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    Wyświetlanie 1-23 z 23
    Tytuł:
    Psychological Well-Being in Women with Insulin Resistance and the Role of Sense of Self-Dignity
    Autorzy:
    Gabryś, Agnieszka
    Gulip, Małgorzata
    Powiązania:
    https://bibliotekanauki.pl/articles/31341014.pdf
    Data publikacji:
    2023
    Wydawca:
    Katolicki Uniwersytet Lubelski Jana Pawła II. Towarzystwo Naukowe KUL
    Tematy:
    insulin resistance
    psychological well-being
    self-dignity
    women with insulin resistance
    Opis:
    The aim of this study was to examine the contribution of the sense of self-dignity in accounting for the variability of psychological well-being in women with insulin resistance. The sample consisted of 109 women diagnosed with insulin resistance. The associations between the variables were examined using correlation and regression analyses. The study found significant relationships between dimensions of the sense of self-dignity and psychological well-being in the surveyed women. The loss dimension of the sense of self-dignity had the highest contribution in accounting for all the dimensions of psychological well-being. Although weaker than for the loss dimension, a statistically significant contribution was also found for the total score of the sense of self-dignity in the surveyed women with insulin resistance.
    Źródło:
    Roczniki Psychologiczne; 2023, 26, 1; 83-93
    1507-7888
    Pojawia się w:
    Roczniki Psychologiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Relationship between obesity, insulin resistance and cell membrane properties
    Autorzy:
    Ahyayauch, Hasna
    Powiązania:
    https://bibliotekanauki.pl/articles/25106323.pdf
    Data publikacji:
    2023-06-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    insulin resistance
    membrane properties
    obesity
    Opis:
    Introduction and aim. The obesity is one of the greatest public health problems in developing countries and it is a triggering factor for diabetes associated with insulin resistance. The importance of cell membrane lipids as essential regulators of insulin resistance, since changes in the dynamic properties of the cell membrane (e.g., membrane fluidity), could be one of the events by which obesity affects insulin sensitivity. Thus, the insulin resistance may not only be a cause but also a consequence of lipid disorders such as dyslipidemia and/or cell membrane phospholipid composition change. The modification of plasma membrane lipid composition can change membrane biophysical properties and thus influencing protein-lipid interactions, enzymatic activity and regulation of surface receptors. Alterations in the lipid composition modify the fluidity of plasma membranes and the expression of membrane functions, such as receptor binding and enzyme activities. This review summarizes the current knowledge on the effects of the modulation of plasma membrane lipid composition and membrane fluidity in the functionality of membrane proteins involved in insulin activity, including the insulin receptor, glucose transport and Na+/K+ ATPase and, in turn, the key features of the metabolic syndrome. Material and methods. References for that article were found through PubMed and Google Scholar, using terms: “obesity”, “insulin resistance” and “membrane properties”. The research was limited to abstracts and available full-text articles. Analysis of the literature. There is a strong relationship between dietary lipids, membrane lipid profiles and insulin resistance. The changes in the dynamic properties of the cell membrane (e.g., membrane fluidity), could be one of the events by which obesity affects insulin sensitivity. The modification of plasma membrane lipid composition can change membrane biophysical properties and thus influencing protein–lipid interactions, enzymatic activity, and regulation of surface receptors. Modifications of membrane phospholipid composition could have a role in the insulin action by altering membrane fluidity and, as a consequence, the insulin signaling pathway. Conclusion. As conclusion the membrane-lipid therapy approach can be used to treat important pathologies such as obesity and many others diseases such as : cancer, cardiovascular pathologies, neurodegenerative processes, obesity, metabolic disorders, inflammation, and infectious and autoimmune diseases. This pharmacological strategy aims to regulate cell functions by influencing lipid organization and membrane fluidity, inducing a concomitant modulation of membrane protein localization and activity which might serve to reverse the pathological state. Through this review we suggest an in-depth analysis of the membrane lipid therapy field, especially its molecular bases and its relevance to the development of innovative therapeutic approaches.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2023, 2; 357-364
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Myocardial remodeling in rats with metabolic syndrome: role of Rho-kinase mediated insulin resistance
