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Wyświetlanie 1-15 z 26
Tytuł:
Interaction of membrane skeletal proteins with membrane lipid domain.
Autorzy:
Sikorski, Aleksander
Hanus-Lorenz, Beata
Jezierski, Adam
Dluzewski, Anton
Powiązania:
https://bibliotekanauki.pl/articles/1044290.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
non-erythroid cells
membrane skeleton
membrane lipid domains
cytoskeleton
red blood cells
Opis:
The object of this paper is to review briefly the studies on the interaction of red blood cell membrane skeletal proteins and their non-erythroid analogues with lipids in model systems as well as in natural membranes. An important question to be addressed is the physiological significance and possible regulatory molecular mechanisms in which these interactions are engaged.
Źródło:
Acta Biochimica Polonica; 2000, 47, 3; 565-578
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Transmembrane segment M2 of glycine receptor as a model system for the pore-forming structure of ion channels.
Autorzy:
Bednarczyk, Piotr
Szewczyk, Adam
Dołowy, Krzysztof
Powiązania:
https://bibliotekanauki.pl/articles/1043689.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
black lipid membrane
ion channels
glycine receptor
Opis:
The glycine receptor belongs to the ligand-gated ion channel superfamily. It is a chloride conducting channel composed of four transmembrane domains. It was previously shown that the second transmembrane domain (M2) of the glycine receptor forms an ion conduction pathway throught lipid bilayers. The amino-acid sequence of the transmembrane segment M2 of the glycine receptor has a high homology to all receptors of the ligand-gated ion channel superfamily. In our report, we have used a synthetic M2 peptide. It was incorporated into a planar membrane of known lipid composition and currents induced by M2 were measured by the Black Lipid Membrane technique. When the planar lipid bilayer was composed of 75% phosphatidylethanolamine and 25% phosphatidylserine, the reversal potential measured in a 150/600 mM KCl (cis/trans) gradient was -19 mV suggesting that the examined pore was preferential to anions, PK/PCl = 0.25. In contrast, when 75% phosphatidylserine and 25% phosphatidylethanolamine was used, the reversal potential was +20 mV and the pore was preferential to cations, PK/PCl = 4.36. Single-channel currents were recorded with two predominant amplitudes corresponding to the main-conductance and sub-conductance states. Both conductance states (about 12 pS and 30 pS) were measured in a symmetric solution of 50 mM KCl. The observed single-channel properties suggest that the selectivity and conductance of the pore formed by the M2 peptide of the glycine receptor depend on the lipid composition of the planar bilayer.
Źródło:
Acta Biochimica Polonica; 2002, 49, 4; 869-875
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Environmental pollution changes in membrane lipids, antioxidants and vitality of Scots pine [Pinus sylvestris L.] pollen
Autorzy:
Pukacki, P M
Chalupka, W.
Powiązania:
https://bibliotekanauki.pl/articles/57005.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Botaniczne
Tematy:
Scotch pine
pollen
pollen grain
Pinus sylvestris
environment pollution
membrane
vitality
fatty acid
antioxidant
freezing stress
membrane lipid
phospholipid
Opis:
Investigations were carried out on pollen grains of Scots pine (Pinus sylvestris L.) collected from trees at 1.5, 3, 4 km and control, 20 km from the Luboń factory producing mineral fertilisers. The percentage of germination of pollen formed close to the pollution source was ca 20% lower compared to the control pollen. Lowered vitality of the pollen was effected in changes of the structure of cytoplasmic membranes. Pollen from the polluted area contained ca 15% less total phospholipids, mainly phosphatidylcholine and phosphatytidylinositol and had a lower content of soluble proteins and less of low molecular antioxidants, such as thiols and ascorbic acid. Composition of total fatty acid in phospholipids fractions showed a significant reduction in the degree of unsaturation of fatty acids. Pollen originating from the polluted area and stored at -30°C showed considerably stronger degradation of cytoplasmic membranes than control.
