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Tytuł:
A comprehensive in silico prediction of the most deleterious missense variants in the bovine LEP gene
Autorzy:
Al-Shuhaib, M.B.S.
Powiązania:
https://bibliotekanauki.pl/articles/80824.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
LEP gene
leptin
biological activity
bovine gene
single nucleotide polymorphism
coding sequence
cattle
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2019, 100, 4
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Combined effects of caffeine and aerobic exercise on leptin levels and some indices of insulin resistance in diabetics
Autorzy:
Amaghani, Akram
Jamali Gharakhanlou, Bahram
Zarghami Khamneh, Ali
Radkhah, Nima
Powiązania:
https://bibliotekanauki.pl/articles/28761958.pdf
Data publikacji:
2023
Wydawca:
Uniwersytet Szczeciński. Wydawnictwo Naukowe Uniwersytetu Szczecińskiego
Tematy:
caffeine
aerobic exercise
type 2 diabetes
leptin
insulin resistance
Opis:
The study aimed to examine the combined effects of caffeine and aerobic exercise on leptin levels and some indices of insulin resistance in diabetics Thirty-two males with type 2 diabetes participated in a quasi-experimental and double-blind design. All participants were divided into four homogeneous groups of 8 individuals, including placebo (P), caffeine supplementation (C), aerobic training (AT), and aerobic training and caffeine (AT + C). The design protocol included eight weeks of aerobic exercise and caffeine consumption. Blood samples were taken to measure serum levels of leptin, glucose, insulin, HbA1c, HOMA-IR, and insulin sensitivity (QUICKI) indices at two phases. Data were analyzed by repeated measure ANOVA, Bonferroni posthoc, and independent T-test at a significant level of a ≤ 0.05. The results showed that the levels of leptin, glucose, insulin, HbA1c, and HOMA-IR in the three intervention groups significantly decreased compared to the placebo group (P = 0.001). In addition, QUICKI was significantly increased in the three groups of caffeine (C), aerobic training (AT), and aerobic training + caffeine (AT + C) compared to the placebo group (P = 0.001). Also, the AT+C group has double effects on the investigated indices compared to the caffeine (C) group (P = 0.001). Regular aerobic exercise and caffeine supplementation may be more effective treatments for improving insulin resistance indicators associated with type 2 diabetes.
Źródło:
Central European Journal of Sport Sciences and Medicine; 2023, 44; 15-26
2300-9705
2353-2807
Pojawia się w:
Central European Journal of Sport Sciences and Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Spectrophotometric assay of renal ouabain-resistant Na+-ATPase and its regulation by leptin and dietary-induced obesity.
Autorzy:
Bełtowski, Jerzy
Jamroz-Wiśniewska, Anna
Nazar, Jarosław
Wójcicka, Grażyna
Powiązania:
https://bibliotekanauki.pl/articles/1041514.pdf
Data publikacji:
2004
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
leptin
obesity
Na+,K+-ATPase
Na+-ATPase
Opis:
Apart from Na+,K+-ATPase, a second sodium pump, Na+-stimulated, K+-independent ATPase (Na+-ATPase) is expressed in proximal convoluted tubule of the mammalian kidney. The aim of this study was to develop a method of Na+-ATPase assay based on the method previously used by us to measure Na+,K+-ATPase activity (Acta Biochim Polon.; 2002, 49: 515-27). The ATPase activity was assayed as the amount of inorganic phosphate liberated from ATP by isolated microsomal fraction. Na+-ATPase activity was calculated as the difference between the activities measured in the presence and in the absence of 50 mM NaCl. Na+-ATPase activity was detected in the renal cortex (3.5 ± 0.2 μmol phosphate/h per mg protein), but not in the renal medulla. Na+-ATPase was not inhibited by ouabain or an H+,K+-ATPase inhibitor, Sch 28080, but was almost completely blocked by 2 mM furosemide. Leptin administered intraperitoneally (1 mg/kg) decreased the Na+,K+-ATPase activity in the renal medulla at 0.5 and 1 h by 22.1% and 27.1%, respectively, but had no effect on Na+-ATPase in the renal cortex. Chronic hyperleptinemia induced by repeated subcutaneous leptin injections (0.25 mg/kg twice daily for 7 days) increased cortical Na+,K+-ATPase, medullary Na+,K+-ATPase and cortical Na+-ATPase by 32.4%, 84.2% and 62.9%, respectively. In rats with dietary-induced obesity, the Na+,K+- ATPase activity was higher in the renal cortex and medulla by 19.7% and 34.3%, respectively, but Na+-ATPase was not different from control. These data indicate that both renal Na+-dependent ATPases are separately regulated and that up-regulation of Na+-ATPase may contribute to Na+ retention and arterial hypertension induced by chronic hyperleptinemia.