    Autorzy:
    Li, Chuan-Bao
    Li, Xiao-Xing
    Chen, Yu-Guo
    Gao, Hai-Qing
    Bao, Cheng-Mei
    Liu, Xiang-Qun
    Bu, Pei-Li
    Zhang, Juan
    Zhang, Yun
    Ji, Xiao-Ping
    Powiązania:
    https://bibliotekanauki.pl/articles/1039743.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Rat
    Metabolism
    Myocardium
    Phosphorylation
    Insulin resistance
    Opis:
    Insulin resistance (IR) plays a critical role in metabolic syndrome (MS). Previous studies have demonstrated that activated ROCK is increased in MS patients. However, the effect of Rho-kinase (ROCK) on IR has not been definitely determined. Thus, the aims of the present study were to determine whether ROCK activation induces IR or affects myocardial structure and function, as well as the possible mechanisms underlying this process. Wistar rats fed high fat, high glucose and high salt diet sewed as model of MS and we used transmission electron microscopy, echocardiogram technology, and terminal deoxynucleotidyl transferase-mediated DNA nick-end labeling staining to identify any myocardial damage. The protein levels of MYPT-1 (characteristic of ROCK activation), IRS-1 and AKT were analyzed by immunohistochemistry and Western blotting. In hearts from MS rats, we found increased protein levels of phospho-MYPT-1 and phospho-IRS-1 (Ser307) and decreased phospho-AKT compared to levels in normal rats. In conclusion, the results suggest that ROCK-mediated IR is involved in the development of myocardial impairments in MS rats and that this effect is mediated probably via the IRS-1/PI3-kinase/AKT pathway.
    Źródło:
    Acta Biochimica Polonica; 2012, 59, 2; 249-254
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Cardiovascular system diseases in patients with polycystic ovary syndrome - the role of inflammation process in this pathology and possibility of early diagnosis and prevention
    Autorzy:
    Marciniak, Aleksandra
    Nawrocka-Rutkowska, Jolanta
    Brodowska, Agnieszka
    Wiśniewska, Berenika
    Starczewski, Andrzej
    Powiązania:
    https://bibliotekanauki.pl/articles/989746.pdf
    Data publikacji:
    2016
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    pcos
    cvd
    insulin resistance
    obesity
    inflammation
    Opis:
    Polycystic ovary syndrome is a disorder which affects 5–10% of women in reproductive age. PCOS is a cause of hyperandrogenism, menstrual disorders and infertility. The most common clinical symptoms are hirsutism, acne and obesity. Patients often suffer from metabolic disorders: insulin resistance, hyperinsulinemia, dislipidemia, leading to atherosclerosis and others irregularities of the metabolic syndrome. Patients are in the high risk group for cardiovascular diseases (CVD) development because of the metabolic abnormalities. Obesity is observed in 35–60% of women with PCOS. Lean women with PCOS are also exposed to a greater risk of glucose intolerance development and abnormalities in lipid profile than women without PCOS with comparable BMI. Adipocytes are the source of many compounds of the paracrine and endocrine activity. Some of them are also markers and mediators of inflammation. Increased levels of proinflammatory cytokines in blood can promote atherosclerosis and cardiovascular disease. Markers: IL-18, TNF, IL-6 and hs-CRP are often elevated in patients with polycystic ovary syndrome. An increase in inflammatory markers may be an early indicator of the risk of developing insulin resistance and atherosclerosis, and may become a useful prognostic and therapeutic tool for monitoring patients with PCOS: lean and those with overweight and obesity. Assessment of the concentrations of inflammatory markers may become a very useful test in evaluating the risk of developing atherosclerosis and cardiovascular disease, long before their clinical manifestation. It will also allow for the appropriate prophylaxis.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2016, 23, 4
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Obesity-diabetes-endocrinopathy – the metabolic connection
    Autorzy:
    Kozakowski, Jarosław
    Dudek, Piotr
    Zgliczyński, Wojciech
    Powiązania:
    https://bibliotekanauki.pl/articles/2216797.pdf
    Data publikacji:
    2022-12-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    diabetes
    endocrinopathy
    hypogonadism
    insulin resistance
    obesity
    Opis:
