plant resistance to disease and plant growth and productivity, being included in a lot of combination of biofertilizers. In order to study these mechanisms, gamma irradiation was used to create mutants that are defective in their association. Culture under in vitro conditions is presented as method for maintaining the useful mutants in pure line.
Źródło:: Nukleonika; 2009, 54, 2; 89-92
0029-5922
1508-5791
Pojawia się w:: Nukleonika
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: Cysteine-rich receptor-like kinases (CRK) in ROS signalling in Arabidopsis thaliana
Autorzy:: Gauthier, A.
Idanheimo, N.
Salojarvi, J.
Wrzaczek, M.
Kangasjarvi, J.
Powiązania:: https://bibliotekanauki.pl/articles/80229.pdf
Data publikacji:: 2013
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: conference
receptor-like kinase
reactive oxygen species
signalling
Arabidopsis thaliana
protein-protein interaction
crk mutant
xanthine oxidase
Źródło:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
0860-7796
Pojawia się w:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 8.

Tytuł:: Effect of EMS on induced morphological mutants and chromosomal variation in cowpea (Vigna unguiculata (L.) Walp)
Autorzy:: Gnanamurthy, S.
Dhanavel, D.
Powiązania:: https://bibliotekanauki.pl/articles/11505.pdf
Data publikacji:: 2014
Wydawca:: Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:: ethyl methanesulphonate
morphological mutant
mutant
chromosome variation
cowpea
Vigna unguiculata
Opis:: Effect of EMS (ethyl methane sulphonate) on induced morphological mutants and chromosomal variation in cowpea was studied using five different doses of mutagen along with a control in randomized blocked design with three replications. The morphological mutants there are two types of viable and chlorophyll mutants. Viable mutant contains tall, dwarf, early maturity, late maturity, leaf mutants pod mutant and flower mutants. The frequency of chlorophyll mutant contains albino, xantha and viridis. This concentration can damage or modify important components of plant cells and have been reported to affect the morphology, anatomy, biochemistry and physiology of plants differentially depending on the concentration level. These effects include changes in the cellular structure and metabolism of the plants e.g., dilation of thylakoid membranes, alteration in photosynthesis, modulation of the antioxidative system and accumulation of phenolic compounds. The morphological and chromosomal variation was found to be mutagen sensitive in somatic cells of cowpea. It was found to increase with increasing the concentration of EMS in Cowpea plants. The chemical mutagen like ethyl methane sulphonate induces high frequency of chromosomal changes like anaphasic bridge; anaphasic laggard, anaphasic bridge and clumbing of chromosome were including control plants also observed.
Źródło:: International Letters of Natural Sciences; 2014, 17
2300-9675
Pojawia się w:: International Letters of Natural Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 9.

Tytuł:: Parallel Mutant Execution Techniques in Mutation Testing Process for Simulink Models
Autorzy:: Hanh, L. T. M.
Binh, N. T.
Tung, K. T.
Powiązania:: https://bibliotekanauki.pl/articles/307992.pdf
Data publikacji:: 2017
Wydawca:: Instytut Łączności - Państwowy Instytut Badawczy
Tematy:: mutant execution
mutation testing
parallel processing
software testing
Opis:: Mutation testing – a fault-based technique for software testing – is a computationally expensive approach. One of the powerful methods to improve the performance of mutation without reducing effectiveness is to employ parallel processing, where mutants and tests are executed in parallel. This approach reduces the total time needed to accomplish the mutation analysis. This paper proposes three strategies for parallel execution of mutants on multicore machines using the Parallel Computing Toolbox (PCT) with the Matlab Distributed Computing Server. It aims to demonstrate that the computationally intensive software testing schemes, such as mutation, can be facilitated by using parallel processing. The experiments were carried out on eight different Simulink models. The results represented the efficiency of the proposed approaches in terms of execution time during the testing process.
Źródło:: Journal of Telecommunications and Information Technology; 2017, 4; 90-100
1509-4553
1899-8852
Pojawia się w:: Journal of Telecommunications and Information Technology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 10.

