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Tytuł:
Synaesthesie Und Autoskopie: Seltene Temporallappensymptome?
Synaesthesia and Autoscopy: Rare Symptoms of The Temporal Lobe?
Autorzy:
KLAWE, Christoph
Powiązania:
https://bibliotekanauki.pl/articles/1033823.pdf
Data publikacji:
2013
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
temporal lobe
“Doppelgänger”-phenomenon
autoscopy
synesthesia
Opis:
In the phenomenon of synaesthesia, adequate stimuli in one sensory modality are accompanied by perceptions in one to four others. Even if descriptions of synaesthesia are well known in the scientific literature, only scarce empirical research results are available yet. Certain characteristics distinguish synesthesias from eidetic imagery. Idiopathic synaesthesias are more common in females, familial clustering occurs. Electrophysiology usually yields no abnormal results, functional imaging and neuropsychology hint to a reduced inhibition of secondary sensory associative areas by the temporal cortex of the speech dominant hemisphere as a neurobiological basis. Secondary synaesthesias are sometimes symptoms of diseases like epilepsy or migraine. Autoscopy is a rare phenomenon, which consists of the pseudohallucinatory visual perception of the own body. The “Doppelgänger” exhibits characteristic features. Psychiatric comorbidity is common, occasionally the appearance of the double is associated with suicidality. The most common cause of autoscopy is temporal lobe epilepsy, a distinct lateralization, however, has not been demonstrated so far. Autoscopy can also be found in migraine attacks and has to be differentiated from other disturbances of body image.
Źródło:
Medicina Internacia Revuo; 2013, 25, 101; 201- 210
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Palaeogeographic reconstruction of the North Podlasie region in the Sokółka area during the Late Pleistocene (NE Poland)
Autorzy:
Rychel, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/2058729.pdf
Data publikacji:
2021
Wydawca:
Państwowy Instytut Geologiczny – Państwowy Instytut Badawczy
Tematy:
glacial lobe
periglacial zone
polygenetic relief
Opis:
A new palaeogeographic reconstruction from the end of the Odranian Glaciation to the end of the Weichslian Glaciation (MIS 2) is based on research carried out at the Knyszewicze site, NE Poland, focusing on the dynamics of the Wartanian Glaciation (MIS 6) and showing the lobed nature of this ice sheet. Reconstruction of deglaciation in the research area was supplemented by analysis of postglacial morpholineaments (MMA). Research carried out at the Jałówka site enabled reconstruction of the processes affecting lake processes during the Eemian (MIS 5e) Interglacial and transformation of this area during the Weichselian Glaciation. The results obtained indicated that the study area was not covered by Weichselian ice, the sediments formerly considered as glacial being slope-related and providing evidence of periglacial conditions. A new conceptual model for the evolution of this area is put forward, showing the polygenetic nature of the relief. The glacial landforms developed during the Warta Stadial and transformed during the Eemian Interglacial were further affected by periglacial processes, which significantly remodelled the relief.
Źródło:
Geological Quarterly; 2021, 65, 1; 12
1641-7291
Pojawia się w:
Geological Quarterly
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Persistent hyperthyroidism in a patient after total thyroidectomy: the thyroid anatomy has implications for treatment
Autorzy:
Młodożeniec, Aleksandra
Gala-Błądzińska, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/2038197.pdf
Data publikacji:
2021-06-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
Grave’s disease
pyramidal lobe
scintigraphy
thyroidectomy
Opis:
Introduction. Grave’s disease (GD) can be treated using three modalities: anti-thyroid medications, radioactive iodine therapy (RAI), or surgery. If surgery is selected, total thyroidectomy is the procedure of choice. Patients with hyperthyroidism frequently have an enlarged thyroid gland, occasionally with a pyramidal lobe. Aim. We point the usefulness of thyroid scintigraphy, which provides valuable information regarding the thyroid anatomy. Description of the case. The manuscript presents a case report of 43-year-old woman with unstable Grave’s disease, who underwent thyroidectomy and developed persistent hyperthyroidism postoperatively. She was referred by an endocrinologist to a nuclear medicine outpatient clinic for RAI therapy. I-iodide scintigraphy revealed two foci with excessive tracer accumulation. One of the foci in the middle of the neck corresponded to the pyramidal lobe. Conclusion. The thyroid anatomy anomalies can lead to unnecessary implications for treatment. Identifying the pyramidal lobe preoperatively and removing it from patients requiring total thyroidectomy may decrease the recurrence rate of hyperthyroidism. Thyroid scintigraphy is a useful diagnostic tool to visualize the pyramidal lobe.
