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Tytuł:
Human microbiome diversity: implications in health, disease, and applications
Autorzy:
Mboto, C. I.
Edet, U. O.
Mbim, E. N.
Zenoh, D. A.
Umego, C. F.
Odidi, F. S.
Tarh, J.
Upula, S. A.
Powiązania:
https://bibliotekanauki.pl/articles/1109197.pdf
Data publikacji:
2018
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Human microbiome
applications of microbiome
gut
health and disease
Opis:
The human microbiome is a complex collection of microorganisms, including their genes and the metabolites colonizing the human body, and playing various functions in health and disease. The arrival of culture-independent molecular techniques such as metagenomics, transcriptomics, proteomics, and metabolomics have removed the limitations imposed by culture-dependent techniques. These advanced techniques have also brought about some paradigm shifts in what is known about the structural and functional diversities of the human microbiome in health and disease. The dynamics of the human microbiome is implicated in a number of human gastrointestinal and non-gastrointestinal diseases. This makes it a contemporary issue in biological and medical sciences. Of interest, some applications have already emerged for the human microbiome. These include being the source of antimicrobial substances, faecal microbiome therapy, probiotics, prebiotics and phage therapy. Given that a number of factors can alter the host microbiome - such as environment, lifestyle, stage of life, occupation, mode of delivery, therapy and so on, there is a need for more human microbiome projects that will help to capture these diversities in various continents. Furthermore, for the full impact of the various applications (both potentials and current) of human microbiome to be felt, there is need for more studies that will fully elucidate their physiology in humans.
Źródło:
World News of Natural Sciences; 2018, 21; 98-117
2543-5426
Pojawia się w:
World News of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparison of the effects of two commercially available prescription diet regimens on the fecal microbiomes of client-owned healthy pet dogs
Autorzy:
Onozawa, E.
Goto, A.
Oda, H.
Seki, S.
Sako, T.
Mori, A.
Powiązania:
https://bibliotekanauki.pl/articles/16539090.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
diet
dog
feces
microbiome
Opis:
In the present study, we used next-generation sequencing to investigate the impacts of two commercially available prescription diet regimens on the fecal microbiomes of eleven client-owned healthy pet dogs. We tested an anallergenic diet on 6 dogs and a low-fat diet on 5 dogs. Before starting the study, each dog was fed a different commercial diet over 5 weeks. After collecting pre-diet fecal samples, the anallergenic or low-fat diet was administered for 5 weeks. We then collected fecal samples and compared the pre- and post-diet fecal microbiomes. In the dogs on the anallergenic diet, we found significantly decreased proportions of Bacteroides, Ruminococcaceae, and Fusobacteriaceae, belonging to the phyla Bacteroidetes, Firmicutes, and Fusobacteria, respectively. The proportion of the genus Streptococcus belonging to the phylum Firmicutes was significantly increased upon administering the anallergenic diet. In the dogs on the low-fat diet, although the phyla Actinobacteria and Bacteroidetes tended to increase (p=0.116) and decrease (p=0.147) relative to the pre-diet levels, respectively, there were no significant differences in the proportions of any phylum between the pre- and post-diet fecal microbiomes. The anallergenic diet induced a significantly lower diversity index value than that found in the pre-diet period. Principal coordinate analysis based on unweighted UniFrac distance matrices revealed separation between the pre- and post-diet microbiomes in the dogs on the anallergenic diet. These results suggest that, even in pet dogs kept indoors in different living environments, unification of the diet induces apparent changes in the fecal microbiome.
Źródło:
Polish Journal of Veterinary Sciences; 2022, 25, 1; 93-101
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Current infectious threats associated with the development of civilization and progress in medicine - methods of prevention and education
Autorzy:
Kozioł-Montewska, M.
Pańczuk, A.
Tokarska-Rodak, M.
Paluch-Oleś, J.
Gładysz, I.
Sikora, A.
Filipek-Czerska, A.
Kawka, E.
Pawłowicz, E.
