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Tytuł:
Inhibition of tumor growth by interleukin 10 gene transfer in B16(F10) melanoma cells
Autorzy:
Walos, Sylwia
Szary, Jarosław
Szala, Stanisław
Powiązania:
https://bibliotekanauki.pl/articles/1044456.pdf
Data publikacji:
1999
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
B16(F10) murine melanoma
antiangiogenic effect
interleukin 10
Opis:
Interleukin 10 (IL-10) is a potent immunosuppressive cytokine with an antitumor activity. The effect of IL-10 on tumor growth was tested in murine melanoma cells manipulated by gene transfer to secrete IL-10. In mice bearing B16(F10) tumors expressing IL-10  tumor growth was decreased depending on the amount of secreted IL-10.
Źródło:
Acta Biochimica Polonica; 1999, 46, 4; 967-970
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Tritolylporphyrin dimer as a new potent hydrophobic sensitizer for photodynamic therapy of melanoma.
Autorzy:
Drzewiecka, Agnieszka
Urbańska, Krystyna
Matuszak, Zenon
Pineiro, Marta
Arnaut, Luis
Habdas, Jan
Ratuszna, Alicja
Stochel, Grażyna
Powiązania:
https://bibliotekanauki.pl/articles/1044198.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
melanoma
porphyrins
photodynamic therapy
Opis:
We report the synthesis, photochemical and photophysical properties and preliminary studies on biological effect of a new tritolylporphyrin dimer (T-D). Absorption and emission properties of T-D suggest its possible use in photodynamic therapy. T-D is capable of singlet oxygen production with 0.8 quantum yield. It also has a high photostability. The photodynamic properties of the dimer were examined following the growth of SKMEL 188 (human melanoma) cells irradiated with red light (cut off <630 nm). The surviving fraction of the cells decreased about 3-fold (vs. non-irradiated cells) for an 81 J/cm2 dose. Our results suggest that tritolylporphyrine dimer T-D may be an interesting hydrophobic sensitizer for photodynamic therapy.
Źródło:
Acta Biochimica Polonica; 2001, 48, 1; 277-282
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of mutations in the p16/ CDKN2A gene in sporadic and familial melanoma in the Polish population.
Autorzy:
Lamperska, Katarzyna
Karczewska, Aldona
Kwiatkowska, Eliza
Mackiewicz, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/1043764.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
familial melanoma
melanoma
mutations
CDKN2A
Opis:
Mutations in CDKN2A have been found in sporadic cutaneous malignant (CMM), in familial CMM and in other syndromes associated with melanoma. In this study DNA was obtained from 207 individuals and five cell lines. There were 157 CMM patients and 50 healthy members of melanoma patients families. The CMM group included patients with one or two melanoma cases in the family, families with dysplastic nevus syndrom (DNS) and patients with a spectrum of other types of cancers in the family. PCR-SSCP analysis and sequencing identified: six substitutions in codon 58 CGA/TGA (Arg/Stop), 16 substitutions GAC/GAT in codon 84 (Asp/Asp), six substitutions CGA /TGA in codon 148 (Arg/Thr), 14 substitutions G/C in 3'UTR and 4 double changes (two in codon 84 and 3'UTR; two in codon 148 and 3'UTR). The mutation identified in codon 58 was found in tissue only. Other substitutions were polymorphisms found in DNA from tissue and blood samples. Most of them were identified in sporadic CMM (six in codon 148 Ala /Thr, 12 in codon 84 Asp/Asp and six in 3'UTR). The frequency of the polymorphisms was also high in DNS and CMM/DNS families (four in codon 84 Asp/Asp and six in 3'UTR). No mutations or polymorphisms were found in CMM patients with one or two melanoma cases and CMM patients, with other cancers in family history. The analysis of the CDKN2A gene mutations in the Polish population demonstrated: (i) no germline mutations; (ii) a relatively high number of genetic changes in sporadic melanoma; (iii) a high number of polymorphisms in DNS and CMM/DNS families.
Źródło:
Acta Biochimica Polonica; 2002, 49, 2; 369-376
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Carbohydrate moieties of N-cadherin from human melanoma cell lines.
