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    Wyświetlanie 1-4 z 4
    Tytuł:
    Trans-1,2-diaminocykloheksan – niezwykła kariera outsidera
    Trans-1,2-diaminocyclohexane – unprecedented outsider’s career
    Autorzy:
    Petryk, M.
    Kwit, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/171507.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    struktura
    chiralność
    konformacja
    synteza asymetryczna
    rozpoznanie molekularne
    structure
    chirality
    conformation
    asymmetric synthesis
    molecular recognition
    Opis:
    An enantiopure trans-1,2-diaminocyclohexane is one of the most widely used chiral diamines in modern organic chemistry. This chiral building block, readily available from waste industrial products, emerges as a major figure in the field of asymmetric synthesis. The unique structural and conformational properties of trans-1,2-diaminocyclohexane make it very useful for the development of new synthetic strategies, taking advantage of its geometrical pre-organization. In this short article, we will highlight the utility of enantiomerically pure trans-1,2-diaminocyclohexane derivatives as broad-range chiral reagents and ligands for catalytic cycles. A brief overview of the aspects of applications in the field of molecular recognition will also be given.
    Źródło:
    Wiadomości Chemiczne; 2013, 67, 5-6; 393-442
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Skręty zwrotne w peptydach i białkach. Mimetyki skrętów zwrotnych. Część 1
    Reverse turns in peptides and proteins. Reverse turns mimetics. Part 1
    Autorzy:
    Owińska, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/171726.pdf
    Data publikacji:
    2016
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    skręt zwrotny
    wiązanie wodorowe
    konformacja
    kąt dwuścienny
    reverse turn
    hydrogen bond
    conformation
    dihedral angle
    Opis:
    The secondary structure of the proteins can be divided into α-helix, βsheet and reverse turns. A reverse turn is defined as a site where a polypeptide chain reverses its overall direction. It leads the chain to fold back on itself by almost 180°. Another condition for defining this motif is the amount of amino acid residues involved in forming the turn that can not be greater then six and polypeptide chain in this region can not be in helical conformation [1]. Turns are classified as: γ-turn, β-turn, α-turn and π-turn, which are formed by 3-, 4-, 5- and 6- amino acid residues, respectively. Turns defined as “closed” are stabilized by intramolecular hydrogen bonds between the main chain carbonyl group from the first residue and the main chain amide group from the last residue in the turn. This results in formation of 7-, 10-, 13- and 16-membered pseudo-rings, respectively (Fig. 1, Fig. 2). The other group of turns also stabilized by hydrogen bond, but conversely between the main chain amide group of the first residue and the carbonyl group of the last residue, are δ-turn (2-residues, 8-membered pseudo-ring) and ε-turn (3-residues, 11-membered pseudo-ring) (Fig. 2) [10–13]. These are seldom found in proteins. Turns are considered irregular structures due to the lack of clearly defined torsion angle preferences. because of that, each of the turn types can be further divided into several different subtypes (Table 1, 2 and 3) [1, 15, 31]. The “open” type structures are not stabilized by hydrogen bonds, but Cα-Cα distance between the first and the last residue in main chain is up to 10 A [10]. As turns can be found mostly on the surface of the proteins they play the important role in folding processes, thus enabling the formation of the tertiary structure [2]. The turns are also responsible for the interactions between proteins, recognition processes and ligand-receptor interactions [3–8]. In the following article, the classification and characterization of the turn types is described. The particular attention was given to the γ and β turns, as these are most commonly found in proteins structure.
    Źródło:
    Wiadomości Chemiczne; 2016, 70, 9-10; 598-611
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Peptydomimetyki i foldamery aromatyczne w chemii biologicznej
    Peptidomimetics and aromatic foldamers in biological chemistry
    Autorzy:
    Ledwoń, Patrycja
    Staśkiewicz, Agnieszka
    Jewgiński, Michał
    Latajka, Rafał
    Powiązania:
    https://bibliotekanauki.pl/articles/2200585.pdf
    Data publikacji:
    2022
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    inhibitors of enzymes
    peptidomimetics
    conformation
    cosmeceutics
    aromatic foldamers
    SAR
    inhibitor enzymu
    peptydomimetyki
    konformacja
    kosmeceutyki
    foldamery aromatyczne
    Opis:
    The interests of the research group working under the supervision of professor Rafał Latajka at the Department of Bioorganic Chemistry at the Wrocław University of Science and Technology are focused on several projects in the field of biological chemistry. Regardless of whether a given project concerns – the synthesis and activity of new enzyme inhibitors, peptides, peptidomimetics, or aromatic foldamers – the thread of correlation between the structure and activity of the studied systems always plays a pivotal role. In this article we are presenting current projects in our research group.
    Źródło:
    Wiadomości Chemiczne; 2022, 76, 5-6; 349--363
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Konformacje pierścienia monosacharydowego
    Monosaccharide ring conformations
    Autorzy:
    Stępień, Ł.
    Liberek, B.
    Powiązania:
    https://bibliotekanauki.pl/articles/172490.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    konformacja
    pseudorotacja
    ekwatorialna orientacja
    oddziaływania 1,3-diaksjalne
    efekt anomeryczny
    efekt allilowy
    winylowy efekt anomeryczny
    stała sprzężenia
    conformation
    pseudorotation
    equatorial orientation
    1,3-diaxial interactions
    anomeric effect
    allylic effect
    vinylogous anomeric effect
    coupling constant
    Opis:
    Conformational studies of the pyranose and furanose rings are important and have been carried out for years. Knowledge of the conformation of monosaccharide is essential for understanding its physical, chemical and biological properties. Additionally, conformation of the sugar ring plays a crucial role in the stereochemistry of the reaction in which it participates. This paper provides a basic knowledge concerning the conformational preferences of a monosaccharide ring. The pyranose ring conformations are defined with reference to a cyclohexane ring [1–3]. Factors influencing stability of the pyranose chair conformation are discussed: the 1,3-diaxial interactions [4–6] and anomeric effect [7–10]. It is shown how to estimate the relative stabilities of the two chair conformations on the basis of the Angyal destabilizing factors [11, 12]. It is also demonstrated how to use the NMR spectroscopy for conformational analysis [13–23]. Conformations of the unsaturated pyranose rings are defined and studied mainly on the glycals [24–29], the monosaccharides with a double bond between the C1 and C2 carbon atoms. Factors influencing stability of the unsaturated pyranose ring are disscused: the allylic effect [30] also named the vinylogous anomeric effect [31–34], and quasi 1,3-diaxial interactions [35, 36]. Finally, the furanose ring conformations and pseudorotational itinerary for a d-aldofuranose ring are presented [37]. Two parameters defining the furanose ring conformation are introduced: the amplitude of pseudorotation [38, 39], named also the maximum torsion angle [4] and pseudorotational phase angle [4]. The possible ways to study the conformation of the furanose ring are disscused [40–44].
    Źródło:
    Wiadomości Chemiczne; 2012, 66, 1-2; 67-92
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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