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Wyświetlanie 1-15 z 18
Tytuł:
„Annehmen. Akzeptieren. Damit leben. Nicht vergessen. Sich erinnern.“ Subversive Erinnerungsverschiebungen der Post-Shoah-Generation in Mirna Funks Roman Winternähe (2015)
„To take. To accept. To live with. Not to forget.” The subversive shift of memory in the post Shoah generation in Mirna Funk’s novel Winternähe (2015)
Autorzy:
Rutka, Anna
Powiązania:
https://bibliotekanauki.pl/articles/2030871.pdf
Data publikacji:
2017-12-16
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
Mirna Funk
contemporary German novel
post Shoah memory discourse
third generation
subversive strategies
współczesna powieść niemiecka
dyskurs pamięci post Szoa
trzecie pokolenie
strategie subwersywne
Opis:
The debut novel Winternähe by the young German-Jewish author Mirna Funk is a paradigmatic illustration of the post Shoah literature of the third, the grandchildren generation. The novel expounds on against background of the death of Shoah-survivors, the new ways of dealing with the family past and transnational Shoah memory in a complex relation to the globality and mobility as current conditions of the modern life. Funk’s novel also expounds on the subversive strategies, which are inherent in modern virtual communication media like Facebook or Instagram.
Źródło:
Tematy i Konteksty; 2017, 12, 7; 372-385
2299-8365
Pojawia się w:
Tematy i Konteksty
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
AmiRNA Designer - new method of artificial miRNA design
Autorzy:
Mickiewicz, Agnieszka
Rybarczyk, Agnieszka
Sarzynska, Joanna
Figlerowicz, Marek
Blazewicz, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/1038843.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
artificial miRNA
RNAi
gene regulation
sequence specific
thermodynamic profiles
Opis:
MicroRNAs (miRNAs) are small non-coding RNAs that have been found in most of the eukaryotic organisms. They are involved in the regulation of gene expression at the post-transcriptional level in a sequence specific manner. MiRNAs are produced from their precursors by Dicer-dependent small RNA biogenesis pathway. Involvement of miRNAs in a wide range of biological processes makes them excellent candidates for studying gene function or for therapeutic applications. For this purpose, different RNA-based gene silencing techniques have been developed. Artificially transformed miRNAs (amiRNAs) targeting one or several genes of interest represent one of such techniques being a potential tool in functional genomics. Here, we present a new approach to amiRNA*design, implemented as AmiRNA Designer software. Our method is based on the thermodynamic analysis of the native miRNA/miRNA* and miRNA/target duplexes. In contrast to the available automated tools, our program allows the user to perform analysis of natural miRNAs for the organism of interest and to create customized constraints for the design stage. It also provides filtering of the amiRNA candidates for the potential off-targets. AmiRNA Designer is freely available at http://www.cs.put.poznan.pl/arybarczyk/AmiRNA/.
Źródło:
Acta Biochimica Polonica; 2016, 63, 1; 71-77
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Arabidopsis thaliana microRNA162 level is posttranscriptionally regulated via splicing and polyadenylation site selection
Autorzy:
Barciszewska-Pacak, Maria
Knop, Katarzyna
Jarmołowski, Artur
Szweykowska-Kulińska, Zofia
Powiązania:
https://bibliotekanauki.pl/articles/1038744.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
miRNA
pri-miRNA
abiotic stress
gene expression
Opis:
Arabidopsis microRNA162 (miRNA162) level regulation was studied under abiotic stresses, such as drought and salinity. The TaqMan® microRNA assay proved that A. thaliana miRNA162 level was elevated under these stresses, confirming its salt and drought responsiveness. The promoter region analyses of A. thaliana miRNA162a and b genes (MIR162a and MIR162b) identified numerous salinity and drought responsive elements. However, our results indicated that Arabidopsis MIR162a was presumably the main locus responsible for the mature ath-miRNA162 accumulation under the stresses tested, and the MIR162b was generally rather weakly expressed, both in control and under the stress conditions. The MIR162a structure was confirmed to be complex and the pri-miRNA162a hairpin structure was shown to span an alternative exon and an intron. The MIR162a transcription generated a few pri-miRNA162a splicing isoforms that could be functional and non-functional. Upon drought and salinity stresses, the regulation of the pri-miRNA162a alternative splicing pattern revealed an increase of a functional pri-miR162a isoform and a preferential distal polyA site selection under the stress conditions. Apart from the potential transcriptional regulation of the miRNA genes (MIRs) expression, the data obtained point to an essential role of posttranscriptional regulation of Arabidopsis microRNA162 level.
