- Tytuł:
- COMBINATIONS OF ISOTHIOCYANATES WITH DRUGS – A CHANCE OR THREAT TO CHEMOPREVENTION AND CANCER TREATMENT?
- Autorzy:
-
Mielczarek, Lidia
Chilmonczyk, Zdzisław
Suchocki, Piotr
Wroczyński, Piotr
Wiktorska, Katarzyna - Powiązania:
- https://bibliotekanauki.pl/articles/895549.pdf
- Data publikacji:
- 2018-08-31
- Wydawca:
- Polskie Towarzystwo Farmaceutyczne
- Tematy:
-
chemotherapy
chemoprevention
combination therapy
sulforaphane
isothiocyanates
drugs combination - Opis:
- Isothiocyanates (ITCs) are a group of compounds of natural origin which exhibit anticancer properties. In addition to the cytotoxic impact on cancer cells, confirmed in the multiple cell lines and the in vivo models, ITCs exhibit the cytoprotective effect in normal cells by regulating the activity of enzymes involved in xenobiotic metabolism. These properties of ITCs have led to a continuing increase in the number of studies which have shown that ITCs can sensitize cancer cells to cytostatic drugs used as standard in cancer therapies. On the other hand these compounds may decrease the effectiveness of drugs by deregulating the metabolising system of the cell. This paper discusses the results of preclinical study on ITCs applications in combination therapy as well as their role in drug metabolism.
- Źródło:
-
Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 4; 829-841
0001-6837
2353-5288 - Pojawia się w:
- Acta Poloniae Pharmaceutica - Drug Research
- Dostawca treści:
- Biblioteka Nauki
Artykuł