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Wyświetlanie 1-15 z 31
Tytuł:
DNA – a molecule that transformed science. A short history of research
Autorzy:
Gabryelska, Marta M.
Szymański, Maciej
Barciszewski, Jan
Powiązania:
https://bibliotekanauki.pl/articles/703398.pdf
Data publikacji:
2009
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
DNA
molecular biology
genomics
genetics
Opis:
Deoxyribonucleic acid (DNA) was identified 140 years ago by a Swiss physician Friedrich Miescher. His discovery was fundamental for the development of biochemistry, genetics and molecular biology. Contemporary biology, biotechnology and medicine largely depends on our ability to analyze, synthesize and manipulate DNA. We present highlights of the history of DNA research from the very beginning to the sequencing of human genome.
Źródło:
Nauka; 2009, 2
1231-8515
Pojawia się w:
Nauka
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
ELF3 as an important factor in carcinogenesis – a brief review of the recent studies
Autorzy:
Domańska, Julia
Poboży, Kamil
Kuryłek, Michał
Fudalej, Marta M.
Sobiborowicz, Aleksandra
Deptała, Andrzej
Badowska-Kozakiewicz, Anna M.
Powiązania:
https://bibliotekanauki.pl/articles/1035652.pdf
Data publikacji:
2020
Wydawca:
Medical Education
Tematy:
ELF3
carcinogenesis
molecular biology
Opis:
Introduction and objective: E74-like transcription factor 3 (ELF3) is mainly expressed in epithelial tissue, being responsible for differentiation and regeneration. Furthermore, it plays a role in inflammation, remodeling, allergy regulation and apoptosis. Various studies on ELF3 conducted since 1997 have also proved its connection with carcinogenesis and metastasis. This review summarizes recent advances in understanding the role of ELF3 in the following cancers: ampullary, bladder, breast, gastric, hepatocellular, nasopharyngeal, thyroid, lung and ovarian ones. State of knowledge: There are still many unresolved and undiscovered issues regarding ELF3 mutations, however, based on research since 2016, a link to many signaling pathways important for carcinogenesis has been shown. There is no simple correlation between a specific ELF3 mutation and effect on cancer cells. In various types of cancers, ELF3 is associated with other pathways, and modifications exerted by silencing or amplifying its or associated genes, cause different effects in patient prediction. An example of the effect of ELF3 on tumor progression is achieved by negatively regulating the ZEB1 transcription factor responsible for metastasis. WNT, RAS, Akt, mTOR, HER2, Cyclin D, IRF6 are other ELF3-related factors that affects pathways crucial for tumorigenesis. Conclusions: Further research and attempts to use ELF3 in the treatment and prognosis of cancer appear to be beneficial.
Źródło:
OncoReview; 2020, 10, 2; 77-81
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Simulation of the electrophoresis of DNA by the method of cellular automata
Autorzy:
Krawczyk, Małgorzata
Kułakowski, Krzysztof
Powiązania:
https://bibliotekanauki.pl/articles/747601.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Matematyczne
Tematy:
Biochemistry, molecular biology
Cellular automata
Opis:
.
The authors give the description of a new cellular automaton for simulating the electrophoresis of gel DNA. This automaton is deterministic, which corresponds to the well-known Monte Carlo rules holding for the electrophoresis at a low temperature and a high intensity electric field. The experimental results indicate that under such conditions the electrophoresis efficiency depends significantly on the string length.
Źródło:
Mathematica Applicanda; 2002, 30, 44/03
1730-2668
2299-4009
Pojawia się w:
Mathematica Applicanda
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Bioengineering in cosmetology – the overview of present state and future prospects
Autorzy:
Betyna, Monika
Powiązania:
https://bibliotekanauki.pl/articles/1178917.pdf
Data publikacji:
2017
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
engineering
innovation
molecular biology
techniques
technology
Opis:
Biological engineering, also referred to as bioengineering, is a branch of biotechnology focused on solving problems of life sciences with the use of the most modern technology, analytical and synthetic methodologies, including possibly lowest cost of the conducted analyses and procedures. Nowadays, bioengineering is in the lead in the scientific world. Unlike traditional engineering techniques, which apply mathematical and physical sciences to analysis processes and structures of biological systems, the biological engineering is capable of molecular analysis due to developing knowledge of molecular biology and progress in technology.