Kosińska, B.
Montewka, M.
Skrzek, A.
Kozioł, M.
Gozd-Barszczewska, A.
Barszczewski, P.
Spisacka, S.
Powiązania:
https://bibliotekanauki.pl/articles/2052218.pdf
Data publikacji:
2014
Wydawca:
Akademia Bialska Nauk Stosowanych im. Jana Pawła II w Białej Podlaskiej
Tematy:
Lyme disease
legionellosis
tuberculosis
microbiome
antibiotic resistance
Opis:
The development of civilization, economic growth, urbanization, industrialization and progress in medicine bring to the society an improvement in the quality of life, but at the same time caused changes in lifestyle, environmental conditions, and changes in the natural environment. All of these led to develop civilization diseases which have critical impact and the adverse effect on our health, about what we not always realize. In the past fifty years, about 30 new pathogens appeared causing diseases such as legionellosis, Lyme disease, and increase unexpectedly tuberculosis incidence which in some regions is associated with HIV infections. Also widespread use of antibiotics caused and still causing bacterial resistance increase to most of them. With the development of medicine and surgery, parallel effects of surgical areas and infections associated with implanted cardiac devices in the majority of the life-saving ones appeared. The development of research techniques allowed for the finding of new relationships between ecosystems in the microbiome of the gastrointestinal tract with of obesity in the society. The presence of new health aspects of civilization diseases impose pressure to create new prevention methods and public education.
Źródło:
Health Problems of Civilization; 2014, 08, 1; 6-14
2353-6942
2354-0265
Pojawia się w:
Health Problems of Civilization
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Microbiome impact on metabolism and function of sex, thyroid, growth and parathyroid hormones
Autorzy:
Kunc, Michał
Gabrych, Anna
Witkowski, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/1038795.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
microbiome
lipopolysaccharide
estrogens
thyroid hormones
growth hormone
Opis:
Commensal bacteria and their genes associated with host are known as microbiome. In recent years, microbial influence on host endocrine system has been under detailed investigation. The role of microbiome in the pathogenesis of insulin resistance and obesity, the function of hypothalamic-pituitary-adrenal axis and secretion of hormones regulating appetite is well described in world literature. In this article we discuss poorly reviewed issues: the microbiome role in modulation of non-peptide (sex and thyroid) and peptide (growth hormone and parathyroid hormone) functions. Understanding complex bidirectional relations between host endocrine system and bacteria is of fundamental importance to understanding microbial impact on host reproduction, risk of endocrine-related cancers, pathogenesis of non-thyroidal illness syndrome, growth failure in children and hormonal changes during chronic kidney disease. This article also highlights effects of dietary compounds on microbiome composition and bacterial enzymes activity, and thus host hormonal status.
Źródło:
Acta Biochimica Polonica; 2016, 63, 2; 189-201
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effects of Different Biostimulants on Seed Germination of Sorghum Plants
Autorzy:
Kalymbetov, Gani Yeskermesovich
Kedelbayev, Bakhytzhan Shilmyrzaevich
Yelemanova, Zhanar Rakhmanberdievna
Sapargaliyeva, Bayan
Powiązania:
https://bibliotekanauki.pl/articles/24201793.pdf
Data publikacji:
2023
Wydawca:
Polskie Towarzystwo Inżynierii Ekologicznej
Tematy:
sorghum
microbiome
nitrogen bacteria
biostimulator
incrustation
germination energy
Opis:
By creating highly productive phytobiomes, selection of new types of biostimulants on the basis of organic substances and microorganism has a decisive role. It could be done by taking into account natural and climatic peculiarities of the region. The article described the importance of sugar sorghum and substantiates the introduction of an adaptive variety to increase the productivity of fodder sorghum and the best option of using growth biostimulants. The results of evaluating the effectiveness of growth biostimulants under laboratory conditions on the main nutritional valuable traits were presented. The treatment of optimal parameters of sugar sorghum seeds with biostimulants in the Research laboratory "Industrial biotechnology" of M. Auezov South Kazakhstan University was determined. It was shown that the "Azotofertil" biostimulator has a high efficiency in pre-sowing seed treatment. For comparative evaluation of potentialities of new biostimulant, MERS biostimulant adapted to climatic conditions was chosen. According to research results, both biostimulants showed high efficiency for seed pre-sowing treatment. The best concentration for treatment of planting material was established. Energy of germination, swelling and the number of germination of seeds of sugar sorghum variety Kazakhstan-16 were determined. In evaluating the activity of biostimulants for efficiency, the dynamics of their friendly germination was traced. At 4% concentration and temperature above 14 °C, the advantage of "Azotofertil" biostimulator based on Azotobacter chroococcum strain was proven. Seeds of sugar sorghum variety Kazakhstan-16 showed the best results with 96 ± 3% germination.
