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Wyświetlanie 1-15 z 253
Tytuł:
Elevated CO2 attenuates oxidative stress caused by drought and elevated temperature in four C3 plant species
Autorzy:
Abd Elgawad, H.
Asard, H.
Powiązania:
https://bibliotekanauki.pl/articles/80040.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
oxidative stress
carbon dioxide
reactive oxygen species
plant species
drought stress
lipid peroxidation
hydrogen peroxide
NADPH oxidase
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Oral Supplementation with Three Vegetable Oils Differing in Fatty Acid Composition Alleviates High-Fat Diet-Induced Obesity in Mice by Regulating Inflammation and Lipid Metabolism
Autorzy:
Aldamarany, Waleed
Taocui, Huang
Liling, Deng
Wanfu, Yang
Zhong, Geng
Powiązania:
https://bibliotekanauki.pl/articles/16538537.pdf
Data publikacji:
2023-02-28
Wydawca:
Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk w Olsztynie
Tematy:
perilla oil
sunflower oil
tea seed oil
anti-obesity effect
inflammation
lipid metabolism
Opis:
Obesity has become one of the most prevalent chronic diseases worldwide, which affects people's health and daily lives. Therefore, this study aimed to investigate the anti-obesity effects of perilla seed oil (PSO), sunflower oil (SFO), and tea seed oil (TSO) and their potential mechanisms in mice fed a high-fat diet (HFD). Mice were divided into five groups: ND, mice fed a normal diet; HFD, mice fed a high-fat diet; PSO, SFO, and TSO, mice fed a high-fat diet supplemented with PSO, SFO, and TSO at 2 g/kg body weight per day, respectively. Our findings showed that oral supplementation with all three oils for 8 weeks significantly reduced body weight, tissue weight, insulin resistance index, serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and free fatty acids (FFA), and markedly alleviated hyperglycemia, hyperlipidemia, and hepatic steatosis in obese mice. It also decreased leptin, pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6, and (IL)-1beta (IL-1β), and increased anti-inflammatory adipokine adiponectin at both secretion and mRNA expression levels in the epididymal adipose tissue (EAT). Moreover, PSO, SFO, and TSO administration increased the expression levels of fatty acid β-oxidation-related genes, including peroxisome proliferator-activated receptor-alpha (PPAR-α), carnitine palmitoyltransferase 1a (CPT1a) and CPT1b, and thermogenesis-related genes such as uncoupling protein 1 (UCP1), and decreased the expression levels of lipid synthesis-related genes, including fatty acid synthase (FAS) and PPAR-γ in EAT. In conclusion, PSO, SFO, and TSO supplementation could have potential anti-obesity effects in HFD-fed mice by reducing inflammation and improving lipid metabolism.
Źródło:
Polish Journal of Food and Nutrition Sciences; 2023, 73, 1; 80-94
1230-0322
2083-6007
Pojawia się w:
Polish Journal of Food and Nutrition Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Seeding cell number required for optimal lipid accumulation during adipocyte differentiation using 3T3-L1 cell line
Autorzy:
Ariyanto, Eko Fuji
Odaiyappan, Naren A/L S.
Lidyana, Lynna
Wikayani, Tenny Putri
Qomarilla, Nurul
Wira, Dwi Wahyudha
Triatin, Rima Destya
Powiązania:
https://bibliotekanauki.pl/articles/1076694.pdf
Data publikacji:
2019
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
3T3-L1 preadipocytes
differentiation
lipid accumulation
seeding cell number
Opis:
Obesity is one of the major causes of metabolic diseases such as diabetes and heart attack, and, hence, can lead to low quality of life. Elaborating adipocyte differentiation is very crucial for formulating the treatment and prevention of obesity. The objective of this study is to investigate the seeding cell number required to obtain optimum lipid accumulation during adipocyte differentiation using the 3T3-L1 cell line. Two sets of 5.48×104 (for Day 0 and Day 8 of differentiation), of 10.96×104 (for Day 8) and of 21.92×104 (for Day 8) of 3T3-L1 cells were seeded in each wells of a 12-well plate. Isobuthylmethylxanthine (IBMX), Dexamethasone, and Insulin-containing differentiation cocktails was added into the medium at Day 0 for 48 hours. The medium was changed every two days. Day 0 and Day 8 samples were then stained using Oil Red O and were examined under the microscope to observe the lipid droplets (red-coloured). The lipid droplets were quantified by measuring the absorbance at wavelength of 550 nm. In the study, seeding the number of 10.96×104 cells produced very significantly higher lipid accumulation, as compared with seeding the number of 5.48×104 cells. However, doubling the seeding number into 21.92×104 cells did not increase the lipid droplets significantly. This study found that the optimum seeding number to obtain the maximum lipid droplets during 3T3-L1 adipocyte differentiation was 10.96×104 cells.