Źródło:
Acta Biochimica Polonica; 2004, 51, 4; 1003-1014
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Spectrophotometric method for the determination of renal ouabain-sensitive H+,K+ -ATPase activity.
Autorzy:
Bełtowski, Jerzy
Wójcicka, Grażyna
Powiązania:
https://bibliotekanauki.pl/articles/1043791.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
leptin
kidney
H+,K+-ATPase
ouabain
Sch 28080
Na+,K+-ATPase
Opis:
The aim of this work was to develop a method for renal H+,K+-ATPase measurement based on the previously used Na+,K+-ATPase assay (Bełtowski et al.: J Physiol Pharmacol.; 1998, 49: 625-37). ATPase activity was assessed by measuring the amount of inorganic phosphate liberated from ATP by isolated microsomal fraction. Both ouabain-sensitive and ouabain-resistant K+-stimulated and Na+-independent ATPase activity was detected in the renal cortex and medulla. These activities were blocked by 0.2 mM imidazolpyridine derivative, Sch 28080. The method for ouabain- sensitive H+,K+-ATPase assay is characterized by good reproducibility, linearity and recovery. In contrast, the assay for ouabain-resistant H+,K+-ATPase was unsatisfactory, probably due to low activity of this enzyme. Ouabain-sensitive H+,K+-ATPase was stimulated by K+ with Km of 0.26 ± 0.04 mM and 0.69 ± 0.11 mM in cortex and medulla, respectively, and was inhibited by ouabain (Ki of 2.9 ± 0.3 μM in the renal cortex and 1.9 ± 0.4 μM in the renal medulla) and by Sch 28080 (Ki of 1.8 ± 0.5 μM and 2.5 ± 0.9 μM in cortex and medulla, respectively). We found that ouabain-sensitive H+,K+-ATPase accounted for about 12% of total ouabain-sensitive activity in the Na+,K+-ATPase assay. Therefore, we suggest to use Sch 28080 during Na+,K+-ATPase measurement to block H+,K+-ATPase and improve the assay specificity. Leptin administered intraperitoneally (1 mg/kg) decreased renal medullary Na+,K+-ATPase activity by 32.1% at 1 h after injection but had no effect on H+,K+-ATPase activity suggesting that the two renal ouabain-sensitive ATPases are separately regulated.