Źródło:
Journal of Ecological Engineering; 2023, 24, 3; 134--142
2299-8993
Pojawia się w:
Journal of Ecological Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Gut microbiome as a biomarker of cardiometabolic disorders
Autorzy:
Gózd-Barszczewska, Anna
Kozioł-Montewka, Maria
Barszczewski, Piotr
Młodzińska, Agata
Humińska, Kinga
Powiązania:
https://bibliotekanauki.pl/articles/991115.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
gut microbiota
atherosclerosis
lipid disorders
microbiome
cardiovascular diseases
Opis:
Introduction and objective. Cardiovascular diseases are the leading cause of death in Europe and worldwide. One of the most important risk factors for atherosclerosis are lipid metabolism disorders, in particular hipercholesterolaemia. The aim of the study was to determine the correlation between gut microbiota composition and atherosclerosis risk factors, so in order that it might be used as a biomarker for coronary artery disease diagnosis. Material and method. The study involved middle-aged men in eastern Poland with central obesity (n=20), subjects with atherosclerosis (n=15) and those with no cardiovascular diseases (n=5). The gut microbiota composition was determined using tag-encoded 16S rRNA gene using Illuminal MiSeq. Data were analyzed with the use of t-test. Results. Firmicutes (49.26%) and Bacteroidetes (44.46%) were the dominant Phyla in the middle-aged men in eastern Poland. Subjects with improper levels of total cholesterol were enriched in Prevotella (p=0.03) and decreased level of Clostridium (p=0.02). They also showed a falling tendency in Faecalibacterium (p=0.07). An upward trend was observed in Prevotella (p=0.07) in subjects with improper LDL-C values. Conclusions. The study showed that intestinal microbiome is likely to play a role in the pathogenesis of atherosclerosis through its role in lipid metabolism. Bacterial genera of particular importance were Prevotella, Bacteroides, Clostridium, Faecalibacterium. However, further studies involving larger groups of subjects are required to confirm these observations.
Źródło:
Annals of Agricultural and Environmental Medicine; 2017, 24, 3
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Multiple sclerosis – new therapeutic directions
Autorzy:
Łowiec, Paweł
Trzonkowski, Piotr
Chwojnicki, Kamil
Powiązania:
https://bibliotekanauki.pl/articles/895817.pdf
Data publikacji:
2019-06-04
Wydawca:
Gdański Uniwersytet Medyczny
Tematy:
multiple sclerosis
neuroprotection
novel therapies
remyelination
gut microbiome
Opis:
Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease which affects the central nervous system. Currently, there are numerous disease-modifying therapies for this condition. Most of them address the inflammatory aspects of the disease and are most effective in the relapsing-remitting stages of multiple sclerosis. However, none of them can completely stop the progression of MS and they are usually associated with adverse effects. There is an ongoing search for novel approaches that involve different modes of action. Here, we discuss examples of new immunomodulating agents such as antigen-specific therapies, neuroprotectants, regenerative strategies and gut microbiota modification.