Źródło:
World Scientific News; 2017, 89; 199-207
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Molecular biology of sporadic vestibular schwannomas including genetic and epigenetic alterations
Autorzy:
Makuszewska, Maria
Litwiniuk-Kosmala, Małgorzata
Bartoszewicz, Robert
Niemczyk, Kazimierz
Powiązania:
https://bibliotekanauki.pl/articles/1399235.pdf
Data publikacji:
2020
Wydawca:
Index Copernicus International
Tematy:
gene expression
merlin
microRNA
molecular biology
neuroblastoma
Opis:
Introduction: Vestibular schwannomas (VS) are benign tumors developing from the myelin-producing Schwann cells, which surround the vestibular branches of the auditory nerve. The vast majority occur sporadically and a small proportion are associated with neurofibromatosis type 2 (NF2). Most sVS are slow-growing neoplasms; however some have a cystic structure, show more rapid growth, cause more frequently paralysis of the facial nerve, and brainstem compression. The molecular hallmark of both sporadic and NF-2 associated VS is the inactivation of the tumor-suppressor gene NF2, also called merlin gene. Purpose: The paper presents the current knowledge on the molecular biology of VS, including: information on genetic and epigenetic aberrations, changes in gene expression and specific microRNA expression profiles.
Źródło:
Polski Przegląd Otorynolaryngologiczny; 2020, 9, 3; 23-29
2084-5308
2300-7338
Pojawia się w:
Polski Przegląd Otorynolaryngologiczny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Współczesna rewolucja naukowa na pograniczu fizyki i biologii
The Present Scientific Revolution on the Borderline between Physics and Biology
Autorzy:
Ślósarek, Genowefa
Powiązania:
https://bibliotekanauki.pl/articles/690980.pdf
Data publikacji:
2012
Wydawca:
Copernicus Center Press
Tematy:
scientific revolution
molecular biology
biophysics
nanotechnology
single-molecule methods
system biology
Opis:
At the end of the 20th century, substantial changes in the paradigms of molecular physics and biology occurred. They have brought two new and entirely independent, fields of scientific research – nanotechnology and systems biology. Thanks to these disciplines, a new paradigm was born opening a new way of research in biology. It enables a holistic treatment of living organisms. As a consequence of these changes, an entirely new picture of the interface between physics and biology emerges.
Źródło:
Zagadnienia Filozoficzne w Nauce; 2012, 51; 96-115
0867-8286
2451-0602
Pojawia się w:
Zagadnienia Filozoficzne w Nauce
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Zastosowanie transferu energii rezonansu fluorescencji (FRET) w ilościowej metodzie oznaczania ekspresji genów na przykładzie sondy TaqMan
The application of fluorescence resonance energy transfer (FRET) method for the quantitative determination of gene expression with using TaqMan probe
Autorzy:
KOZIOROWSKA, Anna
ROMEROWICZ-MISIELAK, Maria
Powiązania:
https://bibliotekanauki.pl/articles/455324.pdf
Data publikacji:
2013
Wydawca:
Uniwersytet Rzeszowski
Tematy:
inżynieria biomedyczna
biologia molekularna
PCR
biomedical engineering
molecular biology
Opis:
„Łańcuchowa reakcja polimerazy (PCR) zajmuje bardzo ważne miejsce w badaniach biologii molekularnej. Wiele technik inżynierii biomedycznej wykorzystuje produkty tej reakcji do dalszych analiz. Real-Time PCR jest metodą opartą na klasycznej metodzie PCR. Mimo swojej krótkiej historii jej popularność i obszar zastosowania wciąż wzrasta. Jej głównymi zaletami jest większa czułość, precyzyjność oraz możliwość ilościowej oceny produktu w komórkach lub tkankach. Zjawisko transferu energii rezonansu fluorescencji (FRET) jest podstawą działania sondy TaqMan jako jednej z wielu wykorzystywanych do monitorowania przyrostu produktu amplifikacji w kolejnych cyklach reakcji. Celem niniejszej pracy był zwięzły opis metody z przedstawieniem jej najważniejszych zalet oraz możliwości zastosowania w praktyce na przykładzie badań prowadzonych w Centrum Biotechnologii Stosowanej i Nauk Podstawowych
Polymerase chain reaction (PCR) takes a very important place in the study of molecular biology. Many biomedical engineering techniques use the products of this reaction for further analysis. Real-Time PCR is a method based on the classical method of PCR. Despite its short history, its popularity and area of use is still increasing. Its main advantages are high sensitivity, precision and the ability to quantitatively evaluate the product in cells or tissues. The phenomenon of fluorescence resonance energy transfer (FRET) is the basis of action TaqMan probe as one of many used for monitoring the growth of the product amplification in the subsequent reaction cycles. The aim of this study was brief description of the method with presentation of the most important advantages and possibilities of practical application as an example of research conducted at the Center for Applied Biotechnology and Basic Sciences.