Źródło:
Acta Biochimica Polonica; 2002, 49, 2; 515-527
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Adipokines and parameters of peritoneal membrane transport in newly started peritoneal dialysis patients
Autorzy:
Golembiewska, Edyta
Safranow, Krzysztof
Ciechanowski, Kazimierz
Bober, Joanna
Bogacka, Anna
Stepniewska, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1039455.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
peritoneal dialysis
serum adiponectin
serum leptin
solute transport
Opis:
Aim: Adiponectin and leptin are two adipokines playing important roles in the regulation of body weight, appetite, carbohydrate and lipid metabolism. In patients with chronic kidney disease (CKD) adipokines accumulate in serum due to reduced renal clearance. Since adipokines have pleiotropic actions, the adipokine balance may have an impact on peritoneal membrane transport. The aim of this study was to assess whether serum adiponectin and leptin levels were related to peritoneal transport and residual renal function (RRF) in newly started peritoneal dialysis patients. Methods: 25 clinically stable patients, 4 to 6 weeks after the onset of PD, were included in the study. For each patient clinical and laboratory data were reviewed and standard PET test was performed. Serum adiponectin and leptin concentrations were determined and leptin/adiponectin (L/A) ratio was calculated. Results: Serum adiponectin correlated negatively with weight, BMI and glucose concentration. Serum leptin and L/A ratio correlated positively with BMI. Serum adiponectin correlated positively with dialysate to plasma (D/P) creatinine ratio and ultrafiltration in PET test. Serum leptin level and L/A ratio correlated strongly negatively with peritoneal creatinine clearance. Conclusions: Serum adiponectin concentration is positively associated with baseline solute transport. Leptin concentration and L/A ratio are negatively associated with dialysis adequacy in newly started PD patients.
Źródło:
Acta Biochimica Polonica; 2013, 60, 4; 617-621
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of histamine H3 receptors on pressor effect of leptin administered centrally in haemorrhage-shocked rats
Wpływ receptorów histaminowych H3 na reakcję presyjną wywołaną przez leptynę podawaną ośrodkowo u szczurów we wstrząsie krwotocznym
Autorzy:
Jasikowska, Karolina
Klose, Aleksandra
Kozieł-Kokosińska, Izabela
Jochem, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/1037764.pdf
Data publikacji:
2015
Wydawca:
Śląski Uniwersytet Medyczny w Katowicach
Tematy:
histamine
h3 receptor
leptin
haemorrhagic shock
rats
histamina
receptor h3
leptyna
wstrząs krwotoczny
szczury
Opis:
INTRODUCTION: Leptin administered intracerebroventricularly (icv) evokes the resuscitating effect in haemorrhage-shocked rats, and the action is associated with activation of the histaminergic system. The aim of the present study was to examine the possible role of the histamine H3 receptor in leptin-evoked cardiovascular effects. MATERIALS AND METHODS: Studies were performed in male Wistar rats subjected to irreversible haemorrhagic shock (0% survival at 2 h) with a mean arterial pressure (MAP) of 20–25 mmHg that were anaesthetized with keta-mine/xylazine (100 mg/kg + 10 mg/kg, intraperitoneally). At 5 minutes of critical hypotension the animals were injec-ted icv with leptin (20 μg) or 0.9% NaCl (5 μl). RESULTS: Haemorrhage resulted in a decrease in pulse pressure (PP) and heart rate (HR). Leptin evoked long-lasting rises in MAP, PP and HR with 100% survival at 2 h. Pre-treatment with histamine H3 receptor inverse agonist/H4 partial agonist clobenpropit (42.5 nmol, icv), but not with H3 receptor neutral antagonist VUF 5681 (50 nmol, icv), inhibited MAP and PP changes evoked by leptin, however, without an influence on HR or survival rate at 2 h. CONCLUSIONS: The histamine H3 receptor can influence the centrally-acting leptin-induced resuscitating effect in haemorrhagic shock in rats.