Autorzy:
Ciołczyk-Wierzbicka, Dorota
Gil, Dorota
Hoja-Łukowicz, Dorota
Lityńska, Anna
Laidler, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1043705.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
melanoma
N-cadherin
N-glycans
Opis:
Expression of N-cadherin an adhesion molecule of the cadherin family, in tumor cells is associated with their increased invasive potential. Many studies suggested the role of N-linked oligosaccharides as important factors that contribute to metastasis by influencing tumor cell invasion and adhesion. N-cadherin is a heavily glycosylated protein. We have analysed the carbohydrate profile of this protein synthesized in human melanoma cell lines: WM35 from the primary tumor site and WM239, WM9, and A375 from different metastatic sites. N-cadherin was immunoprecipitated with anti-human N-cadherin polyclonal antibodies. Characterisation of its carbohydrate moieties was carried out by SDS/PAGE electrophoresis and blotting, followed by immunochemical identification of the N-cadherin polypeptides and analysis of their glycans using highly specific digoxigenin or biotin labelled lectins. The positive reaction of N-cadherin from the WM35 cell line with Galanthus nivalis agglutinin (GNA), Datura stramonium agglutinin (DSA) and Sambucus nigra agglutinin (SNA) indicated the presence of high-mannose type glycans and biantennary complex type oligosaccharides with α2-6 linked sialic acid. N-cadherin from WM239, WM9, and A375 cell lines gave a positive reaction with Phaseolus vulgaris leukoagglutinin (L-PHA) and lotus Tetragonolobus purpureas agglutinin (LTA). This indicated the presence of tri- or tetra-antennary complex type glycans with α-fucose. In addition, N-cadherin from WM9 (lymphomodus metastatic site) and A375 (solid tumor metastatic site) contained complex type chains with α2-3 sialic acid (positive reaction with Maackia amurensis agglutinin - MAA). The results demonstrated that N-glycans of N-cadherin are altered in metastatic melanomas in a way characteristic for invasive tumor cells.
Źródło:
Acta Biochimica Polonica; 2002, 49, 4; 991-998
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Expression of p16 in sporadic primary uveal melanoma.
Autorzy:
Lamperska, Katarzyna
Mackiewicz, Krystyna
Kaczmarek, Aldona
Kwiatkowska, Eliza
Starzycka, Maria
Romanowska, Bożena
Heizman, Janina
Stachura, Jerzy
Mackiewicz, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/1043765.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
sporadic primary uveal melanoma
mutations
p16 protein
Opis:
Expression of p16 protein, intragenic mutations of CDKN2A and hypermethylation of CDKN2A promoter region in 41 sporadic primary uveal melanomas were studied. There were 2 cases of spindle cell B histological type, 11 of A + B and 28 of mixed type. All melanomas infiltrated sclera but in 28 cases infiltration was superficial while in 13 profound. In 7 cases the tumor infiltrated the optic nerve. Expression of p16 was studied by immunohistochemistry and recorded by assessment of the proportion of positive tumor cells and staining intensity. Results were expressed as staining index (IRS). Intragenic mutations were studied by PCR-SSCP followed by sequencing, while hypermethylation of the promoter region by CpG methylation assay. In 15% of cases less than 10% of melanoma cells were p16 positive, in 70% of cases less than 50% of cells, while in 7% more than 80% of cells stained for p16 (mean IRS for all cases was 4.87 ± 2.43). In B type the IRS was 8.5 ± 0.7, in A + B type 6.0 ± 2.1 and in the mixed type 4.17 ± 2.43 (differences statistically significant). In melanomas profoundly infiltrating sclera mean IRS was 4.16, while in those infiltrating optic nerve 3.71 (statistically not significant). Analysis of the intragenic mutations revealed in two patients a GAC/GAT substitution in codon 84 - a silent mutation. No hypermethylation of the CpG island of the p16 promoter region was found. In conclusion, we found that the degree of p16 expression is related to the histological type of tumor but not to the histological indicators of tumor invasiveness and that intragenic mutations and promoter hypermethylation are not major mechanisms of p16 inactivation in sporadic uveal melanoma.
Źródło:
Acta Biochimica Polonica; 2002, 49, 2; 377-385
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Expression of PiT1 and PiT2 retroviral receptors and transduction efficiency of tumor cells*.