Źródło:
European Journal of Translational and Clinical Medicine; 2019, 2, 1; 7-22
2657-3148
2657-3156
Pojawia się w:
European Journal of Translational and Clinical Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Salivary microbial diversity – an investigation on possible biomarkers for polycystic ovarian syndrome from eastern India
Autorzy:
Ghosh, Kusum
Chakraborty, Shreyoshi
Chatterjee, Diptendu
Ratan Bandyopadhyay, Arup
Powiązania:
https://bibliotekanauki.pl/articles/29520460.pdf
Data publikacji:
2023-12-31
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
diagnostic biomarker
PCOS
reproductive health
salivary microbiome
well-being
Opis:
Introduction and aim. Polycystic ovarian syndrome (PCOS) is one of the major reproductive health issues, thought to be multifactorial, needs serious attention as a dual burden (health and economic) mainly for developing countries like India, due to its rapid rise (30%) in the last couple of years. Therefore, widespread and liberal screening for this disorder towards prognosis, diagnosis and intervention seems to be an urgent area of research. In this background, the present study attempts to unravel the association of salivary microbial diversity and PCOS. Material and methods. To achieve the purpose 100 clinically diagnosed PCOS individuals and 110 age matched non-PCOS participants from Bengalee Hindu caste population, West Bengal, India was considered. Obtained salivary samples were identified with 16S rDNA amplification and microbial diversity were determined by Alu I restriction enzyme digestion. Results. The present study revealed an explicit pattern of DNA fragment lengths varied between 200 bp and 225 bp in PCOs in comparison to the non-PCOS group. Conclusion. The cardinal feature of the present study as the first attempt from India envisaged, utilization of salivary microbial diversity as an additional potential and economizing biomarker for PCOS that stimulate new horizon of research in 21st century’s anthropology – the anthropology of microbes.
Źródło:
European Journal of Clinical and Experimental Medicine; 2023, 4; 736-741
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Modulation of Caecal Microbiome in Obese Mice Associated with Administration of Amaranth or Soybean Protein Isolates
Autorzy:
Olguín-Calderón, Diana
González-Escobar, Jorge L.
Ríos-Villa, Rosalva
Dibildox-Alvarado, Elena
De León-Rodríguez, Antonio
Barba de la Rosa, Ana P.
Powiązania:
https://bibliotekanauki.pl/articles/1369552.pdf
Data publikacji:
2019
Wydawca:
Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk w Olsztynie
Tematy:
amaranth
caecal microbiome
obesity
protein intake
short-chain fatty acids
Opis:
Obesity is defined as abnormal or excessive body fat accumulation that may have negative effects on health. Healthy diet induces a balance of gut microbiota, helping in turn to combat this metabolic disorder. Amaranth is well known because of its beneficial properties on health, but its effects on microbiota profile are still unknown. The aim of this study was to analyse the changes of gut microbiota in diet-induced obese mice due to amaranth protein consumption and to compare them with the changes due to soybean protein intake. Male C57BL/6 mice were fed for 8 weeks with regular (RD) or high-fat (HF) diet, without or with complementation with amaranth or soybean protein isolates. Morphological changes in caecum ultrathin sections were measured after hematoxylin/eosin staining. Microbiota was isolated from the caecum and 16S rRNA gene was sequenced. Caecal Short Chain Fatty Acids (SCFAs) were quantified by gas chromatography. The consumption of soybean protein induced the ectopic deposition of fat in the whole intestine while amaranth proteins increased caecal crypt depth and calceiform cells number sustaining its beneficial effect on health. The count of Ruminococcacea family bacteria was increased in mice fed with HF diet, but amaranth proteins intake reduced its abundance. In turn, Lachnospiraceae bacteria abundance decreased in mice fed the Control-HF and amaranth HF diets, but increased in mice fed the soybean diets. In mice fed the RD diets, amaranth induced the abundance of Prevotellaceae, an acetate-producing bacteria. Study results indicate that the modulation of caecal microbiota could be one of the mechanisms by which amaranth exerts its beneficial effects on health.