WSTĘP: Leptyna podawana do komory bocznej mózgu (icv) wywołuje efekt resuscytacyjny u szczurów we wstrząsie krwotocznym; w działaniu tym uczestniczy układ histaminergiczny. Celem obecnej pracy było zbadanie możliwego udziału receptorów histaminowych H3 w wywoływanym przez leptynę wpływie na układ krążenia we wstrząsie. MATERIAŁ I METODY: Badania przeprowadzono u szczurów, samców szczepu Wistar w znieczuleniu ogólnym przy użyciu ketaminy i ksylazyny (100 mg/kg + 10 mg/kg dootrzewnowo), u których wywołano nieodwracalny wstrząs krwotoczny ze średnim ciśnieniem tętniczym (MAP) 20–25 mmHg (wskaźnik przeżycia dwugodzinnego: 0%). W 5 min krytycznej hipotensji zwierzętom podawano icv leptynę (20 μg) bądź 0,9% roztwór NaCl (5 μl). WYNIKI: Utrata krwi prowadziła do obniżenia ciśnienia tętna (PP) i częstości rytmu serca (HR). Leptyna wywoływała długotrwałe wzrosty MAP, PP i HR, a także podwyższenie do 100% wskaźnika przeżycia dwugodzinnego. Premedykacja odwrotnym agonistą receptorów H3/częściowym agonistą receptorów H4 klobenpropitem (42,5 nmol, icv), ale nie neutralnym antagonistą receptorów H3 VUF 5681 (50 nmol, icv), hamowała zmiany MAP i PP wywoływane przez leptynę, jednak bez wpływu na wskaźnik przeżycia dwugodzinnego we wstrząsie. WNIOSKI: Receptory histaminowe H3 mogą wpływać na efekt resuscytacyjny wywoływany przez ośrodkowo działającą leptynę we wstrząsie krwotocznym u szczurów.
Źródło:
Annales Academiae Medicae Silesiensis; 2015, 69; 132-137
1734-025X
Pojawia się w:
Annales Academiae Medicae Silesiensis
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of ghrelin and leptin concentrations in saliva in a selected population of children aged 10-13 years in the Silesia province (Poland)
Analiza stężenia greliny i leptyny w ślinie w wybranej populacji dzieci w wieku 10-13 lat w województwie śląskim (Polska)
Autorzy:
Jonczyk, P.
Potempa-Jeziorowska, M.
Świętochowska, E.
Kucharzewsk, M.
Powiązania:
https://bibliotekanauki.pl/articles/2048074.pdf
Data publikacji:
2021
Wydawca:
Akademia Bialska Nauk Stosowanych im. Jana Pawła II w Białej Podlaskiej
Tematy:
ghrelin
leptin
saliva
school children
eating disorders
Opis:
Background. The measurement of salivary ghrelin and leptin concentrations can be a valuable diagnostic tool for assessing children’s nutrition. Material and methods. The study was conducted in a group of children aged 10-13 years in selected elementary schools in the Silesia Province, Poland. Biological material (saliva) was collected from the study children and anthropometric measurements were taken. Collected saliva was subjected to ELISA analysis. Using the obtained anthropometric data, Body Mass Index was calculated, nutritional status of children was determined based on growth charts. Statistical analyses were performed to evaluate the collected data. Results. A total of 111 children (48 girls and 63 boys) participated in the study. Normal body weight was observed in 55% of boys and 66% of girls; overweight was observed in 21% of girls and 27% of boys and obesity in 12.5% of girls and 14.3% of boys. Ghrelin concentrations in the whole study group correlate significantly with leptin concentrations (Pearson’s r=0.45; p=0.001). Body Mass Index, body weight, waist circumference, as well as hip circumference are statistically associated with ghrelin (p=0.001) and leptin (p=0.001) levels. Conclusions. The factor influencing salivary concentrations of ghrelin and leptin is body weight, whereas gender has no effect on the concentrations of the compounds in question. Body Mass Index values, body weight, height, waist circumference, hip circumference, and waist/hip ratio correlate with salivary concentrations of ghrelin and leptin.
Źródło:
Health Problems of Civilization; 2021, 15, 3; 173-186
2353-6942
2354-0265
Pojawia się w:
Health Problems of Civilization
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The leptin gene polymorphism and the production traits in the young boars
Polimorfizm w genie leptyny a cechy uzytkowosci tucznej i rzeznej knurkow linii 990
Autorzy:
Kolodziej, A
Pietruszka, A.
Jacyno, E.
Kawecka, M.
Stepien-Poleszak, D.
Sobocinska, A.