Źródło:
Acta Societatis Botanicorum Poloniae; 2003, 72, 2
0001-6977
2083-9480
Pojawia się w:
Acta Societatis Botanicorum Poloniae
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The dynamics of the surface layer of lipid membranes doped by vanadium complex : computer modeling and EPR studies
Autorzy:
Olchawa, R.
Man, D.
Pytel, B.
Powiązania:
https://bibliotekanauki.pl/articles/147585.pdf
Data publikacji:
2015
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
EPR probe
lipid membrane
membrane fluidity
Monte Carlo simulation
Opis:
Penetration of the liposome membranes doped with vanadium complex formed in the liquid-crystalline phase from egg yolk lecithin (EYL) by the TEMPO (2,2,6,6-tetramethylpiperidine-1-oxyl) spin probes has been investigated. The penetration process was followed by 360 hours at 24◦C, using the electron spin resonance (EPR) method. The spectroscopic parameter of the partition (F) of this probe indicated that a maximum rigidity of the membrane was at 3% concentration of the vanadium complex. Computer simulations showed that the increase in the rigidity of the membrane corresponds to the closure of gaps in the surface layer of the membrane, and indicates the essential role of the membrane surface in transport processes.
Źródło:
Nukleonika; 2015, 60, No. 3, part 1; 395-398
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Bifunctional surfactants - their potential application as pesticides
Autorzy:
Sarapuk, J.
Powiązania:
https://bibliotekanauki.pl/articles/26511.pdf
Data publikacji:
2000
Wydawca:
Polska Akademia Nauk. Instytut Agrofizyki PAN
Tematy:
new class
surfactant
pesticide
planar lipid membrane
bifunctional surfactant
Źródło:
International Agrophysics; 2000, 14, 3
0236-8722
Pojawia się w:
International Agrophysics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Molecular modelling of membrane activity of amphotericin B, a polyene macrolide antifungal antibiotic
Autorzy:
Baginski, Maciej
Sternal, Kamil
Czub, Jacek
Borowski, Edward
Powiązania:
https://bibliotekanauki.pl/articles/1041370.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
antifungal agents
lipid membrane
cholesterol
amphotericin B
molecular modelling
ergosterol
Opis:
Amphotericin B (AmB) is a well known polyene macrolide antibiotic used to treat systemic fungal infections. Despite its toxicity AmB is still regarded as a life-saving drug. The lack of adequate knowledge of the AmB mechanism of action is a serious obstacle to efficient development of new less toxic derivatives. Complementary to various experimental approaches, computational chemistry methods were used to study AmB mechanism of action. A programme lasting for a decade, that was run by our group covered studies of: i) molecular properties of AmB and its membrane targets, ii) structure and properties of AmB membrane channels, and iii) interaction of AmB with the membrane.
Źródło:
Acta Biochimica Polonica; 2005, 52, 3; 655-658
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of industrial air pollution on membrane lipid composition of Scots pine [Pinus sylvestris L.] needles
Autorzy:
Pukacki, P M
Powiązania:
https://bibliotekanauki.pl/articles/57292.pdf
Data publikacji:
2004
Wydawca:
Polskie Towarzystwo Botaniczne
Tematy:
Scotch pine
needle
industrial pollution
Polska
air pollution
Pinus sylvestris
Kornik area
fatty acid
membrane lipid
phospholipid
composition
heavy metal
Opis:
This work was undertaken to determine lipids changes in needles of Scots pine (Pinus sylvestris L.) populations growning on polluted stands near a phosphate fertilizer factory in Luboń, and copper smelter in Głogów and in a control area in Kórnik. Needles from polluted areas had a lower content of total phospholipids than samples from the unpolluted site. Greater changes were detected in membranes of needles collected in October and January. In comparison with the control total phospholipid in needles of populations from polluted areas were 14 to 33% lower. Phosphatidylcholine (PC) phosphatidylethanolamine (PE) and phosphatidylglicerol (PG) were the dominant phospholipids. The analysis of fatty acids in phospholipid fraction showed a decrease of linoleic acid (18:2) and linolenic acid (18:3) contents. The level of polyunsaturated fatty acids in needles of three populations from polluted areas was up to 40% lower as compared with the control. Moreover, phospholipids and their fatty acids showed seasonal fluctuations. The contents of PC, PG and PE increased in autumn and in winter, during the process of cold acclimation. In July, current-year needles did not show significant differences in membrane lipid composition between the polluted areas of Scots pine populations. The results suggest that the lipid changes of needles could be associated with disturbances in phohospholipid metabolism, caused by environmental pollution.
