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Wyświetlanie 1-15 z 32
Tytuł:
MANGO GINGER SUPPLEMENTATION MAY PROTECT BONE DAMAGE INDUCED BY METHOTREXATE IN RATS
Autorzy:
Sahin, Kazim
Erten, Fusun
Tuzcu, Mehmet
Orhan, Cemal
Ozercan, Ibrahim H.
Balci, Tansel A.
Tuzcu, Zeynep
Juturu, Vijaya
Powiązania:
https://bibliotekanauki.pl/articles/895555.pdf
Data publikacji:
2019-04-30
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
methotrexate
bone mineral density
mango ginger
Opis:
Mango ginger (MG) has antiinflammatory and antioxidant properties. The objective of this study was to investigate the potential protective role of MG and the mechanisms against methotrexate (MTX) induced bone damage in rats. A total of 28 Sprague-Dawley rats were divided into four groups: i) control; ii) MG, rats were treated orally with 50 mg/kg/day of MG, iii) MTX, rats were injected with 0.75 mg/kg of MTX from 8th to 12th day for 5 days and iv) MTX+MG group, rats were treated with 50 mg/kg/day of MG and injected with MTX from 8th to 12th day for 5 days. MTX pretreatment increased blood urea nitrogen and creatinine levels and aminotransferase enzyme activities, while tibia osteocalcin levels and bone mineral density (BMD) decreased (p < 0.001). MG pretreatment markedly attenuated aminotransferases activities and creatinine levels and increased tibia osteocalcin levels and femur BMD in the MTX + MG groups. MTX treatment increased levels of bone nuclear factor kappa beta ligand receptor-activator (RANKL), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) and decreased the bone osteoprotegerin (OPG) and type1 collagen levels (p < 0.001). The effect of MG treatment on RANKL, IL-6, TNF-α, OPG and type1 collagen levels induced by MTX was observed actual effects (p < 0.05). Similarly, the protective effect of MG against MTX was confirmed by histological examination. In conclusion, MG pretreatment reduced the negative effects of MTX on bone damage by improving BMD and modulation of RANKL, IL-6, TNF-α, OPG and type1 collagen expressions in the rats.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 2; 305-312
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Association analysis of vitamin D receptor gene polymorphisms with bone mineral density in young women with Graves disease
Autorzy:
Horst-Sikorska, Wanda
Ignaszak-Szczepaniak, Magdalena
Marcinkowska, Michalina
Kaczmarek, Marta
Stajgis, Malgorzata
Slomski, Ryszard
Powiązania:
https://bibliotekanauki.pl/articles/1040758.pdf
Data publikacji:
2008
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Graves' disease
bone mineral density
VDR polymorphisms
Opis:
Graves' (GD) hyperthyroidism induces accelerated bone turnover that leads to decreased bone mineral density (BMD). The role of the VDR gene in predisposition to primary osteoporosis has been recognized. Recent studies show associations between the VDR gene polymorphisms and susceptibility to autoimmune diseases. Here we analyzed if VDR gene polymorphisms: BsmI, ApaI, TaqI, and FokI may predispose women with Graves' hyperthyroidism to BMD reduction or to disease development. The subjects were 75 premenopausal female Polish patients with GD and 163 healthy women. The genotyping was performed by the use of the restriction fragment length polymorphism analysis (RFLP). We studied the association of the VDR polymorphisms and their haplotypes with patients' BMD and also SNPs and haplotypes association with Graves' disease. We found a strong linkage disequilibrium for the BsmI, ApaI, and TaqI polymorphims that formed three most frequent haplotypes in Graves' women: baT (47.9%), BAt (34.9%), and bAT (16.4%). We did not show statistically significant association of analyzed VDR polymorphisms or haplotypes with decreased bone mineral density in Graves' patients. However, the presence of F allele had a weak tendency to be associated with Graves' disease (with OR=1.93; 95% CI: 0.97-3.84; p=0.058). In conclusion: VDR gene polymorphisms do not predict the risk of decreased BMD in Polish women with Graves'. It may be speculated that the F allele carriers of the VDR-FokI polymorphism are predisposed to Graves' disease development.
