Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

English (EN)·Polski (PL)·Yкраїнський (UK)
Przejdź do strony domowej biblioteki Centralna Biblioteka Wojskowa Link otwiera się w nowym oknie Logo biblioteki Prolib Integro - strona głównaCentralna Biblioteka Wojskowa

Wyszukujesz frazę "interleukin" wg kryterium: Temat

  Lista filtrów
Wyrównaj
Wyświetlanie 1-15 z 35
Tytuł:
Associations between interleukin-8 receptor (CXCR1) and interleukin-6 (IL6) polymorphism and immunity to mastitis in the Black-and-White variety of Polish Holstein-Friesian cows
Poszukiwanie asocjacji pomiędzy polimorfizmem genu receptora interleukiny-8 (CXCR1) oraz interleukiny-6 (IL6) a odpornością na mastitis wśród krów rasy polskiej holsztynsko-fryzyjskiej odmiany czarno-białej
Autorzy:
Stanisławczyk, A.
Wojdak-Maksymiec, K.
Powiązania:
https://bibliotekanauki.pl/articles/2606370.pdf
Data publikacji:
2018
Wydawca:
Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Tematy:
interleukin 8
interleukin 6
polymorphism
immunity
Black-and-White breed
Polish Holstein-Friesian breed
animal breeding
dairy cattle
milk production
milk production trait
mastitis
Źródło:
Acta Scientiarum Polonorum. Zootechnica; 2018, 17, 3; 23-30
1644-0714
Pojawia się w:
Acta Scientiarum Polonorum. Zootechnica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Calcium- and proton-dependent relocation of annexin A6 in Jurkat T cells stimulated for interleukin-2 secretion
Autorzy:
Podszywalow-Bartnicka, Paulina
Strzelecka-Kiliszek, Agnieszka
Bandorowicz-Pikula, Joanna
Pikula, Slawomir
Powiązania:
https://bibliotekanauki.pl/articles/1041071.pdf
Data publikacji:
2007
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
interleukin-2
ionomycin
calcium
annexin A6
Jurkat T cells
vesicular traffic
Opis:
Annexin A6 (AnxA6) is a Ca2+-dependent membrane-binding protein involved in vesicular traffic. The likely participation of AnxA6 in the response of lymphocytes to Ca2+ signals has not been investigated yet. The present study focuses on intracellular relocation of AnxA6 in human Jurkat T lymphoblasts upon stimulation followed by transient increase of intracellular [Ca2+] and exocytosis of interleukin-2 (IL-2). Stimulation of the cells under different experimental conditions (by lowering pH and/or by rising extracellular [Ca2+] in the presence of ionomycin) induced time-dependent transients of intracellular [Ca2+] and concomitant changes in AnxA6 intracellular localization and in IL-2 secretion, with only minor effects on cell viability and apoptosis. In resting conditions (in the presence of EGTA or with no ionophore) AnxA6 was localized uniformly in the cytosol, whereas it translocated to vesicular structures beneath the plasma membrane within 5 min following stimulation of Jurkat T cells and rise of intracellular [Ca2+] at pH 7.4. Lowering the extracellular pH value from 7.4 to 6.0 significantly enhanced this process. AnxA6 changed its location from the cytosol to the secretory granules and early endosomes which seem to represent membranous targets for annexin. In conclusion, AnxA6 is sensitive to variations in intracellular [Ca2+] upon stimulation of Jurkat T cells, as manifested by a switch in its intracellular localization from the cytosol to vesicular structures located in close proximity to the plasma membrane, suggestive of participation of AnxA6 in calcium- and proton-dependent secretion of cytokines by lymphocytes.
Źródło:
Acta Biochimica Polonica; 2007, 54, 2; 261-271
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Central single and chronic administration of morphine stimulates corticosterone and interleukin 9(IL)-6 in adjuvant-induced arthritis
Autorzy:
Zubelewicz, B.
Muc-Wierzgon, M.
Harbuz, M.S.
Brodziak, A.