Źródło:
Polish Journal of Food and Nutrition Sciences; 2019, 69, 1; 35-44
1230-0322
2083-6007
Pojawia się w:
Polish Journal of Food and Nutrition Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Przesłanki wykorzystywania probiotykoterapii celowanej w praktyce klinicznej
Autorzy:
Skowrońska, Agnieszka
Majkowska, Anna
Sosnowska-Turek, Ewelina
Dzioba, Marcin
Sitkiewicz, Dariusz
Sygitowicz, Grażyna
Powiązania:
https://bibliotekanauki.pl/articles/18105174.pdf
Data publikacji:
2023-11-05
Wydawca:
Wydawnictwo Naukowe Medyk sp. z o.o.
Tematy:
mikrobiom jelitowy
legislacja
krioprotekcja
formulacja
gut microbiome
legislation
cryoprotection
formulation
Opis:
The concept of using probiotics in medicine was first mentioned over 500 years ago in China. However, it wasn't until a few decades ago that we witnessed a flourishing of knowledge on this topic. A groundbreaking event in the world of science that paved the way for medical applications of probiotics was the Human Microbiome Project, which took place from 2008 to 2013. These studies changed the paradigm of how we perceive the human body, shifting it towards a superorganism composed of the mammalian body and the microbiota residing within and on it. The probiotics market has grown rapidly, both in the realm of food and dietary supplements aimed at improving the well-being of healthy individuals and in the field of dietary approach in diseases management. The development of the market has been accompanied by attempts to regulate it, with the basis for regulation being the definition of probiotics adopted by the WHO in 2001. This definition created an "class effect " and led probiotics to be treated as a homogeneous group, ignoring the impact of the specific characteristics of individual products, dosages, timing of administration, strain composition, manufacturing methods, and formulations on the benefits of their use.
Koncepcja wykorzystania probiotyków w lecznictwie po raz pierwszy została wzmiankowana ponad 500 lat temu w Chinach. Jednak dopiero od kilku dekad jesteśmy świadkami rozkwitu wiedzy na ten temat. Przełomowym wydarzeniem w świecie nauki, który otworzył probiotykom drogę do zastosowań medycznych, był trwający w latach 2008–2013 Human Microbiome Project. Badania te zmieniły paradygmat postrzegania ludzkiego organizmu w kierunku superorganizmu złożonego z ciała ssaka i zamieszkującej je mikrobioty. Rynek probiotyków rozwinął się dynamicznie zarówno w obszarze żywności i suplementów diety przeznaczonych dla poprawy dobrostanu ludzi zdrowych, jak i w obszarze preparatów do postępowania dietetycznego w chorobie. Rozwojowi rynku towarzyszą próby jego uregulowania, których podstawą stała się definicja probiotyków przyjęta w 2001 r. przez WHO. Definicja ta stworzyła „efekt klasy” i spowodowała, iż probiotyki zaczęto traktować jako jednorodną grupę, ignorując wpływ specyfiki poszczególnych produktów, dawek, czasu przyjmowania, składu szczepowego, metod wytwarzania i formulacji na osiągane korzyści podawania.