    Introduction and aim. The article outlines the mechanisms of interrelationships between obesity, type 2 diabetes, and certain disorders of the endocrine system. The paper explains how insulin resistance develops, which is a key link between obesity and several related disorders, how hypercortisolemia leads to the development of obesity and glucose intolerance, why thyroid dysfunctions are bidirectionally associated with metabolic disturbances, in what way excessive body weight leads to the hypogonadism in men, or how menopause promotes the development of abdominal obesity, carbohydrate intolerance and, in some cases type 2 diabetes. Material and methods. Scientific articles were reviewed by searching for information using the online database with scientific articles, including PubMed, Google Scholar and other available scientific databases. Analysis of the literature. The huge prevalence of obesity, diabetes, and hormonal disorders (e.g., autoimmune thyroid disease, female and male hypogonadism) over the contemporary world together with the serious health consequences of these conditions makes up a specific triangle of metabolic connections, increasingly absorbing the human, organizational and financial resources of health systems. Conclusion. Recognizing the relationship between the components of this triangle and understanding the risks arising from this phenomenon may allow to effectively reduce its impact on our health.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2022, 4; 459-469
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Raised plasma insulin level and homeostasis model assessment (HOMA) score in cerebral malaria: evidence for insulin resistance and marker of virulence
    Autorzy:
    Eltahir, Elrashid
    ElGhazali, Gehad
    A-Elgadir, Thoraya
    A-Elbasit, Ishraga
    Elbashir, Mustafa
    Giha, Hayder
    Powiązania:
    https://bibliotekanauki.pl/articles/1040314.pdf
    Data publikacji:
    2010
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    insulin resistance
    virulence
    hyperglycaemia
    HOMA
    cerebral malaria
    Opis:
    Objective: To study the glycaemic profile of patients with severe malaria (SM). Methods: For this purpose, 110 SM patients were recruited. Pre-treatment random blood glucose and plasma insulin were measured in a subset of donors. An ex-vivo experiment was developed for estimation of glucose consumption by parasitized erythrocytes. Results: Hyperglycaemia was frequent in SM but more commonly associated with cerebral malaria (CM), while hyperinsulinaemia was recognized in severe-malarial-hypotension (median, 25 %-75 %, 188.2, 93.8-336.8 pmol/L). The plasma insulin level was positively correlated with age (CC = 0.457, p < 0.001) and negatively with parasitaemia (CC = -0.368, p = 0.045). Importantly, fatal-CM was associated with hyperglycaemia (12.22, 6.5-14.6 mmol/L), hyperinsulinaemia (141.0, 54.0-186.8 pmol/L) and elevated homeostasis model assessment (HOMA) values. However, there was a trend of higher glucose consumption by parasites in CM compared with that in uncomplicated malaria (UM). Conclusion: Hyperglycaemia, hyperinsulinaemia and elevated HOMA are evidence for insulin resistance and possibly pancreatic B-cell dysfunction in fatal-CM.
    Źródło:
    Acta Biochimica Polonica; 2010, 57, 4; 513-520
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Preparation of patients submitted to thyroidectomy with oral glucose solutions
    Autorzy:
    Lubiszewski, Michał
    Drozda, Rafał
    Śmigielski, Janusz
    Kuzdak, Krzysztof
    Kołomecki, Krzysztof
    Powiązania:
    https://bibliotekanauki.pl/articles/1394599.pdf
    Data publikacji:
    2012
    Wydawca:
    Index Copernicus International
    Tematy:
    postoperative insulin-resistance
    thyroidectomy
    response to injury
    Opis:
    The aim of the study was to determine postoperative insulin-resistance in patients subject to total thyroidectomy, the prevalence of subjective feelings of hunger immediately before surgery, and the incidence of nausea/ vomiting after surgery in patients prepared for elective operations by means of oral glucose solutions. Material and methods. The study group comprised 115 patients, including 71 patients prepared for surgery by means of oral glucose solutions (12.5% glucose) administered 12 and 3 hours before the procedure, at a dose of 800 and 400 ml. The control group comprised 44 patients prepared for surgery by means of the traditional manner- the last meal was served before 2pm the day before the surgical procedure, while fluids before 10pm. Considering both groups, we evaluated glucose and insulin levels three times, as well as determined the insulin-resistance ratio (HOMA-IR) 24 before, and 12 hours and 7 days after surgery. The incidence of nausea and vomiting after surgery, and the subjective feeling of hunger before surgery were also evaluated. Results. Statistically significant differences considering insulin level and HOMA-IR values were observed during the II and III measurements. The glucose and insulin values, and the HOMA-IR insulinresistance ratio, showed no statistically significant differences during measurement I. No statistically significant glucose level differences were observed during measurements II and III. A significantly greater subjective feeling of hunger before surgery and nausea/vomiting afterwards were observed in the control group. Conclusions. The preparation of patients with oral glucose solutions decreases the incidence of postoperative (thyroidectomy) insulin-resistance, and occurrence of nausea/vomiting during the postoperative period.