Autorzy:
Grabarczyk, Piotr
Wysocki, Piotr
Gryska, Katarzyna
Mackiewicz, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/1043759.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
renal carcinoma
retroviral vectors
PiT1 and PiT2 retroviral receptors
human melanoma
Opis:
Recombinant retroviral vectors are still the most common gene delivery vehicles for gene therapy purposes, especially for construction of genetically modified tumor vaccines (GMTV). However, these vehicles are characterized by relatively low titre and in the case of many tumor cell lines, low transduction efficiency. We constructed bicistronic retroviral vector pseudotypes of amphotropic murine leukemia virus (A-MuLV) and gibbon ape leukemia virus (GaLV), encoding enhanced green fluorescent protein (EGFP) as a rapid and easily detectable reporter gene. Transduction of five different human melanoma and four renal carcinoma cell lines by these two virus pseudotypes revealed differences in transduction efficiency, which wase markedly lower for the renal carcinoma cell lines. Stimulation of retroviral receptor expression (PiT1 and PiT2) by phosphate depletion induced a limited increase of receptor mRNA levels, but did not improve the gene transfer efficiency. In contrast, simultaneous transduction with both vector pseudotypes markedly increased the transduction efficiency, compared to GaLV or A-MuLV alone. The same effect could be achieved by several repeated exposures of target cells to fresh vector preparation. Overexpression of GaLV receptor (PiT1) in target cells significantly increased the transduction rate and enabled retrovirus mediated gene transfer into the cells which normally are not transducible by GaLV pseudotypes. We demonstrated that, using different transduction strategies, the relatively inefficient, widely used retroviral vector systems could be significantly improved.
Źródło:
Acta Biochimica Polonica; 2002, 49, 2; 333-339
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Indocyanine green as a prospective sensitizer for photodynamic therapy of melanomas.
Autorzy:
Urbanska, Krystyna
Romanowska-Dixon, Bożena
Matuszak, Zenon
Oszajca, Janusz
Nowak-Sliwinska, Patrycja
Stochel, Grażyna
Powiązania:
https://bibliotekanauki.pl/articles/1043767.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
melanoma
photodynamic therapy
indocyanine green
Opis:
Spectroscopic, photochemical and biological properties of indocyanine green (ICG) are presented. Light over 800 nm is effectively absorbed by ICG. This property as well as photochemical behaviour of ICG make it a very suitable dye for photodynamic treatment of melanoma cells. Cytotoxicity of ICG itself and the effect of photodynamic therapy (PDT) were evaluated by following the growth of human (SKMEL 188) and mouse (S91) melanoma cells. The surviving fraction of the cells irradiated (λex = 830 nm) vs non-irradiated, treated with the same dose of ICG, is significantly decreased (5- to 10-fold). These results show that ICG is a very promising dye for photodynamic therapy of melanomas.
Źródło:
Acta Biochimica Polonica; 2002, 49, 2; 387-391
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Diagnosing skin melanoma: current versus future directions
Autorzy:
Hippe, Z. S.
Bajcar, S.
Blajdo, P.
Grzymała-Busse, J. P.
Grzymała-Busse, J. W.
Knap, M.
Paja, W.
Wrzesień, M.
Powiązania:
https://bibliotekanauki.pl/articles/1954638.pdf
Data publikacji:
2003
Wydawca:
Politechnika Gdańska
Tematy:
melanoma
TDS
machine learning in diagnosis
Opis:
A new database containing 410 cases of nevi pigmentosi, in four categories: benign nevus, blue nevus, suspicious nevus and melanoma malignant, carefully verified by histopathology, is described. The database is entirely different from the base presented previously, and can be readily used for research based on the so-called constructive induction in machine learning. To achieve this, the database features a different set of thirteen descriptive attributes, with a fourteenth additional attribute computed by applying values of the remaining thirteen attributes. In addition, a new program environment for the validation of computer-assisted diagnosis of melanoma, is briefly discussed. Finally, results are presented on determining optimal coefficients for the well-known ABCD formula, useful for melanoma diagnosis.