Źródło:
European Journal of Clinical and Experimental Medicine; 2021, 2; 186-188
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Badanie kontroli wykonawczej za pomocą Testu Interferencji Stroopa u chorych na schizofrenię i osób z uszkodzeniami płatów czołowych
Executive control ability in Stroop task in patients with schizophrenia and in patients with frontal lobe lesions
Autorzy:
Okruszek, Łukasz
Rutkowska, Aleksandra
Powiązania:
https://bibliotekanauki.pl/articles/1178505.pdf
Data publikacji:
2013
Wydawca:
Uniwersytet Kazimierza Wielkiego w Bydgoszczy
Tematy:
Stroop task
executive functions
frontal lobe
schizophrenia
Opis:
The aim of this paper is to compare susceptibility to the Stroop effect in men with schizophrenia and in men with frontal lobe lesions. A sample of 90 men participated in the study. They were divided into three groups: men with schizophrenia (n = 30), men with localized frontal lobe lesions (n = 30) and healthy men (n = 30) as a control group. Significant differences measures found between controls and men with schizophrenia in all of the analyzed variable (Control task execution time p 0,001; Interference task execution time: p 0,001; Difference between two times p 0,05). Men with frontal lobe lesions differed significantly from healthy controls in the terms of speed of the task execution (Control task execution time p 0,01; Interference task execution time: p 0,01), but were no more prone to the Stroop effect than healthy controls. No significant differences were found between schizophrenia and frontal lobe lesion groups.
Źródło:
Polskie Forum Psychologiczne; 2013, XVIII, 2; 215-225
1642-1043
Pojawia się w:
Polskie Forum Psychologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Postglacial morpholineaments as an indicator of ice sheet dynamics during the Saale Glaciation in the Białystok Plateau and Sokółka Hills (NE Poland)
Autorzy:
Rychel, J.
Morawski, M.
Powiązania:
https://bibliotekanauki.pl/articles/2060371.pdf
Data publikacji:
2017
Wydawca:
Państwowy Instytut Geologiczny – Państwowy Instytut Badawczy
Tematy:
morpholineament
Saalian ice-sheet movement
lobe
NE Poland
Opis:
The palaeogeographical reconstruction of the deglaciation process in NE Poland during the Odranian Glaciation Wartanian Stadial (Saale MIS 6) is based mainly on the analysis of glacial morpholineaments, performed using the GIS programs that provide us with better understanding of the glacial landscape evolution, spatial reconstruction of glacial processes, and postglacial landscape development. Analysis of postglacial morpholineaments was carried out based on the Digital Elevation Model (DEM) as well as geological, geomorphological and topographic maps. It resulted in the delimitation of visible linear postglacial landforms, their identification and classification, and the determination of their genetic and chronological relations. Directions of the lineaments were determined through quantitative analysis. Qualitative analysis was applied to determine the spatial and temporal sequence of events, directions of ice movement and its range. Two glacial lobes, Biebrza and Neman, existed in the north-western part of the Białystok Plateau and Sokółka Hills during the last glacial advance. The lobed nature of the ice sheet can be confirmed by field data collected from, e.g., sites in Knyszewicze, and by topographic analysis of Quaternary sediments, combined with their thickness and genesis. The obtained reconstruction of the last glacial advance and retreat in the study area can be used in further regional discussions on the character and dynamics of the last glaciation in this region.
Źródło:
Geological Quarterly; 2017, 61, 2; 334--349
1641-7291
Pojawia się w:
Geological Quarterly
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Petrographic characteristics of fluvioglacial deposits of the Odra lobe, Poland: a statistical analysis
Autorzy:
Górska, M.
Zabielski, R.
