Temat: leptin - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Genetic polymorphisms of leptin and leptin receptor genes in relation with production and reproduction traits in cattle
Autorzy:: Trakovická, Anna
Moravčíková, Nina
Kasarda, Radovan
Powiązania:: https://bibliotekanauki.pl/articles/1039486.pdf
Data publikacji:: 2013
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: cattle
leptin
leptin receptor
milk production
polymorphism
reproduction
Opis:: Leptin and leptin receptor genes are considered as production traits markers in dairy or beef cattle. The aim of this study was to verify the associations of polymorphisms in bovine LEP and LEPR genes with production and reproduction traits in Slovak Spotted and Pinzgau cows. Long-life production was evaluated: milk, protein, and fat yield and reproduction traits: age at first calving, calving interval, days open, and insemination interval. In total, 296 blood samples of Slovak Spotted and 85 hair roots samples of Pinzgau cows were analyzed. In order to detect LEP/Sau3AI (BTA 4, inron 2) and LEPR/T945M (BTA 3, exon 20) genotypes PCR-RFLP method was used. In Slovak Spotted and Pinzgau cows allele frequencies were 0.838/0.162 and 0.694/0.306 for A and B LEP variants, and 0.954/0.046 and 0.912/0.088 for C and T LEPR variants, respectively. For testing the associations between SNPs LEP/Sau3AI and LEPR/T945M and evaluated traits, the General Linear Model procedure in SAS Software was used. Statistical analysis showed that SNP LEP/Sau3AI significantly affected milk, protein and fat yield (P<0.05), and age at first calving (P<0.01) in analyzed population of cows. Statistically, SNP LEPR/T945M affected significantly calving interval (P<0.01) only. Results of our study suggest that especially leptin is a candidate gene, which influences mainly milk production traits and might be implemented in breeding strategies to improve the production performance of both analyzed cattle breeds.
Źródło:: Acta Biochimica Polonica; 2013, 60, 4; 783-787
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Genetic diversity in populations of Slovak Spotted cattle based on single nucleotide polymorphisms analyses
Autorzy:: Moravčíková, Nina
Trakovická, Anna
Navrátilová, Alica
Powiązania:: https://bibliotekanauki.pl/articles/1039494.pdf
Data publikacji:: 2013
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: cattle
growth hormone
leptin
leptin receptor
polymorphism
Opis:: The aim of this study was to identify SNPs in leptin (LEP), leptin receptor (LEPR) and growth hormone (GH) genes in order to analyze genetic diversity of Slovak Spotted cattle. The total numbers of blood samples were taken from 353 Slovak Spotted cows originating from four farms. Genomic DNA was isolated by phenol-chloroform extraction method and analyzed by PCR-RFLP method. After digestion with restriction, enzymes were detected in whole population of cow's alleles with frequency: LEP/Sau3AI A 0.84 and B 0.16 (±0.0152); LEPR/BseGI C 0.95 and T 0.05 (±0.0089) and GH/AluI L 0.70 and V 0.30 (±0.0188). Based on the observed vs. expected genotypes frequencies populations across loci were in Hardy-Weinberg equilibrium (P\>0.05). Predominant for SNP LEP/Sau3AI was AA genotype (0.70), for SNP LEPR/T945M CC genotype (0.91), and LL genotype (0.48) was most frequent for SNP GH/AluI. The observed heterozygosity of SNPs across populations was also transferred to the low or median polymorphic information content 0.24 (He 0.28), 0.08 (He 0.09) and 0.33 (He 0.47) for LEP, LEPR and GH genes, respectively. Within genetic variability estimating negative values of fixation indexes FIS (-0.09-0.05) and FIT (-0.07-0.03) indicating heterozygote excess were observed. The value of FST indexes (0.018-0.023) shows very low levels of genetic differentiation in allele frequencies of loci among evaluated subpopulations. The low values of genetic distances (0.0018-0.0159) indicated high genetic relatedness among animals in subpopulations caused probably by common ancestry used in breeding program at farms.