Źródło:
Acta Biochimica Polonica; 2016, 63, 4; 811-816
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Barley primary microRNA expression pattern is affected by soil water availability
Autorzy:
Swida-Barteczka, Aleksandra
Kruszka, Katarzyna
Grabowska, Aleksandra
Pacak, Andrzej
Jarmolowski, Artur
Kurowska, Marzena
Szarejko, Iwona
Szweykowska-Kulinska, Zofia
Powiązania:
https://bibliotekanauki.pl/articles/1038746.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
pri-miRNA
miRNA
drought
rehydration
barley genotypes
Opis:
MicroRNAs are short molecules of 21-24 nt in length. They are present in all eukaryotic organisms and regulate gene expression by guiding posttranscriptional silencing of mRNAs. In plants, they are key players in signal transduction, growth and development, and in response to abiotic and biotic stresses. Barley (Hordeum vulgare) is an economically important monocotyledonous crop plant. Drought is the world's main cause of loss in cereal production. We have constructed a high-throughput Real-Time RT-qPCR platform for parallel determination of 159 barley primary microRNAs' levels. The platform was tested for two drought-and-rehydration-treated barley genotypes (Rolap and Sebastian). We have determined changes in the expression of primary microRNAs responding to mild drought, severe drought, and rehydration. Based on the results obtained, we conclude that alteration in the primary microRNA expression is relative to the stress's intensity. Mild drought and rehydration mostly decrease the pri-miRNA levels in both of the tested genotypes. Severe drought mainly induces the primary microRNA expression. The main difference between the genotypes tested was a much-stronger induction of pri-miRNAs in Rolap encountering severe drought. The primary microRNAs respond dynamically to mild drought, severe drought, and rehydration treatments. We propose that some of the individual pri-miRNAs could be used as drought stress or rehydration markers. The usage of the platform in biotechnology is also postulated.
Źródło:
Acta Biochimica Polonica; 2016, 63, 4; 817-824
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
CAMPTOTHECIN INHIBITS MIGRATION, INVASION AND CLONOGENIC PROPERTY OF LIVER CANCER CELLS BY MODULATING MICRORNA EXPRESSION
Autorzy:
Liu, Zhenzhong
Wu, Song
Li, Xiaoqian
Powiązania:
https://bibliotekanauki.pl/articles/895460.pdf
Data publikacji:
2020-04-29
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
Hepatocellular Carcinoma
cell proliferation
cell cycle
Camptothecin
miRNA
Opis:
Camptothecin (CPT), an alkaloid natural product, extracted from Camptotheca acuminata bark, has been reported to have potential antitumor activity in diverse cancers. MicroRNAs (MiRNAs) are a class of short, non-coding RNAs that plays a crucial role in the normal physiology by attenuating translation. Here, we showed that the CPT modulates the expression of miRNAs in hepatocellular carcinoma cells (HCC). Microarray analysis reveals that CPT modulates the expression of as many as 39 miRNAs in HCC cells (Huh7), 27 miRNAs were downregulated whereas 12 miRNAs were upregulated. miR-16 is the key miRNA upregulated by CPT and targets key prosurvival proteins (MMP-2, MMP-9 and cyclin D1). Our results demonstrate that CPT is inhibiting cell viability of HCC cells significantly when compared with the untreated cells. Wound healing and colony formation assay confirm inhibition of cell migration and clonogenic property of Huh7 cells respectively, upon the dose-dependent treatment of CPT. Furthermore, the Boyden chamber assay analysis revealed a significant inhibition of number of invasive cells in CPT treated cells with comparison to untreated Huh7 cells. Mechanistically, CPT upregulates miR-16 expression which targets MMP-2, MMP-9, cyclin D1 downregulation and subsequently upregulates the expression of E-cadherin, TIMP1, p21, and p27, thereby inhibits cell migration, invasion and clonogenic property of HCC cells. In summary, CPT treatment in Huh7 cells decreases cell viability and upregulates miR-16 expression, which results in inhibition of cell migration, invasion and clonogenic property of cells, by decreasing MMP-2, MMP-9, cyclin D1 and increasing the expression of cell cycle-regulated proteins p21 and p27.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 2; 295-304