Źródło:
Acta Societatis Botanicorum Poloniae; 2004, 73, 3
0001-6977
2083-9480
Pojawia się w:
Acta Societatis Botanicorum Poloniae
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Physicochemical analysis of phosphatidylcholine-ceramide system in bilayer lipid membranes
Autorzy:
Naumowicz, Monika
Petelska, Aneta
Figaszewski, Zbigniew
Powiązania:
https://bibliotekanauki.pl/articles/1040678.pdf
Data publikacji:
2008
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
equilibrium
ceramide
complex formation
electrochemical impedance spectroscopy
phosphatidylcholine
bilayer lipid membrane
Opis:
Electrochemical impedance spectroscopy was used for the study of two-component lipid membranes. Phosphatidylcholine and ceramide were to be investigated, since they play an important biochemical role in cell membranes. The research on biolipid interaction was focused on quantitative description of processes that take part in a bilayer. Assumed models of interaction between amphiphilic molecules and the equilibria that take place there were described by mathematical equations for the studied system. The possibility of complex formation for two-component system forming bilayers was assumed that could explain the deviation from additivity rule. Equilibria were described by mathematical equations that were further verified experimentally. The determined values of parameters (stability constant, molecular area of complex, capacitance and conductance of the lipid membranes formed from molecules and complexes) were used for calculation of model curves. The comparison of model curves and experimental points verified the assumed model.
Źródło:
Acta Biochimica Polonica; 2008, 55, 4; 721-730
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wpływ anestetyków wziewnych na modelową błonę biologiczną
Influence of inhalation anesthetics on a model biological membrane
Autorzy:
Horochowska, Martyna
Cieślik-Boczula, Katarzyna
Rospenk, Maria
Powiązania:
https://bibliotekanauki.pl/articles/171702.pdf
Data publikacji:
2019
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
anestetyki wziewne
anestezja
słabe oddziaływania międzycząsteczkowe
błona lipidowa
inhalation anesthetics
anesthesia
weak intermolecular interactions
lipid membrane
Opis:
General anesthesia is defined as impairment of the central nervous system (UON) caused by intravenous or volatile anesthetics. The state of loss of consciousness or even amnesia and the disappearance of perception into external stimuli is achieved by the use of a large group of chemical compounds. The use of nitrous oxide in 1844 revolutionized surgery and medicine at that time. From that moment, anesthesiology develops dynamically, allowing more and more complex procedures. Despite more than 170 years of history of anesthesia, understanding the mechanism of reversible loss of awareness and sensitivity to pain caused by the action of general anesthetics is one of the greatest challenges of modern pharmacology and neuroscience. Incredibly high diversity of anesthetics, including both noble gases and complex steroids, combined with human sensation makes the above problem extremely difficult to solve. The reversibility of the anesthesia phenomenon suggests that the analyzed phenomenon is based on disturbance of weak intermolecular interactions, such as hydrogen bond or van der Walls forces. Anesthetic molecules may bind directly to the hydrophobic region of protein, which causes its conformational changes or disturb ion channel activity by anesthetic-induced perturbations of lipid bilayers. The mechanism of anesthesia is thus very often attributed to both protein and lipid membrane targets. The influence of anesthetic molecules on biomolecular systems can be studied successfully using many different physico-chemical methods, such as, infrared, fluorescence or nuclear magnetic resonance spectroscopy. Vibrational circular dichroism as well as differential scanning calorimetry can also be used.
Źródło:
Wiadomości Chemiczne; 2019, 73, 3-4; 263-285
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Electron tomography technique – useful tool for plasmodesmata ultrastructure analysis in maize leaves
Autorzy:
Bilska, A.
Suski, S.
Sowinski, P.