Źródło:
Acta Biochimica Polonica; 2008, 55, 2; 371-380
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of dietary calcium intake on quantitative and qualitative parameters of bone tissue in Polish adults
Autorzy:
Skowrońska-Jóźwiak, Elżbieta
Jaworski, Maciej
Lorenc, Roman
Lewiński, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/990986.pdf
Data publikacji:
2016
Wydawca:
Instytut Medycyny Wsi
Tematy:
calcium intake
bone mineral density
bone stiffness
Opis:
Introduction. The objective of the study was to assess dietary calcium intake in the Polish population and its influence on selected parameters of bone tissue. Materials and method. 1,129 osteoporosis treatment–naive subjects, aged 20–80 years, randomly selected, were involved in the study. Bone status was established using densitometry of spine and hip and quantitative ultrasound of the calcaneus. Dietary calcium intake was calculated according to data gathered in a questionnaire. Results. Median calcium intake was 746 mg; 72% of subjects had calcium intake below the recommended dose. Calcium intake correlated negatively with age (r = -0.15; p<0.001) and positively with BMD in the spine (r = 0.06; p<0.05) and in the femoral neck (r = 0.07; p < 0.05). In subjects with the lowest calcium intake, a significantly lower femoral neck BMD and heel stiffness was noticed than in subjects with the highest calcium intake. However, multiple regression analysis showed that dietary calcium was not a predictor of low BMD, both in the hip and spine, as well as of bone stiffness in contrast to age, low BMI and female gender (p<0.0001). In all factors regression analysis, a weak influence of calcium intake on BMD was shown only in the subgroup of premenopausal women (β = 0.1; p<0.05). Conclusions. In most subjects, dietary calcium intake was below the recommended dose; however, its influence on bone seems to be weak, except for persons with the greatest deficiency of dietary calcium and the subgroup of premenopausal women.
Źródło:
Annals of Agricultural and Environmental Medicine; 2016, 23, 3
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Relationships between bone mineral density and new indices of body composition in young, sedentary men and women
Autorzy:
Kęska, A.
Lutosławska, G.
Bertrandt, J.
Sobczak, M.
Powiązania:
https://bibliotekanauki.pl/articles/2081594.pdf
Data publikacji:
2018
Wydawca:
Instytut Medycyny Wsi
Tematy:
young adults
gender
bone mineral density
body composition
Opis:
Introduction. Data concerning the relationship between body fat and BMD are equivocal since both positive and negative effects have been noted. Recently, the index of fat mass (IFM) representing subjects with different body fat and similar lean mass and index of lean mass (ILM) representing subjects with different lean body mass and similar body fat, have been used to evaluate body composition effect on BMD in middle-aged women. This study aimed at determination of ILM and IFM association with BMD in young men and women. Materials and methods. A total of 212 university students of Public Health (125 women and 87 men) participated in the study. Body composition was determined by the bioelectrical impedance method (BIA) using BC 418 MA equipment (Tanita Co., Japan). Fat mass and fat free mass were used to calculate ILM and IFM. Bone mineral density was measured on the wrist of the non-dominant hand using the DEXA method and EXA 3000 equipment (HFS Ltd., Korea). BMD was evaluated using Z-score, with values lower than -2.0 indicating inadequate BMD for subject chronological age. Results. Exclusively in women, IFM was markedly and positively correlated with Z-score (r=0.366, P<0.001). In both genders, a significant relationship was found between ILM and Z-scores (r=0.420; p<0.001 and r=0.220; p<0.02 in men and women, respectively). Women with lower than median IFM but similar ILM, were characterized by significantly lower Z-scores vs. women with higher IFM (-1.016 vs. -0.512; p<0.001). Irrespective of gender, participants with higher ILM but similar IFM, were characterized by markedly higher Z-score vs. their counterparts with low ILM. Conclusions. The use of IFM and ILM in the present study, allowed the observation that in young adults lean body mass was associated with BMD, regardless of gender, while fat mass is significant for bone mineral density only in women.
