Skocz do pozycji: 1.

Tytuł:

A study on influence of different signs of air-ions on sister-chromatid exchange frequency and chromosome aberration in human peripheral blood lymphocytes

Autorzy:

Wiszniewski, A
Kretowicz, T.

Powiązania:

https://bibliotekanauki.pl/articles/2043653.pdf

Data publikacji:

1999

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

blood lymphocyte
sister-chromatid exchange
man
peripheral blood lymphocyte
lymphocyte
chromosome aberration

Źródło:

Journal of Applied Genetics; 1999, 40, 2; 129-134
1234-1983

Pojawia się w:

Journal of Applied Genetics

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:

Influence of cysteine on mechlorethamine - induced chromosomal aberrations in cultured human lymphocytes

Autorzy:

Blaszczyk, A

Powiązania:

https://bibliotekanauki.pl/articles/2048200.pdf

Data publikacji:

1995

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

cysteine
lymphocyte
human lymphocyte
chromosome aberration
in vitro
mechlorethamine
mutagenicity test

Opis:

The aim of the present paper was to find out by in vitro chromosomal aberration test using human lymphocytes whether cysteine has anticlastogenic properties towards a well-known mutagen - mechlorethamine. The lymphocytes tested were obtained from three healthy donors. Two doses of cysteine (1.0 and 2.0 μg/ml) and three doses of mechlorethamine (0.1,0.2 and 0.3 μg m⁻¹) were tested. It was found that cysteine had anticlastogenic properties and that it reduced the number of metaphases with chromosomal aberrations induced by mechlorethamine.

Źródło:

Journal of Applied Genetics; 1995, 36, 4; 389-393
1234-1983

Pojawia się w:

Journal of Applied Genetics

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:

The effect of florfenicol on lymphocyte subsets and humoral immune response in mice

Autorzy:

Lis, M.
Szczypka, M.
Suszko, A.
Switala, M.
Obminska-Mrukowicz, B.

Powiązania:

https://bibliotekanauki.pl/articles/31732.pdf

Data publikacji:

2011

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

florfenicol
lymphocyte
T lymphocyte
B lymphocyte
humoral immune response
mice
mouse
antibiotic
domestic animal

Opis:

Florfenicol is a broad-spectrum bacteriostatic antibiotic used in domestic animals. The aim of the study was to determine the effect of florfenicol on the total number of lymphocytes in the thymus, spleen and mesenteric lymph nodes and the percentage and the absolute number of T cell subsets (CD4+CD8+, CD4-CD8-, CD4+, CD8+) in the thymus and T (CD3+, CD4+, CD8+) and B (CD19+) lymphocytes in the peripheral lymphatic organs in non-immunized mice and humoral immune response in sheep red blood cells (SRBC)-immunized mice. Florfenicol was administered orally at a dose of 30 mg/kg six times at 24 h intervals to non-immunized mice and four or seven times at 24 h intervals to SRBC-immunized mice. SRBC was injected 2 hours prior to the first dose of the drug. Florfenicol increased the percentage of CD4-CD8- thymocytes and the absolute number of CD4+ and CD8+ thymocytes on day 7. The increased percentage and absolute number of CD3+, CD4+ and CD8+ lymphocytes in mesenteric lymph nodes and decreased percentage of lymphocytes B were also observed 24 hours from the last administration of florfenicol. Florfenicol administered after SRBC immunization reduced the number of plaque forming cells (PFC) and the production of anti-SRBC antibodies on days 4 and 7 after priming.

Źródło:

Polish Journal of Veterinary Sciences; 2011, 14, 2
1505-1773

Pojawia się w:

Polish Journal of Veterinary Sciences

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:

Relationship between DNA replication and DNA repair in human lymphocytes proliferating in vitro in the presence and in absence of mutagen

Autorzy:

Szyfter, K
Wiktorowicz, K.
Wielgosz, M.S.
Zajaczek, S.
Kujawski, M.
Jaloszynski, P.
Czub, M.
Markowska, J.

Powiązania:

https://bibliotekanauki.pl/articles/2048210.pdf

Data publikacji:

1995

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

genotoxicity
DNA replication
human lymphocyte
DNA repair
lymphocyte proliferation
mutagenesis
in vitro

Opis:

The effects of mutagens on DNA replication and DNA repair were studied in peripheral blood lymphocytes (PBL) obtained from 21 healthy subjects, 2 samples from healthy heterozygote of Xeroderma pigmentosum (XP) and 2 samples from patient with clinically recognised XP. Inter-individual variations were found in DNA replication and in the level of spontaneous DNA repair measured under standard culture condition. Exposure of human PBL proliferating in vitro to B(a)P was followed by a partial inhibition of replicative DNA synthesis in all subjects and by an induction of DNA repair in healthy subjects. In XP patients DNA repair synthesis remained at the level attributed to spontaneous DNA repair. The response to mutagen varied individually. Results were analysed statistically. It was established that the studied indices of DNA synthesis correlate well with each other. The highest correlation was found between the levels of spontaneous and B(a)P-induced DNA repair. It is concluded that the level of spontaneous DNA repair is predictive for an estimation of cells ability to repair DNA damage. Inter-individual variations in the inhibition of DNA replication and in DNA repair synthesis are also dependent on the type of mutagen as shown by effects of other mutagens. Different effects of mutagen exposure on the inhibition of DNA replicative synthesis and induction of DNA repair can be explained by genetically controlled differences in the activity of enzymes responsible for mutagen processing and lesion removal.

Źródło:

Journal of Applied Genetics; 1995, 36, 4; 379-388
1234-1983

Pojawia się w:

Journal of Applied Genetics

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:

Cytometric analysis of lymphocytes T and B in rabbits infected with non-haemagglutinogenic strains of RHD virus [rabbit heamorrhagic disease] - Rainham, Frankfurt and Asturias

Autorzy:

Niedzwiedzka-Rystwej, P
Deptula, W.

Powiązania:

https://bibliotekanauki.pl/articles/31408.pdf

Data publikacji:

2010

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

T lymphocyte
B lymphocyte
cytometric analysis
rabbit
rabbit hemorrhagic disease virus
infection
animal infection
non-hemagglutinogenic strain

Opis:

The present paper refers to the cytometric analysis of lymphocytes T (with receptor CD5+), Th (with receptor CD4+), Tc/Ts (with receptor CD8+), lymphocytes CD25+ and lymphocytes B with receptor CD19+ in rabbits experimentally infected with strains of RHD virus - Rainham, Frankfurt and Asturias, not having haemagglutinogenic capacities, which makes them unique, as haemagglutinogenic capacity is a classic and typical property of most strains of this virus. The study was performed in the dynamic system, drawing blood samples from animals at hour 0, namely before the administration of the viral antigen, and then at 4, 8, 12, 24 and 36 h after the infection. The study indicated that Rainham and Asturias strains of RHD virus cause a similar amount of changes as the most immunogenic haemagglutinogenic strains CAMP V-561 and CAMP V-562 of the RHD virus do. In contrast, the Frankfurt strain of the RHD virus is characterised with 5-6-fold lower reactivity in this respect and is most similar to the least immunogenic haemagglutinogenic strain CAMP V-558 of the RHD virus.

Źródło:

Polish Journal of Veterinary Sciences; 2010, 13, 1; 157-162
1505-1773

Pojawia się w:

Polish Journal of Veterinary Sciences

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:

Dose-dependent in vivo effect of Rhodiola and Echinacea on the mitogen-induced lymphocyte proliferation in mice

Autorzy:

Skopińska-Rozewska, E.
Sokolnicka, I.
Siwicki, A.K.
Stankiewicz, W.
Dabrowski, M.P.
Buchwald, W.
Krajewska-Patan, A.
Mielcarek, S.
Mscisz, A.
Furmanowa, M.

Powiązania:

https://bibliotekanauki.pl/articles/31333.pdf

Data publikacji:

2011

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

in vivo effect
Rhodiola rosea
Echinacea purpurea
Echinacea angustifolia
Rhodiola quadrifida
mitogen-induced lymphocyte
lymphocyte
proliferation
mice
mouse

Opis:

Echinacea purpurea (EP) and Echinacea angustifolia (EA) are ones of the most important world’s herbs with immunotropic activity. They were traditional medicinal plants used by North American Indians for the treatment of various illnesses. Now they are cultivated in many countries and are used mainly to treat respiratory tract infections. Rhodiola rosea (RR) and Rhodiola quadrifida (RQ) are medicinal plants originated from Asia and used traditionally as adaptogens, antidepressants, and anti-inflammatory remedies. We previously reported, that extracts of underground parts of RR and RQ exhibited immunotropic activity. We have demonstrated in pigs that in vitro RR or RQ supplementation of blood lymphocyte cultures stimulated T cell proliferative response to Con A in lower, and inhibited it in higher Rhodiola extract concentrations. The aim of this work was to evaluate the in vivo effect of these herbal remedies on the in vitro proliferative response of mouse splenic lymphocytes to another T-cell mitogen- Phaseolus vulgaris haemagglutinin (PHA). We have found significant stimulation of proliferative response, in comparison to the controls, in mice fed lower doses of tested remedies, and inhibition, no effect or lower stimulation, in mice fed higher doses of these drugs.

Źródło:

Polish Journal of Veterinary Sciences; 2011, 14, 2
1505-1773

Pojawia się w:

Polish Journal of Veterinary Sciences

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:

Expression of cellular isoform of prion protein on the surface of peripheral blood lymphocytes among women exposed to low doses of ionizing radiation

Autorzy:

Klucinski, P
Mazur, B.
Hrycek, A.
Masluch, E.
Cieslik, P.
Kaufman, J.
Martirosian, G.

Powiązania:

https://bibliotekanauki.pl/articles/50336.pdf

Data publikacji:

2007

Wydawca:

Instytut Medycyny Wsi

Tematy:

blood lymphocyte
ionizing radiation
low dose
lymphocyte
cellular isoform
woman
radiation exposure
expression
prion protein

Opis:

Ionizing radiation affects the expression of adhesive and co-stimulatory molecules in lymphocytes. The physiological function of cellular isoform of prion protein (PrPc) is little known. Evidences indicate a link between lymphocytes activation and PrPc expression on their surface; however, no direct effect of radiation on PrPc level in these cells was investigated. The objective of this study was to determinate the effect of low doses of ionizing radiation on the expression of PrPc on the surface peripheral blood lymphocytes in the women operating X-ray equipment. In 36 female workers and 30 persons of the control group the PrPc expression on CD3 (T lymphocytes), CD4 (T helper), CD8 (T cytotoxic) and CD19 (B lymphocytes), as well as the percentage of lymphocytes with PrPc on their surface, were tested. Subgroups with respect to age and length of employment were selected. A signifi cant increase was observed in PrPc expression on CD3 and CD4 with lowered PrPc level on CD8 and percentage of CD8 cells with PrPc in workers compared to control. The PrPc level did not show signifi cant changes in subgroups in relation to age (below and over 40 years old) both in the investigated and control groups, whereas a lower percentage of PrPc expressing CD19 cells showed in employed women below 40 years of age. A signifi cant decrease was found in PrPc expression on the surface of CD3, CD4 and CD8 cells in the subgroup employed for over 10 years than in the subgroup with less than 10 years of employment.