Powiązania:
https://bibliotekanauki.pl/articles/2058922.pdf
Data publikacji:
2006
Wydawca:
Państwowy Instytut Geologiczny – Państwowy Instytut Badawczy
Tematy:
Odra lobe
fluvioglacial deposits
petrographical composition
statistical analysis
Opis:
The fluvioglacial deposits of the Odra lobe, laid down during the Pomeranian phase of the last glaciation in northeastern Germany and northwestern Poland, have been analysed petrographically and interpreted in a regional perspective. The deposits have been classified in terms of the percentage of 10 selected petrographical groups and 5 petrographical coefficients. Statistical analysis of their values has shown significant petrographic differences that relate to the morphological characteristics of the study area. The greatest petrographic diversity was observed between Mecklenburg–Western Pomerania and the Odra lobe as well as between the Odra lobe and middle Pomerania. The differentiating features are: crystalline rocks, grey Palaeozoic limestones and flints and all of the petrographical coefficients. The differences within the Odra lobe itself are small by comparison with those in the neighbouring regions. They are the most evident between Uckermark and theMyśliborskie Lakeland. The differentiating features are: flints and quartz as well as a maximumof four out of five petrographical coefficients.
Źródło:
Geological Quarterly; 2006, 50, 2; 239-246
1641-7291
Pojawia się w:
Geological Quarterly
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Rekonstrukcja kierunków ruchu lodu w obrębie lobu górnej Odry
Reconstruction of the ice-flow directions within the Upper Odra Lobe (S Poland)
Autorzy:
Salamon, T.
Powiązania:
https://bibliotekanauki.pl/articles/2074907.pdf
Data publikacji:
2012
Wydawca:
Państwowy Instytut Geologiczny – Państwowy Instytut Badawczy
Tematy:
ice sheet lobe
ice movement direction
Upper Odra Lobe
Odranian glaciation
lob lądolodu
kierunek ruchu lodu
lob górnej Odry
zlodowacenie Odry
Opis:
The Upper Odra Lobe - the southernmost part of the Scandinavian ice sheet during the Odranian (Drenthe) glaciation - was formed in the area of the Niemodlin Plain and the western part of the Racibórz Basin. It created a complex structure consisting of several sublobes: Odra, Nysa, Ruda and Klodnica sublobes. The study focused on the basal till deposited during ice sheet advance. Ice flow directions and the general pattern ofice mass distribution in the Upper Odra Lobe were defined based on the clast fabric. The resulting distribution of ice-flow palaeodirections suggest that the Upper Odra Lobe was formed by the mass of ice moving divergently from the Opole Plain located to the north of the Racibórz Basin. Ice-flow lines coincide with the pattern of major geomorphological units. The most intensive movement of the ice took place in the depression of the central part of the Silesian Lowland. From there, in the vicinity of the Niemodlin Plain, the ice sheet moved in different directions, forming smaller sublobes in several valleys. Strong relationship between the ice flow directions and morphology confirms the idea of a smaller ice sheet extent in the Racibórz Basin and Moravian Gate. Highly concentrated flow of ice in the back-lobe area, interpreted in this study, suggests that the lobe development resulted not only from the ice sheet adapting to the basement relief, but was also conditioned by a spatially varying distribution of ice, i.e. increased ice supply to the Niemodlin Plain and the western part ofthe Racibórz Basin.
Źródło:
Przegląd Geologiczny; 2012, 60, 10; 539--545
0033-2151
Pojawia się w:
Przegląd Geologiczny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Remote sensing of eskers from Vormsi and Väinameri vicinity, northwestern Estonia
Autorzy:
Aber, J. S.
Kalm, V.
Powiązania:
https://bibliotekanauki.pl/articles/2059322.pdf
Data publikacji:
2001
Wydawca:
Państwowy Instytut Geologiczny – Państwowy Instytut Badawczy
Tematy:
Estonia
Palivere
landsat
esker
subglacial meltwater
ice lobe surge
Opis:
We have utilised techniques of remote sensing in combination with ground observations in order to investigate eskers of the Vormsi and Väinameri region of northwestern Estonia. Landsat Thematic Mapper (TM) images were the basis for recognition and regional interpretation of esker systems, and kite aerial photography was employed for detailed, low-height views of selected eskers. A special Landsat TM composite was developed to enhance the display of shallow sea floor features. On this basis, we have extended known, land-based eskers across the sea floor, and we have identified additional probable eskers marked by shallow shoals and tiny islands. The known and suspected eskers of Vormsi and surroundings demonstrate a regular pattern in their distribution, which we suggest represents a subglacial drainage network that was anastomosing in character. The esker network is located along the central pathway of the Väinameri ice lobe, and the overall direction of drainage was toward the Palivere glacial limit. We interpret eskers of the Vormsi-Väinameri vicinity as evidence for substantial meltwater discharge beneath the Väinameri ice lobe, which terminated in a proglacial lake.