Powiązania:
https://bibliotekanauki.pl/articles/45258.pdf
Data publikacji:
2009
Wydawca:
Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Tematy:
boar
young animal
gene polymorphism
leptin
fattening performance
slaughter performance
Polish synthetic 990 line
Źródło:
Acta Scientiarum Polonorum. Zootechnica; 2009, 08, 1-2; 11-17
1644-0714
Pojawia się w:
Acta Scientiarum Polonorum. Zootechnica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of dietary fat type on plasma lipid profile and leptin concentration in rats fed on high-sucrose diets
Autorzy:
Krawczynska, A.
Okreglicka, K.
Olczak, E.
Gromadzka-Ostrowska, J.
Powiązania:
https://bibliotekanauki.pl/articles/3460.pdf
Data publikacji:
2010
Wydawca:
Instytut Medycyny Wsi
Tematy:
dietary fat
fat type
plasma lipid profile
leptin concentration
rat
high sucrose diet
diet
linseed oil
grape seed oil
lipid profile
lard
human nutrition
Źródło:
Journal of Pre-Clinical and Clinical Research; 2010, 04, 1
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Time-dependent effect of leptin on renal Na+,K+-ATPase activity
Autorzy:
Marciniak, Andrzej
Jamroz-Wiśniewska, Anna
Borkowska, Ewelina
Bełtowski, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/1041321.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
mitogen-activated protein kinases
leptin
obesity
arterial hypertension
hydrogen peroxide
Na+,K+-ATPase
Opis:
Leptin, secreted by adipose tissue, is involved in the pathogenesis of arterial hypertension, however, the mechanisms through which leptin increases blood pressure are incompletely elucidated. We investigated the effect of leptin, administered for different time periods, on renal Na+,K+-ATPase activity in the rat. Leptin was infused under anesthesia into the abdominal aorta proximally to the renal arteries for 0.5-3 h. Leptin administered at doses of 1 and 10 µg/min per kg for 30 min decreased the Na+,K+-ATPase activity in the renal medulla. This effect disappeared when the hormone was infused for ≥1 h. Leptin infused for 3 h increased the Na+,K+-ATPase activity in the renal cortex and medulla. The stimulatory effect was abolished by a specific inhibitor of Janus kinases (JAKs), tyrphostin AG490, as well as by an NAD(P)H oxidase inhibitor, apocynin. Leptin increased urinary excretion of hydrogen peroxide (H2O2) between 2 and 3 h of infusion. The effect of leptin on renal Na+,K+-ATPase and urinary H2O2 was augmented by a superoxide dismutase mimetic, tempol, and was abolished by catalase. In addition, infusion of H2O2 for 30 min increased the Na+,K+-ATPase activity. Inhibitors of extracellular signal regulated kinases (ERKs), PD98059 or U0126, prevented Na+,K+-ATPase stimulation by leptin and H2O2. These data indicate that leptin, by acting directly within the kidney, has a delayed stimulatory effect on Na+,K+-ATPase, mediated by JAKs, H2O2 and ERKs. This mechanism may contribute to the abnormal renal Na+ handling in diseases associated with chronic hyperleptinemia such as diabetes and obesity.