    Źródło:
    Polish Journal of Surgery; 2012, 84, 5; 253-257
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Liver mitochondria and insulin resistance
    Autorzy:
    Vial, Guillaume
    Dubouchaud, Hervé
    Leverve, Xavier
    Powiązania:
    https://bibliotekanauki.pl/articles/1040285.pdf
    Data publikacji:
    2010
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    oxidative phosphorylation
    insulin resistance
    mitochondria
    membrane potential
    Opis:
    With a steadily increasing prevalence, insulin resistance (IR) is a major public health issue. This syndrome is defined as a set of metabolic dysfunctions associated with, or contributing to, a range of serious health problems. These disorders include type 2 diabetes, metabolic syndrome, obesity, and non-alcoholic steatohepatitis (NASH). According to the literature in the field, several cell types like β-cell, myocyte, hepatocyte and/or adipocyte, as well as related complex signaling environment involved in peripheral insulin sensitivity are believed to be central in this pathology. Because of the central role of the liver in the whole-body energy homeostasis, liver insulin sensitivity and its potential relationship with mitochondrial oxidative phosphorylation appear to be crucial. The following short review highlights how liver mitochondria could be implicated in IR and should therefore be considered as a specific therapeutic target in the future.
    Źródło:
    Acta Biochimica Polonica; 2010, 57, 4; 389-392
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    AS-30D hepatoma as a model to study on insulin resistance in vitro
    Autorzy:
    Wierzbicka-Bregier, Katarzyna
    Brutkowski, Wojciech
    Borkowska, Anna
    Milewski, Krzysztof
    Zabłocki, Krzysztof
    Powiązania:
    https://bibliotekanauki.pl/articles/1039458.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    AS-30D hepatoma
    insulin resistance
    palmitate
    rosiglitazone
    Opis:
    Studies on insulin resistance of liver cells are often performed with the use of various hepatoma cell lines. Such an approach allows investigating selected biochemical pathways at the cellular level. However, possible modifications of metabolic processes due to the neoplastic nature of such cells must be considered. Expanding the diversity of hepatoma cell lines used in metabolic studies could deliver new data for comparison with those obtained for other cell lines and should reduce the risk of misleading conclusions. In this study rat hepatoma AS-30D cells were tested as a potential model for studies on palmitate-induced insulin resistance. It was found that insulin-induced Akt kinase phosphorylation was substantially reduced in cells incubated with palmitate at a concentration as low as 75 µM. This effect was not accompanied by excessive reactive oxygen species (ROS) generation or increased Jun N-terminal kinase (JNK) phosphorylation. Moreover, preincubation of AS-30D cells with rosiglitazone, an antidiabetic agonist of peroxisome proliferator-activated receptor gamma (PPARγ), efficiently prevented the palmitate-induced insulin resistance. We conclude that AS-30D hepatoma cells may be used as a model sensitive to insulin and vulnerable to palmitate-induced insulin resistance.