Źródło:

Annals of Agricultural and Environmental Medicine; 2007, 14, 2
1232-1966

Pojawia się w:

Annals of Agricultural and Environmental Medicine

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 8.

Tytuł:

Helicobacter pylori increases expression of proapoptotic markers Fas and FasL on CD4 lymphocytes in children

Autorzy:

Kotłowska-Kmieć, Aldona
Bąkowska, Alicja
Szarszewski, Adam
Kamińska, Barbara
Łuczak, Grażyna
Radys, Wojciech
Landowski, Piotr
Brodzicki, Jacek
Korzon, Maria
Liberek, Anna

Powiązania:

https://bibliotekanauki.pl/articles/1040535.pdf

Data publikacji:

2009

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

T cell
H. pylori
FasL
Fas
apoptosis
lymphocyte

Opis:

The pathomechanism of Helicobacter pylori action upon gastric mucosa and its role in the pathogenesis of gastritis have not been fully elucidated. The aim of this study was to evaluate the most prevalent lymphocyte subpopulations of the gastric mucosa in gastritis in children, as well as to evaluate the expression of Fas and Fas ligand receptors (FasL), periapoptotic markers of gastric mucosa lymphocytes before and after H. pylori eradication. Forty nine patients aged 6 to 17 years, investigated due to chronic abdominal pain, were studied. The obtained tissue samples were analysed by immunohistochemistry. Different lymphocyte subsets were quantified on the basis of surface antigen expression (CD3, CD4, CD8, CD20), secreted cytokines (IL-4, IL-6, IFNγ) and Fas and FasL proteins in the gastric mucosa. B and T helper lymphocytes were found to play a major role in the inflammatory infiltration in the gastric mucosa in children during H. pylori infection. Their expression was found to decrease after eradication. The enhanced expression of Fas receptor on lymphocytes before treatment and a decrease of this expression after eradication of H. pylori were shown. It was demonstrated that there is a correlation between CD4 and Fas receptor expression that may induce apoptosis of the helper lymphocytes in infected children.

Źródło:

Acta Biochimica Polonica; 2009, 56, 3; 433-438
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 9.

Tytuł:

Immunoregulation of antigen presenting and secretory functions of monocytic cells by Helicobacter pylori antigens in relation to impairment of lymphocyte expansion

Autorzy:

Mnich, Eliza
Gajewski, Adrian
Rudnicka, Karolina
Gonciarz, Weronika
Stawerski, Paweł
Hinc, Krzysztof
Obuchowski, Michał
Chmiela, Magdalena

Powiązania:

https://bibliotekanauki.pl/articles/1038873.pdf

Data publikacji:

2015

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

H. pylori
antigen presenting cells
lymphocyte expansion

Opis:

The role of Helicobacter pylori (H. pylori) antigens in driving a specific immune response against the bacteria causing gastroduodenal disorders is poorly understood. Using a guinea pig model mimicking the natural history of H. pylori infection, we evaluated the effectiveness of immature and mature macrophages in promoting the blastogenesis of splenocytes from H. pylori infected and uninfected animals, in response to H. pylori antigens: glycine acid extract (GE), cytotoxin associated gene A protein (CagA), urease A (UreA) and lipopolysaccharide (LPS). Lymphocyte expansion was assessed in 72 h cell cultures, containing: immature or mature macrophages derived from bone marrow monocytes, unstimulated or stimulated with H. pylori antigens for 2 h. The proliferation was expressed as a ratio of [3H]-thymidine incorporation into DNA of antigen-stimulated to unstimulated cells and the DNA damage was determined by DAPI cell staining. TGF-β and IFN-γ were assessed immunoenzymatically in cell culture supernatants. Lymphocytes of control and H. pylori-infected animals proliferated intensively in response to phytohaemagglutinin (PHA) and in co-cultures with immature or mature macrophages treated with CagA or UreA (significantly) and GE (slightly) exluding the cultures containing H. pylori or E. coli LPS. This lymphocyte growth inhibition was related to DNA damage of monocytic cells in response to H. pylori or E. coli LPS and secretion of regulatory TGF-β, but not proinflammatory IFN-γ. Impaired homeostasis of monocytic cell function related to DNA damage and TGF-β release, in response to H. pylori LPS may lead to the suppression of adaptive immune response against the bacteria and development of chronic infection.

Źródło:

Acta Biochimica Polonica; 2015, 62, 4; 641-650
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 10.

Tytuł:

Prognostic value of using neutrophil-lymphocyte ratio in patients with burn injury for the diagnosis of sepsis and bacteraemia

Autorzy:

Fuss, Julia
Voloboyeva, Anna
Poliovyj, Victor

Powiązania:

https://bibliotekanauki.pl/articles/1392898.pdf

Data publikacji:

2018

Wydawca:

Index Copernicus International

Tematy:

burns
sepsis
diagnostic
procalcitonin
neutrophil-lymphocyte ratio.

Opis:

Objective: Despite the progress in the treatment of burn injuries, the mortality rate among seriously ill patients still remains high nowadays. The main causes of fatal cases with extensive deep burns are generalized infectious complications, the major of which is sepsis. According to the authors, 25%–85% of those who died of burn injuries in later periods, died from sepsis. The frequency and severity of infectious complications in patients with burn injuries requires an accurate diagnosis of infection that will determine the tactics of therapeutic and surgical treatment of such patients (Di Lonardo A. et al., 1993). However, the clinical diagnosis of wound infection in patients with burn injuries is quite difficult. Materials and methods: The clinical material included 188 patients with burn injuries. The average age of those patients ranged from 20 to 59 years. Men - 98 (52.1%), women - 90 (47.9%). The survey was conducted from April 2014 to July 2016. Results: In our opinion, the strength of NLR (neutrophil-lymphocyte ratio) is the possibility of implementing this parameter simply by using already available biomarkers (neutrophil count and lymphocyte count). Therefore, this ratio is easy to integrate in clinical practice and cost effective. Conclusion: The application of NLR for the diagnosis of sepsis in patients with burn injuries is the option of choice, since its determination requires only a general blood test.

Źródło:

Polish Journal of Surgery; 2018, 90, 5; 13-16
0032-373X
2299-2847

Pojawia się w:

Polish Journal of Surgery

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 11.

Tytuł:

Selected parameters of local immunity and properties of fungi [between and within species] isolated from palatine tonsils

Autorzy:

Kurnatowski, P.
Jaskolowska, A.
Rozga, A.

Powiązania:

https://bibliotekanauki.pl/articles/837821.pdf

Data publikacji:

1998

Wydawca:

Polskie Towarzystwo Parazytologiczne

Tematy:

pathogenicity
Candida albicans
lymphocyte population
palatine tonsil
fungi
host

Źródło:

Annals of Parasitology; 1998, 44, 3
0043-5163

Pojawia się w:

Annals of Parasitology

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 12.

Tytuł:

Cell-mediated response in nodular and ocular forms of human toxoplasmosis

Autorzy:

Dziubek, Z.
Zarnowska, H.
Gorski, A.
Basiak, W.
Kajfasz, P.
Bielawska, M.

Powiązania:

https://bibliotekanauki.pl/articles/838536.pdf

Data publikacji:

1998

Wydawca:

Polskie Towarzystwo Parazytologiczne

Tematy:

toxoplasmosis
cell-mediated response
T lymphocyte
man
humoral response

Źródło:

Annals of Parasitology; 1998, 44, 3
0043-5163

Pojawia się w:

Annals of Parasitology

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 13.

Tytuł:

Beta-2-microglobulin and neopterin in patients with giardiasis

Autorzy:

Czarnowski, D.
Miegoc, H.
Kalinowska, A.
Prokopowicz, D.

Powiązania:

https://bibliotekanauki.pl/articles/840868.pdf

Data publikacji:

1998

Wydawca:

Polskie Towarzystwo Parazytologiczne

Tematy:

parasite
T lymphocyte
neopterin
Giardia
giardiasis
beta-2-microglobulin

Źródło:

Annals of Parasitology; 1998, 44, 3
0043-5163

Pojawia się w:

Annals of Parasitology

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 14.

Tytuł:

Modified neutral comet assay for human lymphocytes

Autorzy:

Wojewódzka, M.
Grądzka, I.
Buraczewska, I.

Powiązania:

https://bibliotekanauki.pl/articles/147130.pdf

Data publikacji:

2002

Wydawca:

Instytut Chemii i Techniki Jądrowej

Tematy:

DNA double strand breaks
human lymphocyte
neutral comet assay

Opis:

Comet assay under neutral conditions allows the detection of DNA double-strand breaks, considered to be the biologically relevant radiation-induced lesion. In this report we describe modifications of the neutral comet method, which simplify and facilitate its use for estimation of DNA double strand breaks in human lymphocytes irradiated with doses of 60Co gamma-rays (from 10 to 100 Gy). The analysis carried out according to this protocol takes less time than those published so far. Also, the use of lysis at 50°C is avoided; this is important in view of the presence of heat-labile sites in the DNA of irradiated cells, recently reported by Rydberg [12]. The comets have well defined, sharp limits, are suitable for computer image analysis and chromatin of the control cells remains condensed.

Źródło:

Nukleonika; 2002, 47, 1; 1-5
0029-5922
1508-5791

Pojawia się w:

Nukleonika

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 15.

