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Tytuł:
Malignancy-associated kidney disease
Autorzy:
Kozłowska, K.
Małyszko, J.
Powiązania:
https://bibliotekanauki.pl/articles/1917719.pdf
Data publikacji:
2016
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
malignancy
acute kidney injury
chronic kidney injury
glomerulopathy
thrombotic microangiopathy
Opis:
Malignancy or its treatment affect kidney in several ways. The most common are acute kidney injury and chronic kidney disease. Other form of kidney diseases can also be present such as nephrotic syndrome, tubulointerstitial nephritis, thrombotic microangipathy etc. In addition, electrolyte abnormalities such as hypercalcemia, hyponatremia and hypernatremia, hypokalemia and hyperkalemia, and hypomagnesemia. are observed. Treatment of malignancy associated kidney disease is usually symptomatic. Cessation of the offending agent or other supportive measures if needed i.e. renal replacement therapy are also implemented.
Źródło:
Progress in Health Sciences; 2016, 6(1); 183-187
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of renal function in primary care
Autorzy:
Musiałowska, B.
Rudzińska, M.
Koc-Żórawska, E.
Żórawski, M.
Powiązania:
https://bibliotekanauki.pl/articles/1918735.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
chronic kidney disease
acute kidney injury
Primary Care
Opis:
Evaluation of renal function is one of the primary tools used in treatment and monitoring kidney injury such as acute kidney injury (AKI) or chronic kidney disease (CKD) in Primary Care patients. Accompanying chronic diseases also have an impact on the assessment of renal function, treatment monitoring and adjustment of drug doses.
Źródło:
Progress in Health Sciences; 2018, 8(2); 202-205
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effects of pre-treatment with inulin on the kidney in lipopolysaccharide-induced endotoxemia in rats
Autorzy:
Kandil, A.
Powiązania:
https://bibliotekanauki.pl/articles/16539091.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
acute kidney injury
endotoxemia
inulin
oxidative stress
Opis:
This study was aimed to evaluate the effects of inulin used as prebiotic on the kidney in lipopolysaccharide (LPS)-induced endotoxemia model. Wistar Albino rats were divided into four groups: Control group, LPS (endotoxemia) group, Inulin + LPS group in which LPS (1.5 mg/kg, E. coli, Serotype 0111: B4) was treated after inulin (500 mg/kg) given by gavage for 21 days and Inulin group. The animals were sacrificed 24 h after the last LPS injection. Kidney samples were taken for biochemical and immunohistochemical analyses. Total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), malondialdehyde (MDA) and myeloperoxidase (MPO) values were determined. In addition, kidney sections were stained for inducible nitric oxide synthase (iNOS), tumor necrosis factor (TNF)-α and interleukine-6 (IL-6) expression, and leukocyte infiltration. LPS caused oxidative stress and inflammation. Inulin administration could prevent oxidative stress and lipid peroxidation. Moreover, inulin decreased iNOS, TNF-α and IL-6 expression. However, it did not change the distribution of leukocytes in kidney tissues. These results suggest to promising benefits of inulin as prebiotic in reducing the effects of endotoxemia. Further studies should be conducted to evaluate the capacity of prebiotics in endotoxemia.
Źródło:
Polish Journal of Veterinary Sciences; 2022, 25, 1; 103-108
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Contrast induced acute kidney injury – is it a real problem these days?
Autorzy:
Musiałowski, P.
Musiałowska, D.
Gościk, E.
Małyszko, J.
Powiązania:
https://bibliotekanauki.pl/articles/1917818.pdf
Data publikacji:
2016
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
contrast media
contrast induced nephropathy
acute kidney injury
Opis:
Acute kidney injury (AKI) is proven risk factor associated with higher mortality and morbidity among hospitalized patients. The widespread use contrast media opens the discussion about the acute kidney injury as a result of used contrast - contrast induced nephropathy (CIN). CIN is defined as an acute, generally reversible decline in renal function that occurs 48-72 hours after intravascular injection of contrast medium. Pre-existing renal insufficiency is characterised independent risk factor for occurrence of CI-AKI, other factors,such as diabetes mellitus, hypertension, advanced age or hemodynamic instability increase the risk of AKI, but are not characterized as independent risk factors. Published new large retrospective single-center studies presented equal risk of AKI among patients receiving contrast enhanced computer tomography if compared to unenhanced computer tomography, based on serum creatinine levels. In our review we would like to present a persisting the problem of CIN after intravenous (iv) as well intra-arterial contrast media administration
Źródło:
Progress in Health Sciences; 2016, 6(1); 177-182
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Fabry disease related nephropathy – case family report and literature review
Autorzy:
Król, Nikola
Trąd, Szymon
Milian-Ciesielska, Katarzyna
Gala-Błądzińska, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/2216794.pdf
Data publikacji:
2022-12-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
. Fabry disease
kidney injury
membranoproliferative glomerulonephritis
rare disease
Opis:
Introduction and aim. Fabry disease (FD) is a ultrarare storage disorder which causes irreversible damage to the brain, heart, and kidneys in young patients. The aim of our study was to draw clinician’s attention to the need of considering FD in the differential diagnosis of kidney disorders. Description of the case. We present the case of a 45-year-old man who has been misdiagnosed for several years with arterial hypertension with organ complications. He was referred to the nephrological ward due to chronic advanced kidney disease of unclear etiology. After 2 months of thorough differential diagnostics, based on the clinical course (past stroke, membranoproliferative glomerulonephritis (MPGN), left ventricular hypertrophy, paroxysmal limb pain) and conducted genetic examination, FD was confirmed. Then, screening tests were performed among the patient’s family members, confirming the presence of the same mutation as in our patient in 4 women of which in 3 were diagnosed cardio-renal syndrome. The authors of other studies report glycolipid deposits in the kidney cells on a needle biopsy, usefulness assess podocyturia, globotriaosylceramide protein in the urine and renal parapelvic cysts in an ultrasound examination in diagnostic FD nephropathy. Conclusions. This is the first case report to describe membranoproliferative glomerulonephritis in a patient suffering from FD. In patients with FD and the same genotype, kidney damage has a different phenotype.