Źródło:
Edukacja-Technika-Informatyka; 2013, 4, 2; 372-377
2080-9069
Pojawia się w:
Edukacja-Technika-Informatyka
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pathogenesis of middle ear acquired cholesteatoma in the light of the research using high throughput, “omics”, technologies of molecular biology
Autorzy:
Makuszewska, Maria
Bartoszewicz, Robert
Niemczyk, Kazimierz
Powiązania:
https://bibliotekanauki.pl/articles/1399639.pdf
Data publikacji:
2019
Wydawca:
Index Copernicus International
Tematy:
aquired cholesteatoma
gene expression
microarray
molecular biology
pathogenesis
proteomic analysis
Opis:
Cholesteatoma is described as cystic lesion consisting of keratinizing squamous cell epithelium, filed with keratin debris, surrounded by inflammatory fibrous tissue, gradually expanding in the middle ear and causing destruction of neighboring bones. This paper presents brief review of existing hypotheses explaining its etiology in the light of the researches using high throughput, “omics”, technologies of molecular biology. Classic theories of pathogenesis of acquired cholesteatoma as: immigration, squamous metaplasia, basal cell hyperplasia or invagination theory have not been able to explain fully all pathological processes observed in cholesteatoma tissue. This also concerns the newer concepts that cholesteatoma is a result of mucosal traction generated by interaction of migrating opposing surfaces, a natural attempt by the body to cure the underlying inflammation in the cavity or chronic wound healing process triggered by micro defects in the basement membrane of the epithelium in the retraction pocket. Introduction of high-throughput, “omics”, technologies of molecular biology to the studies under cholesteatoma pathogenesis allowed identification of cholesteatoma-related gene expression signatures using full-genome microarrays as well as proteomic analysis of cholesteatoma. Those studies confirmed known pathological processes observed in cholesteatoma tissue such as: high proliferative activity, decreased signal transduction, active immunological response, alterations in the extracellular matrix, increased expression of proinflammatory cytokines, neovascularization and may others. This technique allows precise and complete insight into molecular mechanisms in those processes. However, it is still unknown what is the cause that trigger epithelial hyperplasia, inhibited migration and inflammatory response in the preexisting retraction pocket.
Źródło:
Polski Przegląd Otorynolaryngologiczny; 2019, 8, 3; 14-19
2084-5308
2300-7338
Pojawia się w:
Polski Przegląd Otorynolaryngologiczny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ribotyping as a molecular biological technique for studying diversity in Shigella isolates - a review
Autorzy:
Pal, P.