    Źródło:
    Acta Biochimica Polonica; 2013, 60, 4; 635-640
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Combined effects of caffeine and aerobic exercise on leptin levels and some indices of insulin resistance in diabetics
    Autorzy:
    Amaghani, Akram
    Jamali Gharakhanlou, Bahram
    Zarghami Khamneh, Ali
    Radkhah, Nima
    Powiązania:
    https://bibliotekanauki.pl/articles/28761958.pdf
    Data publikacji:
    2023
    Wydawca:
    Uniwersytet Szczeciński. Wydawnictwo Naukowe Uniwersytetu Szczecińskiego
    Tematy:
    caffeine
    aerobic exercise
    type 2 diabetes
    leptin
    insulin resistance
    Opis:
    The study aimed to examine the combined effects of caffeine and aerobic exercise on leptin levels and some indices of insulin resistance in diabetics Thirty-two males with type 2 diabetes participated in a quasi-experimental and double-blind design. All participants were divided into four homogeneous groups of 8 individuals, including placebo (P), caffeine supplementation (C), aerobic training (AT), and aerobic training and caffeine (AT + C). The design protocol included eight weeks of aerobic exercise and caffeine consumption. Blood samples were taken to measure serum levels of leptin, glucose, insulin, HbA1c, HOMA-IR, and insulin sensitivity (QUICKI) indices at two phases. Data were analyzed by repeated measure ANOVA, Bonferroni posthoc, and independent T-test at a significant level of a ≤ 0.05. The results showed that the levels of leptin, glucose, insulin, HbA1c, and HOMA-IR in the three intervention groups significantly decreased compared to the placebo group (P = 0.001). In addition, QUICKI was significantly increased in the three groups of caffeine (C), aerobic training (AT), and aerobic training + caffeine (AT + C) compared to the placebo group (P = 0.001). Also, the AT+C group has double effects on the investigated indices compared to the caffeine (C) group (P = 0.001). Regular aerobic exercise and caffeine supplementation may be more effective treatments for improving insulin resistance indicators associated with type 2 diabetes.
    Źródło:
    Central European Journal of Sport Sciences and Medicine; 2023, 44; 15-26
    2300-9705
    2353-2807
    Pojawia się w:
    Central European Journal of Sport Sciences and Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Serum concentration of visfatin is decreased in patients with chronic heart failure
    Autorzy:
    Straburzyńska-Migaj, Ewa
    Pilaczyńska-Szcześniak, Łucja
    Nowak, Alicja
    Straburzyńska-Lupa, Anna
    Śliwicka, Ewa
    Grajek, Stefan
    Powiązania:
    https://bibliotekanauki.pl/articles/1039706.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    insulin resistance
    C-reactive protein
    heart failure
    lipoproteins
    visfatin
    Opis:
    Background. There is an increasing interest in the role of adipocytokines in cardiovascular pathophysiology. Aim. The aim of the study was to compare visfatin levels, a novel adipokine, in patients with heart failure (HF) due to the left ventricular systolic dysfunction with those in age- and body mass index (BMI) - matched healthy controls in relation to the parameters of glucose metabolism and high sensitivity C-reactive protein (hsCRP) levels. Material/Subjects and Methods. The study population consisted of 28 males with systolic HF referred for cardiopulmonary exercise testing, divided into two subgroups based on their NYHA class (HF patients NYHAI+II, n=17, and HF patients NYHAIII+IV, n=11), and 23 controls. The following indices were measured in a serum samples: visfatin, hsCRP, glucose and lipid metabolism parameters, and the insulin resistance index HOMAIR (homeostasis model assessment insulin resistance) was calculated. Results. Concentrations of visfatin and high-density lipoprotein cholesterol (HDL-cholesterol) in the HF subjects were significantly lower (p≤0.01) than in controls. The Kruskal-Wallis test showed significant differences between three groups (controls and both subgroups of heart failure patients) in mean levels of visfatin, hsCRP, glucose, HOMAIR and HDL-cholesterol. Conclusion. Serum visfatin concentrations in patients with systolic HF, particularly with more advanced NYHA classes, are significantly lower in comparison to healthy controls and are independent of age or anthropometric and metabolic parameters.