Źródło:
TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk; 2003, 7, 2; 289-293
1428-6394
Pojawia się w:
TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Photodynamic effects of two water soluble porphyrins evaluated on human malignant melanoma cells in vitro.
Autorzy:
Szurko, Agnieszka
Krämer-Marek, Gabriela
Wideł, Maria
Ratuszna, Alicja
Habdas, Jan
Kuś, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1043409.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
malignant melanoma
tumour megacolonies in vitro
necrosis
photodynamic therapy
synthetic porphyrins
apoptosis
Opis:
Two water soluble porphyrins: meso-tetra-4-N-methylpyridyl-porphyrin iodide (P1) and 5,10-di-(4-acetamidophenyl)-15,20-di-(4-N-methylpyridyl) porphyrin (P2) were synthesised and evaluated in respect to their photochemical and photophysical properties as well as biological activity. Cytotoxic and phototoxic effects were evaluated in human malignant melanoma Me45 line using clonogenic assay, cytological study of micronuclei, apoptosis and necrosis frequency and inhibition of growth of megacolonies. Both porphyrins were characterised by high UV and low visible light absorptions. Dark toxicity measured on the basis of the clonogenic assay and inhibition of megacolony growth area indicated that P1 was non-toxic at concentrations up to 50 μg/ml (42.14 μM) and P2 at concentrations up to 20 μg/ml (16.86 μM). The photodynamic effect induced by red light above 630 nm indicated that both porphyrins were able to inhibit growth of melanoma megacolonies at non-toxic concentrations. Cytologic examination showed that the predominant mode of cell death was necrosis.
Źródło:
Acta Biochimica Polonica; 2003, 50, 4; 1165-1174
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Recombinant angioarrestin secreted from mouse melanoma cells inhibits growth of primary tumours
Autorzy:
Smagur, Andrzej
Szary, Jarosław
Szala, Stanisław
Powiązania:
https://bibliotekanauki.pl/articles/1041334.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
melanoma
angioarrestin
anti-angiogenic factor
Opis:
Angioarrestin is a recently described anti-angiogenic protein whose expression is down-regulated in solid tumours of various origins. It has a sequence identical to angiopoietin related protein-1. In this study we investigated anti-tumour properties of angioarrestin in B16 (F10) melanoma tumour model. We constructed an expression vector encoding human angioarrestin under the control of EF-1α promoter. This vector was transferred to B16 (F10) cells and recombinant angioarrestin secreted from the transfected cells was tested for anti-angiogenic activity using endothelial cell proliferation assay. Finally, mice were injected subcutaneously with cells that had been transfected with either angioarrestin-encoding vector or empty vector and tumor growth was compared. The obtained recombinant angioarrestin inhibited proliferation of bovine aortic endothelial cells. Tumours derived from an angioarrestin-secreting B16 (F10) cell clone grew in vivo more slowly than tumours derived from a cell clone transfected with empty vector. These data show, to our knowledge for the first time, that angioarrestin can inhibit primary melanoma tumour growth.
Źródło:
Acta Biochimica Polonica; 2005, 52, 4; 875-879
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Up-regulation of human PNPase mRNA by β-interferon has no effect on protein level in melanoma cell lines
Autorzy:
Gewartowski, Kamil
Tomecki, Rafal
Muchowski, Lukasz
Dmochowska, Aleksandra
Dzwonek, Artur
Malecki, Michal
Skurzak, Henryk
Ostrowski, Jerzy
Stepien, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1041287.pdf
Data publikacji:
2006
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
polynucleotide phosphorylase
melanoma
human mitochondria
beta interferon
poly(A) tails
PNPase
Opis:
Human mitochondrial polynucleotide phosphorylase (hPNPase) is an exoribonuclease localized in mitochondria. The exact physiological function of this enzyme is unknown. Recent studies have revealed the existence of a relationship between induction of hPNPase mRNA and both cellular senescence and growth arrest of melanoma cells following β-interferon treatment. The aim of this study was to verify whether the augmented hPNPase mRNA level results in increase of the protein level. In several cell lines established from five metastatic melanoma patients we did not find any such correlation. However, an elevated level of hPNPase protein was observed in interferon-induced HeLa and Jurkat cells. This increase was correlated with a slight shortening of poly(A) tails of mitochondrial ND3 transcript.