Źródło:
World News of Natural Sciences; 2019, 25; 220-226
2543-5426
Pojawia się w:
World News of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Modeling of the phospholipid vesicular nanostructure formation process
Autorzy:
Avdieieva, L.
Chunikhin, O.
Powiązania:
https://bibliotekanauki.pl/articles/79929.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
phospholipid
lipid vesicular nanostructure
mathematical modelling
Petri net based model
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2019, 100, 4
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Molecular modelling of membrane activity of amphotericin B, a polyene macrolide antifungal antibiotic
Autorzy:
Baginski, Maciej
Sternal, Kamil
Czub, Jacek
Borowski, Edward
Powiązania:
https://bibliotekanauki.pl/articles/1041370.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
antifungal agents
lipid membrane
cholesterol
amphotericin B
molecular modelling
ergosterol
Opis:
Amphotericin B (AmB) is a well known polyene macrolide antibiotic used to treat systemic fungal infections. Despite its toxicity AmB is still regarded as a life-saving drug. The lack of adequate knowledge of the AmB mechanism of action is a serious obstacle to efficient development of new less toxic derivatives. Complementary to various experimental approaches, computational chemistry methods were used to study AmB mechanism of action. A programme lasting for a decade, that was run by our group covered studies of: i) molecular properties of AmB and its membrane targets, ii) structure and properties of AmB membrane channels, and iii) interaction of AmB with the membrane.
Źródło:
Acta Biochimica Polonica; 2005, 52, 3; 655-658
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Trans-arachidonic acids: new mediators of inflammation
Autorzy:
Balazy, M.
Powiązania:
https://bibliotekanauki.pl/articles/69394.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
arachidonic acid
lipid
uric acid
protein
dairy fat
inflammation
fatty acid
free radical
DNA
Źródło:
Journal of Physiology and Pharmacology; 2000, 51, 4,1
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Lipid-binding proteins as stabilizers of membrane microdomains - possible physiological significance.
Autorzy:
Bandorowicz-Pikuła, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1044288.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
lipid-protein interactions
lipid-binding proteins
membrane microdomains
Opis:
Below the melting point temperature of lipids, artificial lipid membranes usually exist in the ordered gel phase. Above these temperatures lipid acyl chains become fluid and disordered (liquid-crystalline phase). Depending on the chemical composition of artificial membranes, phase separation may occur, leading to the formation of transient or stable membrane domains. A similar phase separation of lipids into ordered and disordered domains has been observed in natural membranes at physiological temperature range. Moreover, it has been reported that certain proteins prefer certain organization of lipids, as for example glycosylphosphatidylinositol-anchored proteins or Src family of tyrosine kinases. The aim of present review is to discuss the possibility that some lipid microdomains are induced or stabilized by lipid-binding proteins that under certain conditions, for example due to a rise of cytosolic Ca2+ or pH changes, may attach to the membrane surface, inducing clustering of lipid molecules and creation of ordered lipid microdomains. These domains may than attract other cytosolic proteins, either enzymes or regulatory proteins. It is, therefore, postulated that lipid microdomains play important roles within a cell, in signal transduction and enzymatic catalysis, and also in various pathological states, as Alzheimer's disease, anti-phosphatidylserine syndrome, or development of multidrug resistance of cancer cells.
Źródło:
Acta Biochimica Polonica; 2000, 47, 3; 553-564
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A comparison of the effects of drought on proline accumulation and peroxidases activity in leaves of Festuca rubra L. and Lolium perenne L.
Autorzy:
Bandurska, H
Jozwiak, W.