Źródło:
Lek w Polsce; 2023, 389, 10; 7-11
2353-8597
Pojawia się w:
Lek w Polsce
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Zoonotic bacteria in the vicinity of animal farms as a factor disturbing the human microbiome: a review
Autorzy:
Kozajda, Anna
Miśkiewicz, Emilia
Jeżak, Karolina
Powiązania:
https://bibliotekanauki.pl/articles/31341039.pdf
Data publikacji:
2024-05-20
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
environmental exposure
microbiome
livestock
antibiotic resistance microorganisms
ARG
farm vicinity
Opis:
This review is aimed at summarizing the current state of knowledge about the relationship between environmental exposure to the bioaerosol emitted by intensive livestock farming and changes in the microbiome of people living in livestock farm vicinity. The PubMed, Scopus and Web of Science databases were searched by crossing keywords from the following 3 groups: a) “livestock,” “animal farms,” “animal breeding”; b) “microbiome,” “resistome”; c) “livestock vicinity,” “farm vicinity,” “neighborhoods and health” in 2010–2022. Literature screening did not reveal any paper related to the full microbiome composition in the population studied. In the study, the authors included 7 papers (5 from the Netherlands, 1 from the USA, and 1 from China). The studies confirmed the carriage of Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA), livestock-associated MRSA (LA-MRSA MC398) and multidrug-resistant S. aureus (MDRSA) in the nasal microbiome of adults and children living within 500–2000 m from a livestock farm. Clostridium difficile, including LA-ribotype RT078 carriage, was detected in the intestinal microbiome of adults living within 500–1000 m. Extended-spectrum β-lactamase (ESBL) producing Enterobacteriaceae were confirmed in the intestinal microbiome of adults living within 500–6200 m. Knowledge on the composition of the microflora of people living in livestock farm vicinity is insufficient to conclude about changes in the microbiome caused by the environmental emission of bioaerosol. The carriage prevalence of the LA-bacteria, including both strains with antimicrobial resistance and antimicrobial resistance genes, confirms the presence of zoonotic bacteria in the human microflora in populations without occupational contact with animals. It cannot be ruled out that zoonotic bacteria, as a component of the microbiome, have a negative impact on people’s health.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2024, 37, 2; 138-152
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Exposure to particulate matter 2.5 leading to lung microbiome disorder and the alleviation effect of Auricularia auricular-judae polysaccharide
Autorzy:
Zhang, Yanshu
He, Bin
Wu, Lei
Mi, Xiaoyi
Zhang, Lijin
Li, Shuang
Wang, Jian
Yu, Xiaoyu
Powiązania:
https://bibliotekanauki.pl/articles/2152971.pdf
Data publikacji:
2022
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
PM 2.5
inflammatory damage
lung injury
BALF
microbiome disorder
AAP
Opis:
Objectives The aim of the paper is to explore the role of lung microbiome disorder in lung tissue injury induced by exposure to particulate matter with a maximum diameter of 2.5 μm (PM2.5) and the alleviation effect of auricularia auricular-judae polysaccharide (AAP). Material and Methods Sprague Dawley rats were given PM2.5 suspension at a dose of 20 mg/l twice a week for 8 weeks. Then, 100 mg/kg or 200 mg/kg of AAP was administered to the rats after PM2.5 exposure. The bronchoalveolar lavage fluid (BALF) and lung tissue samples were collected at the end of the experiment. The BALF was meant to detect changes in lung microbiome by 16S sequences and cluster analysis, with the application of the principal component analysis and the partial least squares discriminant analysis. The levels of interferon-γ (IFN-γ), and interleukin (IL)-4, IL-8, and IL-10 in lung tissue were detected by the enzyme-linked immunosorbent assay method. The pathological changes in lung tissue were observed by hematoxylin and eosin staining. Results After PM2.5 exposure, the alveolar septum was widened, and the structures of alveolar walls were destroyed. There was inflammatory cells infiltration in the alveolar space and the interstitial space. Alpha diversity in BALF showed that the Chao1, ACE, Simpson, and Shannon values were increased, and the lung microbiome analysis revealed that the relative abundance of Firmicutes and Clostridium increased, while the relative abundance of Bacteroidetes and Akkermansia decreased. The contents of IFN-γ and IL-8 in lung tissue increased while the content of IL-10 decreased. After the administration of AAP, the alveolar structure damage was alleviated, and the interstitial hemorrhage, edema, and inflammatory cells infiltration were reduced. The Chao1 and ACE values decreased, and the taxonomic abundance values of Akkermansia were much higher. Simultaneously, the contents of IFN-γ, IL-4, and IL-8 decreased, and the content of IL-10 increased. Conclusions It was found that PM2.5 resulted in lung microbiome disorder, which might lead to the inflammation of lung tissue. It was also revealed that AAP could alleviate the inflammatory damage of lung tissue induced by PM2.5.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2022, 35, 6; 651-664
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Przesłanki personalizowanej probiotykoterapii w praktyce lekarskiej
Rationales for Personalized Probiotic Therapy in Medical Practice
Autorzy:
Skowrońska, Agnieszka
Majkowska, Anna
Sosnowska-Turek, Ewelina
Dzioba, Marcin
Sitkiewicz, Dariusz
Sygitowicz, Grażyna
Powiązania:
https://bibliotekanauki.pl/articles/17855065.pdf
Data publikacji:
2023-10-31
Wydawca:
Wydawnictwo Naukowe Medyk sp. z o.o.