Źródło:: Acta Biochimica Polonica; 2013, 60, 4; 807-810
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Znaczenie polimorfizmu rs1137100 LEPR w rozwoju nadwagi i otyłości w badanej populacji
The role of rs1137100 LEPR in pathogenesis of overweight and obesity among study population
Autorzy:: Szejnoga, Karolina
Niemczyk, Agnieszka
Pyryt, Magdalena
Wichary, Agnieszka
Szweda, Nikola
Gola, Mateusz
Śnit, Mirosław
Grzeszczak, Władysław
Powiązania:: https://bibliotekanauki.pl/articles/1035570.pdf
Data publikacji:: 2018
Wydawca:: Śląski Uniwersytet Medyczny w Katowicach
Tematy:: receptor leptyny
leptyna
otyłość
nadwaga
leptin receptor
leptin
overweight
obesity
Opis:: INTRODUCTION: Overweight and obesity have become serious public health problems. They are associated with leptin and the leptin receptor (LEPR). LEPR is one of the gp130 family proteins, which plays a great role in the human body. A number of studies have evaluated many LEPR polymorphisms. MATERIAL AND METHODS: The study included a group of 510 patients residing in the Upper Silesian Agglomeration (divided into healthy, overweight and obesity groups). The LEPR gene polymorphism was investigated using the Applied Biosystems 7300 Real-Time PCR System. The analysis was carried out with fluorescent-labeled probes by means of ready-to-use assay kits for single nucleotide polymorphism detection. RESULTS: There were no statistically significant differences in the distribution of genotypes in the healthy and overweight and obese subjects either in the whole group or in the male and female groups (p > 0.05). The incidence of allele A was 76.73% and allele G 23.27%. CONCLUSIONS: There were no significant differences in the distribution of the rs1137100 LEPR polymorphism for the development of overweight and obesity pathogenesis.
WSTĘP: Nadwaga i otyłość stały się w obecnych czasach poważnym problemem zdrowia publicznego. Patogenezę tych schorzeń można wiązać m.in. z hormonem tkankowym – leptyną, a także jej receptorem kodowanym przez gen LEPR. Receptor leptyny, należący do rodziny białek gp130, odgrywa ogromną rolę w ludzkim organizmie m.in. w patogenezie nadwagi i otyłości. MATERIAŁ I METODY: Badaniem objęto 510 osób. Grupę badaną podzielono na trzy grupy: kontrolną – zdrowych, z nadwagą oraz otyłością. Polimorfizm genu dla receptora leptyny K109R (rs1137100) zbadano w reakcji łańcuchowej polimerazy za pomocą aparatu 7300 Real Time PCR System (Applied Biosystems). Do genotypowania wykorzystano komplementarne do badanych alleli, fluorescencyjnie znakowane sondy TaqMan Predesigned SNP Genotyping Assay (Applied Biosystems). WYNIKI: Nie wykazano znamiennych statystycznie różnic w rozkładzie genotypów między pacjentami zdrowymi a badanymi z nadwagą i z otyłością zarówno w całej grupie, jak i w grupach kobiet i mężczyzn (p > 0,05). Częstość występowania allelu A wynosiła 76,73%, allelu G 23,27%. WNIOSKI: Brak znamiennych różnic w rozkładzie polimorfizmu rs1137100 LEPR w patogenezie nadwagi i otyłości.
Źródło:: Annales Academiae Medicae Silesiensis; 2018, 72; 141-146
1734-025X
Pojawia się w:: Annales Academiae Medicae Silesiensis
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Serum Leptin and Ghrelin Levels in Patients in the Early Stages of Acute Biliary Pancreatitis and Different Degrees of Severity
Autorzy:: Panek, Józefa
Bonior, Joanna
Pieton, Jonathan
Jaworek, Jolanta
Powiązania:: https://bibliotekanauki.pl/articles/1395832.pdf
Data publikacji:: 2014-05-01
Wydawca:: Index Copernicus International
Tematy:: acute pancreatitis
leptin
ghrelin
Opis:: Acute pancreatitis (AP) is a potentially fatal disease. In animal experiments leptin and ghrelin were shown to modulate the course of AP. The aim of the study was to estimate the relationship between the severity of acute biliary pancreatitis (ABP) and serum levels of leptin and ghrelin in nonobese patients in the first seven days of the hospitalization. Material and methods. The study included nine patients with mild ABP (MABP), eleven patients with severe ABP (SABP) and twenty healthy controls, appropriately matched age, sex and weight. Serum concentrations of leptin and ghrelin were measured in patients on the first, third, fifth, and seventh days of hospitalization using leptin and ghrelin RadioImmunoAssay (RIA) kits. Results. At admission and throughout the study the mean serum leptin concentration in SABP patients was higher than in the controls but without statistical significance. Serum ghrelin concentrations on admission were significantly lower in patients with ABP than in the controls. We observed steadily increasing serum ghrelin levels in both groups of the patients during the course of ABP. Conclusions. The results of our study do not support the role of leptin as a marker of the severity of ABP. On the other hand, rising serum ghrelin levels during the course of ABP may be a marker of recovery and an indicator of the healing process
Źródło:: Polish Journal of Surgery; 2014, 86, 5; 211-217
0032-373X
2299-2847
Pojawia się w:: Polish Journal of Surgery
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Effects of dietary fibre on metabolism and performance in sows
Autorzy:: Papatsiros, V.G.