Powiązania:
https://bibliotekanauki.pl/articles/58679.pdf
Data publikacji:
2010
Wydawca:
Polskie Towarzystwo Botaniczne
Tematy:
red fescue
grass
drought
proline accumulation
peroxidase
enzyme activity
leaf
Festuca rubra
Lolium perenne
lipid peroxidation
rye-grass
Opis:
The effect of soil drought on leaf water content, proline content, and the activity of guaiacol (GuPX) and ascorbate (APX) peroxidases as well as the level of lipid peroxidation were investigated in leaves of drought resistant red fescue (Festuca rubra) and drought sensitive perennial ryegrass (Lolium perenne). Plants were grown under glasshouse conditions in soil pot culture. 26 day-old grasses were exposed to drought by withholding irrigation for 18 days. Water content in leaves of perennial ryegrass decreased more than in red fescue throughout the experimental period. On the other hand, proline content (PC) was higher in red fescue. The activity of APX and GuPX increased in leaves of red fescue, while it did not change in perennial ryegrass. Our data demonstrate that both red fescue and perennial ryegrass were able to survive applied drought, as shown by a lack of stress-induced lipid peroxidation and hence no evidence of oxidative damage. We speculate, that the observed drought stress tolerance at cellular level was associated with the ability to accumulate proline, and to maintain high activity of APX and GuPX, resulting in protection against oxidative damage and lipid peroxidation. It seems that this mechanism works better in red fescue.
Źródło:
Acta Societatis Botanicorum Poloniae; 2010, 79, 2; 111-116
0001-6977
2083-9480
Pojawia się w:
Acta Societatis Botanicorum Poloniae
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Health benefits of dietary antioxidants
Autorzy:
Bartnikowska, E.
Powiązania:
https://bibliotekanauki.pl/articles/1372830.pdf
Data publikacji:
1995
Wydawca:
Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk w Olsztynie
Tematy:
beta-carotene
vitamin C
vitamin E
ascorbic acid
heart disease
health benefit
carotenoid
lipid peroxide
free radical
polyphenol
tocopherol
antioxidative enzyme
cancer
dietary antioxidant
Opis:
The sources of free radicals and antioxidant defence systems in living organisms are reviewed. Attention is focused on the role of dietary lipid oxidation products and antioxidants to maintain balance between factors promoting free radical mediated oxidation and the antioxidant defence mechanisms. Particular attention is paid to the influence of intake of vitamins with oxidative properties (vitamin C, vitamin E and ß-carotene) and polyphenols compounds in the prevention of coronary heart disease and cancer.
Źródło:
Polish Journal of Food and Nutrition Sciences; 1995, 04, 4; 3-22
1230-0322
2083-6007
Pojawia się w:
Polish Journal of Food and Nutrition Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Unsaturated trans fatty acid - nutritional problem?
Autorzy:
Bartnikowska, E.
Obiedzinski, M.
Powiązania:
https://bibliotekanauki.pl/articles/1373046.pdf
Data publikacji:
1995
Wydawca:
Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk w Olsztynie
Tematy:
human organism
food product
tissue lipid
trans fatty acid
oxidation
acylation
Polska
trans isomer
cis configuration
consumption
lipid metabolism
isomeric fatty acid
isomer
health
trans configuration
metabolism
linoleic acid
metabolic effect
nutrition
fatty acid
cancer
Opis:
This review summarizes the up-to-date data on the consumption pattern of trans fatty acids in different countries including Poland, as well as the metabolism and metabolic effects of trans fatty acids in human organism. The health hazards linked with the consumption of trans fatty acids are also discussed.
Źródło:
Polish Journal of Food and Nutrition Sciences; 1997, 06, 3
1230-0322
2083-6007
Pojawia się w:
Polish Journal of Food and Nutrition Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Transmembrane segment M2 of glycine receptor as a model system for the pore-forming structure of ion channels.
Autorzy:
Bednarczyk, Piotr
Szewczyk, Adam
Dołowy, Krzysztof
Powiązania:
https://bibliotekanauki.pl/articles/1043689.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
black lipid membrane
ion channels
glycine receptor
Opis:
The glycine receptor belongs to the ligand-gated ion channel superfamily. It is a chloride conducting channel composed of four transmembrane domains. It was previously shown that the second transmembrane domain (M2) of the glycine receptor forms an ion conduction pathway throught lipid bilayers. The amino-acid sequence of the transmembrane segment M2 of the glycine receptor has a high homology to all receptors of the ligand-gated ion channel superfamily. In our report, we have used a synthetic M2 peptide. It was incorporated into a planar membrane of known lipid composition and currents induced by M2 were measured by the Black Lipid Membrane technique. When the planar lipid bilayer was composed of 75% phosphatidylethanolamine and 25% phosphatidylserine, the reversal potential measured in a 150/600 mM KCl (cis/trans) gradient was -19 mV suggesting that the examined pore was preferential to anions, PK/PCl = 0.25. In contrast, when 75% phosphatidylserine and 25% phosphatidylethanolamine was used, the reversal potential was +20 mV and the pore was preferential to cations, PK/PCl = 4.36. Single-channel currents were recorded with two predominant amplitudes corresponding to the main-conductance and sub-conductance states. Both conductance states (about 12 pS and 30 pS) were measured in a symmetric solution of 50 mM KCl. The observed single-channel properties suggest that the selectivity and conductance of the pore formed by the M2 peptide of the glycine receptor depend on the lipid composition of the planar bilayer.