Źródło:
Acta Biochimica Polonica; 2006, 53, 1; 179-188
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The CDKN2a common variants: 148 Ala/Thr and 500 C/G in 3 UTR, and their association with clinical course of melanoma
Autorzy:
Lamperska, Katarzyna
Przybyła, Anna
Kycler, Witold
Mackiewicz, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/1041123.pdf
Data publikacji:
2007
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
melanoma
statistical analysis
CDKN2a polymorphisms
3' UTR
Opis:
Changes in CDKN2a gene are known to be linked with sporadic melanoma and hereditary predisposition to this cancer. In the Polish population mutations in the coding region of the CDKN2a gene are rather rare, therefore the attention has been focused on polymorphisms and alterations in uncoding regions such as 3' UTR. The aim of this study was to analyze two common polymorphisms, Ala148Thr and 500 C/G, and correlate them with the clinical course of melanoma. DNA from 285 patients was analyzed and found polymorphisms were correlated with the clinical parameters employing statistical methods. The obtained results allow us to conclude: (i) survival times of 500 C/G carriers vs. cumulating proportion surviving was not statistically significant; (ii) CDKN2a polymorphism 500 C/G correlated with Ala148Thr; (iii) no correlation was observed between the 500 C/G polymorphism and age of diagnosis, localization of primary melanoma and survival time; (iv) we did not find correlation between 500 C/G and type of cancer in the family; (v) changes in the CDKN2a gene were not found in patients with second cancer.
Źródło:
Acta Biochimica Polonica; 2007, 54, 1; 119-124
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Antitumoral effect of IL-12 gene transfected via liposomes into B16F0 cells
Autorzy:
Speroni, Lucía
Gasparri, Julieta
de los A. Bustuoabad, Victoria
Chiaramoni, Nadia
Smagur, Andrzej
Szala, Stanisław
Taira, María
del V. Alonso, Silvia
Powiązania:
https://bibliotekanauki.pl/articles/1040572.pdf
Data publikacji:
2009
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
stearylamine
liposomes
B16F0 cells
B16 melanoma
IL-12
Opis:
Murine melanoma B16F0 cells were transfected with SA:DPPC:DOPE (2:1:1 molar ratio) liposomes associated with a plasmid encoding murine IL-12. Stearylamine, a cationic lipid, showed a greater transfection efficiency compared to DOTAP-containing liposomes. The lipid:DNA ratio was 2:1 (w/w). Control groups were mock transfected or transfected with an empty plasmid (pNeo). pNeo or IL-12 transfected cells and controls were inoculated intradermically into the dorsal region of the foot or the lateral flank of C57BL6 mice. Results showed that IL-12 expression had a marked effect on in vivo growth of B16 melanoma tumors developed in both anatomic sites, significantly retarding their growth and prolonging host survival.
Źródło:
Acta Biochimica Polonica; 2009, 56, 2; 249-253
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Chimeric protein ABRaA-VEGF121 is cytotoxic towards VEGFR-2-expressing PAE cells and inhibits B16-F10 melanoma growth
Autorzy:
Smagur, Andrzej
Boyko, Mariya
Biront, Nadiya
Cichoń, Tomasz
Szala, Stanisław
Powiązania:
https://bibliotekanauki.pl/articles/1040641.pdf
Data publikacji:
2009
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
melanoma B16-F10
abrin-a A-chain
chimeric protein
VEGF121
Opis:
It has been known that VEGF121 isoform can serve as a carrier of therapeutic agents targeting tumor endothelial cells. We designed and constructed synthetic cDNA that encodes a chimeric protein comprising abrin-a (ABRaA) toxin A-chain and human VEGF121. Expression of the ABRaA-VEGF121 chimeric protein was carried out in E. coli strain BL21(DE3). ABRaA-VEGF121 preparations were isolated from inclusion bodies, solubilized and purified by affinity and ion-exchanged chromatography (Ni-agarose and Q-Sepharose). Finaly, bacterial endotoxin was removed from the recombinant protein. Under non-reducing conditions, the recombinant protein migrates in polyacrylamide gel as two bands (about 84 kDa homodimer and about 42 kDa monomer). ABRaA-VEGF121 is strongly cytotoxic towards PAE cells expressing VEGFR-2, as opposed to VEGFR-1 expressing or parental PAE cells. The latter are about 400 times less sensitive to the action of this fusion protein. The biological activity of the ABRaA domain forming part of the chimeric protein was assessed in vitro: ABRaA-VEGF121 inhibited protein biosynthesis in a cell-free translation system. Preincubation of ABRaA-VEGF121 with antibody neutralizing the biological activity of human VEGF abolished the cytotoxic effect of the chimeric protein in PAE/KDR cells. Experiments in vivo demonstrated that ABRaA-VEGF121 inhibits growth of B16-F10 murine melanoma tumors.