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Deciphering the soybean molecular stress response via high-throughput approaches
Autorzy:
Tyczewska, Agata
Gracz, Joanna
Kuczyński, Jakub
Twardowski, Tomasz
Powiązania:
https://bibliotekanauki.pl/articles/1038715.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
soybean
transcriptome
miRNA
proteome
stress conditions
Opis:
As a result of thousands of years of agriculture, humans had created many crop varieties that became the basis of our daily diet, animal feed and also carry industrial application. Soybean is one of the most important crops worldwide and because of its high economic value the demand for soybean products is constantly growing. In Europe, due to unfavorable climate conditions, soybean cultivation is restricted and we are forced to rely on imported plant material. The development of agriculture requires continuous improvements in quality and yield of crop varieties under changing or adverse conditions, namely stresses. To achieve this goal we need to recognize and understand the molecular dependencies underlying plant stress responses. With the advent of new technologies in studies of plant transcriptomes and proteomes, now we have the tools necessary for fast and precise elucidation of desirable crop traits. Here, we present an overview of high-throughput techniques used to analyze soybean responses to different abiotic (drought, flooding, cold stress, salinity, phosphate deficiency) and biotic (infections by F. oxysporum, cyst nematode, SMV) stress conditions at the level of the transcriptome (mRNAs and miRNAs) and the proteome.
Źródło:
Acta Biochimica Polonica; 2016, 63, 4; 631-643
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Free-Circulating miRNAs as Biomarkers in Amyotrophic Lateral Sclerosis and Hereditary Spastic Paraplegias
Wolne krążące miRNA jako biomarkery w stwardnieniu bocznym zanikowym i dziedzicznej spastycznej paraplegii
Autorzy:
Tomczuk, Filip
Sułek, Anna
Powiązania:
https://bibliotekanauki.pl/articles/30146460.pdf
Data publikacji:
2023
Wydawca:
Uczelnia Łazarskiego. Oficyna Wydawnicza
Tematy:
miRNA
biomarkers
motor neuron disorders
rare disease
neurodegeneration
biomarkery
neurodegeneracja
choroby neuronu ruchowego
choroba rzadka
Opis:
The development of biomarker research is essential to enhance the diagnostic workup for neurodegenerative disorders and to facilitate the monitoring of effective disease-modifying therapies. While DNA testing remains a predominant biomarker for identifying mutations in familial forms of neurodegenerative diseases, various types of RNA have more recently been linked to both familial and sporadic forms of these diseases. miRNAs, a subset of endogenous non-coding RNA, bind to partially complementary sequences in mRNAs and inhibits mRNA translation by either blocking translational machinery or degrading mRNAs. They are involved in a variety of cellular processes, including cell cycle, development, metabolism, and synaptic plasticity. Dysregulation of miRNA expression and function has been reported in various neurological disorders (NDs) of the central nervous system, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS), and hereditary spastic paraplegias (HSP). If a specific profile of dysregulated miRNAs is identified in patients suffering from NDs, this could serve as a biomarker for earlier diagnosis and monitoring of the disease progression. Identifying the role of miRNAs in normal cellular processes and understanding how miRNA expression is linked to their neurological effects are also critical in developing new therapeutic strategies for NDs. In this review, we will focus on free-circulating miRNA and their association between ALS and HSP, as both diseases share the same neurodegeneration process of the upper and lower motor neurons. This suggests that they may also share the same miRNA pattern, which might be considered a shared biomarker.