Katsarou, M.-S.
Drakoulis, N.
Maragkakis, G.
Tzika, E.
Maes, D.
Tassis, P.D.
Lagiou, M.
Christodoulopoulos, G.
Powiązania:: https://bibliotekanauki.pl/articles/2087173.pdf
Data publikacji:: 2021
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: insulin
ghrelin
leptin
fibre
dysgalactia
pig
Źródło:: Polish Journal of Veterinary Sciences; 2021, 24, 2; 271-279
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: Characterization of serum adiponectin and leptin in healthy perinatal dairy cows or cows with ketosis, and their effectson ketosis involved indices
Autorzy:: Shen, L.
Qian, B.
Xiao, J.
Zhu, Y.
Hussain, S.
Deng, J.
Peng, G.
Zuo, Z.
Zou, L.
Yu, S.
Ma, X.
Zhong, Z.
Ren, Z.
Wang, Y.
Liu, H.
Zhou, Z.
Cai, D.
Hu, Y.
Zong, X.
Cao, S.
Powiązania:: https://bibliotekanauki.pl/articles/2087289.pdf
Data publikacji:: 2020
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: adiponectin
dairy cows
ketosis
leptin
perinatal period
Źródło:: Polish Journal of Veterinary Sciences; 2020, 23, 3; 373-381
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: Relationship of adiponectin, leptin, visfatin and IGF-1 in cow’s venous blood and venous cord blood with calf birth weight
Autorzy:: Shen, L.
Zhu, Y.
Xiao, J.
Deng, J.
Peng, G.
Zuo, Z.
Yu, S.
Ma, X.
Zhong, Z.
Ren, Z.
Zhou, Z.
Liu, H.
Zong, X.
Cao, S.
Powiązania:: https://bibliotekanauki.pl/articles/2087491.pdf
Data publikacji:: 2019
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: adiponectin
leptin
IGF-1
birth weights
cow
Źródło:: Polish Journal of Veterinary Sciences; 2019, 3; 541-548
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 8.

Tytuł:: Analysis of ghrelin and leptin concentrations in saliva in a selected population of children aged 10-13 years in the Silesia province (Poland)
Analiza stężenia greliny i leptyny w ślinie w wybranej populacji dzieci w wieku 10-13 lat w województwie śląskim (Polska)
Autorzy:: Jonczyk, P.
Potempa-Jeziorowska, M.
Świętochowska, E.
Kucharzewsk, M.
Powiązania:: https://bibliotekanauki.pl/articles/2048074.pdf
Data publikacji:: 2021
Wydawca:: Akademia Bialska Nauk Stosowanych im. Jana Pawła II w Białej Podlaskiej
Tematy:: ghrelin
leptin
saliva
school children
eating disorders
Opis:: Background. The measurement of salivary ghrelin and leptin concentrations can be a valuable diagnostic tool for assessing children’s nutrition. Material and methods. The study was conducted in a group of children aged 10-13 years in selected elementary schools in the Silesia Province, Poland. Biological material (saliva) was collected from the study children and anthropometric measurements were taken. Collected saliva was subjected to ELISA analysis. Using the obtained anthropometric data, Body Mass Index was calculated, nutritional status of children was determined based on growth charts. Statistical analyses were performed to evaluate the collected data. Results. A total of 111 children (48 girls and 63 boys) participated in the study. Normal body weight was observed in 55% of boys and 66% of girls; overweight was observed in 21% of girls and 27% of boys and obesity in 12.5% of girls and 14.3% of boys. Ghrelin concentrations in the whole study group correlate significantly with leptin concentrations (Pearson’s r=0.45; p=0.001). Body Mass Index, body weight, waist circumference, as well as hip circumference are statistically associated with ghrelin (p=0.001) and leptin (p=0.001) levels. Conclusions. The factor influencing salivary concentrations of ghrelin and leptin is body weight, whereas gender has no effect on the concentrations of the compounds in question. Body Mass Index values, body weight, height, waist circumference, hip circumference, and waist/hip ratio correlate with salivary concentrations of ghrelin and leptin.