Źródło:
Acta Biochimica Polonica; 2005, 52, 4; 803-809
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Genetic diversity in populations of Slovak Spotted cattle based on single nucleotide polymorphisms analyses
Autorzy:
Moravčíková, Nina
Trakovická, Anna
Navrátilová, Alica
Powiązania:
https://bibliotekanauki.pl/articles/1039494.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
cattle
growth hormone
leptin
leptin receptor
polymorphism
Opis:
The aim of this study was to identify SNPs in leptin (LEP), leptin receptor (LEPR) and growth hormone (GH) genes in order to analyze genetic diversity of Slovak Spotted cattle. The total numbers of blood samples were taken from 353 Slovak Spotted cows originating from four farms. Genomic DNA was isolated by phenol-chloroform extraction method and analyzed by PCR-RFLP method. After digestion with restriction, enzymes were detected in whole population of cow's alleles with frequency: LEP/Sau3AI A 0.84 and B 0.16 (±0.0152); LEPR/BseGI C 0.95 and T 0.05 (±0.0089) and GH/AluI L 0.70 and V 0.30 (±0.0188). Based on the observed vs. expected genotypes frequencies populations across loci were in Hardy-Weinberg equilibrium (P\>0.05). Predominant for SNP LEP/Sau3AI was AA genotype (0.70), for SNP LEPR/T945M CC genotype (0.91), and LL genotype (0.48) was most frequent for SNP GH/AluI. The observed heterozygosity of SNPs across populations was also transferred to the low or median polymorphic information content 0.24 (He 0.28), 0.08 (He 0.09) and 0.33 (He 0.47) for LEP, LEPR and GH genes, respectively. Within genetic variability estimating negative values of fixation indexes FIS (-0.09-0.05) and FIT (-0.07-0.03) indicating heterozygote excess were observed. The value of FST indexes (0.018-0.023) shows very low levels of genetic differentiation in allele frequencies of loci among evaluated subpopulations. The low values of genetic distances (0.0018-0.0159) indicated high genetic relatedness among animals in subpopulations caused probably by common ancestry used in breeding program at farms.
Źródło:
Acta Biochimica Polonica; 2013, 60, 4; 807-810
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Impact of Nine Month Health Training and a Single Exercise on Changes in Ghrelin, Leptin and Free Fatty Acids Levels in Women’s Blood
Autorzy:
Murawska-Ciałowicz, Eugenia
Wierzbicka-Damska, Iwona
Bakońska-Pacoń, Ewa
Kałwa, Małgorzata
Dzięgiel, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1055070.pdf
Data publikacji:
2015
Wydawca:
Uniwersytet Szczeciński. Wydawnictwo Naukowe Uniwersytetu Szczecińskiego
Tematy:
free fatty acids
ghrelin
health training
leptin
single exercise
women
Opis:
The aim of the research was to assess changes in ghrelin, leptin and free fatty acids (FFA) levels in women’s blood after training. The research was carried out in women aged 45.55 ±11.33 years and with the BMI of 26.49 ±4.49. Health training at 50–66% VO2max took place twice a week for 9 months. In the baseline phase and in the 3rd, 6th and 9th month of the training, body mass and composition were measured, cardiorespiratory fitness was checked after a 10-minute exercise test on a cycloergometer, and fasting levels of ghrelin, leptin and FFA in the serum were assayed and 15 minutes after the exercise test. Body mass was reduced in the 6th month of the training. Fasting ghrelin level increased because of training, leptin and FFA decreased. After single 10-minute exercises performed every 3 months level of ghrelin and FFA increased while leptin decreased. An increase in ghrelin level in the blood after the single exercise can be the result of negative energy expenditure. An increase in fasting ghrelin level after training can be one of the adaptive physiological mechanisms connected with energy saving. A mechanism that is switched on as a result of a long-lasting stimulus that leads to energy losses, reduction in body mass and a decrease in leptin level in the blood.
Źródło:
Central European Journal of Sport Sciences and Medicine; 2015, 9, 1; 5-15
2300-9705
2353-2807
Pojawia się w:
Central European Journal of Sport Sciences and Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wybrane adipocytokiny i ich potencjalne zastosowanie w kontroli przebiegu przewlekłego wirusowego zapalenia wątroby typu B i C
Selected adipocytokines and their potential role in the control of the course of chronic hepatitis B and C
Autorzy:
Olszok, Joanna
Wyganowska, Anna
Tarabura-Dragon, Joanna
Mazur, Franciszek
Nowak, Mariusz
Powiązania:
https://bibliotekanauki.pl/articles/1037750.pdf
Data publikacji:
2015
Wydawca:
Śląski Uniwersytet Medyczny w Katowicach
Tematy:
adipocytokiny
przewlekłe wirusowe zapalenie wątroby typu b
przewlekłe wirusowe zapalenie wątroby typu c
wątroba
włóknienie
stłuszczenie
adiponektyna
leptyna
rezystyna
wisfatyna
liver
adipokines
chronic hepatitis b
chronic hepatitis c
fibrosis
steatosis
adiponectin
leptin
resitin
visfatin
Opis:
Chronic hepatitis B and C are among the most common liver diseases. A prolonged necroinflammatory process may lead to life-threatening complications although in some cases the liver condition remains stable for many years. Due to its unpredictable prognosis, a great deal of research has been carried out to find additional factors that modify the course of these diseases. Adipocytokines, substances secreted mainly by adipose tissue cells, have become the object of various studies due to their pluripotent impact. This paper aims to present the interrelationship of selected adipo-cytokines and hepatitis B and C, as well as the potential use of this knowledge in medical practice.