Źródło:
Geological Quarterly; 2001, 45, 4; 365-372
1641-7291
Pojawia się w:
Geological Quarterly
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ice-sheet dynamics of warta glaciation (saale) in the marginal zone of Knyszewicze area, north eastern Poland
Autorzy:
Rychel, Joanna
Woronko, Barbara
Karasiewicz, Mirosław T.
Szymczuk, Paweł
Morawski, Marcin
Powiązania:
https://bibliotekanauki.pl/articles/2025794.pdf
Data publikacji:
2015
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
ice lobe
marginal zone
glaciotectonic disturbances
thrust-block push moraines
morpholineaments
Opis:
The pa per pres ents a re search on a mar ginal zone near Knyszewicze in the south ern part of Sokó³ka Hills (north east ern Po land). Ter mi nal mo raine hills are ar ranged amphitheatrically in a lobal pat tern. Dy nam ics of the Knyszewicze frontal ice-sheet lobe dur ing the Saale Gla ci ation and suc ces sive stages of the mar ginal zone near the vil lage of Knyszewicze were re con structed based on sed i men tary and geomorphological anal y sis, us ing a dig i tal el e va tion model and morpholineaments. Three main phases of the Knyszewicze gla cial-lobe ac tiv ity were iden ti fied in clud ing ac cu mu la - tion of glaciofluvial de pos its, ad vances of the ice mar gin and ice-lobe re treat. Mo raine hills de vel oped at a sta ble ice-lobe ter mi nus, ini tially as short end-mo raine fans with the fol low ing se quence of lithofacies GhÞSGhÞSh or GmÞGhÞSh. Such a se quence in di cates cy clic sheet-floods. Dur ing a small but dy namic ad vance of the ice sheet termi nus, these de pos its were moved for ward and monoclinally folded, then fur rowed with slop ing faults due to hor i zontal pres sure. Typ i cal thrust-block push mo raines de vel oped in this way. Ice sheet ad vance took place when per ma frost was pres ent in the sub stra tum and very high wa ter pres sure oc curred at gla cial ter mi nus. In side a lobal con fig u ra tion of mo raines, there is a rich in ven tory of gla cial forms with a clas sic ter mi nal de pres sion in the cen tral part. Based on this landform pat tern, their shape, rhythm and glaciotectonic dis tur bances, the land re lief may be re ferred to as a hill-hole pair. The struc ture of Horczaki Knoll, de pos ited on the sub-Qua ter nary tec tonic struc ture, sig nif i cantly con trib uted to a de vel op ment of this mar ginal zone.
Źródło:
Studia Quaternaria; 2015, 32; 79-90
1641-5558
2300-0384
Pojawia się w:
Studia Quaternaria
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Palaeoglaciology of the Weichselian Odra ice lobe, NE Germany and NW Poland
Autorzy:
Hermanowski, P.
Powiązania:
https://bibliotekanauki.pl/articles/295026.pdf
Data publikacji:
2010
Wydawca:
Stowarzyszenie Geomorfologów Polskich
Tematy:
subglacial drainage
subglacial landforms
Odra lobe
Weichselian glaciation
ice movement dynamics
Opis:
Southern part of the Scandinavian Ice Sheet terminated in large lobes projecting tens of kilometres beyond the main ice sheet margin. One of the main ice lobe was the Odra lobe localized in NE Germany and NW Poland. In this study concise description of current morphology of the Odra lobe area is given with special reference to subglacial hydraulic conditions during the ice sheet advance. Subglacial conditions were simulated by using time-dependant three-dimensional numerical model, and obtained results were compared to geological observations. The results show entire groundwater system alternation that affected the ice/bed coupling and influenced formation of specific subglacial landforms. Coupling the simulation results with empirical estimates of basal melting rate suggests that only a small fraction of basal meltwater could have drained to the ice forefield as groundwater. Adverse slope of the low-permeable ice bed hampered water drainage, and led to water accumulation at the ice/bed interface that in turn facilitated basal sliding and bed deformation.