Źródło:
European Journal of Clinical and Experimental Medicine; 2022, 4; 482-487
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The significance of NGAL and KIM-1 proteins for diagnosis of acute kidney injury (AKI) in clinical practice
Autorzy:
Kubrak, Tomasz
Podgórski, Rafał
Aebisher, David
Gala-Błądzińska, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/454694.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
NGAL proteins
KIM-1 proteins
acute kidney injury (AKI)
Opis:
Introduction. Despite advances in medical care AKI (acute kidney injury) is associated with high morbidity and mortality. The lack of adequate early renal injury biomarkers is often a problem for an early AKI diagnosis. In recent years, numerous scientific studies have been carried out which reveal new urine and serum markers to assess the period of the kidney injury before revealing its late clinical effects. In most clinical settings, AKI is due to acute renal tubular necrosis which results in protein accumulation in urine. Determination of the concentrations of proteins such as NGAL (neutrophil gelatinase-associated lipocalin) and KIM-1 (kidney injury molecule-1) are of great significance in the diagnosis of AKI. Aim. The purpose of the study was to review the literature about significance of NGAL and KIM-1 proteins for diagnosis of acute kidney injury (AKI) in clinical practice. Materials and method. Analysis of Polish and foreign literature.
Źródło:
European Journal of Clinical and Experimental Medicine; 2018, 1; 28-33
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The characteristics and outcomes of toxin-induced massive rhabdomyolysis
Autorzy:
Waldman, Wojciech
Sein Anand, Jacek
Kabata, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/2116541.pdf
Data publikacji:
2020-09-17
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
drugs
acute kidney injury
rhabdomyolysis
acute poisoning
musculoskeletal injury
novel psychoactive substance
Opis:
ObjectivesThis study investigates common patterns in patients with exceptionally high creatine kinase (CK) levels to identify factors that could have contributed to the development of severe rhabdomyolysis in the studied cohort.Material and MethodsThe authors present a retrospective analysis of patients with massive rhabdomyolysis (measured CK activity >50 000 U/l) caused by xenobiotics. The patients were selected from a group of 7708 patients treated at the Regional Toxicological Center.ResultsThe most frequent causative agents were recreational drugs, sedatives and anti-epileptics. Six patients developed multi-organ failure, including 1 who died. Substance abuse disorder was diagnosed in 90% of the patients. Each patient had at least 1 contributory factor present (hypothermia, hyperthermia, injury, an episode of agitation, seizures, prolonged immobilization), and the median was 3 factors. Acute kidney injury was observed in 90% of the patients, and 70% needed renal replacement therapy due to acute renal failure, which meant a longer hospital stay. Creatinine concentration differences between days 2 and 1 of the presentation (Cdiff) correlated with the length of hospital stay (r = 0.73, p = 0.02). All patients with negative Cdiff values did not need dialysis. No patients experienced liver failure.ConclusionsMassive rhabdomyolysis seems to be the effect of coincidence of several factors rather than the myotoxic effect alone. A creatinine concentration difference between days 2 and 1 of hospitalization was a good prognostic factor for the need for further dialysis.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2020, 33, 5; 661-673
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effectiveness of novel iron regulators in the treatment of diabetic nephropathy
Autorzy:
Banerjee, Dekai
Kaur, Ginpreet
Chatterjee, Bappaditya
Joshi, Hemant
Ramniwas, Seema
Singh Tuli, Hardeep
Powiązania:
https://bibliotekanauki.pl/articles/29519511.pdf
Data publikacji:
2023-09-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
acute kidney injury
chronic kidney disease
end-stage renal disease
iron chelators
renal iron handling
Opis:
Introduction and aim. The novel advancements of upcoming iron regulators used to treat diabetic nephropathy have implicated a common manifestation of combination chelation therapy used to eliminate end-stage renal disease associated with inflammation and iron imbalance that is altered by renal iron absorption. However, iron accumulation in the clustered kidneys that filter blood may cause problems that affect diabetic blood sugar regulation. Material and methods. A well-designed method was employed to discover relevant research publications on iron chelators and their potential to treat diabetic nephropathy. “Iron chelators”, “diabetic nephropathy”, “end-stage renal disease”, and “chelation therapy” were searched in Google Scholar, Web of Science, PubMed, and EMBASE. Analysis of literature. Although the specific etiology and development have not been fully explored, emerging evidence on iron pathophysiology helps comprehend the pathogenesis of acute kidney damage and chronic kidney disease, which crucially provides novel iron chelation therapy techniques. Ferroptosis and hepcidin marker proteins increase oxidative/nitrifying stress and kidney injury. Iron chelator medicines including deferoxamine, deferasirox, and deferiprone were tested as prophylactic strategies. Conclusion. This article covers both preclinical and clinical aspects of iron chelators to avoid diabetic nephropathy, including novel iron therapies that must be reviewed when selecting dosing regimens.