Tytuł:: Biosynteza beta-glukanaz przez mutanty Trichoderma reesei podczas hodowli okresowych
Autorzy:: Janas, P
Targonski, Z.
Rudnicka-Pilat, T.
Powiązania:: https://bibliotekanauki.pl/articles/826322.pdf
Data publikacji:: 2002
Wydawca:: Polskie Towarzystwo Technologów Żywności
Tematy:: hodowla mikroorganizmow
mutanty
biosynteza
Trichoderma reesei
mikroorganizmy
beta-glukanazy
microorganism culture
mutant
biosynthesis
microorganism
beta-glucan
Opis:: Cztery mutanty T. reesei były testowane pod kątem produkcji beta-glukanaz podczas hodowli okresowych w obecności różnych źródeł węgla. Nadproducent enzymów autolitycznych Trichoderma viride F- 19 został użyty jako mutant porównawczy. Najwyższe aktywności beta-glukanaz oznaczono w filtratach otrzymanych po hodowlach T. viride F-19 i T. reesei VTT-D-78085 na pożywkach zawierających 1% mieszaniny glukanu i chityny w stosunku 1:1. Stwierdzono wysokie aktywności proteolityczne filtratów podczas hodowli mutantów w obecności 1% glukanu, które były związane z zanieczyszczeniem tego substratu substancjami białkowymi, działającymi indukcyjnie na produkcję tych enzymów. Beta - gluka- nazy produkowane przez T. reesei M-7 były odporne na glukozową represję kataboliczną.
Four Trichoderma reesei mutants have been tested during batch cultivations for beta-glucanases production on the medium with different source of carbon. Trichoderma viride F-19 has been used as high-lytic enzyme-production reference strain. The highest activities of beta-glucanases have been estimated in culture filtrates obtained after cultivation of T. reesei VTT-D-78085 and T. viride F-19 on the medium with 1% mixture of chitin and glucan at the ratio 1:1. High proteolytic activities of culture filtrates obtained during cultivation in the presence of 1% of glucan were connected with high protein content in this substrate which acting as inducer of production of these enzymes. Beta-glucanases produced by T. reesei M-7 were resistant to glucose catabolite repression.
Źródło:: Żywność Nauka Technologia Jakość; 2002, 09, 2; 30-42
1425-6959
Pojawia się w:: Żywność Nauka Technologia Jakość
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 11.

Tytuł:: Izolacja i wstepna charakterystyka niskoproteazowych mutantow Trichoderma reesei
Autorzy:: Janas, P
Fiedurek, J
Targonski, Z
Mleko, S
Powiązania:: https://bibliotekanauki.pl/articles/828717.pdf
Data publikacji:: 2003
Wydawca:: Polskie Towarzystwo Technologów Żywności
Tematy:: mutanty
aktywnosc proteolityczna
grzyby
aktywnosc enzymatyczna
Trichoderma reesei
enzymy celulolityczne
biomasa
serwatka
laktoza
mutant
proteolytic activity
fungi
enzyme activity
cellulolytic enzyme
biomass
whey
lactose
Opis:: Po mutagenizacji promieniowaniem UV i NTG szczepu Trichoderma reesei M-7 i selekcji na podłożu z dodatkiem żelatyny wyizolowano około 960 niskoproteazowych mutantów. Dziesięć z nich zostało przetestowanych podczas hodowli okresowych w zakresie produkcji celulaz, proteaz i beta-galaktozydazy w obecności serwatki i laktozy jako źródła węgla. Aktywności proteolityczne oznaczone po hodowlach 9 mutantów w obecności laktozy były niższe od szczepu wyjściowego. Zaobserwowano większy indukcyjny wpływ serwatki niż laktozy, na sekrecję proteaz przez wszystkie badane szczepy. Czysta laktoza okazała się bardziej efektywnym induktorem produkcji beta-galaktozydazy niż zawarta w serwatce. Plony biomasy większości mutantów po hodowlach na serwatce były tylko nieznacznie wyższe od oznaczonych po hodowlach na czystej laktozie. Było to prawdopodobnie związane z litycznym mechanizmem kompensującym proteaz, przejawiających wyższe aktywności w filtratach pochodzących z hodowli w obecności serwatki. Praca jest wstępem do dalszych badań nad zależnościami pomiędzy proteazami i innymi enzymami w filtratach pohodowlanych Trichoderma reesei.
It has been isolated 960 low-protease mutants after mutagenisation using UV radiation and NTG and selection on medium with addition of gellatine. Ten of them have been tested during batch cultivation for the production of cellulases, proteases and beta-galactosidase in the presence of whey and lactose as a source of carbon. Proteolytic activities estimated after cultivation of 9 mutants in the presence of lactose were lower then parental strain. It has been observed better inductive effect of whey then lactose on the secretion of proteases by all mutants tested. Pure lactose appeared to be more effective inducer of the production of beta-galactosidase then contains in whey. Biomass concentration of most mutants after cultivation on whey was only slightly higher then estimated after cultivation on pure lactose. It was probably connected with lytic compensatory mechanism of proteases exhibited higher activities in culture filtrates from cultivation in the presence of whey. This work is an introduction for future studies on correlation between proteases and other enzymes in culture filtrates of Trichoderma reesei.
Źródło:: Żywność Nauka Technologia Jakość; 2003, 10, 2; 17-26
1425-6959
Pojawia się w:: Żywność Nauka Technologia Jakość
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 12.

Tytuł:: Improving the monacolin K to citrinin production ratio in red yeast rice by an X-ray-induced mutant strain of Monascus purpureus
Autorzy:: Kanpiengjai, A.
Mahawan, R.
Pengnoi, P.
Lumyong, S.
Khanongnuch, C.
Powiązania:: https://bibliotekanauki.pl/articles/80836.pdf
Data publikacji:: 2018
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: Red Yeast Rice
Monascus purpureus
solid state fermentation
citrinin
monacolin K
mutagenesis
X-ray
mutant strain
ionizing radiation
Źródło:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2018, 99, 2
0860-7796
Pojawia się w:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 13.