Tematy:
mikrobiom jelitowy
enterotypy
probiotykoterapia
personalizacja
intestinal microbiome
enterotypes
probiotic therapy
personalization
Opis:
W ostatnich latach opublikowano szereg badań mikrobioty jelitowej rozmaitych populacji z wielu części świata. Zaobserwowano znaczące różnice międzyosobnicze w składzie taksonomicznym, poziomie różnorodności, liczebności oraz aktywności metabolicznej. Rozbieżności te przypisuje się czynnikom wewnętrznym, takim jak: enterotyp jelitowy czy wskaźnik BMI pacjenta oraz czynnikom zewnętrznym, takim jak: styl życia, poziom aktywności fizycznej, przynależność etniczna, zwyczaje dietetyczne oraz kulturowe. Złożoność stosowania probiotyków w sytuacjach klinicznych komplikuje fakt istnienia wewnątrzosobniczych oraz międzyosobniczych różnic taksonomicznych i funkcjonalnych w obszarze mikrobioty jelitowej. Labilność na poziomie produktu oraz biocenozy układu pokarmowego pacjenta stanowi przesłankę do wykorzystania personalizacji w procesie doboru probiotyków do zastosowań medycznych oraz okołomedycznych. W niniejszym opracowaniu omówione zostaną istotne, z punktu widzenia praktyki lekarskiej, właściwości mikrobioty jelitowej człowieka oraz probiotyków, które są wykorzystywane do jej kształtowania.
In recent years, numerous studies on the gut microbiota of various populations from different parts of the world have been published. Significant inter-individual differences have been observed in taxonomic composition, diversity levels, abundance, and metabolic activity. These variations are attributed to both internal factors such as gut enterotype or patient BMI and external factors such as lifestyle, physical activity levels, ethnic background, dietary habits, and cultural practices. The complexity of using probiotics in clinical situations is compounded by the presence of intra-individual and inter-individual taxonomic and functional differences in the gut microbiota. The product instability and the variability within the patient's gastrointestinal biocenosis provide a rationale for employing personalization in the selection of probiotics for medical and near-medical applications. This paper will discuss the significant aspects, from a medical practice perspective, of the human gut microbiota and the probiotics used to shape it.
Źródło:
Gabinet Prywatny; 2023, 290, 4; 29-34
2353-8600
Pojawia się w:
Gabinet Prywatny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The role of microbiota in the development of allergic diseases
Rola mikrobioty w rozwoju chorób alergicznych
Autorzy:
Boyarchuk, O.
Chornomydz, A.
Chornomydz, I.
Krytska, H.
Horishniy, I.
Powiązania:
https://bibliotekanauki.pl/articles/2053518.pdf
Data publikacji:
2019
Wydawca:
Akademia Bialska Nauk Stosowanych im. Jana Pawła II w Białej Podlaskiej
Tematy:
microbiota
microbiome
allergic diseases
hygienic theory
mikrobiota
mikrobiom
choroby alergiczne
teoria higieniczna
Opis:
Scientific progress, industrial development, urbanization, and the “sterile” way of life have a significant negative side, namely, the sustained growth of allergic diseases. The “hygienic theory” is used to explain the unceasing increase in the incidence of allergies in the population. At the same time, an important link in the development of allergic diseases is the microbiological environment and our own microbiota. In our literature review we gathered new data on the pathogenetic relationships between the violation of the quantitative and qualitative composition of our microbiocenosis and the development of allergic diseases. The basic mechanisms by which microbiota influence the development of an allergic process have been established, in particular: influence on T-cell immunity, synthesis of cytokines, etc. In this review, particular attention is paid to factors that lead to microbiocenosis and contribute to the development of allergies. Among them it is worth to highlight inappropriate nutrition, “sterile” style of life, widespread using of antiseptics and antibiotics, etc. Therefore, the most important step in the prevention of allergic diseases is the modification of lifestyle, breastfeeding of children, frequent staying in the open air and contact with nature, rational use of antiseptics and antibiotics.