Źródło:
Acta Biochimica Polonica; 2009, 56, 1; 115-124
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Sztuczne źródła promieniowania słonecznego jako czynnik ryzyka nowotworów skóry
Artificial solar radiation as a risk factor for skin tumor
Autorzy:
Woźniak-Holecka, Joanna
Holecki, Tomasz
Rokicka, Urszula
Powiązania:
https://bibliotekanauki.pl/articles/1039992.pdf
Data publikacji:
2009
Wydawca:
Śląski Uniwersytet Medyczny w Katowicach
Tematy:
promieniowanie ultrafi oletowe
sztuczne źródła promieniowania
nowotwory skóry
czerniak złośliwy (melanoma malignum)
edukacja zdrowotna
czynnik ryzyka
uv radiation
skin tumor
malignant melanoma (melanoma malignum)
health education
risk
factor
Opis:
Up to the ’70 one noticed mainly positive influence of solar radiation, and its component UV radiation. Only in next decade solar radiation was recognized as a main cause of many pathological skin changes, herein malicious tumor. At the same time there was a belief that using sun bathing beds is safe in relation to solar radiation. Nowadays in many countries it is recommended to popularize knowledge about the dangers of solariums, especially among youth. United States and Germany implemented restrictions forbidding under aged using sun beds without parental consent. Great Britain or Sweden are planning similar restrictions. Due to the latest scientific research published by the Lancet Oncology, starting using solarium sun bathing under 30 increases the skin cancer probability up to 70%. It was also proved that every solar radiation is carcinogenic, even though previously only UV-UVB was thought as carcinogenic.
Do lat 70-tych XX wieku dostrzegano głównie pozytywne aspekty oddziaływania promieniowania słonecznego, w tym i jego składowej - promieniowania ultrafi oletowego (UV) na zdrowie, propagowano właściwości przeciwkrzywicze światła słonecznego w kontekście roli jaką odgrywa w produkcji witaminy D3. Dopiero w następnym dziesięcioleciu promieniowanie słoneczne zostało uznane za czynnik sprawczy wielu zmian patologicznych w obrębie skóry, w tym nowotworów złośliwych. Jednocześnie uznawano, iż korzystanie z łóżek opalających jest bezpieczne w relacji do promieniowania słonecznego. Obecnie w wielu krajach zaleca się upowszechnianie wiedzy o potencjalnym niebezpieczeństwie opalania w solariach, zwłaszcza wśród młodzieży. W Stanach Zjednoczonych i Niemczech już wprowadzono restrykcyjne zakazy uniemożliwiające korzystanie z łóżek opalających przez młodzież do 18 roku życia, bez zgody opiekunów. Podobne obostrzenia są planowane w innych krajach np. Wielkiej Brytanii, Szwecji. W świetle najnowszych doniesień naukowych opublikowanych w Lancet Oncology szacuje się iż u osób, które zaczynają korzystać z solarium przed ukończeniem 30-go roku życia, ryzyko zachorowania na raka skóry wzrasta do 70%. Wykazano ponadto, że wszystkie typy promieniowania ultrafioletowego są rakotwórcze, podczas gdy dotąd sądzono, że niebezpieczny jest tylko jeden typ promieniowania UV – UVB.
Źródło:
Annales Academiae Medicae Silesiensis; 2009, 63, 6; 75-80
1734-025X
Pojawia się w:
Annales Academiae Medicae Silesiensis
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 52

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