Powiązania:
https://bibliotekanauki.pl/articles/80747.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
plasmodesma
cytoplasmic microchannel
plant cell
protein-lipid membrane
ultrastructure analysis
maize
leaf
electron tomography technique
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 3
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Lipid-binding proteins as stabilizers of membrane microdomains - possible physiological significance.
Autorzy:
Bandorowicz-Pikuła, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1044288.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
lipid-protein interactions
lipid-binding proteins
membrane microdomains
Opis:
Below the melting point temperature of lipids, artificial lipid membranes usually exist in the ordered gel phase. Above these temperatures lipid acyl chains become fluid and disordered (liquid-crystalline phase). Depending on the chemical composition of artificial membranes, phase separation may occur, leading to the formation of transient or stable membrane domains. A similar phase separation of lipids into ordered and disordered domains has been observed in natural membranes at physiological temperature range. Moreover, it has been reported that certain proteins prefer certain organization of lipids, as for example glycosylphosphatidylinositol-anchored proteins or Src family of tyrosine kinases. The aim of present review is to discuss the possibility that some lipid microdomains are induced or stabilized by lipid-binding proteins that under certain conditions, for example due to a rise of cytosolic Ca2+ or pH changes, may attach to the membrane surface, inducing clustering of lipid molecules and creation of ordered lipid microdomains. These domains may than attract other cytosolic proteins, either enzymes or regulatory proteins. It is, therefore, postulated that lipid microdomains play important roles within a cell, in signal transduction and enzymatic catalysis, and also in various pathological states, as Alzheimer's disease, anti-phosphatidylserine syndrome, or development of multidrug resistance of cancer cells.
Źródło:
Acta Biochimica Polonica; 2000, 47, 3; 553-564
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Physical properties of lipid bilayer membranes: relevance to membrane biological functions.
Autorzy:
Subczynski, Witold
Wisniewska, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1044298.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
lipid exchange
hydrophobic barrier
oxygen transport
lipid unsaturation
membrane domains
lipid bilayer
Opis:
Over the last 25 years one of us (WKS) has been investigating physical properties of lipid bilayer membranes. In 1991 a group led by WKS was organized into the Laboratory of Structure and Dynamics of Biological Membranes, the effective member of which is AW. Using mainly the electron paramagnetic resonance (EPR) spin-labeling method, we obtained unexpected results, which are significant for the better understanding of the functioning of biological membranes. We have developed a new pulse EPR spin-labeling method for the detection of membrane domains and evaluation of lipid exchange rates. This review will be focused on our main results which can be summarized as follows: (1) Unsaturation of alkyl chains greatly reduces the ordering and rigidifying effects of cholesterol although the unsaturation alone gives only minor fluidizing effects, as observed by order and reorientational motion, and rather significant rigidifying effects, as observed by translational motion of probe molecules; (2) Fluid-phase model membranes and cell plasma membranes are not barriers to oxygen and nitric oxide transport; (3) Polar carotenoids can regulate membrane fluidity in a way similar to cholesterol; (4) Formation of effective hydrophobic barriers to the permeation of small polar molecules across membranes requires alkyl chain unsaturation and/or the presence of cholesterol; (5) Fluid-phase micro-immiscibility takes place in cis-unsaturated phosphatidylcholine-cholesterol membranes and induces the formation of cholesterol-rich domains; (6) In membranes containing high concentrations of transmembrane proteins a new lipid domain is formed, with lipids trapped within aggregates of proteins, in which the lipid dynamics is diminished to the level of gel-phase.
