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Wyszukujesz frazę "magnetic resonance imaging relaxation time" wg kryterium: Temat

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    Wyświetlanie 1-3 z 3
    Tytuł:
    Infliximab MRI relaxation time in solution
    Autorzy:
    Bober, Zuzanna
    Bar, Piotr
    Pasternak, Grzegorz
    Galiniak, Sabina
    Bartusik-Aebisher, Dorota
    Filip, Rafał
    Aebisher, David
    Powiązania:
    https://bibliotekanauki.pl/articles/454757.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    infliximab
    magnetic resonance imaging relaxation time
    Opis:
    Introduction. The use of Quantitative Magnetic Resonance Imaging to drug monitoring in vitro or in vivo can provides a powerful means to map the effects of drugs on tissue activity. Aim. The purpose of this study was to measure relaxation time of antibody phantom. For this purpose, infliximab sample was used. Material and methods. The selected methods to detect relaxation time of antibody was Magnetic Resonance Imaging technique. We detected spin-lattice (T1 ) relaxation time and discuss differences where compare to water. Results. The measurements ofspin-lattice (T1 ) relaxation time showed significant differences. The results obtained in phantom indicate that we can use this result for measurements of relaxation time in vitro. Conclusion. Infliximab is approved for severe cases of rheumatoid arthritis, together with methotrexate, for pronounced psoriasis and psoriasis-arthritis, ankylosing spondylitis as well as for chronic inflammatory bowel disease. We conclude, that Quantitative Magnetic Resonance Imaging can be used to monitor drug effects
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 1; 22-25
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The larynx cancer in vitro study by MRI relaxtion time of water
    Autorzy:
    Domka, Wojciech
    Ożóg, Łukasz
    Bartusik-Aebisher, Dorota
    Aebisher, David
    Powiązania:
    https://bibliotekanauki.pl/articles/2038279.pdf
    Data publikacji:
    2020-09-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    larynx tissue
    magnetic resonance imaging
    T2 mapping
    T2 relaxation time
    Opis:
    Introduction. Squamous cell carcinoma (SCC) of the larynx accounts for a significant percentage of all head and neck cancers. Aim. In this paper we determine the differences in magnetic resonance relaxation time (MRI) of water in cancerous and healthy larynx tissues. Material and methods. This study is aimed on T2 MRI modalities for monitoring morphology of larynx tissue. Results. Our results showed that T2 MRI relaxation time measured in larynx tissue can be used to assess early cancer condition of larynx tissues. The changes of T2 MRI correspond to tumor growth within normal tissue. Conclusion. The study showed potential of MRI for the non-invasive monitoring of larynx condition.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 3; 185-187
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Evaluation of MR relaxation times following trastuzumab treatment of breast cancer cells in a 3D bioreactor
    Autorzy:
    Bartusik-Aebisher, Dorota
    Aebisher, David
    Czmil, Anna
    Mazur, Damian
    Powiązania:
    https://bibliotekanauki.pl/articles/895234.pdf
    Data publikacji:
    2020-02-29
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    magnetic resonance imaging (MRI)
    breast cancer cell cultures
    hollow-fiber bioreactor (HFBR)
    relaxation time maps
    Opis:
    The three dimensional tumor environment can be mimicked with the use of cells cultured within a hollow-fiber bioreactor (HFBR). In this work, magnetic resonance imaging (MRI) was used to monitor changes in relaxation time in breast cancer cells following treatment with Trastuzumab in a HFBR system. Breast cancer cells were inoculated into the HFBR system and cultured over a period of 4 weeks. Relaxation time maps were generated according to MRI techniques in three dimensional (3D) cultures of MCF7/Her2 breast cancer and MCF7/Neo4 control cells. MRI measurements showed a variation in values of spin-lattice (T1) and spin-spin (T2) relaxation times related to cell density. Differences in both values (T1 and T2) were noted between untreated cells and cells treated with trastuzumab in the HFBR device. Additionally, 1H MRI was able to provide information about drug penetration in breast cancer cell culture organized in 3D. In conclusion, MRI in vitro can provide direct, noninvasive visualization of cell density in 3D geometry and cell viability as a function of drug uptake. Both T1 and T2 values were higher for lower cell density and accordingly both values, T1 and T2, were lower for higher cell density.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 1; 35-41
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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