Negatywnym aspektem postępu naukowego, rozwoju przemysłowego, urbanizacji i „sterylnego” stylu życia jest stały wzrost zachorowań na choroby alergiczne. Zależność tę wyjaśnia tzw. „teoria higieniczna”, tłumacząca nieprzerwany wzrost liczby alergii wśród społeczeństwa. Równie istotnym czynnikiem w rozwoju chorób alergicznych jest środowisko mikrobiologiczne i nasza własna mikrobiota. W tym artykule staraliśmy się zebrać nowe dane na temat zależności patogenetycznych, pomiędzy naruszeniem ilościowego i jakościowego składu naszej mikrobiocenozy, a rozwojem chorób alergicznych. Podstawowe mechanizmy wpływu mikrobioty oraz procesu powstawania alergii zostały już ustalone, są to przede wszystkim: wpływ komórek T na odporność, synteza cytokin, itp. Obecnie, szczególną uwagę poświęca się czynnikom, które prowadzą do powstawania mikrobiocenoz i przyczyniają się do rozwoju alergii. Należą do nich m.in. niewłaściwe odżywianie, „sterylny” styl życia, częste stosowanie środków antyseptycznych i antybiotyków. Z tego powodu najważniejszym krokiem w profilaktyce chorób alergicznych jest zmiana stylu życia, karmienie dzieci piersią, częste przebywanie na świeżym powietrzu, kontakt z naturą i rozsądne stosowanie środków antyseptycznych i antybiotyków.
Źródło:
Health Problems of Civilization; 2019, 13, 2; 135-146
2353-6942
2354-0265
Pojawia się w:
Health Problems of Civilization
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The Horizontal-Ontological Nature of The Physical Culture of Cancers
Autorzy:
DeCarlo, John F.
Powiązania:
https://bibliotekanauki.pl/articles/2044643.pdf
Data publikacji:
2022-04-30
Wydawca:
Uniwersytet Warszawski. Wydział Filozofii
Tematy:
vertical and horizontal evolution
metabolic microbiome
ontological metastatic multiplicity
synchronistic unity of actions
Opis:
Whereas classical Darwinian evolution is based on the model of vertical development, per species, and related sexual selection and natural mutations, along with environmental selective pressures, epi-genetics presents a supplemental view of horizontal development as DNA is both selectively transcribed and translated by mRNA and influenced by a process of horizontal gene transfer, including genetic melding of microbes, organelles, plants, animals and other types of hominoids. Thus, a philosophy of physical culture is offered in which cancers are conceived of as an extension of a horizontal physical culture in which organisms thrive via a cooperative and synergistic sense of community. However, they are also conceived of as an extreme which manifest a unique type of ontological multiplicity whereby they not only propagate para-sexually leading to vast genetic variations, but also manipulate and appropriate cells and systems of the host, constructing horizontally connected and lethal tumor sites. Is there any hope against such a formidable ontological structure? Cultivation of human metabolism via broad and healthy dietary patterns can support the horizontal microbiome, thus maintaining synchronized and unified horizontal relations between DNA, mRNA and long non-coded RNA functions.
Źródło:
Eidos. A Journal for Philosophy of Culture; 2021, 5, 4; 101-112
2544-302X
Pojawia się w:
Eidos. A Journal for Philosophy of Culture
Dostawca treści:
Biblioteka Nauki
Artykuł
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