Źródło:
Acta Biochimica Polonica; 2000, 47, 3; 613-625
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Phosphatidic acid - a simple phospholipid with multiple faces
Autorzy:
Zegarlińska, Jolanta
Piaścik, Magda
Sikorski, Aleksander
Czogalla, Aleksander
Powiązania:
https://bibliotekanauki.pl/articles/1038384.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
phosphatidic acid
protein-lipid interaction
signaling
membrane curvature
membrane model systems
Opis:
Phosphatidic acid (PA) is the simplest glycerophospholipid naturally occurring in living organisms, and even though its content among other cellular lipids is minor, it is drawing more and more attention due to its multiple biological functions. PA is a precursor for other phospholipids, acts as a lipid second messenger and, due to its structural properties, is also a modulator of membrane shape. Although much is known about interaction of PA with its effectors, the molecular mechanisms remain unresolved to a large degree. Throughout many of the well-characterized PA cellular sensors, no conserved binding domain can be recognized. Moreover, not much is known about the cellular dynamics of PA and how it is distributed among subcellular compartments. Remarkably, PA can play distinct roles within each of these compartments. For example, in the nucleus it behaves as a mitogen, influencing gene expression regulation, and in the Golgi membrane it plays a role in membrane trafficking. Here, we discuss how a biophysical experimental approach enabled PA behavior to be described in the context of a lipid bilayer and to what extent various physicochemical conditions may modulate the functional properties of this lipid. Understanding these aspects would help to unravel specific mechanisms of PA-driven membrane transformations and protein recruitment and thus would lead to a clearer picture of the biological role of PA.
Źródło:
Acta Biochimica Polonica; 2018, 65, 2; 163-171
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Alzheimers disease: Its origin at the membrane, evidence and questions.
Autorzy:
Buchet, Rene
Pikuła, Sławomir
Powiązania:
https://bibliotekanauki.pl/articles/1044315.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
β-amyloid precursor protein
membrane proteases
Alzheimer's disease
lipid composition
membrane microdomains
Opis:
Numerous results on membrane lipid composition from different regions of autopsied Alzheimer's disease brains in comparison with corresponding fractions isolated from control brains revealed significant differences in serine- and ethanolamine-containing glycerophospholipid as well as in glycosphingolipid content. Changes in membrane lipid composition are frequently accompanied by alterations in membrane fluidity, hydrophobic mismatch, lipid signaling pathways, transient formation and disappearance of lipid microdomains, changes in membrane permeability to cations and variations of other membrane properties. In this review we focus on possible implications of altered membrane composition on β-amyloid precursor protein (APP) and on proteolysis of APP leading eventually to the formation of neurotoxic β-amyloid (Aβ) peptides, the major proteinaceous component of extracellular senile plaques, directly involved in Alzheimer's disease pathogenesis.
Źródło:
Acta Biochimica Polonica; 2000, 47, 3; 725-733
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Membrane lipids under norm and pathology
Autorzy:
Marzoog, Basheer Abdullah
Ivanovna Vlasova, Tatyana
Powiązania:
https://bibliotekanauki.pl/articles/2040262.pdf
Data publikacji:
2021-03-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
cholesterol
lipid distress syndrome
membrane lipids, peroxidation phosphatidylcholine plasmenylethanolamine
Opis:
Introduction. Lipid is an essential component of the cell and its organelles membrane. The uniqueness and selectivity of lipids to specific functions and asymmetry of lipid distribution in the organelle’s membrane give the cell ability of being highly qualified and specified. Aim. The paper provides a comprehensive review of membrane lipids in different tissues and organelles of the cell in norm and disease. Material and methods. The paper analyzed the present literature data on membrane lipids behavior in physiology and pathology. Analysis of the literature. The major structural and functional lipids of the cell membrane are phosphatidylcholine > phosphatidylethanolamine. The absence/deficiency or augmentation of a specific type of lipid results in serious defects and usually life-threatening with a permanent disability. The observations discussed here suggest, the lipid peroxidation severity depends on the membrane lipid composition of the cell. Some tissue cells can handle lipoperoxidation and protect themselves from the peroxidation damaging products better, while other cells cannot compensate. Therefore, some organs are highly sensitive to peroxidation and irreversible changes occur rapidly. Conclusion. To sum up, the understanding of lipid’s role in norm and disease is clinically crucial to evaluate a novel therapeutic target to treat many metabolic disorders such as metabolic syndrome and some lysosomal storage disorders via targeting specific new signaling pathways, lipid molecules, and enzymes
Źródło:
European Journal of Clinical and Experimental Medicine; 2021, 1; 59-75
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 26

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