Powiązania:
https://bibliotekanauki.pl/articles/11905.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
ribotyping
molecular biology
diversity
Shigella
isolate
bacteria
systematics
enteropathogen
taxonomy
Opis:
Diarrhoea in developing countries is caused by an increasingly long list of bacterial, viral, and parasitic pathogens with rotavirus, Enterotoxigenic Escherichia coli, Campylobacter, Shigella, and Salmonella heading the list. Using methods to detect most of the known enteropathogens, one or more enteropathogen(s) is isolated in two-thirds of diarrhoeal illnesses in the developing world. Deoxyribonucleic acid probes have proved very useful in detecting pathogens such as enterotoxigenic (ETEC), enteroinvasive (EIEC), enteropathogenic E. coli (EPEC), and Shigella but have not yet proved to be particularly rapid or less expensive. Molecular biology has proved useful in epidemiological studies as a means of strain identification and detection of genome diversity. Since the introduction of ribonucleic acid gene restriction patterns as taxonomic tools in 1986, ribotyping has become an established method for systematics, epidemiological, ecological population and genome diversity studies of microorganisms including Shigella. The technological development culminated in the automation of ribotyping which allowed for high-throughput applications. PCR ribotyping has proved being a highly discriminatory, flexible, robust and cost-efficient routine technique which makes inter-laboratory comparison and build of ribotype databases possible, too. The aim of the present review is to determine the present status of ribotyping technique in detecting the diversity in Shigella isolates.
Źródło:
International Letters of Natural Sciences; 2014, 14
2300-9675
Pojawia się w:
International Letters of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Look at gene, chromosome and genome – molecular cytogenetic investigations
Autorzy:
Małuszyńska, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/703863.pdf
Data publikacji:
2007
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
chromosome
cytogenetics
DNA
FISH
genome research
chromosome aberrations
evolution
molecular biology
Opis:
Cytogenetics is complementary to genetic and molecular analysis of genome structure and function. From the beginning it has been mainly used for identification of chromosomes and karyotype construction. Most significant for the progress in cytogenetics was development of chromosome banding techniques and in situ hybridization, especially fluorescent in situ hybridization (FISH) and its different modifications which have become the most important techniques in molecular cytogenetics. FISH allows physical gene mapping and localization of different non-coding DNA sequences on chromosomes and interphase nuclei. Repetitive DNA sequences can generate unique FISH-signal patterns on individual chromosomes valuable for karyotyping and phylogenetic analysis. These studies have important implications for basic research and practical applications. The understanding of the structure, function, organization and evolution of genomes enabled many new cytogenetic applications to both medicine and agriculture, particularly in diagnosis and plant breeding.
Źródło:
Nauka; 2007, 4
1231-8515
Pojawia się w:
Nauka
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Segmented hybridization probes: modulating target affinity and base pairing selectivity
Autorzy:
Egetenmeyer, S.
Geiger, E.
Richert, C.
Powiązania:
https://bibliotekanauki.pl/articles/81071.pdf
Data publikacji:
2012
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
oligonucleotide
DNA
RNA
hybridization
base pairing
molecular biology
polymerase chain reaction
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2012, 93, 3
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Piotr Słonimski co-founder of molecular genetics – in memoriam
Autorzy:
Zagórski, Włodzimierz
Powiązania:
https://bibliotekanauki.pl/articles/703689.pdf
Data publikacji:
2009
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
Piotr Słonimski
yeast molecular biology
non-mendelian genetics
mosaic genes
genomic
Opis:
Piotr Słonimski, full professor of genetics at University Paris 6 and associate professor on Institute of Biochemistry and Biophysics P.A.S. Born in Warsaw 9.11.1922 died in Paris 25.04.2009. He was full member of French Academy of Science and foreign member of Polish Academy of Sciences, Polish Academy of Arts and Sciences as well as of several others European Academies and dr. hc of many European Universities. He was honored by number of scientific prizes, and was holder of several high decorations, French and Polish. Piotr Słonimski studied medicine during the II World War in Warsaw Underground University, and started after the war his scientific career getting in 1946 his M.D. title at Jagiellonian University in Cracow. Being under occupation the active member of Polish underground and soldier of Warsaw 44 insurrection against Nazis, in Poland incorporated into soviet block he did not escaped the repressions falling on the anti-nazi independence fighters and was arrested by communist secret services. After a few months in prison he was liberated and left Poland for France, were in laboratory of Boris Ephrussi he started his career in CNRS, where from 1971 to 1992 was Director of Centre de Genetique Moleculaire. In line with solid french tradition yeast S. cerevisiae was preferred model of his studies. Here he demonstrated non-standard heritage of mitochondrial traits and become one of co-founders of non-mendelian genetics in Eucatyota. By subtle genetic analysis of selected mitochondrial genes he was first to demonstrate the existence of mosaic genes and pointed towards the regulatory function of information carried on by introns. In nineties Piotr Słonimski was a spiritus movens of European yeast genomics program, acknowledged by special issue of Nature, giving full gene repertoire of the first eucaryotic organism. His scientific interest stayed then in genomes. Here with advanced cryptology methods he was looking for the existence of non-trivial rhythms in coding DNA sequences. His death left in sorrow not only his family but also all the scientist of “yeast community” as well as his comrades in arms from underground and Solidarity movement.