Tytuł:

Prognostic significance of C-reactive protein/albumin and neutrophil/lymphocyte ratios in patients with COVID-19

Autorzy:

Beyazal Polat, Hatice
Arpa, Medeni
Polat, Zehra
Beyazal, Mehmet
Beyazal Çeliker, Fatma
Ayaz, Teslime
Ertürk, Ayşe

Powiązania:

https://bibliotekanauki.pl/articles/40570858.pdf

Data publikacji:

2024-06-30

Wydawca:

Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego

Tematy:

COVID-19
C-reactive protein/albumin
neutrophil/lymphocyte

Opis:

Introduction and aim. COVID-19 causes an uncontrolled and generalized inflammatory response of the host immune system. Early recognition of the disease and early prediction of the clinical course are of great importance. The aim of this study was to evaluate the predictive role of the C-reactive protein/albumin ratio (CAR) and the neutrophil/lymphocyte ratio (NLR) for mortality in patients hospitalized with the diagnosis of COVID-19. Material and methods. The patients, who were hospitalized for COVID-19 and whose CRP, albumin, neutrophil, and lymphocyte levels were documented within the first 24 hours after admission, were analyzed retrospectively. Patients were divided into survivors and non-survivors; the groups were compared. Univariate and multivariate Cox regression models were developed to evaluate the CAR and the NLR as risk factors for mortality in COVID-19 patients. Results. One hundred and thirty patients were included in this study. The mean age of the survivor group (n=114) was 60±16 and 52% were male. The mean age of the non-survivor group (n=16) was 75±13 and 56% were male. In the non-survivor group, the CAR detected at the time of admission to the hospital was significantly higher compared to patients in the survivor group (p=0.026). Conclusion. As a result, the CAR, the NLR and LDH are independent risk factor indicators of mortality in hospitalized patients.

Źródło:

European Journal of Clinical and Experimental Medicine; 2024, 22, 2; 327-333
2544-2406
2544-1361

Pojawia się w:

European Journal of Clinical and Experimental Medicine

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 16.

Tytuł:

Changes in phosphorylation of histone H2A.X and p53 in response of peripheral blood lymphocytes to gamma irradiation

Autorzy:

Vilasová, Zdeňka
Řezáčová, Martina
Vávrová, Jiřina
Tichý, Aleš
Vokurková, Doris
Zoelzer, Friedo
Řeháková, Zuzana
Osterreicher, Jan
Lukášová, Emilie

Powiązania:

https://bibliotekanauki.pl/articles/1040760.pdf

Data publikacji:

2008

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

lymphocyte
ionizing radiation
p53
phytohemagglutinin (PHA)
apoptosis
DNA damage

Opis:

The main aim of this study was to compare the reaction of quiescent and proliferating, i.e. phytohemagglutinin (PHA)-stimulated, human peripheral blood mononuclear cells (PBMCs) to γ-radiation, and analyse changes of proteins related to repair of DNA damage and apoptosis, such as γH2A.X, p53, p53 phosphorylation at serines-15 and -392, and p21 and their dose dependence. Freshly isolated PBMCs in peripheral blood are predominantly quiescent, in G0 phase, and with very low amounts of proteins p53 and p21. Using confocal microscopy we detected dose dependent (0.5-5 Gy) induction of foci containing γH2A.X (1 h after γ-ray exposure), which are formed around radiation-induced double strand breaks of DNA. Apoptosis was detected from 24 h after irradiation by the dose of 4 Gy onwards by Annexin V binding and lamin B cleavage. Seventy two hours after irradiation 70% of CD3+ lymphocytes were A+. Neither increase in p53 nor its phosphorylation on serine-392 after irradiation was detected in these cells. However, massive increase in p21 (cyclin-dependent kinase inhibitor 1A) was detected after irradiation, which can be responsible for late occurrence of apoptosis in these quiescent cells. PHA-stimulation itself (72 h) caused an increase in early apoptosis (A+PI-) in comparison to non-stimulated PBMCs (38% A+ resp. 13.4%). After PHA-stimulation also the amount of γH2A.X, p53, and p21 increased, but no phosphorylation of p53 on serine-392 or -15 was detected. Reaction to γ-radiation was different in PHA-stimulated lymphocytes: the p53 pathway was activated and p53 was phosphorylated on serines-15 and -392 4 h after irradiation by the dose of 4 Gy. Phosphorylation of p53 at serine-15 increased in a dose-dependent manner in the studied dose range 0.2-7.5 Gy. Also the amount of p21 increased after irradiation. Seventy two hours after irradiation of PHA-stimulated CD3+ T lymphocytes by the dose of 4 Gy 65% of cells were A+.

Źródło:

Acta Biochimica Polonica; 2008, 55, 2; 381-390
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 17.

Tytuł:

Neutrophil-lymphocyte ratio and mean platelet volume as predictive factors for liver fibrosis and steatosis in patients with chronic hepatitis B

Autorzy:

Pokora-Rodak, A.
Kiciak, S.
Tomasiewicz, K.

Powiązania:

https://bibliotekanauki.pl/articles/2081973.pdf

Data publikacji:

2018

Wydawca:

Instytut Medycyny Wsi

Tematy:

neutrophil-lymphocyte ratio
hepatitis B
liver fibrosis
liver steatosis

Opis:

Objective. Evaluation of the neutrophil-lymphocyte ratio and mean platelet volume as predictive factors for liver fibrosis and steatosis in HBV patients qualified for antiviral treatment. Materials and method. The study comprised 38 CHB patients who had commenced antiviral treatment, and 20 healthy volunteers who constituted the clinical control group. All patients had their blood count taken and underwent hepatic assessment using transient elastography with CAP (controlled attenuation parameter). Results. It was found that the mean hepatic fibrosis was 8.7 kPa (±8.8) and the mean liver steatosis – 286 db/m (±64). Mean NLR – 2.78(±1.1), whereas in the control group the mean NLR value was 1.64(±0.98). A negative linear correlation (r= -0.34; p=0.035) was found between liver fibrosis and the NLR value in the study group. No correlation was observed between hepatic steatosis and the NLR. Mean MPV – 12.6fl (±3.1), which was considerably higher in the CBH patients than in the control group. A positive correlation (r= 0.79, p= 0.001) was found between MPV and disease severity evaluated with transient elastography. Conclusions. The NLR and the MPV were significantly higher in the CHB patients than in the healthy volunteers. Both the NLR and the MPV can be treated as predictive factors for liver fibrosis in this group of patients.

Źródło:

Annals of Agricultural and Environmental Medicine; 2018, 25, 4; 690-692
1232-1966

Pojawia się w:

Annals of Agricultural and Environmental Medicine

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 18.

Tytuł:

Age-related changes in mRNA expression of selected surface receptors in lymphocytes of dairy calves

Autorzy:

Flaga, J.
Korytkowski, Ł.
Górka, P.
Kowalski, Z.M.

Powiązania:

https://bibliotekanauki.pl/articles/2087753.pdf

Data publikacji:

2018

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

immune system development
clusters of differentiation
marker
lymphocyte maturation

Źródło:

Polish Journal of Veterinary Sciences; 2018, 21, 1; 213-216
1505-1773

Pojawia się w:

Polish Journal of Veterinary Sciences

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 19.

Tytuł:

Functional exhaustion of T lymphocytes in chronic toxoplasmosis

Autorzy:

Dlugonska, H.
Grzybowski, M.M.

Powiązania:

https://bibliotekanauki.pl/articles/6364.pdf

Data publikacji:

2013

Wydawca:

Polskie Towarzystwo Parazytologiczne

Tematy:

functional exhaustion
T lymphocyte
chronic toxoplasmosis
toxoplasmosis
parasitic infection
parasite
Toxoplasma gondii

Źródło:

Annals of Parasitology; 2013, 59, 3
0043-5163

Pojawia się w:

Annals of Parasitology

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 20.

Tytuł:

Dependence of immune complexes circulation level on antibody titres to the Lyme pathogenic organism

Autorzy:

Jakovleva, V.V.
Kolchanova, L.P.
Stepanova, T.F.
Shonin, A.L.
Kalgina, G.A.
Postnikova, T.F.

Powiązania:

https://bibliotekanauki.pl/articles/837857.pdf

Data publikacji:

1998

Wydawca:

Polskie Towarzystwo Parazytologiczne

Tematy:

immunofluorescence
titre
immune complex
lymphocyte
Lyme disease
B cell
antibody

Źródło:

Annals of Parasitology; 1998, 44, 3
0043-5163

Pojawia się w:

Annals of Parasitology

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 21.

Tytuł:

Does in vitro replicative senescence of human CD8+ cells reflect the phenotypic changes observed during in vivo ageing?

Autorzy:

Brzezinska, Agnieszka

Powiązania:

https://bibliotekanauki.pl/articles/1041348.pdf

Data publikacji:

2005

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

lymphocyte subpopulations
ageing
CD28
in vitro culture
proliferation
CD8

Opis:

Immunosenescence is viewed as a remodeling process with the exhaustion of naïve T cells and filling up of the immunological space with memory cells. In this study some phenotypic changes of CD8+ human cells during in vivo ageing were compared with those observed in long term cultures of lymphocytes derived from cord blood or from peripheral blood from donors of different age. Both in vivo and in vitro a significant decrease of the fraction of CD8+CD28+ cells was observed. Comparing the proportions of other T cell subpopulations (the CD4/CD8+ ratio, CD56, CD57, CD27) made it possible to conclude that replicative senescence in vitro partially reflects in vivo ageing.

Źródło:

Acta Biochimica Polonica; 2005, 52, 4; 931-935
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 22.

Tytuł:

Experimental inflammatory bowel disease - role of T cells

Autorzy:

Szczepanik, M.
Gryglewski, A.
Bryniarski, K.
Stachura, J.
Ptak, W.

Powiązania:

https://bibliotekanauki.pl/articles/70282.pdf

Data publikacji:

2000

Wydawca:

Polskie Towarzystwo Fizjologiczne

Tematy:

myeloperoxidase
B lymphocyte
inflammatory bowel disease
chronic colitis
colitis
T cell

Źródło:

Journal of Physiology and Pharmacology; 2000, 51, 2
0867-5910

Pojawia się w:

Journal of Physiology and Pharmacology

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 23.

