Temat: insulin-mimetic action - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Związki wanadu i chromu jako potencjalne insulino-mime tyki wykorzystywane w leczeniu cukrzycy
Vanadium and chromium compounds as the potential insulin-mimetics used in the treatment of diabetes
Autorzy:: Drzeżdżon, Joanna
Malinowski, Jacek
Zych, Dominika
Jacewicz, Dagmara
Powiązania:: https://bibliotekanauki.pl/articles/972299.pdf
Data publikacji:: 2019
Wydawca:: Polskie Towarzystwo Chemiczne
Tematy:: związki wanadu
związki chromu
działanie insulino-naśladowcze
właściwości przeciwcukrzycowe
leczenie cukrzycy u ludzi
vanadium derivatives
chromium derivatives
insulin mimetic action
antidiabetic properties
human diabetic treatment
Opis:: The report focuses on the antidiabetic, also termed insulin-like, effect of various vanadium and chromium derivatives, proposed mechanisms of their activity, their use in in vivo and in vitro studies, as well as in diabetic patients, their toxicity and effectiveness in controlling clinical signs of diabetes. Studies indicate that compounds of vanadium and chromium is necessary for regulation of carbohydrate and lipid metabolism mainly due to increasing the number of insulin receptors and its activation by phosphorylation. Some authors believe that compounds of chromium(III) deficiency can lead to glucose intolerance and symptoms of type 2 diabetes. However, due to methodological limitations of many clinical studies, the statements of major diabetes associations concerning recommendation of various vanadium and chromium derivatives supplementation in individuals with diabetes and obesity still remains negative. Additional studies are urgently needed to elucidate the mechanism of action of chromium and vanadium compounds and its role in the prevention and control of diabetes.
Źródło:: Wiadomości Chemiczne; 2019, 73, 11-12; 753-775
0043-5104
2300-0295
Pojawia się w:: Wiadomości Chemiczne
Dostawca treści:: Biblioteka Nauki

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Tytuł:: Biochemical and medical importance of vanadium compounds
Autorzy:: Korbecki, Jan
Baranowska-Bosiacka, Irena
Gutowska, Izabela
Chlubek, Dariusz
Powiązania:: https://bibliotekanauki.pl/articles/1039732.pdf
Data publikacji:: 2012
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: inflammation
cancer
vanadium
diabetes
insulin-mimetic action
pollution
Opis:: Vanadium belongs to the group of transition metals and is present in the air and soil contaminants in large urban agglomerations due to combustion of fossil fuels. It forms numerous inorganic compounds (vanadyl sulfate, sodium metavanadate, sodium orthovanadate, vanadium pentoxide) as well as complexes with organic compounds (BMOV, BEOV, METVAN). Depending on the research model, vanadium compounds exhibit antitumor or carcinogenic properties. Vanadium compounds generate ROS as a result of Fenton's reaction or of the reaction with atmospheric oxygen. They inactivate the Cdc25B2 phosphatase and lead to degradation of Cdc25C, which induces G2/M phase arrest. In cells, vanadium compounds activate numerous signaling pathways and transcription factors, including PI3K-PKB/Akt-mTOR, NF-κB, MEK1/2-ERK, that cause cell survival or increased expression and release of VEGF. Vanadium compounds inhibit p53-dependent apoptosis and promote entry into the S phase of cells containing functional p53 protein. In addition, vanadium compounds, in particular organic derivatives, have insulin-mimetic and antidiabetic properties. Vanadium compounds lower blood glucose levels in animals and in clinical trials. They also inhibit the activity of protein tyrosine phosphatase 1B. By activating the PI3K-PKB/Akt pathway, vanadium compaunds increase the cellular uptake of glucose by the GLUT4 transporter. The PKB/Akt pathway is also used to inactivate glycogen synthase kinase-3. The impact of vanadium compounds on inflammatory reactions has not been fully studied. Vanadium pentoxide causes expression of COX-2 and the release of proinflammatory cytokines in a human lung fibroblast model. Other vanadium compounds activate NF-κB in macrophages by activating IKKβ.
Źródło:: Acta Biochimica Polonica; 2012, 59, 2; 195-200
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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