Źródło:
Annals of Agricultural and Environmental Medicine; 2018, 25, 1; 23-25
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Association between estrogen receptor alpha gene polymorphisms and bone mineral density in Polish female patients with Graves disease
Autorzy:
Ignaszak-Szczepaniak, Magdalena
Horst-Sikorska, Wanda
Dytfeld, Joanna
Gowin, Ewelina
Słomski, Ryszard
Stajgis, Marek
Powiązania:
https://bibliotekanauki.pl/articles/1039960.pdf
Data publikacji:
2011
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Graves' disease
bone mineral density
ESR1 gene polymorphisms
premenopausal women
Opis:
Graves' (GD) hyperthyroidism leads to reduced bone mineral density (BMD) accompanied by accelerated bone turnover. Ample studies have identified association between estrogen receptor (ESR1) gene polymorphism and decreased BMD and osteoporosis. In contrast, number of publications that link ESR1, BMD and Graves' disease is limited. The purpose of this study was to identify the association between ESR1 polymorphisms and BMD in premenopausal women with GD and to determine whether ESR1 polymorphic variants can predispose to GD. The study included 75 women aged 23-46 years with GD and 163 healthy controls. BMD was measured at lumbar spine and femoral neck. We investigated two SNPs in the ESR1 gene and analyzed genetic variants in the form of haplotypes reconstructed by statistical method. Three out of four possible haplotypes of the PvuII and XbaI restriction fragment length polymorphisms were found in GD patients: px (55.3 %), PX (33.3 %) and Px (11.4 %). Women homozygous for xx of XbaI and for pp of PvuII had the lowest BMD at lumbar spine. Moreover, the px haplotype predisposed to reduced lumbar BMD. No associations were observed for femoral neck BMD. No statistically significant relationship were found between ESR1 polymorphisms or their haplotypes and GD. These results indicate that the PvuII and the XbaI polymorphisms of ESR1 gene are associated with bone mineral density in premenopausal women with GD and may help to estimate the risk of bone loss particularly at lumbar spine. However, none of the ESR1 gene alleles predict the risk of GD in Polish female patients.
Źródło:
Acta Biochimica Polonica; 2011, 58, 1; 101-109
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Bone mineral density and bone mineral content of the bilateral first phalanges of the thoracic limbs in horses
Autorzy:
Dzierzecka, M.
Charuta, A.
Powiązania:
https://bibliotekanauki.pl/articles/31956.pdf
Data publikacji:
2012
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
bone mineral density
bone mineral content
first phalanx
thoracic limb
horse
bone tissue
Opis:
The bone mineral density (BMD) and the bone mineral content (BMC) in the bone tissue of the bilateral first phalanges of horses’ thoracic limbs were analysed. The research material consisted of isolated pastern bones derived from 22 horses. The research was conducted with the use of a Norland model Excell Plus densitometer (Fort Atkinson WI, USA), using affinited beam X-ray technology and an animal research programme (Research Scan, 3.9.6. version) at the following parameters: scanning resolution of 1.5 x 1.5 mm, scanning speed 60 mm/s. The differences between BMC and BMD values in bilateral first phalanges in the thoracic limbs in horses were found to be nonsignificant. It also appeared that there are statistically significant positive correlations between values of the left and right bone of both analysed variables.
Źródło:
Polish Journal of Veterinary Sciences; 2012, 15, 1
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Degree of mineralisation of bones in children with idiopathic scoliosis. Do these children show a reduced bone mineral density?
Stopień mineralizacji kości dzieci ze skoliozą idiopatyczną. Czy występuje u nich obniżona gęstość mineralna kości?