Powiązania:
https://bibliotekanauki.pl/articles/69429.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
interleukin 6
arthritis
cytokine
corticosterone
morphine
central nervous system
neuroendocrine change
rat
hypothalamic-pituitary-adrenal axis
immune response
Źródło:
Journal of Physiology and Pharmacology; 2000, 51, 4,2
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Changes in the cellular behaviour of human colonic cell line Caco-2 in response to butyrate treatment.
Autorzy:
Dzierżewicz, Zofia
Orchel, Arkadiusz
Węglarz, Ludmiła
Latocha, Małgorzata
Wilczok, Tomasz
Powiązania:
https://bibliotekanauki.pl/articles/1043829.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
colonocytes
sodium butyrate
interleukin-8
apoptosis
differentiation
Caco-2 cells
Opis:
Gut-derived adenocarcinoma Caco-2 cells were treated with sodium butyrate (NaB) at physiologically relevant concentrations. We characterized its effects on proliferation, differentiation, apoptosis, adhesion to the solid support and interleukin-8 secretion. Differentiation was determined by brush border alkaline phosphatase activity. Apoptosis was assessed by acridine orange and Hoechst stains. Differentiation and apoptosis were analyzed in both adherent and floating cell populations. The transformed Caco-2 cells did not retain their malignant phenotype in the presence of NaB. They appeared to undergo a change in the phenotype induced by NaB, as indicated by reduced proliferation, enhanced differentiation, stimulation of apoptosis leading to decreased viability of cells, and stimulation of interleukin-8 secretion. Considering all the above facts and data, we postulate that Caco-2 cells cultured in NaB supplemented medium could regain the phenotypic characteristics of the phenotype of the parent cell from which originated the Caco-2 line.
Źródło:
Acta Biochimica Polonica; 2002, 49, 1; 211-220
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Combination of IL-12 gene therapy and CTX chemotherapy inhibits growth of primary B16(F10) melanoma tumors in mice
Autorzy:
Mitrus, Iwona
Delić, Klaudia
Wróbel, Natalia
Missol-Kolka, Ewa
Szala, Stanisław
Powiązania:
https://bibliotekanauki.pl/articles/1041249.pdf
Data publikacji:
2006
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
antiangiogenic therapy
interleukin-12 gene
combined therapy
Opis:
We investigated suppression of murine B16(F10) melanoma tumor growth following a therapy which involved concomitant administration of cyclophosphamide and plasmid DNA bearing interleukin-12 gene. Since both therapeutic factors display antiangiogenic capabilities, we assumed that their use in blocking the formation of new blood vessels would result in augmented inhibition of tumor growth. This combined therapy regimen indeed resulted in a considerable suppression of tumor growth. We observed a statistically significant extension of treated animals' lifespan. Interestingly, the therapeutic effect was also obtained using a plasmid without an interleukin gene insert. This observation suggests that plasmid DNA, which has been widely applied for treating neoplastic tumors, contains element(s) that elicit immune response in mice.
Źródło:
Acta Biochimica Polonica; 2006, 53, 2; 357-360
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Compensatory effect of TNFα on low natural killer activity in the elderly.
Autorzy:
Myśliwska, Jolanta
Bryl, Ewa
Trzonkowski, Piotr
Myśliwski, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/1044353.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
NK activity
interleukin 2
ageing
TNFα
Opis:
Regulatory effect of CD25, an activation antigen the α subunit of interleukin 2 receptor (IL2R) on the activity of natural killer (NK) cells was studied in fifty elderly (57-70 years old) and fifty young people (19-35 years old). Cytotoxic NK activity was assessed by 51Cr release assay, the levels of interleukin 2 (IL2) and tumour necrosis factors α (TNFα) were measured using bioassays and expression of CD16 and CD25 proteins by flow cytometry. Low NK activity in the elderly was associated with decline of full health, lowered serum concentration of IL2 and increased production of TNFα during NK reaction. Inhibition of TNFα activity by anti-TNF monoclonal antibody suppressed exclusively NK activity of low NK responders. Moreover, stimulation in vitro of blood mononuclear cells, with TNFα induced in the elderly low NK responders a significantly higher increase of the CD25 expression on the surface of NK cells as compared with that in the elderly high responders. Since the CD25 molecule constitutes a subunit of the high affinity receptor, binding IL2 to immunocompetent cells, its increased expression on NK cells of low NK responders would enable them to bind even low amounts of the endogenous IL2 available in this group of the elderly. Thus, an overproduction of TNFα seems to be a mechanism compensating, in the non-fully healthy elderly, for the decreased IL2 production, promoting efficient cytotoxic reaction.