Rozwój badań w dziedzinie badań biomarkerów jest niezbędny do usprawnienia diagnostyki chorób neurodegeneracyjnych i skutecznego monitorowania terapii modyfikujących przebieg choroby. Chociaż badania DNA pozostają dominującym biomarkerem pozwalającym na identyfikację mutacji w chorobach neurodegeneracyjnych, ostatnio powiązano różne typy RNA zarówno z rodzinnymi, jak i sporadycznymi postaciami tych chorób. miRNA, endogenne niekodujące cząsteczki RNA, wiąże się z częściowo komplementarnymi sekwencjami w mRNA i hamuje translację mRNA albo poprzez blokowanie mechanizmu translacji, albo przez degradację mRNA. miRNA, bierze udział w różnych procesach komórkowych, w tym w cyklu komórkowym, rozwoju, metabolizmie i plastyczności synaptycznej. Potwierdzono ich udział w zaburzeniach ekspresji i funkcji miRNA w różnych schorzeniach neurologicznych (ND) ośrodkowego układu nerwowego, takich jak m.in. choroba Alzheimera (AD), choroba Parkinsona (PD), choroba Huntingtona (HD), stwardnienie boczne zanikowe (ALS) i dziedziczne spastyczne paraplegie (HSP). Jeśli u pacjentów cierpiących na choroby neurodegeneracyjne zostanie zidentyfikowany specyficzny profil ekspresji miRNA, może on posłużyć jako biomarker do wcześniejszej diagnozy i monitorowania postępu choroby. Identyfikacja roli miRNA w prawidłowych procesach komórkowych i zrozumienie, w jaki sposób ekspresja miRNA jest powiązana z ich skutkami, ma również kluczowe znaczenie w opracowywaniu nowych strategii terapeutycznych dla ND. W tym artykule skupiamy się na wolno krążących cząsteczkach miRNA i ich związku pomiędzy ALS i HSP, ponieważ w obu chorobach występuje ten sam proces neurodegeneracji górnych i dolnych neuronów ruchowych. Sugeruje to, że mogą one również mieć ten sam profil ekspresji miRNA, który można będzie uznać za wspólny biomarker.
Źródło:
Review of Medical Practice; 2023, XIX, 4; 62-71
2956-4441
2956-445X
Pojawia się w:
Review of Medical Practice
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Glioblastoma - actual knowledge and future perspectives
Glejak - aktualna wiedza oraz perspektywy
Autorzy:
Bilicki, Dominik
Zbrożek, Mikołaj
Fudalej, Marta
Deptała, Andrzej
Badowska-Kozakiewicz, Anna
Powiązania:
https://bibliotekanauki.pl/articles/2159008.pdf
Data publikacji:
2022-06-30
Wydawca:
Medical Education
Tematy:
glioblastoma multiforme
oncology
miRna
pathogenesis
siRNA
glejak wielopostaciowy
onkologia
miRNA
patogeneza
Opis:
Glioblastoma is the most severe IV-class glioma and therefore the prognosis for patients remains poor despite some improvement in the treatment area. The neurological or psychiatric symptoms especially fast-developing ones should be fully investigated. This article aims to summarize actual knowledge of glioblastoma and present future perspectives. The underlying causes are usually associated with mutations of EGFR, PTEN, IDH1, p53 genes. The MRI scan, MGMT promoter methylation status, GFAP immunohistochemical detection and Karnofsky performance status are valuable diagnostic tools and some other potential biomarkers with high specificity are proposed. The standard of care is surgery and Stupp protocol which is the combination of radiotherapy and chemotherapy with temozolomide. Nevertheless, after remission the treatment possibilities are limited. Many efforts have been devoted to elaborate novel therapeutic strategies using e.g. CAR-T cells, nanoparticles, monoclonal antibodies, miRNA, siRNA or proteasome inhibitors.
Glejak wielopostaciowy klasyfikowany jest do grupy najbardziej złośliwych glejaków o IV stopniu złośliwości ze szczególnie niekorzystnymi prognozami związanymi z jego leczeniem. Pojawienie się u pacjenta szybko postępujących objawów zarówno psychiatrycznych, jak i neurologicznych powinno być zawsze dokładnie zbadane. Artykuł ma na celu zebranie oraz podsumowanie aktualnej wiedzy na temat glejaka oraz zaprezentowanie możliwych perspektyw rozwoju metod diagnostyczno-leczniczych. Rozwój glejaka ma zazwyczaj związek z mutacjami w genach EGFR, PTEN, IDH1 lub p53. Do użytecznych narzędzi diagnostycznych należą m.in. badanie MRI, analiza metylacji promotora genu MGMT oraz immunohistochemiczne oznacznie GFAP. W leczeniu glejaków wielopostaciowych najczęściej stosowanym schematem jest protokół Stuppa bazujący na połączeniu radioterapii z chemioterapią temozolomidem. Niemniej jednak, dalsze możliwości leczenia są limitowane. Zintegrowane wysiłki naukowców są ukierunkowane na poszukiwanie nowych strategii leczenia przy użyciu m.in. teraapii CAR-T, nanocząteczek, przeciwciał monoklonalnych, miRNA, siRNA oraz inhibitorów proteasomów
Źródło:
OncoReview; 2022, 12, 2; 35-44
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
How short RNAs impact the human ribonuclease Dicer activity: putative regulatory feedback-loops and other RNA-mediated mechanisms controlling microRNA processing
Autorzy:
Koralewska, Natalia
Hoffmann, Weronika
Pokornowska, Maria
Milewski, Marek
Lipinska, Andrea
Bienkowska-Szewczyk, Krystyna
Figlerowicz, Marek
Kurzynska-Kokorniak, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1038739.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
ribonuclease Dicer
miRNA processing
regulatory RNAs
regulation of Dicer activity
regulatory feedback-loops
Opis:
Ribonuclease Dicer plays a pivotal role in RNA interference pathways by processing long double-stranded RNAs and single-stranded hairpin RNA precursors into small interfering RNAs (siRNAs) and microRNAs (miRNAs), respectively. While details of Dicer regulation by a variety of proteins are being elucidated, less is known about non-protein factors, e.g. RNA molecules, that may influence this enzyme's activity. Therefore, we decided to investigate the question of whether the RNA molecules can function not only as Dicer substrates but also as its regulators. Our previous in vitro studies indicated that the activity of human Dicer can be influenced by short RNA molecules that either bind to Dicer or interact with its substrates, or both. Those studies were carried out with commercial Dicer preparations. Nevertheless, such preparations are usually not homogeneous enough to carry out more detailed RNA-binding studies. Therefore, we have established our own system for the production of human Dicer in insect cells. In this manuscript, we characterize the RNA-binding and RNA-cleavage properties of the obtained preparation. We demonstrate that Dicer can efficiently bind single-stranded RNAs that are longer than ~20-nucleotides. Consequently, we revisit possible scenarios of Dicer regulation by single-stranded RNA species ranging from ~10- to ~60-nucleotides, in the context of their binding to this enzyme. Finally, we show that siRNA/miRNA-sized RNAs may affect miRNA production either by binding to Dicer or by participating in regulatory feedback-loops. Altogether, our studies suggest a broad regulatory role of short RNAs in Dicer functioning.
Źródło:
Acta Biochimica Polonica; 2016, 63, 4; 773-783
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Hsa-miR-331-3p inhibits VHL expression by directly targeting its mRNA 3-UTR in HCC cell lines
Autorzy:
Cao, Yiyi
Zhang, Jinnan
Xiong, Dongmei
Wang, Dan
Wu, Ting
Huang, Ailong
Tang, Hua
Powiązania:
https://bibliotekanauki.pl/articles/1039137.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
HCC
HBV
miRNA
Hsa-miR-331-3p and VHL
Opis:
Dysregulation of miRNA is widely involved in human cancers, including hepatocellular carcinoma (HCC). Array data for miRNAs indicated that miR-331-3p might be one of the disorderly expressed miRNAs in HCC cell lines, but the function of miR-331-3p in HCC remains unclear. In this study, quantitative real time polymerase chain reaction (qRT-PCR) results indicated that miR-331-3p was up-regulated in HepG2.2.15 cells, Ad-HBV-HepG2 cells and pCH9/3091transfected SMMC7721 cells compared with their control group, respectively. miRNA target prediction software was used, and VHL was found to be one of the target genes of miR-331-3p. qRT-PCR and western blot analysis indicated VHL expression was decreased when miR-331-3p was over-expressed and increased when miR-331-3p was inhibited in SMMC7721 cells. The luciferase reporter activity was inhibited in SMMC7721 cells when co-transfected with miR-331-3p expression vector and VHL 3'-UTR wild type vector and increased in HepG2.2.15 transfected with miR-331-3p inhibitor compared to its control group respectively. When co-transfected with miR-331-3p expression vector and VHL 3'-UTR mutated type vector in SMMC7721 cells the luciferase reporter activity was recovered. All of these results show that HBV up-regulated miR-331-3p expression in HCC cell lines and miR-331-3p could inhibit VHL expression by directly targeting its 3'-UTR. This provided useful information in exploring the mechanism of HCC induced by HBV infection.
Źródło:
Acta Biochimica Polonica; 2015, 62, 1; 77-82
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
MicroRNA-mediated regulation of flower development in grasses
Autorzy:
Smoczynska, Aleksandra
Szweykowska-Kulinska, Zofia
Powiązania:
https://bibliotekanauki.pl/articles/1038724.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
miRNA
grasses
flower development
ABCDE model
Opis:
Flower structure in grasses is very unique. There are no petals or sepals like in eudicots but instead flowers develop bract-like structures - palea and lemma. Reproductive organs are enclosed by round lodicule that not only protects reproductive organs but also plays an important role during flower opening. The first genetic model for floral organ development was proposed 25 years ago and it was based on the research on model eudicots. Since then, studies have been carried out to answer the question whether this model could be applicable in the case of monocots. Genes from all classes found in eudicots have been also identified in genomes of such monocots like rice, maize or barley. What's more, it seems that miRNA-mediated regulation of floral organ genes that was observed in the case of Arabidopsis thaliana also takes place in monocots. MiRNA172, miRNA159, miRNA171 and miRNA396 regulate expression of floral organ identity genes in barley, rice and maize, affecting various features of the flower structure, ranging from formation of lemma and palea to the development of reproductive organs. A model of floral development in grasses and its genetic regulation is not yet fully characterized. Further studies on both, the model eudicots and grasses, are needed to unravel this topic. This review provides general overview of genetic model of flower organ identity specification in monocots and it's miRNA-mediated regulation.
Źródło:
Acta Biochimica Polonica; 2016, 63, 4; 687-692
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
miRNA Multiplayers in glioma. From bench to bedside
Autorzy:
Rolle, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/1038962.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
cancer
glioblastoma multiforme (GBM)
miRNA
anti-cancer therapy
diagnosis
prognosis
Opis:
Glioblastoma multiforme (GBM) is the most common type of malignant gliomas, characterized by genetic instability, intratumoral histopathological variability and unpredictable clinical behavior. Disappointing results in the treatment of gliomas with surgery, radiation and chemotherapy have fuelled a search for a new therapeutic targets and treatment modalities. A novel small non-coding RNA molecules, microRNAs (miRNAs), appear to represent one of the most attractive target molecules contributing to the pathogenesis of various types of tumors. They play crucial roles in tumorigenesis, angiogenesis, invasion and apoptosis. Some miRNAs are also associated with clinical outcome and chemo- and radiotherapy resistance. Moreover, miRNA have the potential to affect the responses to molecular-targeted therapies and they also might be associated with cancer stem cell properties, affecting tumor maintenance and progression. The expression profiles of miRNAs are also useful for subclassification of GBM, what underscores the heterogeneity of diseases that all share the same WHO histopathological grade. Importantly, molecular subtypes of GBM appear to correlate with clinical phenotypes, tumor characteristic and treatment outcomes. miRNAs are then biological markers with possible diagnostic and prognostic potential. They could also serve as one of the promising treatment targets in human glioblastoma.
Źródło:
Acta Biochimica Polonica; 2015, 62, 3; 353-365
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
miRNA zaangażowane w proces starzenia i kiełkowania nasion
miRNAs involved in the seed ageing and germination process
Autorzy:
Puchta, Marta
Powiązania:
https://bibliotekanauki.pl/articles/2199377.pdf
Data publikacji:
2020-10-22
Wydawca:
Instytut Hodowli i Aklimatyzacji Roślin
Tematy:
miRNA
starzenie nasion
żywotność
kiełkowanie
seed aging
vitality
germination
Opis:
Starzenie nasion jest procesem prowadzącym do nieodwracalnych zmian powodujących utratę ich wartości siewnej w czasie. W proces ten zaangażowanych jest wiele wzajemnie powiązanych zmian molekularnych, biochemicznych, fizjologicznych oraz metabolicznych. W związku z degradacją środowiska naturalnego wymagana jest intensywna ochrona gatunkowa roślin. Zachowanie zdolności do kiełkowania nasion odgrywa kluczową rolę w ochronie bioróżnorodności gatunkowej. Przeprowadzone dotychczas badania wskazują na udział miRNA w dynamicznym procesie kiełkowania nasion. Jednak niewiele wiadomo na temat zagadnień dotyczących regulacji miRNA i ich genów docelowych, które są potencjalnie ważnymi czynnikami przyczyniającymi się do starzenia nasion podczas długotrwałego przechowywania.Praca obejmuje przegląd wybranej literatury dotyczącej badania roli miRNA w regulacji procesów zaangażowanych w starzenie i kiełkowanie nasion.
The ageing of seeds is a process that leads to irreversible changes that cause the loss of seed value over time. Many interrelated molecular, biochemical, physiological and metabolic processes are involved in it. The degradation of the natural environment requires intensive plant species protection. Preserving germination capacity plays a key role in protecting the biodiversity damaged by genetic erosion. The studies conducted so far show that miRNAs are involved in the dynamic germination process of seeds. However, little is known about the state of specific miRNA regulations and their targets. These, are potentially important factors contributing to the ageing of seeds during long-term storage.This review includes literature review of research concerning the role of miRNA in the regulation of processes leading to seed ageing and germination.
Źródło:
Biuletyn Instytutu Hodowli i Aklimatyzacji Roślin; 2020, 290; 21-26
0373-7837
2657-8913
Pojawia się w:
Biuletyn Instytutu Hodowli i Aklimatyzacji Roślin
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
New functionality of RNAComposer: an application to shape the axis of miR160 precursor structure
Autorzy:
Antczak, Maciej
Popenda, Mariusz
Zok, Tomasz
Sarzynska, Joanna
Ratajczak, Tomasz
Tomczyk, Katarzyna
Adamiak, Ryszard
Szachniuk, Marta
Powiązania:
https://bibliotekanauki.pl/articles/1038732.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
RNA 3D structure prediction
RNAComposer
plant miRNA precursor
Opis:
RNAComposer is a fully automated, web-interfaced system for RNA 3D structure prediction, freely available at http://rnacomposer.cs.put.poznan.pl/ and http://rnacomposer.ibch.poznan.pl/. Its main components are: manually curated database of RNA 3D structure elements, highly efficient computational engine and user-friendly web application. In this paper, we demonstrate how the latest additions to the system allow the user to significantly affect the process of 3D model composition on several computational levels. Although in general our method is based on the knowledge of secondary structure topology, currently the RNAComposer offers a choice of six incorporated programs for secondary structure prediction. It also allows to apply a conditional search in the database of 3D structure elements and introduce user-provided elements into the final 3D model. This new functionality contributes to a significant improvement of the predicted 3D model reliability and it facilitates a better model adjustment to the experimental data. This is exemplified based on the RNAComposer application for modelling of the 3D structures of precursors of the miR160 family members.
Źródło:
Acta Biochimica Polonica; 2016, 63, 4; 737-744
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Regulatory RNAs in Planarians
Autorzy:
Pawlicka, Kamila
Perrigue, Patrick
Barciszewski, Jan
Powiązania:
https://bibliotekanauki.pl/articles/1038722.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
planarians
RNAi
miRNA
regeneration
stem cells
Opis:
The full scope of regulatory RNA evolution and function in epigenetic processes is still not well understood. The development of planarian flatworms to be used as a simple model organism for research has shown a great potential to address gaps in the knowledge in this field of study. The genomes of planarians encode a wide array of regulatory RNAs that function in gene regulation. Here, we review planarians as a suitable model organism for the identification and function of regulatory RNAs.
Źródło:
Acta Biochimica Polonica; 2016, 63, 4; 681-686
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
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