Autorzy:
Deja, Agata
Nowacka-Pikuła, Danuta
Powiązania:
https://bibliotekanauki.pl/articles/1798804.pdf
Data publikacji:
2015
Wydawca:
Akademia Wychowania Fizycznego im. Bronisława Czecha w Krakowie
Tematy:
Scoliosis
bone mineral density
Osteoporosis
Densitometry
skolioza
gęstość mineralna kości
osteoporoza
densytometria
Opis:
Introduction: Idiopathic scoliosis constitutes a serious clinical problem due to the risk of progression, trunk deformation and possible respiratory disorders. The relation between the bone mineral density (BMD) and the risk of scoliosis developing in children is still unclear. However, confirmation of such a relation could result in both modifications of the current treatment and an earlier rehabilitation in children with decreased bone mineral density. Aim: The aim of the study was to assess the BMD in children with idiopathic scoliosis, in accordance with the guidelines of the International Society of Clinical Densitometry (ISCD). Materials and methods: a total of 57 children with idiopathic scoliosis aged 5.5 to 18.0 years took part in the study. Anteroposterior (AP) radiographs were taken to determine the Cobb angles. Also, the trunk axial rotation angles according to Bunnell were evaluated using Adam’s test with a scoliometer. The densitometric examinations of the L1-L4 spine were performed using a densitometer, based on Dual-energy X-ray absorptiometry (DEXA). Results: Among the 57 patients with scoliosis, a Z-score equal or below – 2.0 SD occurred in 5 of the examined children (9%). a statistically significant correlation between the BMD and the spine angle, and between the Z-score value and the spine angle, was not observed. Conclusions: Our study indicates that a decreased bone mineral density is not observed in the population of children with scoliosis. The densitometric examination of the children with scoliosis is difficult to interpret, due to their continuous skeletal grow and the great differences in bone size between individuals of the same age, as well as rotations of the analysed vertebrae, and the limited growth due to scoliosis.
Wstęp: Skolioza idiopatyczna jest trójpłaszczyznową deformacją kręgosłupa o nieznanej etiologii. Stanowi ona u dzieci poważny problem kliniczny z uwagi na możliwość jej progresji, deformacji tułowia oraz możliwych zaburzeń oddychania. Wciąż nie jest do końca jasny związek między mineralizacją kości a ryzykiem rozwoju skoliozy u dzieci. Potwierdzenie takiej korelacji mogłoby przyczynić się zarówno do zmiany dotychczasowego leczenia, jak również do wczesnej interwencji rehabilitacyjnej dzieci z obniżoną gęstością kości. Cel pracy: Celem pracy była ocena gęstości mineralnej kości u dzieci ze skoliozą idiopatyczną, zgodnie z wytycznymi Międzynarodowego Towarzystwa Densytometrii Klinicznej (ISCD). Materiał i metody: 57 dzieci ze skoliozą idiopatyczną w wieku od 5,5 do 18 lat. Kąt skoliozy wyznaczano na zdjęciu rtg kręgosłupa metodą Cobba. Kąt rotacji tułowia wg Bunnella oceniano w teście Adamsa za pomocą skoliometru. Badania densytometryczne kręgosłupa L1-L4 wykonano za pomocą densytometru, opartego o metodę absorpcjometrii promieniowania rentgenowskiego o podwójnej energii (DEXA). Wyniki: Spośród 57 pacjentów ze skoliozą Z-score równy lub poniżej – 2,0 SD występował u 5 badanych dzieci (9%). Nie zaobserwowano statystycznie istotnej korelacji między gęstością mineralną kości a skrzywieniem kręgosłupa, jak również między wartością Z-score a skrzywieniem kręgosłupa. Wnioski: Nasze badania wskazują, że u dzieci ze skoliozą nie obserwuje się obniżonej gęstości mineralnej kości. Badanie densytometryczne u dzieci ze skoliozą jest trudne do interpretacji, ponieważ obok czynników związanych z ciągłym procesem rośnięcia szkieletu i dużymi różnicami międzyosobniczymi w rozmiarze kości u dzieci w tym samym wieku, na wynik wpływają też czynniki związane ze skoliozą, tj. rotacja kręgu w miejscu pomiaru oraz deficyt wzrostu związany ze skrzywieniem kręgosłupa.