Źródło:: Health Problems of Civilization; 2021, 15, 3; 173-186
2353-6942
2354-0265
Pojawia się w:: Health Problems of Civilization
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 9.

Tytuł:: Spectrophotometric assay of renal ouabain-resistant Na+-ATPase and its regulation by leptin and dietary-induced obesity.
Autorzy:: Bełtowski, Jerzy
Jamroz-Wiśniewska, Anna
Nazar, Jarosław
Wójcicka, Grażyna
Powiązania:: https://bibliotekanauki.pl/articles/1041514.pdf
Data publikacji:: 2004
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: leptin
obesity
Na+,K+-ATPase
Na+-ATPase
Opis:: Apart from Na+,K+-ATPase, a second sodium pump, Na+-stimulated, K+-independent ATPase (Na+-ATPase) is expressed in proximal convoluted tubule of the mammalian kidney. The aim of this study was to develop a method of Na+-ATPase assay based on the method previously used by us to measure Na+,K+-ATPase activity (Acta Biochim Polon.; 2002, 49: 515-27). The ATPase activity was assayed as the amount of inorganic phosphate liberated from ATP by isolated microsomal fraction. Na+-ATPase activity was calculated as the difference between the activities measured in the presence and in the absence of 50 mM NaCl. Na+-ATPase activity was detected in the renal cortex (3.5 ± 0.2 μmol phosphate/h per mg protein), but not in the renal medulla. Na+-ATPase was not inhibited by ouabain or an H+,K+-ATPase inhibitor, Sch 28080, but was almost completely blocked by 2 mM furosemide. Leptin administered intraperitoneally (1 mg/kg) decreased the Na+,K+-ATPase activity in the renal medulla at 0.5 and 1 h by 22.1% and 27.1%, respectively, but had no effect on Na+-ATPase in the renal cortex. Chronic hyperleptinemia induced by repeated subcutaneous leptin injections (0.25 mg/kg twice daily for 7 days) increased cortical Na+,K+-ATPase, medullary Na+,K+-ATPase and cortical Na+-ATPase by 32.4%, 84.2% and 62.9%, respectively. In rats with dietary-induced obesity, the Na+,K+- ATPase activity was higher in the renal cortex and medulla by 19.7% and 34.3%, respectively, but Na+-ATPase was not different from control. These data indicate that both renal Na+-dependent ATPases are separately regulated and that up-regulation of Na+-ATPase may contribute to Na+ retention and arterial hypertension induced by chronic hyperleptinemia.
Źródło:: Acta Biochimica Polonica; 2004, 51, 4; 1003-1014
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 10.

Tytuł:: Adipokines and parameters of peritoneal membrane transport in newly started peritoneal dialysis patients
Autorzy:: Golembiewska, Edyta
Safranow, Krzysztof
Ciechanowski, Kazimierz
Bober, Joanna
Bogacka, Anna
Stepniewska, Joanna
Powiązania:: https://bibliotekanauki.pl/articles/1039455.pdf
Data publikacji:: 2013
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: peritoneal dialysis
serum adiponectin
serum leptin
solute transport
Opis:: Aim: Adiponectin and leptin are two adipokines playing important roles in the regulation of body weight, appetite, carbohydrate and lipid metabolism. In patients with chronic kidney disease (CKD) adipokines accumulate in serum due to reduced renal clearance. Since adipokines have pleiotropic actions, the adipokine balance may have an impact on peritoneal membrane transport. The aim of this study was to assess whether serum adiponectin and leptin levels were related to peritoneal transport and residual renal function (RRF) in newly started peritoneal dialysis patients. Methods: 25 clinically stable patients, 4 to 6 weeks after the onset of PD, were included in the study. For each patient clinical and laboratory data were reviewed and standard PET test was performed. Serum adiponectin and leptin concentrations were determined and leptin/adiponectin (L/A) ratio was calculated. Results: Serum adiponectin correlated negatively with weight, BMI and glucose concentration. Serum leptin and L/A ratio correlated positively with BMI. Serum adiponectin correlated positively with dialysate to plasma (D/P) creatinine ratio and ultrafiltration in PET test. Serum leptin level and L/A ratio correlated strongly negatively with peritoneal creatinine clearance. Conclusions: Serum adiponectin concentration is positively associated with baseline solute transport. Leptin concentration and L/A ratio are negatively associated with dialysis adequacy in newly started PD patients.
Źródło:: Acta Biochimica Polonica; 2013, 60, 4; 617-621
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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