Źródło:
Acta Biochimica Polonica; 2002, 49, 4; 869-875
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Utilization of microorganisms for production of monoacylglycerols
Autorzy:
Bednarski, W.
Kowalewska-Piontas, J.
Adamczak, M.
Zadernowski, R.
Powiązania:
https://bibliotekanauki.pl/articles/1371615.pdf
Data publikacji:
1993
Wydawca:
Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk w Olsztynie
Tematy:
production
utilization
microorganism
monoacylglycerol
waste lipid
Źródło:
Polish Journal of Food and Nutrition Sciences; 1993, 02, 4; 99-103
1230-0322
2083-6007
Pojawia się w:
Polish Journal of Food and Nutrition Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of dietary-induced obesity on lipid peroxidation, antioxidant enzymes and total plasma antioxidant capacity
Autorzy:
Beltowski, J.
Wojcicka, G.
Gorny, D.
Marciniak, A.
Powiązania:
https://bibliotekanauki.pl/articles/70421.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
diabetes mellitus
hyperlipidemia
oxidative stress
arterial hypertension
free radical
antioxidative enzyme
obesity
lipid peroxidation
atherosclerosis
Źródło:
Journal of Physiology and Pharmacology; 2000, 51, 4,2
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Species- and substrate-specific stimulation of human plasma paraoxonase 1 (PON1) activity by high chloride concentration.
Autorzy:
Bełtowski, Jerzy
Wójcicka, Grażyna
Marciniak, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/1043697.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
paraoxonase
arylesterase
lipid peroxidation
oxidative stress
Opis:
Paraoxonase 1 (PON1), contained in plasma high-density lipoproteins, plays an important role in the protection of plasma lipoproteins and cell membranes from oxidative damage. Previous studies indicate that human PON1 is stimulated by high NaCl concentrations. The aim of this study was to characterize in more detail the effect of salts on serum PON1. Paraoxon-hydrolyzing activity of human serum was stimulated by 81.6% following the addition of 1 M NaCl. The effect of NaCl was dose-dependent between 0.5 and 2 M. PON1 activity toward phenyl acetate was reduced by 1 M NaCl by 55.2%. Both the paraoxon- and phenyl acetate-hydrolysing activity was slightly lower in heparinized plasma than in serum, but NaCl had similar stimulatory and inhibitory effects on these activities, respectively. In rat, rabbit, and mouse, NaCl reduced PON1 activity. KCl had a similar effect on human PON1 as NaCl. Sodium nitrite also stimulated human PON1 but much less effectively than chloride salts. In contrast, sucrose, sodium acetate and sodium lactate had no significant effect. NaBr was a less effective PON1 activator than NaCl, whereas the effect of NaJ was non-significant. The activity of human PON1 toward homogentisic acid lactone and γ-decanolactone was unaltered by NaCl. These data indicate that: 1) high concentrations of chlorides stimulate human PON1 activity toward paraoxon but not other substrates, 2) PON1 is inhibited by Cl- in other mammalian species, 3) the potency of human PON1 activation by halogene salts increases with decreasing atomic mass of the halide anion.
Źródło:
Acta Biochimica Polonica; 2002, 49, 4; 927-936
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Studies on the effects of lipopolysaccharide on lipid peroxidation of erythrocyte and its reversal by mannitol and glycerol
Autorzy:
Bhattacharyya, J.
Datta, A.G.
Powiązania:
https://bibliotekanauki.pl/articles/70788.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
infection
mannitol
lipopolysaccharide
sepsis
erythrocyte
blood
septic shock
lipid peroxidation
glycerol
Źródło:
Journal of Physiology and Pharmacology; 2001, 52, 1
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 253

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