Źródło:
Medical Rehabilitation; 2015, 19(2); 5-9
1427-9622
1896-3250
Pojawia się w:
Medical Rehabilitation
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Relationship between body composition and bone mineral density in American football players
Relación entre composición corporal y densidad mineral ósea en jugadores de fútbol americano
Autorzy:
López García, Ricardo
Lagunes Carrasco, José Omar
Carranza García, Luis Enrique
Navarro Orocio, Ricardo
Powiązania:
https://bibliotekanauki.pl/articles/1491262.pdf
Data publikacji:
2020-12-27
Wydawca:
Atena Research Association
Tematy:
Fútbol americano
mineral óseo
masa magra
DEXA
IMC.
American football
bone mineral density
lean mass
BMI
Opis:
Objetivos: El objetivo de este estudio fue relacionar el índice de masa corporal (IMC) y la composición corporal con la densidad mineral ósea (DMO) en jugadores de fútbol americano universitario. Métodos: Participaron un total de 90 jugadores (22.44 + 1.71 años de edad), de la liga mayor de fútbol americano universitario en México. Se utilizó el equipo de la absorciometría dual de rayos X (DEXA), en la cual se obtuvieron los valores del IMC, masa grasa, masa magra, masa total y la DMO. Resultados: Los jugadores que presentaron un mayor IMC obtuvieron una mayor DMO. Conclusiones: si observamos que la mayoría de los jugadores suelen tener problemas de sobrepeso y obesidad, encontramos que la masa grasa no se asocia con la DMO, es decir, que el jugador a pesar de tener un peso corporal elevado, su beneficio de la elevada DMO se debe a la alta cantidad de masa magra.
Objectives: The objective of this study was to assess the relation between body composition and body mass index (BMI) to bone mineral density (BMD) in college American football players. Methods: A total of 90 players (22.44 + 1.71 years old) from the major college football league in Mexico participated. The dual-energy X-ray absorptiometry (DEXA) equipment was used, in which the values of BMI, fat mass, lean mass, total mass and BMD were obtained. Findings: Players who had higher BMI got higher BMD. The strongest significant positive correlations found were lean mass, body weight, and BMI with BMD of the arms, legs, trunk, and spine. Conclusions: Most of the players analyzed had problems of excess weight and obesity, however, those who had a higher BMI such as obesity type I, II and III had also higher BMD than those with excess weight and normal weight, with significant differences in the regions of arms, legs, spine and total body.
Źródło:
Atena Journal of Sports Sciences; 2021, 3; 2-2
2695-4486
Pojawia się w:
Atena Journal of Sports Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The peripheral quantitative computed tomographic and densitometric analysis of skeletal tissue in male Wistar rats after chromium sulfate treatment
Autorzy:
Bieńko, Marek
Radzki, Radosław Piotr
Wolski, Dariusz
Powiązania:
https://bibliotekanauki.pl/articles/991127.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
rat
chromium sulfate
bone
densitometry
peripheral quantitative computed tomography
bone mineral density and content
Opis:
Introduction. This study evaluates the effects of three different doses of chromium sulphate on bone density and the tomographic parameters of skeletal tissue of rats. Materials and method. The experiment was performed on 40 male Wistar rats which received, by gavage, during 90 days, a chromium sulphate in either a daily dose of 400, 600 or 800 μg/kg BW. At the end of experiment, the rats were scanned using the densitometry method (DXA) to determine the bone mineral density, bone mineral content of total skeleton and vertebral column (L2-L4) and parameters of body composition (Lean Mass and Fat Mass). The isolated femora were scanned using peripheral a quantitative computed tomography method (pQCT) for a separate analysis of the trabecular and cortical bone tissue. The ultimate strength, work to ultimate and the Young modulus of femora was also investigated by the threepoint bending test. Results. The negative impact of chromium was observed in relation to bone tissue. All doses significantly decreased total skeleton density and mineral content, and also had impact upon the isolated femora and vertebral column. Trabecular volumetric bone mineral density and trabecular bone mineral content measured by pQCT in distal femur metaphysis were significantly lower in the experimental groups than in the control. Higher doses of chromium also significantly decreased values of ultimate strength and Young modulus in the investigated femora. Conclusions. The results of the experiment demonstrate that chromium sulphate is dose dependent, and exerts a disadvantageous effect on the skeleton, as it decreases bone density and resistance.