Źródło:
European Journal of Clinical and Experimental Medicine; 2023, 3; 639-647
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ostre uszkodzenie nerek w gabinecie lekarza rodzinnego – opis przypadku
Acute Kidney Injury in the General Practice – case report
Autorzy:
Moszczyński, Adam
Aman Ur Rahman, Waleed
Kowalska, Joanna
Matyjaszczyk, Michał
Powiązania:
https://bibliotekanauki.pl/articles/2138942.pdf
Data publikacji:
2022-04-01
Wydawca:
Wydawnictwo Naukowe Medyk sp. z o.o.
Tematy:
Acute Kidney Injury
AKI
renal failure
kidney transplantation
dialysis
ostre uszkodzenie nerek
niewydolność nerek
przeszczep nerki
dializa
Opis:
In this publication we describe case of 9-year old girl with acute kidney injury, treated with dialysis and kidney transplantation 10 months after diagnosis. Patient without comorbidities, without infection prior to AKI. The key role in fast diagnostic and treatment took parent’s and GP’s alertness and dialysis added to hospital treatment at early stage. Clinical features and result of biopsy were suggesting rapidly progressive glomerulonephritis, but finally unequivocal diagnosis was not possible.
W niniejszej pracy przedstawiono opis przypadku 9-letniej dziewczynki z ostrym uszkodzeniem nerek (ang. Acute Kidney Injury, AKI), leczonym dializoterapią z przeszczepieniem narządu po 10 miesiącach od rozpoznania. Pacjentka bez chorób towarzyszących, bez infekcji poprzedzającej wystąpienie AKI. Kluczową rolę w szybkiej diagnostyce i leczeniu odegrała czujność rodziców, lekarza POZ oraz szybko wdrożone leczenie nerkozastępcze w oddziale szpitalnym. Dynamika choroby oraz obraz w biopsji najbardziej przemawiały za gwałtownie postępującym kłębuszkowym zapaleniem nerek, mimo to ostatecznie nie było możliwe postawienie jednoznacznego rozpoznania.
Źródło:
Gabinet Prywatny; 2022, 284, 04; 41-44
2353-8600
Pojawia się w:
Gabinet Prywatny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Increased AST/ALT ratio in azotaemic dogs infected with Babesia canis
Autorzy:
Zygner, W.
Gojska-Zygner, O.
Norbury, L.J.
Wedrychowicz, H.
Powiązania:
https://bibliotekanauki.pl/articles/31893.pdf
Data publikacji:
2012
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
dog
animal disease
infection
Babesia canis
azotemia
canine babesiosis
babesiosis
kidney injury
protozoan parasite
Opis:
The AST/ALT ratio was estimated in 182 dogs infected with Babesia canis. Among these dogs 65 had anaemia and 68 were azotaemic. Student’s t test was used to compare means of the AST/ALT ratio in anaemic and non-anaemic dogs, and in azotaemic and non-azotaemic dogs (p < 0.05). The differences in AST/ALT ratio between anaemic (1.52 ± 1.15) and non-anaemic (1.76 ± 1.34) dogs were statistically insignificant (p = 0.23), however, the comparison of AST/ALT ratio between azotaemic (2.68 ± 1.52) and non-azotaemic (1.08 ± 0.53) dogs revealed a significantly higher value of this index in azotaemic dogs (p = 0.00). The present results suggest that kidney injury contributed to increased AST activity in these dogs.
Źródło:
Polish Journal of Veterinary Sciences; 2012, 15, 3
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
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