Tytuł:: Genetic variation of hordein polypeptides in grains of mutants of hulless spring barley [Hordeum vulgare L.] breeding line
Autorzy:: Kapala, A
Rybinski, W
Powiązania:: https://bibliotekanauki.pl/articles/2047707.pdf
Data publikacji:: 1996
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: polypeptide spectrum
breeding line
barley
mutant
Hordeum vulgare
hordein polypeptide
hull
Opis:: Hordein polypeptides patterns of 146 mutants in M7 from a hulless spring barley breeding line were examined. The mutants were obtained after treatment of grains of Polish hulless spring barley breeding line, 1N/86, with the chemomutagens N-nitroso-N-methylurea and sodium azide. The mutants were distinguished from the parental line with regard to morphological and yield structure traits. SDS-PAGE of the main hordein fractions, B and C, showed that the electrophoretic patterns of the majority of the analysed mutants were similar to the hordein polypeptide spectrum of the parental line. However, specific hordein patterns were obtained from six of the mutants. In the previous study, the same mutants showed a significantly better feeding value as compared to hulled cultivars and the rest of the analysed mutants.
Źródło:: Journal of Applied Genetics; 1996, 37, 1; 29-35
1234-1983
Pojawia się w:: Journal of Applied Genetics
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 14.

Tytuł:: Variability of seed protein composition of hulless mutants of spring barley [Hordeum vulgare L.]
Autorzy:: Kapala, A
Rybinski, W.
Powiązania:: https://bibliotekanauki.pl/articles/2048149.pdf
Data publikacji:: 1995
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: grain
barley
crude fibre
protein
mutant
spring barley
hull
seed
nutritional value
Opis:: Nutritional value of protein in 146 mutants of hulless spring barley was estimated. Evaluation of protein quality was based on the portion of a relative content of protein fractions with different amino acid composition and, therefore, with different nutritional value. The ratio of albumins, globulins and glutelins to hordein, determining nutritional value of protein in the initial genotype was 1.1; in mutants it was within the range of 0.9-1.5. Several mutants with a high protein content and good nutritional value have been distinguished.
Źródło:: Journal of Applied Genetics; 1995, 36, 2; 129-135
1234-1983
Pojawia się w:: Journal of Applied Genetics
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 15.

Tytuł:: Somaclonal selection of physiological mutants and several problems related to rice cell breeding
Autorzy:: Kinoshita, T
Mori, K.
Powiązania:: https://bibliotekanauki.pl/articles/2044460.pdf
Data publikacji:: 1998
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: chromosome variation
japonica rice
Oryza
African rice
physiological mutant
gamma-radiation
anther culture
hybrid plant
protoplast isolation
callus induction
callus formation
aneuploidy
indica rice
herbicide tolerance
hybrid
Kitaake cultivar
gametoclonal variation
somatic hybrid
rice
Opis:: Tolerance to a new herbicide, pyributycarb, was evaluated both at the plant and cellular levels. Several highly or moderately tolerant strains chosen at the plant level, showed a parallel relation of to tolerance at the cellular level. However, on the whole, correlation between total tolerance indices and survival rates of calli was not significant in 18 out of the 80 studied strains. As a result of somaclonal selection for two herbicides, lines NB-200 and NM-100 were regenerated from the tolerant calli screened with benthiocarb at 200 ppm, and molinate at 100 ppm, respectively. In the R₂ generation, both the lines displaned a stable tolerance both at the plant and cellular levels. Thus the highly tolerant mutant lines were developed from a moderately tolerant line, N-61, via in vitro selection. To achieve a short-cut method in the interspecific genetic exchange, a series of techniques related to cell fusion were established in rice and related species. Two kinds of somatic hybrids between the cultivar Kitaake and tetraploid Oryza species, O. punctata and O. officinalis, were successfully produced. Among the somatic hybrid plants, a wide range of chromosomal variation was observed. Aneuploid plants with a chromosome number around 2n = 72 (hexaploid), which are expected from a symmetric fusion between diploid and tetraploid strains, were obtained showing mixoploidy within a plant. Most of the somatic hybrids were characterized by intermediate features of plant-type showing high sterility, shattering of spikelets and reduced plant height. As an exception, a diploid plant, which was identified by RFLP analysis using the rDNA gene probe, closely resembled Kitaake and produced viable seeds. A tetraploid hybrid plant was also promising for the introduction of economically important characters through the reduction of chromosome numbers by doubled haploids. Gametoclonal variation and gamma radiation was applied to Kitaake. The mutation frequency was prominently increased by gamma ray treatment, especially at high doses of 200 Gy or 300 Gy. In the M₃R₂ or M₄R₃ generations, most of the variants showed unfavourable characters. Most of the mutant characters were governed by single or double recessive genes. Several mutants such as short culm and early flowering time might be used for rice breeding.
Źródło:: Journal of Applied Genetics; 1998, 39, 1; 9-35
1234-1983
Pojawia się w:: Journal of Applied Genetics
Dostawca treści:: Biblioteka Nauki

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