Źródło:
Annals of Agricultural and Environmental Medicine; 2017, 24, 3
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Relationship between the mineral content of human trabecular bone and selected parameters determined from fatigue test at stepwise-increasing amplitude
Autorzy:
Mazurkiewicz, A. J.
Topoliński, T.
Powiązania:
https://bibliotekanauki.pl/articles/306367.pdf
Data publikacji:
2017
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
gęstość mineralna kości
kość beleczkowa
test wytrzymałości
bone mineral density
trabecular bone
fatigue test
stepwise load
ash density
Opis:
Purpose: The study aimed to investigate a relationship between the mineral content of the human trabecular bone and parameters determined from compression fatigue tests at stepwiseincreasing amplitude. Methods: Mineral content of the trabecular bone was estimated as ash density and bone mineral density values. The relationship between the ash density, bone mineral density and factors obtained from fatigue test: fatigue life, cumulative elastic energy and cumulative energy of dissipation was determined. Results: The results from the measurements of ash density and bone mineral density show good correlation with the fatigue test results. The relationship was estimated based on the correlation coefficient R within 0.74-0.79 for the particular pairs of factors. Conclusions: The study shows that the ash density and the bone mineral density are good predictors to estimate the fatigue life of trabecular bone. The study also validates the applicability of the tests at stepwise-increasing amplitude in determining the mechanical properties of trabecular bone.
Źródło:
Acta of Bioengineering and Biomechanics; 2017, 19, 3; 19-26
1509-409X
2450-6303
Pojawia się w:
Acta of Bioengineering and Biomechanics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Heavy-mineral analysis in Polish investigations of Quaternary deposits: a review
Autorzy:
Marcinkowski, Bogusław
Mycielska-Dowgiałło, Elżbieta
Powiązania:
https://bibliotekanauki.pl/articles/94664.pdf
Data publikacji:
2013
Wydawca:
Uniwersytet im. Adama Mickiewicza w Poznaniu
Tematy:
heavy mineral analysis
heavy mineral resistance
heavy mineral habit
heavy mineral density
Polska
analiza ciężkich minerałów
odporność ciężkich minerałów
gęstość mineralna
Polska
Opis:
The composition of heavy-mineral assemblages is one of the main textural features of sediments because they can have significant value for the interpretation of, among others, their depositional environment, their depositional processes, and their stratigraphic position. Distinctive features of heavy minerals include their resistance to chemical weathering and mechanical abrasion, their habit, and their density. These parameters are the most widely used in the heavy-mineral research of Quaternary deposits in Poland, as well as in such research in other countries conducted by Polish scientists. Several other heavy-mineral parameters can also be used in various types of interpretation. It is discussed whether heavy-mineral analysis is decisive in the evaluation of deposits or whether it plays mainly a role that may support evidence obtained by other types of analysis. The attention is mainly devoted to transparent heavy minerals; the significance of opaque heavy minerals for interpretational purposes is only mentioned.
Źródło:
Geologos; 2013, 19, No. 1-2; 5-23
1426-8981
2080-6574
Pojawia się w:
Geologos
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Thyroid hormone and thyreotropin (TSH) association with densitometric parameters in children
Autorzy:
Porwik, E.
Matusik, P.
Drzyzdzyk, K.