Źródło:
Acta Biochimica Polonica; 2000, 47, 2; 301-311
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Contact allergy to nickel: Patch test score correlates with IL-5, but not with IFN-gamma nickel-specific secretion by peripheral blood lymphocytes
Autorzy:
Czarnobilska, E
Jenner, B.
Kaszuba-Zwoinska, J.
Kapusta, M.
Obtulowicz, K.
Thor, P.
Spiewak, R.
Powiązania:
https://bibliotekanauki.pl/articles/49735.pdf
Data publikacji:
2009
Wydawca:
Instytut Medycyny Wsi
Tematy:
allergic contact dermatitis
patch test
contact allergy
lymphocyte
interleukin 5
interferon gamma
risk estimation
nickel
peripheral blood
chronic disease
Źródło:
Annals of Agricultural and Environmental Medicine; 2009, 16, 1; 37-41
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Correlation between clinical efficacy on pruritus and serum interleukin-31 levels in dogs with atopic dermatitis treated with lokivetmab
Autorzy:
Calesso, J.R.
Marques, V.S.
de Carvalho, O.V.
Costa-Val, A.P.
Powiązania:
https://bibliotekanauki.pl/articles/16647579.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
atopic dermatitis
interleukin-31
lokivetmab
monoclonal antibody
pruritus
Opis:
Studies on serum interleukin (IL)-31 levels in dogs with atopic dermatitis (AD) and their correlation with disease severity are limited. To the author’s knowledge, there are no studies that measured serum IL-31 in dogs treated with lokivetmab injections, a selective inhibitor of this key cytokine in pruritus. The aim of the study was to evaluate serum IL-31 levels in dogs treated with lokivetmab and correlate it with the severity of canine atopic dermatitis using the pruritus visual analog scale (pVAS) and canine atopic dermatitis extent and severity index (CADESI-04). Ten client-owned dogs diagnosed with AD received two injections of lokivetmab four weeks apart. Disease severity was assessed using the pVAS and CADESI-04 scores before and after both injections. In addition, canine serum IL-31 levels were measured at the same moments. Serum IL-31 was detected in all dogs in the study. There was a significant reduction in pVAS scores and serum IL-31 after administrations. However, there was no difference in CADESI-04 scores, and there was no significant correlation between CADESI-04 scores and serum IL-31 in dogs diagnosed with AD. Nonetheless, a significant positive correlation was observed between the pVAS scores and serum IL-31 levels with lokivetmab therapy, which reinforces the role of IL-31 in the pathogenesis of pruritus in dogs with AD. The data presented here provide further evidence that IL-31 is directly involved in pruritus pathogenesis in dogs with AD. In addition, blocking IL-31 has a significant antipruritic effect, but has no influence on skin lesion severity and extension.
Źródło:
Polish Journal of Veterinary Sciences; 2023, 26, 2; 231-238
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Differential responses of hematopoietic and non-hematopoietic cells to anti-inflammatory cytokines: IL-4, IL-13 and IL-10
Autorzy:
Guzdek, A.
Stalinska, K.
Guzik, K.
Koj, A.
Powiązania:
https://bibliotekanauki.pl/articles/69534.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
non-hematopoietic cell
macrophage
interleukin 10
blood
hepatoma
antiinflammatory cytokine
in vitro
hematopoietic cell
interleukin 4
man
tumour necrosis factor-alpha
cytokine
interleukin 13
monocyte
Źródło:
Journal of Physiology and Pharmacology; 2000, 51, 3
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Endogenous nitric oxide proves not to be involved in the inhibition by IL-1beta of TGF-alpha-stimulated proliferation of RGM1 cells
Autorzy:
Ishikawa, M.
Tsukimi, Y.
Ogawa, T.
Okabe, S.