Przewlekłe wirusowe zapalenie wątroby (WZW) typu B i C należą do najczęstszych chorób wątroby. Długotrwały proces martwiczo-zapalny może prowadzić do groźnych dla życia powikłań, choć u niektórych pacjentów stan wątroby jest stabilny przez wiele lat. Ze względu na zróżnicowane rokowanie w przebiegu przewlekłego wirusowego zapalenia wątroby (PWZW) typu B i C, poszukuje się obecnie dodatkowych czynników hamujących postęp tych chorób. Obiektem wielu badań stały się adipocytokiny, substancje o wielokierunkowym oddziaływaniu, wytwarzane m.in. przez komórki tkanki tłuszczowej. W pracy przedstawiono wzajemne zależności wybranych adipocytokin i WZW typu B i C oraz potencjalne wykorzystanie tej wiedzy w praktyce lekarskiej.
Źródło:
Annales Academiae Medicae Silesiensis; 2015, 69; 1-7
1734-025X
Pojawia się w:
Annales Academiae Medicae Silesiensis
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Serum Leptin and Ghrelin Levels in Patients in the Early Stages of Acute Biliary Pancreatitis and Different Degrees of Severity
Autorzy:
Panek, Józefa
Bonior, Joanna
Pieton, Jonathan
Jaworek, Jolanta
Powiązania:
https://bibliotekanauki.pl/articles/1395832.pdf
Data publikacji:
2014-05-01
Wydawca:
Index Copernicus International
Tematy:
acute pancreatitis
leptin
ghrelin
Opis:
Acute pancreatitis (AP) is a potentially fatal disease. In animal experiments leptin and ghrelin were shown to modulate the course of AP. The aim of the study was to estimate the relationship between the severity of acute biliary pancreatitis (ABP) and serum levels of leptin and ghrelin in nonobese patients in the first seven days of the hospitalization. Material and methods. The study included nine patients with mild ABP (MABP), eleven patients with severe ABP (SABP) and twenty healthy controls, appropriately matched age, sex and weight. Serum concentrations of leptin and ghrelin were measured in patients on the first, third, fifth, and seventh days of hospitalization using leptin and ghrelin RadioImmunoAssay (RIA) kits. Results. At admission and throughout the study the mean serum leptin concentration in SABP patients was higher than in the controls but without statistical significance. Serum ghrelin concentrations on admission were significantly lower in patients with ABP than in the controls. We observed steadily increasing serum ghrelin levels in both groups of the patients during the course of ABP. Conclusions. The results of our study do not support the role of leptin as a marker of the severity of ABP. On the other hand, rising serum ghrelin levels during the course of ABP may be a marker of recovery and an indicator of the healing process
Źródło:
Polish Journal of Surgery; 2014, 86, 5; 211-217
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effects of dietary fibre on metabolism and performance in sows
Autorzy:
Papatsiros, V.G.
Katsarou, M.-S.
Drakoulis, N.
Maragkakis, G.
Tzika, E.
Maes, D.
Tassis, P.D.
Lagiou, M.
Christodoulopoulos, G.
Powiązania:
https://bibliotekanauki.pl/articles/2087173.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
insulin
ghrelin
leptin
fibre
dysgalactia
pig
Źródło:
Polish Journal of Veterinary Sciences; 2021, 24, 2; 271-279
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 25

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