Źródło:
Nauka; 2009, 4
1231-8515
Pojawia się w:
Nauka
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Modelling the virtual physiological human
Autorzy:
Sansom, C.
Mendes, M.
Coveney, P
Powiązania:
https://bibliotekanauki.pl/articles/80904.pdf
Data publikacji:
2011
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
modelling
molecular biology
genomics
protein
experimental biology
computational biology
human physiology
heart
cancer
modern biology
mathematical model
immune system
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2011, 92, 3
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Nitryfikacja w osadzie czynnym - mikrobiologiczne spojrzenie na procesy utleniania amoniaku
Nitrification in activated sludgem - microbiological insight into nitrogen oxidation process
Autorzy:
Ziembińska, A.
Powiązania:
https://bibliotekanauki.pl/articles/1207747.pdf
Data publikacji:
2011
Wydawca:
Stowarzyszenie Inżynierów i Techników Przemysłu Chemicznego. Zakład Wydawniczy CHEMPRESS-SITPChem
Tematy:
narzędzia biologii molekularnej
nitryfikacja
oczyszczanie ścieków
tools of molecular biology
nitrification
wastewater treatment
Opis:
Osad czynny jest uznawany za najbardziej efektywną i popularną metodę oczyszczania ścieków. W osadzie czynnym zachodzi znaczna ilość złożonych przemian chemicznych i biochemicznych, prowadzących do otrzymania wysokiej jakości produktu. Nitryfikacja, czyli usuwanie nieorganicznych form azotu, jest kluczowym elementem oczyszczania ścieków. Aktualny stan wiedzy i rozwój metod biologii molekularnej pozwala na badania mieszanin mikroorganizmów na poziomie kwasów nukleinowych i daje możliwość zaprezentowania ogromnej różnorodności form nitryfikatorów i innych grup bakteryjnych występujących w osadzie czynnym. Celem tego artykułu jest krótki opis współczesnych metod biologii molekularnej, użytecznych w badaniach nitryfikatorów w osadzie czynnym i pomocnych w monitoringu nitryfikacji. Artykuł ma również zwrócić uwagę na ścisłe powiązanie biologii i chemii w biochemicznych procesach zachodzących w środowisku.
Activated sludge is known to be one of the most effective and popular methods of wastewater treatment. A wide range of complex biochemical and chemical processes are performed in this biocenosis, which result in obtaining a highly purified product. Nitrification, the removal of inorganic nitrogen compounds, is a crucial wastewater treatment process. Knowledge and the development of molecular biology techniques help in research performed on complex mixtures of microorganisms at the level of their nucleic acids and reveal the vast diversity of nitrifiers and other bacterial groups. The aim of this article is to provide a brief description of modern molecular methods that are useful in research into the biodiversity of nitrifiers in activated sludge and the nitrification monitoring. It was also a goal of the article to underline that biology and chemistry are closely linked mainly in the case of the biochemical processes performed in the environment.
Źródło:
Chemik; 2011, 65, 3; 192-199
0009-2886
Pojawia się w:
Chemik
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 31

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