Powiązania:
https://bibliotekanauki.pl/articles/70156.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
epidermal growth factor
interleukin 1
interleukin
cell
proliferation
DNA synthesis
nitric oxide
gastric mucosal cell
rat
Źródło:
Journal of Physiology and Pharmacology; 2000, 51, 3
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Expression of avian influenza haemagglutinin (H5) and chicken interleukin 2 (chIL-2) under control of the ptcB promoter in Lactococcus lactis
Autorzy:
Szatraj, Katarzyna
Szczepankowska, Agnieszka
Sączyńska, Violetta
Florys, Katarzyna
Gromadzka, Beata
Łepek, Krzysztof
Płucienniczak, Grażyna
Szewczyk, Bogusław
Zagórski-Ostoja, Włodzimierz
Bardowski, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/1039270.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Lactococcus lactis
ptcB promoter
heterologous gene expression
avian influenza H5N1
H5 haemagglutinin
chicken interleukin-2
Opis:
Gram-positive and nonpathogenic lactic acid bacteria (LAB) are considered to be promising candidates for the development of new, safe systems of heterologous protein expression. Recombinant LAB has been shown to induce specific local and systemic immune response against selected pathogens, and could be a good alternative to classical attenuated carriers. The main goal of our study was to express the avian influenza haemagglutinin (H5) and chicken interleukin 2 (chIL-2) in Lactococcus lactis. Results of this study were anticipated to lead to construction of lactococcal strain(s) with potential vaccine properties against the avian influenza A (H5N1) virus. Expression of the cloned H5 gene, its His-tagged variant and chIL-2 gene, under the control of the ptcB gene promoter was attested by RT-PCR on transcriptional level and Western or dot blot analysis on translational level, demonstrating that system can be an attractive solution for production of heterologous proteins. The results of the preliminary animal trial conducted in mice are a promising step toward development of a vaccine against avian bird flu using Lactococcus lactis cells as antigen carriers.
Źródło:
Acta Biochimica Polonica; 2014, 61, 3; 609-614
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Graficzna interpretacja wyników regresji logistycznej w badaniu klinicznym dla dwustanowej zmiennej zależnej
Graphical interpretation of logistic regression results for clinical investigation with binomial output variable
Autorzy:
Korohoda, P.
Miklaszewska, M.
Pietrzyk, J. A.
Powiązania:
https://bibliotekanauki.pl/articles/154895.pdf
Data publikacji:
2012
Wydawca:
Stowarzyszenie Inżynierów i Techników Mechaników Polskich
Tematy:
regresja logistyczna
logit
szansa
nomogram
interleukina 6 w surowicy
ostre uszkodzenie nerek
logistic regression
odds
urine interleukin 6 concentration
acute kidney injury
Opis:
W artykule zaproponowano graficzną formę prezentacji wyników regresji logistycznej, zastosowanej dla dwustanowej zmiennej zależnej i dwóch numerycznych zmiennych pomiarowych. Przed wyznaczeniem współczynników regresji jedna z tych zmiennych została poddana transformacji z wykorzystaniem logarytmu o podstawie 2. Opisano sposób przeprowadzenia odpowiednich obliczeń i zaprezentowano przykładowe wyniki, bazując na wynikach badania klinicznego (dla N=47 pacjentów) stężeń interleukiny 6 w surowicy dzieci poddawanych zabiegom kardiochirurgicznym w krążeniu pozaustrojowym, narażonych na ryzyko wystąpienia ostrego uszkodzenia nerek (OUSzN). Metoda pozwala na szybką identyfikację ryzyka i podjęcie właściwych działań terapeutycznych, w tym - terapii nerkozastępczej.
In the paper there are proposed nomograms being graphical presentation of logistic regression results. Such graphs depict the probability and odds functions of the considered feature in a readable form. The investigated particular case is suited for the binomial output variable and two numerical input variables. The suggested presentation form has been selected with focus on clinical personnel accustomed to such form of data presentation. After introductory explanation of the logistic regression essentials with emphasis on the Gaussian-based distribution, there are presented assumption and resulting - alternative model formulation supported by the simulation experiment results, basing on the clinically collected data from 47 patients suspected to experience acute kidney injury (AKI) diagnosed accordingly to interleukin 6 serum concentration. The interpretation of unit selection for each input variable is shortly discussed along with the consequences of possible logarithmic transformation. The presented method allows for either quick, graphical, bedside risk identification and mapping of lifethreating condition or early introduction of renal replacement therapy.
