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Wyszukujesz frazę "monocytes" wg kryterium: Temat

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    Wyświetlanie 1-4 z 4
    Tytuł:
    Monocytes in children with leukemias and lymphomas - down-regulation of HLA and costimulatory molecules.
    Autorzy:
    Łuczyński, Włodzimierz
    Stasiak-Barmuta, Anna
    Krawczuk-Rybak, Maryna
    Szymański, Marcin
    Malinowska, Iwona
    Mitura-Lesiuk, Małgorzata
    Powiązania:
    https://bibliotekanauki.pl/articles/1041525.pdf
    Data publikacji:
    2004
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    infection
    lymphoma
    costimulation
    leukemia
    monocytes
    Opis:
    The aim of the study was to evaluate the function of monocytes in children with leukemias and lymphomas based on the expression of critical costimulatory, activatory and adhesion molecules (CD80, CD86, HLA-DR and CD54 = ICAM-1), estimated with tricolor flow cytometry. In comparison to the control group we found a lower percentage of monocytes with costimulatory molecules (CD80 before and CD86 after lipopolysaccharide stimulation) at the time of diagnosis and of monocytes with HLA-DR molecules after remission induction. We also noted a lower percentage of monocytes with HLA-DR expression in the group with severe or therapy resistant infections. The results of our investigation suggest some defect in costimulation and antigen presentation in lymphoproliferative diseases in children.
    Źródło:
    Acta Biochimica Polonica; 2004, 51, 4; 1067-1073
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The role of different monocyte subsets and macrophages in asthma pathogenesis
    Autorzy:
    Grubczak, K.
    Moniuszko, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/1917322.pdf
    Data publikacji:
    2015
    Wydawca:
    Uniwersytet Medyczny w Białymstoku
    Tematy:
    Monocytes
    Macrophages
    Glucocorticoids
    monocyte subsets
    Asthma
    Opis:
    Monocytes are comprised of three phenotypically and functionally distinct subsets: classical CD14++CD16-, intermediate CD14++CD16+ and non-classical CD14+CD16++ cells that can play differential roles in regulation of both systemic and local inflammatory processes. In addition, these monocyte subsets represent differential developmental stages with CD16-positive monocytes being the most mature cells that can be considered direct precursors of tissue macrophages. Monocytes and, most significantly, monocyte-derived macrophages constitute an important component of both normal and asthmatic airways. Here we summarize the current knowledge on the roles of monocytes and macrophages in asthma pathogenesis. In addition, we discuss here the usefulness of standard and potential monocyte-directed anti-asthmatic therapeutic approaches.
    Źródło:
    Progress in Health Sciences; 2015, 5, 1; 176-184
    2083-1617
    Pojawia się w:
    Progress in Health Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Can the leukocyte`s parameters in peripheral blood smear predict the risk of in-hospital death of patients undergoing high-risk gastrointestinal surgery?
    Autorzy:
    Pluta, Michał
    Krzych, Łukasz
    Powiązania:
    https://bibliotekanauki.pl/articles/1392359.pdf
    Data publikacji:
    2019
    Wydawca:
    Index Copernicus International
    Tematy:
    Peripheral blood morphology
    perioperative medicine
    risk
    monocytes
    Opis:
    Introduction. White blood cell (WBC) count constitutes a part of routine peripheral blood examination (FBC, full blood count). Precise analysis of leukocytes’ parameters in blood smear is usually performed only when leukopenia or leukocytosis is found. We aimed to assess the usefulness of leukocytes’ smear test in predicting in-hospital death of patients undergoing high-risk gastrointestinal (GI) surgery. Materials & Methods. We prospectively enrolled 101 subjects undergoing high-risk GI surgery from 01.01.2017 till 31.12.2017. Blood tests were performed preoperatively, with analysis focused on the assessment of total WBC count, as well as the count of neutrophils (NEUT), lymphocytes (LYM), monocytes (MONO), eosinophils (EOS) and basophils (BASO). Indices of NEUT/LYM (NLR) and MONO/LYM (MLR) were calculated. In-hospital mortality was considered the outcome. Results. Mortality reached 5%. There was no significant difference in WBC count between survivors and the deceased (p=0.2) and WBC failed to predict the outcome (AUC=0.69; p=0.3). MONO (p=0.009) and BASO (p=0.02) counts, as well as MLR (p=0.007) were significantly higher in patients who died. MONO count and MLR index predicted in-hospital death with good accuracy, respectively: AUC[MONO]=0.85 (p<0.001) and AUC[MLR]=0.86 (p<0.001). Other investigated parameters played no significant role in outcome prediction. Conclusion. Routine peripheral blood smear evaluation should be considered in all patients undergoing high-risk GI surgery, because the number of monocytes can be a valuable predictor of in-hospital death.
    Źródło:
    Polish Journal of Surgery; 2019, 91, 1; 22-28
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Modulation of GAPDH expression and cellular localization after vaccinia virus infection of human adherent monocytes.
    Autorzy:
    Nahlik, Krystyna
    Mleczko, Anna
    Gawlik, Magdalena
    Rokita, Hanna
    Powiązania:
    https://bibliotekanauki.pl/articles/1043440.pdf
    Data publikacji:
    2003
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    human adherent monocytes
    vaccinia virus
    subcellular localization
    glyceraldehyde-3-phosphate dehydrogenase
    apoptosis
    Opis:
    Vaccinia virus is able to replicate in many cell types and is known to modulate apoptosis in infected cells. In this study, expression of apoptosis-related genes was screened in human adherent monocytes after vaccinia infection using a DNA array. A marked increase of the key glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) expression was found. Increased expression and nuclear translocation of GAPDH have recently been reported to participate in apoptosis of many cell types. To confirm the array results, levels of GAPDH mRNA were estimated by RT-PCR, showing an increase at 4 h p.i. followed by a slight decrease, which correlated with the viral anti-apoptotic E3L gene transcript levels. Subcellular localization of the enzyme in human monocytes was examined by Western blot and immunostaining of the infected cells. Both experiments revealed accumulation of GAPDH in the nucleus at 14 h p.i., which was completely suppressed at 24 h p.i. This might indicate GAPDH as a novel target for vaccinia anti-apoptotic modulation.
    Źródło:
    Acta Biochimica Polonica; 2003, 50, 3; 667-676
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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