Powiązania:
https://bibliotekanauki.pl/articles/333097.pdf
Data publikacji:
2009
Wydawca:
Uniwersytet Śląski. Wydział Informatyki i Nauki o Materiałach. Instytut Informatyki. Zakład Systemów Komputerowych
Tematy:
tyreotropina
hormon tarczycy
densytometria
gęstość mineralna kości
dzieci
thyrotropin
thyroid hormone
densitometry
bone mineral density
children
Opis:
The influence of TSH on bones is still vastly unknown and the information that is known is considered controversial. This important relationship has not been studied in detail. The aim of our research was to assess the correlation between TSH, thyroid hormone and bone mineral density in children measured by DXA scanning. Our study group included 36 children (16 girls and 20 boys) mean age 12.9 š 3.3 years. Basic anthropometrical measurements were performed (height, weight, body mass index-BMI), in all subjects. Blood was collected and measured for TSH and FT4. Bone mineral density of lumbar spine (L2-L4 BMD) and total body (Total Body BMD) were measured by DXA and expressed as bone mineral content (BMC [g]) and bone mineral density (BMD [g/cm2]). BMD Z-Score was also calculated. Correlation between the parameters obtained by DXA and anthropometrical data, TSH and thyroid hormone concentration were calculated. A statistically significant positive correlation was observed between height, weight and BMI and BMD which was calculated. Weight and BMI also had a statically significant correlation with Z-Score and total bone mineral content (BMC – expressed in grams). There was a statistically significant positive correlation between TSH level and Z-Score for both L2-L4 lumbar spine and for total body. TSH did not correlate significantly with BMD [g/cm2] and BMC [g]. FT4 was negatively and significantly correlated with Z-Score for both L2-L4 lumbar spine and for total body. There was also no significant correlation between FT4 and BMD [g/cm2] and BMC [g]. Conclusion: 1. Thyroid stimulating-hormone (TSH) appears to be associated with maintenance of bone mineral density in children. 2. BMD Z-Score especially from L2-L4 lumbar spine assessed by DXA scanning is correlated best with hormonal and biochemical factors potentially influencing bone mineralization in children.
Źródło:
Journal of Medical Informatics & Technologies; 2009, 13; 141-144
1642-6037
Pojawia się w:
Journal of Medical Informatics & Technologies
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Osteoimmunologia, czyli o wzajemnych oddziaływaniach komórek układów kostnego i odpornościowego
Osteoimmunology - interactions of the immune cells and bone tissue
Autorzy:
Majewski, Paweł
Powiązania:
https://bibliotekanauki.pl/articles/1034013.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Przyrodników im. Kopernika
Tematy:
bone metabolism
bone mineral density
osteoimmunology
PHEX
phosphatonins
fosfatoniny
gęstość mineralna kości
metabolizm tkanki kostnej
osteoimmunologia
Opis:
Wzajemne oddziaływania pomiędzy komórkami układu odpornościowego, a komórkami tkanki kostnej są opisywane od ponad 40 lat. Pomimo upływu czasu, w polskiej literaturze, stosunkowo rzadko się o nich wspomina, a termin osteoimmunologia będący określeniem interdyscyplinarnej nauki zajmującej się tymi oddziaływaniami, praktycznie nie jest używany. Celem niniejszego artykułu jest próba przybliżenia tej dziedziny wiedzy, opisania nowości w spojrzeniu na regulację metabolizmu tkanki kostnej oraz zwrócenia uwagi na szerszy kontekst regulacyjny, związany z istnieniem osi nerki - kości - jelito. Homeostaza zarówno poziomu składników mineralnych osocza krwi, jak i gęstości mineralnej kości zostaje zachowana na skutek dynamicznych zmian aktywności komórek kościotwórczych osteoblastów, komórek kościogubnych osteoklastów oraz osteocytów, będących jedną z końcowych form dojrzewających osteoblastów, aktywnie regulujących te procesy. Równowaga pomiędzy aktywnością wszystkich typów komórek jest regulowana między innymi przez hormony i cytokiny oraz przez bezpośredni kontakt z komórkami odpornościowymi. Czynniki te wpływają na poziom uwalniania i odkładania substancji mineralnych, odpowiednio przez osteoklasty i osteoblasty.
Interactions between cells of the immune system and cells of bone tissue are reported for over 40 years. Despite the passage of time, relatively little about them is mentioned in Polish literature and the term osteoimmunology is practically not used. The purpose of this article is an attempt to outline shortly current knowledge in this field, with particular attention paid to regulation of bone tissue metabolism linked to the existence of the kidney-bone-gut axis.. Homeostasis of both the level of minerals in the blood plasma and the mineral density of the bone is maintained as a result of dynamic changes in the activity of osteoblasts, osteoklasts and osteocytes, being one of the final forms of maturing osteoblasts, actively regulating these processes. The balance between the activities of these cells is regulated by, inter alia, hormones and cytokines as well as direct contact with immune cells. These factors affect the level of mineral release and deposition by osteoclasts and osteoblasts, respectively.