Tytuł:

Evaluation of Outcomes and Treatment Safety of Patients with Metastatic Colorectal Cancer to the Liver with Estimation of Prognostic Factors

Autorzy:

Zeman, Marcin
Maciejewski, Adam
Półtorak, Stanisław
Kryj, Mariusz

Powiązania:

https://bibliotekanauki.pl/articles/1396271.pdf

Data publikacji:

2013-06-01

Wydawca:

Index Copernicus International

Tematy:

colorectal cancer liver metastases
liver resection
neutrophil to lymphocyte ratio
fibrinogen

Opis:

Liver resection is essential part of colorectal cancer liver metastases (CLM) treatment. Mean 5-year overall survival after resection achieves 30-45%. There are many factors influencing long-term outcomes, and among them the inflammatory response to tumor plays an important role. The aim of the study was evaluation of outcomes and treatment safety of patients with metastatic colorectal cancer to the liver with estimation of prognostic factors. Material and methods. 130 consecutive patients (70 men and 60 women) operated in MSC Institute and Cancer Center in Gliwice from 2001 to 2009 due to colorectal liver metastases were analysed. Age of the patients ranged from 33 to 82 years (median 60 years). 96 (74%) patients underwent potentially radical resection, and in remaining 34 (26%) was performed radiofrequency ablation (RFA) alone or combined with the resection. In the resection group 37 right hepatectomies, 11 left hepatectomies, 28 segmentectomies and 20 metastasectomies were performed. Disease-free survival (DFS) and overall survival (OS) were statistically analysed using the Kaplan-Meier method. Factors determining DFS and OS were analysed using Cox regression model. Results. In the resection group the 3- and 5-years OS was 64,5% and 46,6% respectively, and the 3- and 5-years DFS was 32% and 30,5% respectively. In the RFA group the 3- and 5-years OS was 33% and 9,5%. Statistically significant prognostic factors in the resection group in uni- and multivariate analysis were: grade and nodal involvement of the primary tumor, diameter of metastatic focus, positive and narrow (<1 mm) resection margins, preoperative fibrinogen level, preoperative neutrophil to lymphocyte ratio and leukocyte amount of the peripheral blood. The perioperative mortality rate was 3%. Conclusions. Liver resection due to colorectal liver metastases is a safe and effective method resulting in high survival rates. We confirmed some generally accepted prognostic factors influencing longterm outcomes and shown the impact of inflammatory response. We also confirmed the hypothesis that preoperative plasma fibrinogen level influences outcomes after liver resection due to CLM.

Źródło:

Polish Journal of Surgery; 2013, 85, 6; 333-339
0032-373X
2299-2847

Pojawia się w:

Polish Journal of Surgery

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 24.

Tytuł:

Investigations of the changes of peripheral blood T lymphocytes subpopulations using the flow cytofluorimetry technique in serum of T.spiralis infected mice

Autorzy:

Boczon, K.
Wargin, B.
Kostrzewa, A.
Derda, M.
Wiktorowicz, K.

Powiązania:

https://bibliotekanauki.pl/articles/836212.pdf

Data publikacji:

1998

Wydawca:

Polskie Towarzystwo Parazytologiczne

Tematy:

peripheral blood
mouse
mice
serum
T lymphocyte
trichinellosis
blood
larva
cytofluorimetry technique
Trichinella spiralis

Źródło:

Annals of Parasitology; 1998, 44, 3
0043-5163

Pojawia się w:

Annals of Parasitology

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 25.

Tytuł:

Vitamin C decreases intracellular calcium level in human lymphoid cells

Autorzy:

Ozturk, G.
Mulholland, C.W.
Hannigan, B.M.

Powiązania:

https://bibliotekanauki.pl/articles/70935.pdf

Data publikacji:

2001

Wydawca:

Polskie Towarzystwo Fizjologiczne

Tematy:

intracellular calcium
vitamin C
calcium
ascorbic acid
man
lymphocyte
lymphoid cell
leucocyte
antioxidative enzyme

Źródło:

Journal of Physiology and Pharmacology; 2001, 52, 2
0867-5910

Pojawia się w:

Journal of Physiology and Pharmacology

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 26.

Tytuł:

Neutrophil-lymphocyte ratio and creatinine reduction ratio predict good early graft function among adult cadaveric donor renal transplant recipients. Single institution series

Autorzy:

Hogendorf, Piotr
Suska, Anna
Skulimowski, Aleksander
Rut, Joanna
Grochowska, Monika
Wencel, Aleksandra
Dziwisz, Filip
Nowicki, Michał
Szymański, Dariusz
Poznańska, Grażyna
Durczyński, Adam
Strzelczyk, Janusz

Powiązania:

https://bibliotekanauki.pl/articles/1392878.pdf

Data publikacji:

2018

Wydawca:

Index Copernicus International

Tematy:

neutrophil-lymphocyte ratio
creatinine reduction ratio
graft function
cadaveric donor
delayed graft function kidney transplant

Opis:

The Background Delayed graft function (DGF) is a common complication following kidney transplantation and is associated with ischemia-reperfusion injury (IRI). Lymphocytes contribute to the pathogenesis of IRI and ischemia-reperfusion related to delayed graft function. Materials and Methods : 135 Caucasian patients received a kidney graft from deceased heart-beating organ donors. We divided patients into 2 groups - patients with the eGFR>=30 on the 21st day post-transplantation (n=36) and patients with the eGFR<30 on the 21st day post-transplantation (n=99) to assess kidney graft function. We measured serum creatinine levels on 1st and 2nd post-transplant day and preoperative levels of monocytes, lymphocytes, platelets, and neutrophils and their ratios. Results: We have found statistically significant differences between the eGFR<30 and the eGFR>=30 groups in the average lnLymphocytes (0.36 +/-0.6 vs. -0.016 +/-0.74, respectively p=0.004) lnNLR (1,27 +/-0.92 vs. 1.73+/-1.08 p=0.016) lnLMR (1.01 +/-0.57 vs. 0.73 +/-0.64 p=0.02), lnPLR (4.97 +/-0.55 vs. 5.26 +/- 0.67 p=0.023), and CCR 2% (-20.20 +/- 21.55 vs. -4.29 +/- 29.62 p=0.004. In the univariate analysis, factors of lnLymphocytes >=0.22 (OR=0.331 95%CI 0.151-0.728 p=0.006), lnLMR>=1.4 (OR=0.255 95%CI 0.072-0.903 p=0.034) were associated with a worse graft function, while lnNLR>=1.05 (OR=2.653 95%CI 1.158-6,078 p=0.021), lnPLR>=5.15 (OR=2.536 95%CI 1.155-5.566 p=0.02) and CRR2 (OR=3.286 95% CI 1.359-7.944 p=0.008) indicated a better graft function. Conclusion: A higher absolute lymphocyte count (lnLymphocytes) and lnLMR, as well as lower lnNLR and lnPLR were associated with a lower eGFR on the 21st day after kidney transplantation. In the multivariate analysis, CRR2 in combination with either lnLymphocytes, lnNLR or lnPLR improved the accuracy of detecting patients with poor graft function.

Źródło:

Polish Journal of Surgery; 2018, 90, 2; 28-33
0032-373X
2299-2847

Pojawia się w:

Polish Journal of Surgery

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 27.

Tytuł:

Immunostimulation effect of extract ethanol white oyster mushroom (Pleurotus ostreatus Jacq Fr. Kumm) on mice

Autorzy:

Nita, Elvina W.
Afrida, A. I.
Muchtan, Sujatno
Sitorus, Trully D.
Huda, Fathul

Powiązania:

https://bibliotekanauki.pl/articles/1163986.pdf

Data publikacji:

2018

Wydawca:

Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN

Tematy:

Pleurotus ostreatus
immunostimulating
lymphocyte
serum gamma-globulin
thickness of the mice’s feet white oyster mushroom

Opis:

Acknowledging the immunostimulation effect of ethanol extract white oyster mushroom to animal experiments which were desensitized with red blood cell of lamb. This study is an experimental study, 14 healthy male swiss Webster mices were used. The subjects are randomly divided into two groups. The first group is a control group and the second group is a treatment group. The immunostimulation effect is assessed by specific immune response to desensitized of lamb’s RBC. Humoral immune response was assessed through a hemagglutination test. Cellular immune response was assessed with a delayed type hypersensitivity test by measuring the thickness of edema of the mice’s foot Specific immune response is assessed through total of blood lymphocyte using flowcytometry method. We found an increase of total blood lymphocyte level on the primary sensitization of placebo and Ethanol extract of white oyster mushroom (EEWOM). After secondary sensitization, the total blood lymphocyte level on placebo and EEWOM showed a significant difference. EEWOM increases the total antibody titre significantly compare to placebo. The level of serum gamma-globulin of treatment mice is significantly higher than placebo. On the 24th and 48th hour after the sensitization of lamb’s RBC, the increase of thickness of the mice's feet which were given placebo and EEWOM have significant difference. EEWOM has an immunostimulating effect towards specific immune response.

Źródło:

World Scientific News; 2018, 108; 123-132
2392-2192

Pojawia się w:

World Scientific News

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 28.

Tytuł:

Increased constitutional chromosome sensitivity to bleomycin in patients with hereditary non-polyposis colorectal cancer [HNPCC]

Autorzy:

Kladny, J
Zajaczek, S
Lubinski, J

Powiązania:

https://bibliotekanauki.pl/articles/2047245.pdf

Data publikacji:

1996

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

chromosome sensitivity
lymphocyte
hereditary non-polyposis colorectal cancer
tumour
colorectal cancer
bleomycin
genotoxic effect

Opis:

It has been suggested that mutagen sensitivity is a constitutional factor which may be useful in identification of patients with an increased risk for the development of tumors. In this study, the chromosome sensitivity to bleomycin was measured according to Hsu in patients with hereditary non-polyposis colorectal cancer (HNPCC), sporadic colorectal cancer and in control persons with no tumor history in family. In vitro lymphocytes were exposed to bleomycin according to Hsu and chromosomal damage was quantified by scoring breaks of 100 cells. A significant difference (P < 0.01) in the mean number of breaks per cell (b/c) was found between HNPCC patients (0.59 ± 0.14; n = 12; mean age 55.4 yrs) and control individuals (0.35 ± 0.13: n = 12; mean age 55.8 yrs). In contrast, patients with sporadic colorectal cancer showed a mean b/c value of 0.43 ± 0.14 (n = 14; mean age 63.4 yrs) which was not significantly higher than that in control individuals for this group (0.42 ± 0.15; n = 14; mean age 63.1 yrs). Selenium protected lymphocytes of HNPCC patients against bleomycin activity in vitro.

Źródło:

Journal of Applied Genetics; 1996, 37, 4; 385-392
1234-1983

Pojawia się w:

Journal of Applied Genetics

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 29.

Tytuł:

Effect of different lymphocyte-bacteria ratios and bacterial toxins on apoptosis of bovine mammary gland lymphocytes
Wpływ stosunku stężeń limfocytów do bakterii oraz toksyn bakteryjnych na śmierć limfocytów sutków jałówek

Autorzy:

Slama, P.
Sladek, Z.
Rysanek, D.