Źródło:
Pomiary Automatyka Kontrola; 2012, R. 58, nr 4, 4; 316-318
0032-4140
Pojawia się w:
Pomiary Automatyka Kontrola
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Haemocytometric profile and plasma levels of selected cytokines in patients at various stages of cervical cancer
Autorzy:
Alani Jimoh, Mutiu
Adekunle Onifade, Abdulfatah
Mpakaboari Abbiyesuku, Fayeofori
Fabian Edem, Victory
Kadiri Rahamon, Sheu
Ganiyu Arinola, Olatunbosun
Powiązania:
https://bibliotekanauki.pl/articles/29520454.pdf
Data publikacji:
2023-12-31
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
cancer stage
cervical cancer
haemocytometry
interleukin-6
parity
Opis:
Introduction and aim. Reports have shown that there is alteration in haematological and inflammatory processes in patients with cervical cancer. However, there is the dearth of information on the pattern of alteration in Nigerian patients with cervical cancer at various stages of the disease. Therefore, haemocytometric profile and plasma levels of interleukin-6 (IL-6) and IL-12 were determined in Nigerian patients with cervical cancer at various stages of the disease. Material and methods. Eighty-nine adults consisting of 49 patients with cervical cancer and 40 apparently healthy controls were enrolled into this study. Haemocytometric profile was determined using automated haematology analyzer while the plasma levels of interleukin-6 (IL-6) and IL-12 were determined using ELISA. Results. Of the participants with cervical cancer, 6.12%, 24.49%, 53.06% and 16.33% were in stages I, II, III and IV respectively. The mean plasma IL-6 level was significantly higher in patients at stage IV of the cancer compared with those in stages I, II and III. No significant differences were observed in the mean plasma IL-12 level, and the haemocytometric profile when patients in different stages of the cancer were compared with one another. Plasma IL-6 had significant positive correlation with the lymphocytes count and cancer stage but had significant negative correlation with packed cell volume (PCV), haemoglobin and total white blood cells count (WBC) in patients with cervical cancer. Conclusion. Interleukin-6 appears to play an important role in the progression of cervical cancer and could be involved in cervical cancer-associated alteration in haemocytometric profile.
Źródło:
European Journal of Clinical and Experimental Medicine; 2023, 4; 696-703
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Histamine in stress ulcer prophylaxis in rats
Autorzy:
Warzecha, Z.
Dembinski, A.
Brzozowski, T.
Ceranowicz, P.
Dembinski, M.
Stachura, J.
Konturek, S.J.
Powiązania:
https://bibliotekanauki.pl/articles/69120.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
gastric ulcer
histamine
gastric blood flow
interleukin 1beta
DNA synthesis
gastric acid secretion
prophylaxis
gastroprotection
rat
stress ulcer
gastrin
Źródło:
Journal of Physiology and Pharmacology; 2001, 52, 3
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Immunotherapy with interleukin-2: a study based on mathematical modeling
Autorzy:
Banerjee, S.
Powiązania:
https://bibliotekanauki.pl/articles/907902.pdf
Data publikacji:
2008
Wydawca:
Uniwersytet Zielonogórski. Oficyna Wydawnicza
Tematy:
komórka
efektor
nowotwór
opóźnienie czasowe
interleukina
effector cells
tumor cells
interleukin-2
discrete time delay
Opis:
The role of interleukin-2 (IL-2) in tumor dynamics is illustrated through mathematical modeling, using delay differential equations with a discrete time delay (a modified version of the Kirshner-Panetta model). Theoretical analysis gives an expression for the discrete time delay and the length of the time delay to preserve stability. Numerical analysis shows that interleukin-2 alone can cause the tumor cell population to regress.
Źródło:
International Journal of Applied Mathematics and Computer Science; 2008, 18, 3; 389-398
1641-876X
2083-8492
Pojawia się w:
International Journal of Applied Mathematics and Computer Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 35

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies