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Tytuł:
Phytochemical potential of Ficus species for the control of the phytonematode Meloidogyne javanica
Autorzy:
Alves, J.R.
De Assis, J.N.
Padua, C.C.A.
Balbino, H.M.
Lima, L.L.
De Souza Gouveia, A.
Vital, C.E.
Buonicontro, D.S.
De Freitas, L.G.
Leite, J.P.V.
De Oliveira Ramos, H.J.
Powiązania:
https://bibliotekanauki.pl/articles/2082765.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
gas chromatography/mass spectrometry (GC/MS)
metabolite profiling
pest
control
phytochemistry
Opis:
Root-knot nematodes, genus Meloidogyne, are among the most plant damaging pathogens worldwide. The action of natural products against plant pathogens has been investigated to assess their effectiveness in the control of diseases. Thus, the present study aimed to evaluate the phytochemistry potential of the Ficus species for the control of Meloidogyne javanica. In vitro inhibitory activity assays were performed with crude ethanolic extracts of leaves and branches from 10 Ficus species. Among these, Ficus carica extracts exhibited strong paralysis activity against second stage juveniles (J2) (EC50 = 134.90 μg ∙ ml–1 ), after 72 hours. In addition, high efficacy was observed in egg-hatching inhibition at different embryonic stages. Microscopy analysis revealed severe morphological alterations in the nematode tissues at the J2 stage, as well as immotility of juveniles released from eggs in the presence of F. carica extracts. The efficacy of the treatments for the other species was very low. These differences were supported by the variation in the compound classes, mainly for alkaloids and metabolite profiles by Gas Chromatography/Mass Spectrometry (GC/MS) when F. carica was compared with the other species. The results indicated that F. carica is a promising source for the isolation and identification of molecules capable of acting in the control of M. javanica.
Źródło:
Journal of Plant Protection Research; 2020, 60, 2; 193-206
1427-4345
Pojawia się w:
Journal of Plant Protection Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pozostalosci chlorowanych weglowodorow w watrobach noworodkow, niemowlat i dzieci
Autorzy:
Amarowicz, R
Sulik, M.
Korczakowska, B.
Brykalska, A.
Powiązania:
https://bibliotekanauki.pl/articles/877353.pdf
Data publikacji:
1993
Wydawca:
Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny
Tematy:
niemowleta
weglowodory chloropochodne
noworodki
dzieci
toksykologia
metabolity
DDT
insektycydy
watroba
infant
chlorinated hydrocarbon
neonate
child
toxicology
metabolite
insecticide
liver
Opis:
W wątrobach zmarłych 4 noworodków, 2 niemowląt i 2 dzieci oznaczono poziom pozostałości chlorowanych węglowodorów.
In the liver of 4 newborns, 2 infants and 2 children the levels of residues of chlorinated hydrocarbons were determined .The highest levels of ƩHCH (817 mcg/kg of fat, 17.1 mcg/kg of tissue) were found in a 2-day-old newborn, the lowest ones (43 mcg/kg of fat, 1.8 mcg/kg of tissue) were m an infant aged 12 months. The content of ƩDDT was highest (3044 mcg/kg of fat, 93.8 mcg/kg of tissue) in the liver of an infant aged 13 days, the lowest values (322 mcg/kg of fat, 5.6 mcg/kg of tissue) in the liver of a child aged 12 years. The results are comparable to those obtained in this country in the liver of adults and in human placenta.
Źródło:
Roczniki Państwowego Zakładu Higieny; 1993, 44, 4; 379-382
0035-7715
Pojawia się w:
Roczniki Państwowego Zakładu Higieny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Investigation of a wide spectrum of inherited metabolic disorders by 13C NMR spectroscopy
Autorzy:
Bal, Dominika
Kraska-Dziadecka, Anna
Gradowska, Wanda
Gryff-Keller, Adam
Powiązania:
https://bibliotekanauki.pl/articles/1040823.pdf
Data publikacji:
2008
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
urine
13C NMR
inherited metabolic disease
1H NMR
marker metabolite
Opis:
High-resolution 1H NMR spectroscopy of body fluids has proved to be very useful in diagnostics of inherited metabolic diseases, whereas 13C NMR remains almost unexploited. In this paper the application of 13C NMR spectroscopy of fivefold concentrated urine samples for diagnosis of selected metabolic diseases is reported. Various marker metabolites were identified in test urine samples from 33 patients suffering from 10 different diseases, providing information which could be crucial for their diagnoses. Spectra were accumulated for 2 h or overnight when using spectrometers operating at 9.4 or 4.7 T magnetic fields, respectively. Interpretation of the measurement results was based on a comparison of the peak positions in the measured spectrum with reference data. The paper contains a table with 13C NMR chemical shifts of 73 standard compounds. The method can be applied individually or as an auxiliary technique to 1H NMR or any other analytical method.
Źródło:
Acta Biochimica Polonica; 2008, 55, 1; 107-118
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
In vitro cultures of carnivorous plants from the Drosera and Dionaea genus for the production of biologically active secondary metabolites
Autorzy:
Banasiuk, R.
Kawiak, A.
Krolicka, A.
Powiązania:
https://bibliotekanauki.pl/articles/80172.pdf
Data publikacji:
2012
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
antimicrobial activity
antioxidant
cytotoxic activity
flavonoids
micropropagation
naphthoquinone
in vitro culture
carnivorous plant
Drosera
extract
phytotherapy
pulmonary disease
cough
biological activity
secondary metabolite
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2012, 93, 2
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The alterations in genetic apparatus of somatic and generative cells of the host caused by helminths metabolites
Autorzy:
Bekish, V J
Powiązania:
https://bibliotekanauki.pl/articles/838630.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
metabolite
alteration
mice
cell
helminth
host
generative cell
mouse
bone marrow
testicle
Ascaris suum
genetic apparatus
somatic cell
Hymenolepis nana
Toxocara canis
Opis:
Alterations in the genetic apparatus of mice bone marrow cells and testicles caused by Hymenolepis nana, Ascaris suum and Toxocara canis metabolites have been investigated by means of micronuclear test application. The activity of spermatogenesis has been investigated at experimental hymenolepidosis, migrating ascariasis and toxocarosis with the use of ³H-timidine. Helminths metabolites have been established to exert a mutagenie effect on somatic cells of bone marrow, spermatogonies and also on the generative cells (spermatides) of helminths in invaded mice. The concurrent increase in micronucleus number in erythrocytes, spermatogonies and in spermatides (to a lesser degree) of invaded mice has been revealed. The decrease in spermatogenesis activity has been established in experimental hymenolepidosis, migrating ascariasis and toxocarosis in invaded mice.
Źródło:
Annals of Parasitology; 2001, 47, 4
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The alterations in genetic apparatus of somatic and generative cells of the host caused by helminths metabolites
ZMIANY W APARACIE GENETYCZNYM KOMÓREK SOMATYCZNYCH I PŁCIOWYCH ŻYWICIELA WYWOŁANE METABOLITAMI HELMINTÓW
Autorzy:
Bekish, V. J.
Powiązania:
https://bibliotekanauki.pl/articles/2148471.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
metabolite
alteration
mice
cell
helminth
host
generative cell
mouse
bone marrow
testicle
Ascaris suum
genetic apparatus
somatic cell
Hymenolepis nana
Toxocara canis
Opis:
Alterations in the genetic apparatus of mice bone marrow cells and testicles caused by Hymenolepis nana, Ascaris suum and Toxocara canis metabolites have been investigated by means of micronuclear test application. The activity of spermatogenesis has been investigated at experimental hymenolepidosis, migrating ascariasis and toxocarosis with the use of ³H-timidine. Helminths metabolites have been established to exert a mutagenie effect on somatic cells of bone marrow, spermatogonies and also on the generative cells (spermatides) of helminths in invaded mice. The concurrent increase in micronucleus number in erythrocytes, spermatogonies and in spermatides (to a lesser degree) of invaded mice has been revealed. The decrease in spermatogenesis activity has been established in experimental hymenolepidosis, migrating ascariasis and toxocarosis in invaded mice.
Źródło:
Wiadomości Parazytologiczne; 2001, 47, 4; 891-896
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A full-size ABCG transporter modulates the level of isoflavonoids in Medicago truncatula
Autorzy:
Biala, W.
Banasiak, J.
Jasinski, M.
Powiązania:
https://bibliotekanauki.pl/articles/80086.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
ABC protein
biotic stress
abiotic stress
isoflavonoids
Medicago truncatula
hairy root
signalling molecule
secondary metabolite
plasma membrane
oligosaccharide
gene coding
phenylpropanoid
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 3
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of selenium on antifungal activity of secondary metabolites of transformed root cultures of Tropaeolum majus, Schkuhria pinnata and Saussurea nepalensis
Autorzy:
Bogusz, D.
Janas, J.
Wielanek, M.
Sklodowska, M.
Powiązania:
https://bibliotekanauki.pl/articles/81243.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
root culture
Tropaeolum majus
Schkuhria pinnata
Saussurea nepalensis
selenium
antifungal activity
secondary metabolite
glucosinolate
thiarubrine
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 3
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Relationships of the capsaicinoid content between the fruit parts of hot pepper (Capsicum annuum L.)
Relacje w zawartości kapsaicynoidów między częściami owoców papryki ostrej (Capsicum annuum L.)
Autorzy:
Buczkowska, H.
Nurzyńska-Wierdak, R.
Łabuda, H.
Sałata, A.
Powiązania:
https://bibliotekanauki.pl/articles/11543287.pdf
Data publikacji:
2016
Wydawca:
Uniwersytet Przyrodniczy w Lublinie. Wydawnictwo Uniwersytetu Przyrodniczego w Lublinie
Tematy:
relationship
capsaicinoid content
fruit part
hot pepper
Capsicum annuum
Solanaceae
plant cultivar
harvest time
secondary metabolite
Opis:
Capsaicinoids are secondary metabolites characteristic of plants of the genus Capsicum and are only found in the pepper fruit. Their biosynthesis occurs mainly in the placental cells as well as in the interlocular septa of the fruit. In the present study, the content of capsaicinoids (capsaicin and dihydrocapsaicin) was determined by HPLC in two hot pepper cultivars (‘Orkan’ and ‘Bronowicka Ostra’), identifying the percentage of these compounds in the whole fruit and in the following fruit parts: placenta, seeds, pericarp, and pedicle. Significantly more capsaicinoids were found in ‘Bronowicka Ostra’ peppers (262 mg∙kg⁻¹) compared to ‘Orkan’ peppers (175 mg∙kg⁻¹). The highest capsaicin and dihydrocapsaicin content was found in the placenta (401 mg∙kg⁻¹). The capsaicin content in the whole fruit and its parts is on average more than 10 times higher in relation to the dihydrocapsaicin content. Fruit harvest time contributes to the differences in the capsaicinoid content in the individual fruit parts. A higher capsaicin content was shown in the pericarp and seeds, while the dihydrocapsaicin content was higher in the pedicle of peppers harvested at the later date.
Kapsaicynoidy są metabolitami wtórnymi charakterystycznymi tylko dla roślin z rodzaju Capsicum i występują tylko w owocach papryki. Ich biosynteza zlokalizowana jest głównie w komórkach łożyska oraz w przegrodach nasiennych owoców. W niniejszej pracy metodą HPLC oznaczono zawartość kapsaicynoidów (kapsaicyny i dihydrokapsaicyny) w całych owocach i w ich częściach: łożysku, nasionach, perykarpie oraz szypułce dwóch odmian papryki ostrej: Orkan i Bronowicka Ostra. Istotnie więcej kapsaicynoidów oznaczono w owocach odmiany Bronowicka Ostra (262 mg∙kg⁻¹) w porównaniu z owocami odmiany Orkan (175 mg∙kg⁻¹). Największą zawartość kapsaicyny i dihydrokapsaicyny stwierdzono w łożysku (401 mg∙kg⁻¹). Zawartość kapsaicyny w całych owocach oraz w poszczególnych ich częściach była średnio ponad 10-krotnie większa porównaniu z zawartością dihydrokapsaicyny. Terminy zbioru owoców miał wpływ na zróżnicowanie zawartości kapsaicynoidów w poszczególnych częściach owoców. Większą zawartość kapsaicyny wykazano w perykarpie oraz nasionach, a dihydrokapsaicyny w szypułkach owoców z późniejszego terminu zbioru.
Źródło:
Acta Scientiarum Polonorum. Hortorum Cultus; 2016, 15, 4; 185-198
1644-0692
Pojawia się w:
Acta Scientiarum Polonorum. Hortorum Cultus
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Volatile profiles of toxigenic and non-toxigenic Aspergillus flavus using SPME for solid phase extraction
Autorzy:
De, Lucca A J
Boue, S.M.
Carter-Wientjes, C.H.
Bland, J.M.
Bhatnagar, D.
Cleveland, T.E.
Powiązania:
https://bibliotekanauki.pl/articles/50286.pdf
Data publikacji:
2010
Wydawca:
Instytut Medycyny Wsi
Tematy:
Aspergillus flavus
toxigenic strain
non-toxigenic strain
secondary metabolite
aflatoxin
maize
volatile profile
solid-phase microextraction
solid-phase extraction
potato
isolate
Źródło:
Annals of Agricultural and Environmental Medicine; 2010, 17, 2; 301-308
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Recent advances in occupational and environmental health hazards of workers exposed to gasoline compounds
Autorzy:
Ekpenyong, Christopher E.
Asuquo, Asuquo E.
Powiązania:
https://bibliotekanauki.pl/articles/2161925.pdf
Data publikacji:
2017-02-21
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
Oxidative stress
exposure
toxicity
gasoline
humans
reactive metabolite
Opis:
The impact of health and environmental hazards, associated with the constituents of gasoline, on occupationally exposed workers has been recorded over the past few decades. However, the scientific literature on their pathogenic potential remains incomplete, which could affect the current understanding of the associated health risks. This review provides current information based on recently improved research techniques to evaluate gasoline toxicity profiles for humans. Our current knowledge provides insight into the intricate mechanism of gasoline-induced adverse effects, including the formation of reactive metabolites via bio-activation and subsequent generation of reactive oxygen species (ROS) and oxidative stress, which are involved in multiple mechanisms that are central to the aetiology of gasoline-induced toxicity. These mechanisms include covalent binding to deoxyribonucleic acid (DNA), leading to oxidative damage, tumor-suppression gene activity, and activation of pro-oncogenes. Furthermore, it results in induction of autoimmunity and local inflammatory responses, disruption of multiple neurotransmitters and immune cell function, derangement of various enzyme activities (e.g., sodiumpotassium adenosine triphosphate (Na+/K+/ATPase) activity, cytochrome P450 (CYP450), nitric oxide synthase (NOS), antioxidant enzyme activities, etc.), conjugation of bile, and non-specific cell membrane interaction, leading to damage of the membrane lipid bilayer and proteins. Available data suggests that exposure to gasoline or gasoline constituents have the potential to cause different types of illnesses. The data highlights the need to maintain safety measures via suitable research, medical surveillance, regulatory control, life style modification, early detection, and intervention to minimize exposure and manage suspected cases. They also present novel opportunities to design and develop effective therapeutic strategies against gasoline-induced detrimental effects. Int J Occup Med Environ Health 2017;30(1):1–26
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2017, 30, 1; 1-26
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Production of bioactive metabolites from different marine endophytic Streptomyces species and testing them against methicillin-resistant Staphylococcus aureus (MRSA) and cancer cell lines
Autorzy:
El-Gendy, M.M.A.A.
Mohamed, Z.K.
Hekal, N.Z.
Ali, F.M.
Yousef, A.E.M.
Powiązania:
https://bibliotekanauki.pl/articles/81078.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
Staphylococcus aureus
infection
methicillin-resistant Staphylococcus aureus
endophyte
Streptomyces
bioactive metabolite
Actinomycetes
marine invertebrate
anticancer activity
cancer cell line
lung cancer
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2018, 99, 1
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Studies on fungistatic activity of Bacillus coagulans against Trichothecium roseum and characterictics of the bacterial metabolites
Autorzy:
Folkman, W.
Lisiecka, B.
Stachowiak, B.
Trojanowska, K.
Gulewicz, K.
Powiązania:
https://bibliotekanauki.pl/articles/66743.pdf
Data publikacji:
2003
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
alkaloid-rich lupin
fungistatic activity
active metabolite
compost straw
antagonism
Bacillus coagulans
lupin
Trichothecium roseum
bacterial metabolite
Źródło:
Journal of Plant Protection Research; 2003, 43, 2
1427-4345
Pojawia się w:
Journal of Plant Protection Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
In vitro regeneration and secondary metabolites of Viola caspia subsp. sylvestrioides Marcussen
Autorzy:
Gharari, Z.
Sharafi, A.
Bagheri, K.
Yazdinezhad, A.
Bijani, S.
Powiązania:
https://bibliotekanauki.pl/articles/81001.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
Viola caspia ssp.sylvestrioides
medicinal herb
in vitro
regeneration
secondary metabolite
organogenesis
thidiazuron
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2019, 100, 4
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pharmacokinetics of tramadol and metabolites after injective administrations in dogs
Autorzy:
Giorgi, M.
Del Carlo, S.
Lebkowska-Wieruszewska, B.
Kowalski, C.J.
Saccomanni, G.
Powiązania:
https://bibliotekanauki.pl/articles/30304.pdf
Data publikacji:
2010
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
pharmacokinetics
tramadol
metabolite
dog
bioavailability
intravenous injection
intramuscular injection
plasma
tramadol concentration
Opis:
The aim of this study was to determine the pharmacokinetics of tramadol and its main metabolites after IV and IM injections. The pharmacokinetic cross-over study was carried out on 6 healthy male beagle dogs. Tramadol was administered by intravenous (IV) and intramuscular (IM) injection at 4 mg/kg. Tramadol and its main metabolites O-desmethyl-tramadol (M1), N-,N-didesmethyl-tramadol (M2) and N-,O-didesmethyl-tramadol (M5) concentrations were measured in plasma samples by a HPLC coupled with fluorimetric detection; pharmacokinetic evaluations were carried out with a compartmental and non-compartmental model for tramadol and its metabolites, respectively. The bioavailability of the drug, ranging between 84-102% (mean 92%), was within the generally accepted values for a positive bioequivalence decision of (80-125%). After the IM injection the mean plasma drug concentration peak was reached after a Tmax of 0.34 h with a Cmax of 2.52 μg/mL. No therapeutic relevant differences were observed between IM and IV administration. The minimal effective plasma concentration was reached after a few minutes and maintained for about 6-7 h in both administrations. M1 plasma concentration was low and the amounts of the other metabolites produced were analogous in both routes of administration. In conclusion, tramadol was rapidly and almost completely absorbed after IM administration and its systemic availability was equivalent to the IV injection. The different onset time and duration of action observed were very small and probably therapeutically irrelevant. The IM injection is a useful alternative to IV injection in the dog.
Źródło:
Polish Journal of Veterinary Sciences; 2010, 13, 4
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
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