Źródło:
Landform Analysis; 2010, 14; 12-24
1429-799X
Pojawia się w:
Landform Analysis
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Basal till and subglacial conditions at the base of the Upper Odra Lobe (southern Poland) during the Odranian Glaciation
Autorzy:
Salamon, T.
Powiązania:
https://bibliotekanauki.pl/articles/2060468.pdf
Data publikacji:
2014
Wydawca:
Państwowy Instytut Geologiczny – Państwowy Instytut Badawczy
Tematy:
till
subglacial conditions
ice-sheet dynamics
Upper Odra Lobe
Pleistocene
Southern Poland
Opis:
The objective of this contribution is detail characteristics of the basal till and the conditions in the base of Upper Odra Lobe. The lobe was formed in a foremountain area. Its central part was a Niemodlin Plain and the W part of the Racibórz Basin, surrounded by areas that have a much more varied relief.Particular attention is paid to the conditions at the ice sheet base, generatingthe dynamics ofglaciermovement. The study is based on analysis of the basal till. Three sites with basal till lying on different types of substratum (more typical for the study area) are presented. The basal till of the Upper Odra Lobe is characterized by spatial variations. Different intensities of its deformation indicate that large lateral differences in conditions occurred in the lobe substratum. The lithology controlled the rate of basal water pressure, and thus the strength of both the subglacial sediments and the ice-bed coupling. Various strain rates in the till profiles indicate that the conditions at the ice-sheet base also changed with time. The ice sheet was highly mobile, even on the coarse-grained substratum. The low permeability of the Quaternary substratum, and the relatively small thickness of the Quaternary sands and gravels resulted in a high water pressure at the ice-sheet base. The movement of the Upper Odra Lobe was concentrated in the basal zone of the ice sheet. The main mechanism of basal motion was sliding and deformation of the subglacial sediments. Deformation probably occurred in restricted areas and did not have a pervasive character.
Źródło:
Geological Quarterly; 2014, 58, 4; 779--794
1641-7291
Pojawia się w:
Geological Quarterly
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Internal structure of stone-banked lobes and terraces on Rink Plateau, James Ross Island, Antarctic Peninsula region
Autorzy:
Mori, Junko
Fukui, Kotaro
Sone, Toshio
Strelin, Jorge A.
Torielli, Cesar A.
Powiązania:
https://bibliotekanauki.pl/articles/2051858.pdf
Data publikacji:
2007
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
Antarctic Peninsula
James Ross Island
ground penetrating radar
stone-banked lobe
solifluction
Źródło:
Polish Polar Research; 2007, 1; 23-30
0138-0338
2081-8262
Pojawia się w:
Polish Polar Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The role of executive processes in working memory deficits in Parkinson’s Disease
Autorzy:
Gruszka, Aleksandra
Bor, Daniel
Barker, Roger R.
Necka, Edward
Owen, Adrian M.
Powiązania:
https://bibliotekanauki.pl/articles/430574.pdf
Data publikacji:
2016-04-01
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
Parkinson’s disease
spatial working memory
verbal working memory
frontal lobe
executive function
Opis:
Idiopathic Parkinson’s disease (PD) impairs working memory, but the exact nature of this deficit in terms of the underlying cognitive mechanisms is not well understood. In this study patients with mild clinical symptoms of PD were compared with matched healthy control subjects on a computerized battery of tests designed to assess spatial working memory and verbal working memory. In the spatial working memory task, subjects were required to recall a sequence of four locations. The verbal working memory task was methodologically identical except for the modality of the stimuli used, requiring subjects to orally recall a sequence of six digits. In either case, half of the sequences were structured in a way that allowed ‘chunking’, while others were unstructured. This manipulation was designed to dissociate the strategic component of task performance from the memory-load component. Mild medicated patients with PD were impaired only on the structured versions of the verbal working memory tasks. The analogous deficit in the spatial working memory was less pronounced. These findings are in agreement with the hypothesis that working memory deficits in PD reflect mainly the executive component of the tasks and that the deficits may be at least partly modality-independent.