Powiązania:

https://bibliotekanauki.pl/articles/127193.pdf

Data publikacji:

2011

Wydawca:

Towarzystwo Chemii i Inżynierii Ekologicznej

Tematy:

bacteria
bacterial toxin
apoptosis
lymphocyte
mammary gland
bakterie
toksyny bakteryjne
apoptoza limfocytów
gruczoł sutkowy

Opis:

Staphylococcus aureus and Streptococcus uberis delay apoptosis of bovine mammary gland lymphocytes following intramammary infusion and in in vitro studies with lymphocyte-bacteria ratio 1:1. In this study, we investigated the effect of different lymphocyte-bacteria ratios on apoptosis of bovine mammary gland lymphocytes in vitro. We found out that lymphocyte-bacteria (S. aureus or S. uberis) ratios 1:10, 1:50 and 1:100 have different effect on apoptosis of lymphocytes than ratio 1:1. Lymphocyte apoptosis was induced 6 hours following incubation with S. aureus or S. uberis with mentioned ratios (1:10, 1:50 and 1:100). In our previous preliminary experiments focused on exploration of chemical components of bacteria on apoptosis of lymphocytes, we established the effect of muramyl dipeptide and lipopolysaccharide on lymphocyte apoptosis only in vitro. Therefore, in the second part of the present study we focused our experiments on investigation of the effect of Gram-negative bacterial toxin lipopolysaccharide on apoptosis of bovine mammary gland lymphocytes in vivo. The results of these experiments suggest that lipopolysaccharide induces apoptosis of lymphocytes following intramammary application. These data need next exploration to reveal detail effects of bacteria or bacterial toxins on lymphocyte programmed cell death in connection with inflammatory process.

Źródło:

Proceedings of ECOpole; 2011, 5, 1; 109-113
1898-617X
2084-4557

Pojawia się w:

Proceedings of ECOpole

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 30.

Tytuł:

CD4 and CD8 cells in mice infected with Trichinella spiralis and treated with cyclosporine A

Autorzy:

Karmanska, K
Houszka, M.
Mista, D.
Stefaniak, E.

Powiązania:

https://bibliotekanauki.pl/articles/836501.pdf

Data publikacji:

1994

Wydawca:

Polskie Towarzystwo Parazytologiczne

Tematy:

immunoenzymatic method
mouse
infection
mice
cell
T lymphocyte
immunofluorescent method
cyclosporin A
larva
Trichinella spiralis

Opis:

Studies were undertaken to evaluate by parasitological techniques the course of intestinal and muscular invasions in mice infected with Trichinella spiralis and treated with TFX-Thymomodulin (TFX-Th). Studies were conducted on 120 mice of BALB/c and SWISS strains, infected each with a mean invasive dose of 300 T. spiralis larvae. TFX-Th (Thymoorgan GmbH Pharmazie Co. KG, Vienenburg, Germany) was administered subcutaneously at 30 mg/kg body weight. Depending upon duration of TFX-Th administration and stages of intestinal and muscular invasions, three experiments were distinguished in the study. The results indicated that TFX-Th promoted eradication of larvae from muscles, whether administered at the early of the late stage of T. spiralis invasion.

Źródło:

Annals of Parasitology; 1994, 40, 4
0043-5163

Pojawia się w:

Annals of Parasitology

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 31.

Tytuł:

The influence of glucocorticoid [depemedrol] treatment on the changes of peripheral blood T lymphocytes in serum of T.spiralis infected mice

Autorzy:

Boczon, K.
Kostrzewa, A.
Wargin, B.
Derda, M.
Wiktorowicz, K.

Powiązania:

https://bibliotekanauki.pl/articles/840872.pdf

Data publikacji:

1998

Wydawca:

Polskie Towarzystwo Parazytologiczne

Tematy:

glucocorticoid
parasite
peripheral blood
infection
mouse
mice
serum
T lymphocyte
trichinellosis
depomedrol
blood
Trichinella spiralis

Źródło:

Annals of Parasitology; 1998, 44, 3
0043-5163

Pojawia się w:

Annals of Parasitology

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 32.

Tytuł:

CD4+ and CD8+ cells in mice infected with Trichinella spiralis and treated with cyclosporine A

Autorzy:

Karmańska, K.
Houszka, M.
Miśta, D.
Stefaniak, E.

Powiązania:

https://bibliotekanauki.pl/articles/2151487.pdf

Data publikacji:

1994

Wydawca:

Polskie Towarzystwo Parazytologiczne

Tematy:

immunoenzymatic method
mouse
infection
mice
cell
T lymphocyte
immunofluorescent method
cyclosporin A
larva
Trichinella spiralis

Opis:

Studies were undertaken to evaluate by parasitological techniques the course of intestinal and muscular invasions in mice infected with Trichinella spiralis and treated with TFX-Thymomodulin (TFX-Th). Studies were conducted on 120 mice of BALB/c and SWISS strains, infected each with a mean invasive dose of 300 T. spiralis larvae. TFX-Th (Thymoorgan GmbH Pharmazie Co. KG, Vienenburg, Germany) was administered subcutaneously at 30 mg/kg body weight. Depending upon duration of TFX-Th administration and stages of intestinal and muscular invasions, three experiments were distinguished in the study. The results indicated that TFX-Th promoted eradication of larvae from muscles, whether administered at the early of the late stage of T. spiralis invasion.

Źródło:

Wiadomości Parazytologiczne; 1994, 40, 4; 357-362
0043-5163

Pojawia się w:

Wiadomości Parazytologiczne

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 33.

Tytuł:

Stosunek liczby neutrofilów do limfocytów oraz wskaźnik redukcji kreatyniny pozwalają na przewidzenie dobrej wczesnej czynności przeszczepu nerki u dorosłych

Autorzy:

Hogendorf, Piotr
Suska, Anna
Skulimowski, Aleksander
Rut, Joanna
Grochowska, Monika
Wencel, Aleksandra
Dziwisz, Filip
Nowicki, Michał
Szymański, Dariusz
Poznańska, Grażyna
Durczyński, Adam
Strzelczyk, Janusz

Powiązania:

https://bibliotekanauki.pl/articles/1392885.pdf

Data publikacji:

2018

Wydawca:

Index Copernicus International

Tematy:

neutrophil-lymphocyte ratio
creatinine reduction ratio
graft function
cadaveric donor
delayed graft function kidney transplant

Opis:

Opóźniona funkcja nerki przeszczepionej (DGF) jest częstym powikłaniem po transplantacji nerki. Jest związana z uszkodzeniem niedokrwienno-reperfuzyjnym (IRI). Do patogenezy uszkodzenia niedokrwienno-reperfuzyjnego związanego z opóźnioną funkcją przeszczepu przyczyniają się limfocyty. Materiał i metody: 135 pacjentów rasy kaukaskiej otrzymało przeszczep nerki od zmarłych dawców z bijącym sercem. W celu oceny funkcji przeszczepu pacjenci zostali podzieleni na dwie grupy – pacjentów z eGFR30 w 21. dniu po przeszczepieniu (n = 36) oraz pacjentów z eGFR <30 w 21. dniu po przeszczepieniu (n = 99). Zmierzony został poziomy kreatyniny w surowicy w 1. oraz 2. dniu po przeszczepie oraz przedoperacyjne ilość monocytów, limfocytów, płytek krwi i neutrofilów, jak również proporcje pomiędzy nimi. Wyniki: Stwierdzono statystycznie istotne różnice między grupami eGFR <30 i eGFR 30 w ilości limfocytów (0,36 +/- 0,6 vs -0,016 +/- 0,74; odpowiednio p = 0,004) lnNLR (stosunek neutrofili do limfocytów) (1,27 +/- 0,92 vs 1,73 +/- 1,08; p = 0,016) lnLMR (stosunek limfocytów do monocytów) (1,01 +/- 0,57 vs 0,73 +/- 0,64; p = 0,02), lnPLR (stosunek płytek do limfocytów) (4,97 +/- 0,55 vs 5,26 +/- 0,67; p = 0,023), i CCR 2% (-20,20 +/- 21,55 vs -4,29 +/- 29,62; p = 0,004). W analizie jednowymiarowej, czynniki, takie jak: ilość limfocytów 0,22 (OR = 0,331; 95% CI 0,151–0,728; p = 0,006), LnLMR1,4 (OR = 0,255; 95% CI 0,072–0,903; p = 0,034) były związane z gorszą funkcją przeszczepu, podczas gdy lnNLR 1,05 (OR = 2,653 95% CI 1,1158–6,078; p = 0,021), lnPLR 5,15 (OR = 2,536; 95% CI 1,155–5,566; p = 0,02) i CRR2 (współczynnik redukcji kreatyniny w drugim dniu) (OR = 3,286; 95% CI 1,359 –7,944; p = 0,008) wskazywało na lepszą funkcję przeszczepu. Podsumowanie: Wyższa bezwzględna liczba limfocytów (lnLymphocytes) i lnLMR, a także niższy poziom lnNLR i lnPLR były związane z niższym eGFR w 21. dniu po przeszczepie nerki. W analizie wieloczynnikowej CRR2 w połączeniu z limfocytami lnNLR lub lnPLR umożliwiły wyższą dokładność w identyfikacji pacjentów z nieprawidłową funkcją przeszczepu.

Źródło:

Polish Journal of Surgery; 2018, 90, 2; 28-33
0032-373X
2299-2847

Pojawia się w:

Polish Journal of Surgery

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 34.

Tytuł:

Prognostic value of lymphocyte-related systemic inflammatory biomarkers in triple negative breast cancer
Wartość prognostyczna biomarkerów stanu zapalnego powiązanych z limfocytami w potrójnie ujemnym raku piersi

Autorzy:

Oraczewski, Rafał Karol
Czerniawska-Meler, Małgorzata
Korzeniewicz, Martyna
Kade, Grzegorz
Kozielec, Zygmunt
Michalak, Maciej
Król, Magdalena
Zdaniukiewicz, Adam
Bodnar, Lubomir

Powiązania:

https://bibliotekanauki.pl/articles/2159007.pdf

Data publikacji:

2022-06-29

Wydawca:

Medical Education

Tematy:

triple negative breast cancer
neutrophil-to-lymphocyte ratio
platelet-to-lymphocyte ratio
the systemic immune inflammation index
prognostic factor
potrójnie ujemny rak piersi
czynnik prognostyczny
stosunek neutrofilów do limfocytów
stosunek płytek do limfocytów
wskaźnik ogólnoustrojowej reakcji immunologiczno-zapalnej

Opis:

The aim was to evaluate inflammatory biomarkers as prognostic factors in patients with triple negativbreast cancer. We have collected data from 143 patients and evaluated using Chi-Squared test, Wilcoxon–Mann–Whitney test and Cox regression. We found a relationship between high neutrophil- to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immune inflammation index and local advancement features: tumor (T3/T4) (P = 0.0001, P = 0.0198, P = 0.0001), positive regional lymph nodes (P = 0.0014, P = 0.0075, P = 0.0206). In the multivariate analysis metastatic disease, worse performance status and high NLR (Hazard ratio: 4.48 [2.05–9.80], P=0.0002; 2.23 [1.24–4.03], P=0.0010; 2.23 [1.24–4.03], P=0.0075) were adverse prognostic factors. High neutrophil-to-lymphocyte ratio with worse performance status turned out an adverse independent prognostic factors.
Celem pracy było określenie wartości prognostycznej markerów stanu zapalnego u pacjentów z potrójnie ujemnym rakiem piersi. Zebrano dane dotyczące 143 chorych i oceniono używając testu chi-kwadrat, testu Wilcoxon–Mann–Whitney oraz regresji Coxa. Stwierdzono związek między wysokim poziomem stosunku neutrofilów do limfocytów, płytek do limfocytów, wskaźnikiem ogólnoustrojowej reakcji immunologiczno-zapalnej a miejscowym stopniem zaawansowania: guz (T3/T4) (P=0.0001, P=0.0198, P=0.0001), dodatnie regionalne węzły chłonne (P=0.0014, P=0.0075, P=0.0206). Wielowymiarowa analiza wykazała, że choroba rozsiana, gorszy stan sprawności oraz wysoki stosunek neutrofilów do limfocytów (Hazard ratio: 4.48 [2.05-9.80], P=0.0002; 2.23 [1.24-4.03], P=0.0010; 2.23 [1.24-4.03], P=0.0075) stanowią negatywne czynniki prognostyczne. Wysoki stosunek neutrofilów do limfocytów oraz gorszy stan sprawności stanowią niezależne negatywne czynniki prognostyczne.