Źródło:
Kosmos; 2017, 66, 4; 665-675
0023-4249
Pojawia się w:
Kosmos
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Differences in trabecular bone mechanical strength measured by the x-ray microcomputed tomography and compressive test
Autorzy:
Binkowski, M.
John, A.
Nowak, R.
Bożek, M.
Bielecki, M.
Powiązania:
https://bibliotekanauki.pl/articles/333606.pdf
Data publikacji:
2010
Wydawca:
Uniwersytet Śląski. Wydział Informatyki i Nauki o Materiałach. Instytut Informatyki. Zakład Systemów Komputerowych
Tematy:
rentgenowska tomografia komputerowa
gęstość mineralna kości
wytrzymałość mechaniczna
x-ray microcomputed tomography
bone mineral density
mechanical strength
Opis:
The article describes the concept of measurement of the mechanical strength of trabecular bone dissected from human femoral head. When the studies are performed based on the human trabecular bone, there is a risk that correlation can be not achieved due to high discrepancy in the distribution of the bone density and mechanical properties. The compressive tests and X-ray microcomputed tomography with associated density phantom were used to deliver quantitative data. There is a conclusion that the selection of the region in the femoral head has to be performed very carefully. The region where cylinder is dissected can influence the results and produce fake data, which could not be correlated in the density of bone.
Źródło:
Journal of Medical Informatics & Technologies; 2010, 15; 163-168
1642-6037
Pojawia się w:
Journal of Medical Informatics & Technologies
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Computed tomographic and densitometric analysis of tibiotarsal bone mineral density and content in postnatal Peking ducks (Anas platyrhynchos var. domestica) as influenced by age and sex
Autorzy:
Charuta, A.
Cooper, R.G.
Powiązania:
https://bibliotekanauki.pl/articles/31058.pdf
Data publikacji:
2012
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
computer tomography
densitometric analysis
tibio-tarsal bone
mineral density
bone density
volumetric density
postnatal period
Pekin duck
Anas platyrhynchos f.domestica
age
sex
Opis:
The bone mineral density BMD and content BMC were analysed in the tibiotarsal bones of ducks in the postnatal development as influenced by age and sex. One hundred birds from the nesting till the slaughtering maturity were included in the experiment. The analysis was conducted using a densitometer, Norland - Excell Plus and pQCT computed tomography, XCT Research SA Plus. The statistical analysis was conducted using the Kruskal-Wallis one-way analysis of variance (age) and the U-Mann -Withney test (sex). All calculations were performed in Statistica 9.0 (StatSoft, Inc. Tulsa, USA), at P ≤ 0.05. Two-factor analysis of variance ANOVA was applied and Pearson’s correlation coefficients were calculated. The densitometer research showed that BMD and BMC increased in the postnatal development for both sexes. The volumetric bone mineral density vBMD analysis using computed tomography showed that volumetric bone mineral density vBMD of the middle of the diaphyses in situ gradually attenuated during the postnatal development both in males and females, i.e. from 620 mg/cm3 (2 wk) to 500 mg/cm3 (8 wk). The biggest vBMD loss was observed in the diaphyses of females in 4 and 6 wk (r = - 0.63 and r = - 0.79; P ≥ 0.05). The BMC decrease was observed in the proximal metaphyses between 4 and 6 wk for both sexes, r = - 0.52 (males), r = - 0.53 (females); P ≤ 0.05. The gradual loss may be the cause of deformities and fractures of the tibiotarsal bones observed from 4 wk in particular bone sections of both sexes. The achieved results may constitute a helpful source of information for water poultry breeders to prevent limb diseases.
Źródło:
Polish Journal of Veterinary Sciences; 2012, 15, 3
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 32

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