Źródło:
Polish Psychological Bulletin; 2016, 47, 1; 123-130
0079-2993
Pojawia się w:
Polish Psychological Bulletin
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Partial purification and identification of cardiodepressant factor from the posterior pituitary lobe in rats
Autorzy:
Goraca, A.
Walkowiak, B.
Powiązania:
https://bibliotekanauki.pl/articles/69490.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
myocardial depressant factor
posterior pituitary lobe
hemorrhagic shock
cardiodepressant factor
purification
rat
identification
Źródło:
Journal of Physiology and Pharmacology; 2000, 51, 1
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
SRC kinase mRNA transcription changes in testosterone-induced rat ventral prostate lobes under the influence of Epilobium angustifolium extract
Zmiany liczby transkryptów kinazy SRC w brzusznym płacie prostaty szczurów indukowanych hormonalnie pod wpływem wyciągu z ziela Epilobium angustifolium
Autorzy:
Kujawski, R.
Bartkowiak-Wieczorek, J.
Bogacz, A.
Karasiewicz, M.
Mikolajczak, P.L.
Czerny, B.
Mrozikiewicz, P.M.
Powiązania:
https://bibliotekanauki.pl/articles/72053.pdf
Data publikacji:
2013
Wydawca:
Instytut Włókien Naturalnych i Roślin Zielarskich
Tematy:
Src kinase
mRNA
transcription change
testosterone
rat
ventral prostate lobe
prostate
Epilobium angustifolium
plant extract
Opis:
The aim of this study was to investigate the influence of standardized crude aqueous Epilobium angustifolium L. extract [100 mg/kg/day, p.o.] on the expression level of SRC kinase mRNA - a representatives of non-genomics xenobiotics signaling pathway in prostate ventral lobes of testosterone-induced, castrated rats. We have shown that in all analyzed groups induced by testosterone an elevation of SRC kinase mRNA transcription was observed, in comparison to control animals (not receiving the testosterone), (p<0.05). Finasteride in rats induced by testosterone caused the strongest inhibition of SRC mRNA transcription (p<0.05). In rats receiving testosterone and the plant extract a ca. 90% decrease of mRNA level was observed vs. testosterone-induced animals (p<0.05), while in testosterone-induced animals receiving concomitantly E. angustifolium extract and finasteride the observed reduction reached 87.3% (p<0.05). We did not observed, however, any positive feedback between studied plant extract and finasteride in the inhibitory activity (p<0.05). Further experimental studies should be performed in order to the understanding the molecular basis of interactions, the efficacy and safety of tested plant extract.
Celem pracy było zbadanie wpływu standaryzowanego ekstraktu z ziela Epilobium angustifolium L. [100 mg/kg/dzień, p.o.] na poziom transkrypcji mRNA kinazy SRC - przedstawiciela androgenozależnego, niegenomowego szlaku sygnalizacji komórkowej w brzusznym płacie prostat indukowanych hormonalnie, kastrowanych szczurów. We wszystkich grupach szczurów indukowanych testosteronem zaobserowaliśmy wzrost liczby transkryptów kinazy SRC, w porównaniu do zwierząt kontrolnych (p<0.05). U szczurów indukowanych hormonalnie finasteryd wykazał najsilniejsze właściwości hamujące transkrypcję mRNA (p<0.05). U zwierząt otrzymujących testosteron wraz z wyciągiem z E. angutifolium stwierdziliśmy obniżenie liczby badanych transkryptów o blisko 90%, w porownaniu ze zwierzętami z grupy kontrolnej, indukowanymi testosteronem (p<0.05). U szczurów otrzymujących jednocześnie testosteron i ekstrakt roślinny łącznie z finasterydem redukcja poziomu mRNA kinazy SRC sięgała 87.3% (p<0.05). Nie zaobserwowaliśmy dodatniego sprzężenia w inhibicji transkrypcji badanego mRNA u szczurów otrzymujących badany ekstrakt wraz z finasterydem (p<0.05). Istnieje potrzeba przeprowadzenia dalszych badań zmierzających do wyjaśnienia molekularnego podłoża interakcji, mechanizmu działania oraz skuteczności badanego wciągu roślinnego.
Źródło:
Herba Polonica; 2013, 59, 4
0018-0599
Pojawia się w:
Herba Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł

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