Źródło:

OncoReview; 2022, 12, 2; 25-34
2450-6125

Pojawia się w:

OncoReview

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 35.

Tytuł:

Influence of diethylenetriamine [DETA] and sodium nitroprusside [NaNP] on sister chromatid exchange frequency and cell kinetics in cultured human lymphocytes

Autorzy:

Perkowska, M
Szczygiel, M.
Wozniak, A.
Limon, J.

Powiązania:

https://bibliotekanauki.pl/articles/2041984.pdf

Data publikacji:

2001

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

cell cycle
sodium nitroprusside
restenosis
genetics
man
cell kinetics
lymphocyte
diethylenetriamine
sister chromatid exchange
myocardial ischaemia

Źródło:

Journal of Applied Genetics; 2001, 42, 2; 233-235
1234-1983

Pojawia się w:

Journal of Applied Genetics

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 36.

Tytuł:

Molecular analysis of a large novel constitutional deletion in a patient with sporadic unilateral retinoblastoma

Autorzy:

Zajaczek, S
Cragg, H.
Jakubowska, A.
Gorski, B.
Krzystolik, Z.
Cowell, J.K.
Lubinski, J.

Powiązania:

https://bibliotekanauki.pl/articles/2043635.pdf

Data publikacji:

1999

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

retinoblastoma
large deletion
patient
Rb-1 gene
constitutional mutation
peripheral blood lymphocyte
molecular analysis
sporadic unilateral retinoblastoma
DNA
cancer

Źródło:

Journal of Applied Genetics; 1999, 40, 3; 233-239
1234-1983

Pojawia się w:

Journal of Applied Genetics

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 37.

Tytuł:

Contact allergy to nickel: Patch test score correlates with IL-5, but not with IFN-gamma nickel-specific secretion by peripheral blood lymphocytes

Autorzy:

Czarnobilska, E
Jenner, B.
Kaszuba-Zwoinska, J.
Kapusta, M.
Obtulowicz, K.
Thor, P.
Spiewak, R.

Powiązania:

https://bibliotekanauki.pl/articles/49735.pdf

Data publikacji:

2009

Wydawca:

Instytut Medycyny Wsi

Tematy:

allergic contact dermatitis
patch test
contact allergy
lymphocyte
interleukin 5
interferon gamma
risk estimation
nickel
peripheral blood
chronic disease

Źródło:

Annals of Agricultural and Environmental Medicine; 2009, 16, 1; 37-41
1232-1966

Pojawia się w:

Annals of Agricultural and Environmental Medicine

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 38.

Tytuł:

Complementary analysis of the initial value problem for a system of o.d.e. modelling the immune system after vaccinations

Autorzy:

Foryś, Urszula
Żołek, Norbert

Powiązania:

https://bibliotekanauki.pl/articles/1208222.pdf

Data publikacji:

2000

Wydawca:

Polska Akademia Nauk. Instytut Matematyczny PAN

Tematy:

VT-complex
antibody
antigen
B-cell
plasma cell
stationary state
stability
ordinary differential equations
lymphocyte
phase space

Opis:

Complementary analysis of a model of the human immune system after a series of vaccinations, proposed in [7] and studied in [6], is presented. It is shown that all coordinates of every solution have at most two extremal values. The theoretical results are compared with experimental data.

Źródło:

Applicationes Mathematicae; 2000, 27, 1; 103-111
1233-7234

Pojawia się w:

Applicationes Mathematicae

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 39.

Tytuł:

Effects of acetylsalicylic acid and a new pyrazine derivative PD-101 on sister chromatid exchange frequency and cell kinetics in cultured human lymphocytes

Autorzy:

Wozniak, A
Limon, J.
Petrusewicz, J.
Kaliszan, R.

Powiązania:

https://bibliotekanauki.pl/articles/2044238.pdf

Data publikacji:

1998

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

pyrazine
cell cycle
human lymphocyte
cytogenetic analysis
sister chromatid exchange
kinetics
chromosome aberration
in vitro
acetylsalicylic acid

Opis:

Acetylsalicylic acid (ASA) and α-2-pyrazylidene-α-cyano N-butyl acetamide (PD-101), a new antiaggregatory pyrazine derivative were tested for their genotoxicity in human lymphocytes in vitro using the sister chromatid exchange (SCE) technique. Both compounds were found to be inactive in inducing SCE in concentration from 1 µM up to 1000 µM. The agents displayed inhibitory effect on cell kinetics.

Źródło:

Journal of Applied Genetics; 1998, 39, 3; 281-287
1234-1983

Pojawia się w:

Journal of Applied Genetics

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 40.

Tytuł:

Lymphocyte subpopulations and apoptosis of immune cells in rabbits experimentally infected with a strain of the RHD virus having a variable haemagglutination capacity

Autorzy:

Niedzwiedzka-Rystwej, P.
Deptula, W.

Powiązania:

https://bibliotekanauki.pl/articles/31022.pdf

Data publikacji:

2012

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

lymphocyte subpopulation
apoptosis
immune cell
rabbit
experimental infection
RHD virus
hemagglutination capacity
granulocyte
T cell
B cell

Opis:

The paper describes the immunological response in the matter of percentage of T cells (receptor CD5+) and subpopulations (Th with receptor CD4+, Tc/Ts with receptor CD8+, T with receptor CD25+) and B cells with receptor CD19+, as well as the percentage of apoptotic granulocytes and lymphocytes, in rabbits experimentally infected with the Hagenow strain of the RHD virus. The material chosen for the experiment is special, as among all strains of RHD virus, there are only two strains which carry the variable haemagglutination capacity of red cells. The results of the study show that the Hagenow strain gives an untypical picture of T and B lymphocytes, whereas the results in inducing apoptosis seems to corespond with previous data, confirming the inclusion of apoptosis from 4 h p.i. and the intensity of the phenomenon being higher in granulocytes.

Źródło:

Polish Journal of Veterinary Sciences; 2012, 15, 1
1505-1773

Pojawia się w:

Polish Journal of Veterinary Sciences

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 41.

Tytuł:

Anatoxin-a induces apoptosis of leukocytes and decreases the proliferative ability of lymphocytes of common carp (Cyprinus carpio L.) in vitro

Autorzy:

Bownik, A.
Rymuszka, A.
Sieroslawska, A.
Skowronski, T.

Powiązania:

https://bibliotekanauki.pl/articles/31172.pdf

Data publikacji:

2012

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

anatoxin
apoptosis
leucocyte
proliferative ability
lymphocyte
common carp
Cyprinus carpio
in vitro culture
immunotoxicity
fish
anatoxin-a
cyanotoxin
necrosis

Opis:

Cyanobacteria (Cyanophyta, Cyanoprocaryota, Cyanobacteria) (blue-green algae) are procaryotic phototrophic microorganisms playing an important ecological role in the freshwater and marine environment as primary producers. However, as a consequence of water eutrophication observed in many reservoirs in different parts of the world, these microorganisms form massive scums, known as water blooms, releasing cyanotoxins hazardous to fish and other aquatic organisms. Cyanotoxins are cyanobacterial secondary metabolites of various chemical structures harmful to humans, terrestial and aquatic animals such as fish. The most abundant cyanotoxins are microcystins and hepatotoxins inducing toxic changes in fish liver, kidney, gills, digestive tract and immune system. Very little is known on the effects of alkaloid neurotoxic anatoxin-a on fish and their immunity. The aim of this study was to assess the in vitro influence of anatoxin-a on immune cells isolated from the common carp (Cyprinus carpio L.). The leukocyte intracellular level of ATP was reduced only at the highest concentration of anatoxin-a. Apoptotic and necrotic leukocytes were observed at the lower and the highest concentrations of anatoxin-a, respectively. Elevated activity of caspases 3/7 after 2 hours and a concentration-dependent decrease in the proliferative ability of T and B lymphocytes was also observed. The results suggest that anatoxin-a could be a possible immunotoxic agent in the aquatic environment and may increase the susceptibility of fish to infectious and neoplastic diseases. Therefore, constant monitoring of anatoxin-a and its producers in lakes and fish ponds should be performed.

Źródło:

Polish Journal of Veterinary Sciences; 2012, 15, 3
1505-1773

Pojawia się w:

Polish Journal of Veterinary Sciences

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 42.

Tytuł:

Isolation and characterization of rat gastric microvascular endothelial cells as a model for studying gastric angiogenesis in vitro

Autorzy:

Jones, M.K.
Wang, H.
Tomikawa, M.
Szabo, I.L.
Kawanaka, H.
Sarfeh, I.J.
Tarnawski, A.S.

Powiązania:

https://bibliotekanauki.pl/articles/71014.pdf

Data publikacji:

2000

Wydawca:

Polskie Towarzystwo Fizjologiczne

Tematy:

capillary microvessel
gastric endothelial cell
T lymphocyte
endothelial cell
monoclonal antibody
monocyte
angiogenesis
microvasculature
stomach
in vitro
rat
platelet

Źródło:

Journal of Physiology and Pharmacology; 2000, 51, 4,2
0867-5910

Pojawia się w:

Journal of Physiology and Pharmacology

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 43.

Tytuł:

Evaluation of the influence of meloxicam and flunixin meglumine on the apoptosis of peripheral blood CD4plus and CD8plus T cells in calves

Autorzy:

Maslanka, T
Jaroszewski, J.J.
Markiewicz, W.
Jabubowski, P.

Powiązania:

https://bibliotekanauki.pl/articles/31556.pdf

Data publikacji:

2010

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

peripheral blood
T cell
calf
CD4plus T cell
CD8plus T cell
apoptosis
meloxicam
flunixin meglumine
lymphocyte
antiinflammatory drug

Opis:

The aim of the study was to determine whether treatment with recommended doses of meloxicam or flunixin had an effect on the apoptosis of peripheral blood T lymphocytes in calves. The study was carried out on 4-5 months old calves (n = 24, 8 per group). Experimental animals were injected subcutaneously with a single dose of 0.5 mg . kg-1 of meloxicam or intravenously with 3 doses of 2.2 mg . kg-1 day-1 of flunixin. The non-treatment animals served as control. Blood samples were taken at day 0 and at days 1, 2, 3, 5, 7 and 14 after the first NSAIDs injection. Apoptosis was determined by flow cytometry using Annexin V-PE/7-AAD staining. The kinetic analysis of apoptosis in the total lymphocyte population, as well as in the CD4+ and CD8+ subsets did not reveal significant differences in the frequency of early apoptotic cells between control and experimental groups throughout the period studied. Although, 24 h after administration of the first dose of NSAIDs, late-stage apoptosis/necrosis was significantly increased in the total lymphocyte population (the meloxicam group), as well as in the CD4+ (the meloxicam group and the flunixin group) and CD8+ (the flunixin group) subsets of T cells. However, this disturbance was transient, relatively poorly expressed and, thus, unlikely to be of clinical significance. Our results indicate that the use of meloxicam or flunixin in accordance with the recommended dosage regimen in cattle do not have a clinically significant influence on apoptosis of peripheral blood T cells.

Źródło:

Polish Journal of Veterinary Sciences; 2010, 13, 1; 3-12
1505-1773

Pojawia się w:

Polish Journal of Veterinary Sciences

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 44.

Tytuł:

Effect of chlorpyrifos on the profile of subpopulations immunocompetent cells B, T and NK in in vivo model

Autorzy:

Noworyta-Glowacka, J.
Beresinska, M.
Bankowski, R.
Wiadrowska, B.
Siennicka, J.
Ludwicki, J.K.

Powiązania:

https://bibliotekanauki.pl/articles/875152.pdf

Data publikacji:

2014

Wydawca:

Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny

Tematy:

chlorpyrifos
pesticide
human exposure
immunomodulation
B cell
T cell
natural killer cell
in vivo model
immune system
lymphocyte
organophosphorus pesticide

Opis:

Background. Current studies have indicated many environmental factors, such as pesticides, that cause immune system disorders through inducing changes in humoral and cellular responses thereby increasing the risk of contracting infectious diseases and cancer. The literature suggests that low exposures to certain organophosphorus pesticides stimulate the immune system, whilst high exposures result in decreased function. Precise mechanisms for the fall in immunocompetence are often unclear, however it can be predicted that the intimate interaction between the nervous and immune systems can potentially lead to toxicity. Objectives. To determine the effects of organophosphorus pesticide, chlorpyrifos that is often used in Poland, on selected immunological responses, such as immune-competent cell proportions formed experimentally in-vivo by cells of Wistar rats during subchronic exposures after 45 and 90 days. Materials and Methods. The test was carried out on ten male and ten female Wistar rats in each of three test groups, who received 3 chlorpyrifos doses for 90 days intragastrically, according to OECD guidelines (No. 401). Two control groups were given olive oil. After completion, the animals were deeply anaesthetised by a mixture of ketamine (Vetaketam) and xylazine (Vetaxym). Immuno-competent cells were profiled by a commercial monoclonal antibody method. In order to measure the dynamics of any changes, the aforementioned immunological responses were investigated after 45 days using the same procedures for obtaining the relevant biological test material. Results. Test animals exposed to chlorpyrifos had altered number of white bood cells which were either increased or decreased relative to controls after 45 and 90 days for all exposure levels used. Conclusions. The study demonstrated changes in white-blood cell (lymphocyte) response profiles, reflecting an immunomodulation although such changes were equivocal, where both suppression and stimulation were observed.
Wprowadzenie. Współczesne badania naukowe wskazują, iż wiele czynników środowiskowych, wliczając w to pestycydy, powoduje zaburzenia układu odpornościowego poprzez indukowanie zmian w odpowiedzi humoralnej i komórkowej, co w efekcie może prowadzić do zwiększonej zapadalności na choroby zakaźne i nowotworowe. Doniesienia literaturowe sugerują, że niskie poziomy narażenia na niektóre pestycydy fosforoorganiczne powodują stymulację układu odpornościowego, zaś wyższe, obniżenie funkcji immunologicznych. W wielu przypadkach nie jest poznany dokładny mechanizm spadku odporności, jednak poprzez związek funkcji neurologicznych i immunologicznych można przewidzieć potencjalne skutki działania toksycznego. Cel. Celem badań było określenie wpływu chloropiryfosu na wybrane parametry odpowiedzi immunologicznej, takie jak skład odsetkowy komórek immunokompetentnych w modelu doświadczalnym in vivo szczurów laboratoryjnych szczepu Wistar, w trakcie ekspozycji subchronicznej 45 i 90 dniowej. Materiał i metody. Badanie wykonano na samcach (10 szt.) i samicach (10 szt.) szczurów rasy Wistar. Zwierzętom z grupy badanej podawano dożołądkowo chloropiryfos przez 90 dni, zgodnie z zaleceniami OECD (Guideline No 401). Grupa kontrolna otrzymywała oliwę z oliwek. Po zakończeniu eksperymentu zwierzęta poddawano głębokiej narkozie przy użyciu mieszaniny: ketaminy (Vetaketam) i ksylazyny (Vetaxym). W celu określenia dynamiki ewentualnych zmian zbadano wyżej wymienione parametry immunologiczne po 45 dniach doświadczenia przy zachowaniu tych samych procedur uzyskania materiału badawczego. Wyniki. Uzyskane wyniki wskazują, że narażanie zwierząt doświadczalnych na chloropiryfos zmieniało skład odsetkowy komórek immunokompetentnych w modelu doświadczalnym in vivo zwiększając albo zmniejszając ich wartość w stosunku do poziomów oznaczonych u grupy zwierząt kontrolnych po 45 i 90 dniowej ekspozycji i na wszystkich poziomach narażania. Wnioski. Odnotowane w wyniku przeprowadzonych badań zmiany w profilu białokrwinkowym świadczące o działaniu immunomodulującym były niejednoznaczne przyjmując formę zarówno immunosupresji jak i immunostymulacji.

Źródło:

Roczniki Państwowego Zakładu Higieny; 2014, 65, 4
0035-7715

Pojawia się w:

Roczniki Państwowego Zakładu Higieny

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 45.

Tytuł:

The presence of CD25 on bovine WC1 plus gamma delta T cells is positively correlated with their production of IL-10 and TGF-beta, but not IFN-gamma

Autorzy:

Maslanka, T.
Jaroszewski, J.J.
Markiewicz, W.
Ziolkowski, H.
Barski, D.

Powiązania:

https://bibliotekanauki.pl/articles/32183.pdf

Data publikacji:

2012

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

cattle
WC1 cell
T cell
T lymphocyte
transforming growth factor-beta
interleukin 10
interferon-gamma
CD25 antigen
CD25 molecule

Opis:

WC1+ cells in cattle exhibit both regulatory and effector activities. However, it has not been elucidated whether they are so plastic that both activities co-exist in one cell or there are separate subpopulations of effector and regulatory cells. Since the production of IFN-γ and IL-10 seems to be related to WC1+ cells’ effector and regulatory function, respectively, the main aim of this study was to determine whether those cytokines are produced by separate subpopulations of WC1+, or are co-produced by the same cells. Due to increasingly frequent emphasised role of consumption of IL-2 in the mechanism of suppressor action of mouse CD25+CD4+ T regulatory cells, expression of the receptor’s α chain for interleukin 2 (CD25) on WC1+ lymphocytes has been evaluated. An average of 5.21% of WC1+ cells obtained from PBMCs of 12-month-old heifers show constitutive expression of the CD25 molecule, with CD25highWC1+ and CD25lowWC1+ cells accounting for 1.05% and 4.10% of WC1+ lymphocytes, respectively. For detection of intracellular cytokine production, PBMCs were stimulated with concanavalin A. Both IFN-γ- and IL-10-producing cells within the CD25-WC1+ and CD25+WC1+ subpopulations were mainly separate subpopulations. The average percentage of IFN-γ+IL-10-, IFN-γ-IL-10+ and IFN-γ+IL-10+ cells among CD25-WC1+ lymphocytes was 4.03%, 2.67% and 0.51%, respectively. A positive correlation was observed between the presence of the CD25 molecule on WC1+ lymphocytes and production of IL-10 and TGF-β, because the average percentage of IFN-γ-IL-10+ and IFN-γ+IL-10+ among CD25+WC1+ lymphocytes was 3 and 4.5 times higher as compared to the corresponding cells in the CD25-WC1+ subpopulation, whereas the percentage of IFN-γ+IL-10- cells in both the subpopulations was not significantly different. The percentage of TGF-β+ cells within the CD25+WC1+ subpopulation was 2.72 times as high as that of CD25-WC1+ lymphocytes. Therefore, with respect to the production of IFN-γ, IL-10 and TGF-β, CD25+WC1+ lymphocytes turn out to have a more suppressor profile than CD25-WC1+.

Źródło:

Polish Journal of Veterinary Sciences; 2012, 15, 1
1505-1773

Pojawia się w:

Polish Journal of Veterinary Sciences

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 46.

Tytuł:

Molecular follow up of donor lymphocyte infusion in CML children after allogeneic bone marrow transplantation

Autorzy:

Ladon, D
Pieczonka, A.
Jolkowska, J.
Wachowiak, J.
Witt, M.

Powiązania:

https://bibliotekanauki.pl/articles/2048295.pdf

Data publikacji:

2001

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

minimal residual disease
in situ
human genetics
bone marrow
hybridization
fluorescence
donor lymphocyte infusion
chronic myeloid leukemia
child
polymerase chain reaction
transplantation

Źródło:

Journal of Applied Genetics; 2001, 42, 4; 547-552
1234-1983

Pojawia się w:

Journal of Applied Genetics

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 47.

Tytuł:

Analiza poziomu wybranych parametrów stanu zapalnego, krążących kompleksów immunologicznych oraz związanych z nimi wskaźników (neutrofi l/limfocyt, płytki/limfocyt, CRP/KKI) w raku płuc
Analysis of the concentration of selected parameters of inflammation, circulating immune complexes and related indicators (neutrophil/ lymphocyte, platelet/lymphocyte, CRP/CIC) in patients with lung cancer

Autorzy:

Pilaczyńska-Cemel, Marta
Gołda, Ryszard
Dąbrowska, Anita
Przybylski, Grzegorz

Powiązania:

https://bibliotekanauki.pl/articles/527812.pdf

Data publikacji:

2019

Wydawca:

Krakowska Akademia im. Andrzeja Frycza Modrzewskiego

Tematy:

circulating immune complexes
neutrophil-lymphocyte ratio
platelet-lym-phocyte ratio
lung cancer
krążące kompleksy immunologiczne
wskaźnik neutrofil/limfocyt
wskaźnik płytka krwi/limfocyt
rak płuca

Opis:

Introduction: Lung cancer is the most frequent malignancy in Poland and is the first cause of death in oncology. The aim of the study is to analyze selected parameters of inflammation in lung cancer. Material and methods: 48 patients with lung cancer were included in the study group and 30 persons in the control group. The group was divided according to the level of severity - 19 with low/moderate stage (I-IIIA), 29 with high (IIIB and IV) and to histopatho- logical type - 9 with small cell carcinomas, 39 with non-small cell carcinomas (therein 18 - adenocarcinomas and 21 squamous carcinomas). The concentrations of circulating immune complexes (CIC), C-reactive protein (CRP), neutrophils, lymphocytes and their associated indicators were examined: CRP/CIC, NLR (neutrophil/lymphocyte ratio), PLR (platelet/lymphocyte ratio). Results: The average parameter values were significantly higher among people with lung cancer. The median value of CIC was significantly higher in the group with advanced cancer (0.30 vs 0.23, p<0.01 compare to stage I-IIIA). The median PLR and platelet counts among patients with squamous cell carcinoma were significantly higher compared to adenocarcinomas (215 vs 138.5, p = 0.037, 388.0 thousand/ul vs 277.5 thousand/ul, p = 0.034). Conclusion: Based on the results of our work, we suggested the dominance of a specific humoral response in the more advanced stage of lung cancerogenesis. The process of carcinogenesis is associated with various activities of neutrophils and lymphocytes.
Wprowadzenie: Rak płuca jest najczęstszym nowotworem w Polsce i pierwszą przyczyną zgonów w onkologii. Celem pracy jest analiza wybranych parametrów stanu zapalnego w raku płuca. Materiał i metody: Grupę badaną stanowiło 48 chorych z rakiem płuca oraz 30 przypadków grupy kontrolnej. Chorych podzielono wg stopnia zaawansowania - 19 z niskim/ umiarkowanym stopniem zaawansowania (I-IIIA), 29 z wysokim (IIIB i IV), a także wg typu histopatologicznego - 9 z rakiem drobnokomórkowym, 39 z niedrobnokomórkowym (w tym 18 z gruczolakorakiem i 21 z rakiem płaskonabłonkowym). Zbadano stężenia krążących kompleksów immunologiocznych (KKI), białka C-reaktywnego (ang. C-reactive protein, CRP), neutrofilów, limfocytów oraz związanych z nimi wskaźników: CRP/KKI, neutrofil/limfocyt (ang. neutrophil/lymphocyte ratio, NLR), płytka krwi/limfocyt (ang. platelet/lymphocyte ratio, PLR). Wyniki: Średnie wartości badanych parametrów były istotnie wyższe wśród osób z rakiem płuca. Mediana wartości KKI była istotnie wyższa w grupie z zaawansowanym nowotworem (0,30 vs 0,23, p<0,01 w porównaniu ze stopniem I-IIIA). Mediany wskaźnika PLR oraz liczby płytek krwi wśród osób z rakiem płaskonabłonkowym były istotnie wyższe porównując do gruczolakoraka (215 vs 138,5, p = 0,037; 388,0 tys/ul vs 277,5 tys/ul, p = 0,034). Wnioski: Na podstawie wyników pracy zasugerowaliśmy dominację swoistej odpowiedzi humoralnej w bardziej zaawansowanym stadium kancerogenezy płuca. Proces kancerogenezy związany jest z różną aktywnością neutrofili i limfocytów.

Źródło:

Państwo i Społeczeństwo; 2019, 4; 9-25
1643-8299
2451-0858

Pojawia się w:

Państwo i Społeczeństwo

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 48.

Tytuł:

Analysis of chromosome aberrations, sister chromatid exchanges [SCE] and cell division kinetics in human lymphocytes exposed in vitro to new monophosphates of pyrimidine acyclonucleosides

Autorzy:

Ferenc, T
Rutkowski, M.
Bratkowska, W.
Hubner, H.
Draminski, M.

Powiązania:

https://bibliotekanauki.pl/articles/2044452.pdf

Data publikacji:

1998

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

statistical analysis
chromatid gap
chromosome number
enzyme activity
chromosome aberration
in vitro
chromosome gap
pyrimidine
phosphorylase
acyclonucleoside monophosphate
human lymphocyte
sister chromatid exchange
cell division

Opis:

Five newly synthesised monophosphates of two pyrimidine acyclonucleoside series, namely 1-N-[(2’-hydroxy)ethoxymethyl] and l-N-[(l’,3’-dihydroxy)- 2’-propoxymethyl] derivatives of 5- and 5,6-alkylated uracils were tested in vitro for chromosome aberrations and sister chromatid exchanges (SCE). Metaphase plates were obtained via microculture of human lymphocytes from heparinized peripheral blood. The compounds were tested in doses: 10, 20, 40, 80 and 150 µg per mL of culture. The tested compounds induced mainly chromatid gaps, less frequently chromosome gaps. A low number of mitoses with chromatid and chromosome breaks, acentric fragments, dicentric chromosomes and exchange figures were also observed. The tested compounds in doses: 40, 80 and 150 µg per mL, doubled or tripled the percentage of cells with chromatid gaps and chromosome gaps as compared to the control. The percentage o cells with aberrations (excluding gaps) induced by the tested compounds in all doses did not exceed 2%. The tested compounds induced a higher number of SCE per cell but less than double frequency as compared to the control. SCE frequencies and replication index (RI) values varied depending on the examined compounds. For the highest dose of the tested compounds (150 µg per mL) a significant decrease in RI values was observed for l-N-[(2’-hydroxy)ethoxymethyl]-5,6-tetramethyleneuracil monophosphate and for l-N-[(2’-hydroxy)ethoxymethyl]-5,6-dimethyluracil monophosphate. So far, the results have indicated potential clastogenicity of all the tested compounds except acycloguanosine monophosphate.

Źródło:

Journal of Applied Genetics; 1998, 39, 1; 113-127
1234-1983

Pojawia się w:

Journal of Applied Genetics

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 49.

Tytuł:

Searching for in vitro biomarkers of susceptibility to prostate and cervical cancers by analysis of chromosomal instability, gamma-H2AX foci, polymorphisms in DNA repair genes and apoptosis

Autorzy:

Wegierek-Ciuk, A.
Arabski, M.
Kedzierawski, P.
Florek, A.
Solowiej, D.
Gozdz, S.
Lisowska, H.
Kowalik, A.
Kowalska, M.
Wojcik, A.
Polanska, J.
Lankoff, A.

Powiązania:

https://bibliotekanauki.pl/articles/3629.pdf

Data publikacji:

2015

Wydawca:

Instytut Medycyny Wsi

Tematy:

in vitro biomarker
susceptibility
prostate
cervical cancer
cancer
patient
human disease
lymphocyte
man
ionizing radiation
chromosome instability
gamma-H2AX biomarker
polymorphism
DNA repair gene
apoptosis

Opis:

Introduction and objective. According to the cancer epidemiology databases, cancer is the second leading cause of death in developing countries. Moreover, the WHO predicts a continuing increase in the incidence of cancer, extending this trend well into the next several decades. Hence, it seems obvious that the prediction of cancer susceptibility and early diagnosis is an important goal for modern biomedical sciences. The aim of this study is to clarify the value of chromosomal damage, capacity for the repair of double-strand breaks (DSBs), polymorphisms in DNA repair genes, and apoptosis as prognostic markers for prostate and cervical cancer. Materials and methods. 30 prostate cancer patients and 30 cervical cancer patients were enrolled into the study. In addition, 30 healthy female donors and 30 healthy male donors served as controls. The following endpoints were investigated: frequency of micronuclei, gamma-H2AX fluorescence, XRCC1 194C>T, XRCC1 399G>A, XRCC3 IVS5–14 A>G, OGG1 326 Ser>Cys polymorphisms and apoptosis. Results. Among all tested factors, only the homozygous variant (Arg/Arg) in XRCC1 (399 Arg/Gln) was strongly associated with prostate cancer risk, and only a low apoptotic response was connected with cervical cancer risk. The presented study confirmed a positive association between the frequency of MN and increased prostate and cervical cancer risk. However, such a biomarker is not cancer specific. In addition, the information gained by analyzing the gamma-H2AX fluorescence, as well apoptosis, had no value for predicting the risk of prostate and cervical cancers. Conclusions. The final conclusion of the study is that cancer susceptibility is a complex phenotype not readily detectable in relatively small studies by functional assays or analysis of SNP in few, selected genes.

Źródło:

Journal of Pre-Clinical and Clinical Research; 2015, 09, 2
1898-2395

Pojawia się w:

Journal of Pre-Clinical and Clinical Research

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 50.

Tytuł:

The stimulation and inhibition of T cell proliferation by Helicobacter pylori components

Autorzy:

Chmiela, M
Lelwala-Guruge, J.A.
Wadstrom, T.
Rudnicka, W.

Powiązania:

https://bibliotekanauki.pl/articles/69409.pdf

Data publikacji:

1996

Wydawca:

Polskie Towarzystwo Fizjologiczne

Tematy:

polyacrylamide gel electrophoresis
blood leucocyte
sodium dodecyl sulphate
horse
stimulation
macrophage
chronic active gastritis
Helicobacter pylori
antibody
gastric carcinoma
cell proliferation
peripheral blood
ulcer
plasma cell
lymphocyte
infiltration
inhibition
gastric lymphoma

Źródło:

Journal of Physiology and Pharmacology; 1996, 47, 1
0867-5910

Pojawia się w:

Journal of Physiology and Pharmacology

Dostawca treści:

Biblioteka Nauki

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