    Źródło:
    Acta Biochimica Polonica; 2012, 59, 3; 339-343
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Hepatocyte nuclear factor 4 alpha P2 promoter variants associate with insulin resistance
    Autorzy:
    Saif-Ali, Riyadh
    Harun, Roslan
    Al-Jassabi, S.
    Wan Ngah, Wan
    Powiązania:
    https://bibliotekanauki.pl/articles/1039910.pdf
    Data publikacji:
    2011
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    insulin resistance
    HNF4 alpha
    single nucleotide polymorphisms
    haplotypes
    Opis:
    This study aimed to investigate the associations of hepatocyte nuclear factor 4 (HNF4) alpha single nucleotide polymorphisms (SNPs) and haplotype with insulin resistance and metabolic syndrome parameters. Nine SNPs spanning the HNF4 alpha P2 promoter (rs4810424, rs1884613 and rs1884614) and coding region (rs2144908, rs6031551, rs6031552, rs1885088, rs1028583 and rs3818247) were genotyped in 160 subjects without diabetes or metabolic syndrome. The HNF4 alpha P2 promoter SNPs rs4810424, rs1884613 and rs1884614 were associated with insulin resistance (p = 0.017; 0.037; 0.024) and body mass index (BMI) (p = 0.03; 0.035; 0.039). The intron 1D SNP rs2144908 was associated with high-density lipoprotein cholesterol (HDLc) (p = 0.020) and the intron 9 SNP rs3818247 showed association with systolic (p = 0.02) and diastolic (p = 0.034) blood pressure. HNF4 alpha common haplotype CCCGTC associated with higher insulin resistance (p = 0.022), fasting blood glucose (FBG) (p = 0.035) and lower HDLc (p = 0.001). In conclusion, subjects with HNF4 alpha P2 variants and haplotypes have been shown to have a higher insulin resistance and are therefore at a higher risk for developing type 2 diabetes mellitus.
    Źródło:
    Acta Biochimica Polonica; 2011, 58, 2; 179-186
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Randomized Clinical Trial to Compare the Effects of Preoperative Oral Carbohydrate Loading versus Placebo on Insulin Resistance and Cortisol Level after Laparoscopic Cholecystectomy
    Autorzy:
    Pędziwiatr, Michał
    Pisarska, Magdalena
    Matłok, Maciej
    Major, Piotr
    Kisielewski, Michał
    Wierdak, Mateusz
    Natkaniec, Michał
    Budzyński, Piotr
    Rubinkiewicz, Mateusz
    Budzyński, Andrzej
    Powiązania:
    https://bibliotekanauki.pl/articles/1394369.pdf
    Data publikacji:
    2015
    Wydawca:
    Index Copernicus International
    Tematy:
    laparoscopic cholecystectomy
    insulin resistance
    preoperative carbohydrate loading
    perioperative care
    Opis:
    Postoperative insulin resistance, used as a marker of stress response, is clearly an adverse event. It may induce postoperative hyperglycemia, which according to some authors can increase the risk of postoperative complications. One of the elements of modern perioperative care is preoperative administration of oral carbohydrate loading (CHO-loading), which shortens preoperative fasting and reduces insulin resistance. The aim of the study is to establish the influence of CHO-loading on the level of insulin resistance and cortisol in patients undergoing elective laparoscopic cholecystectomy. Material and methods. Patients were randomly allocated to one of 2 groups. The intervention group included 20 patients who received CHO-loading (400 ml Nutricia pre-op®) 2 hours prior surgery. The control group received a placebo (clear water). In every patient blood samples were taken 2 hours prior to surgery, immediately after surgery, and on the 1st postoperative day. Levels and changes in glucose, cortisol and insulin resistance were analyzed in both groups. Results. Although there were differences in the levels of cortisol, insulin, and insulin resistance, no statistically significant differences were observed between groups in every measurement. The length of stay and postoperative complications were comparable in both groups. Conclusions. We believe that CHO-loading is not clinically justified in case of laparoscopic cholecystectomy. No effect on the levels of glucose, insulin resistance and cortisol was observed. Even though such procedure is safe, in our opinion there is no clinical benefit from CHO-loading prior to laparoscopic cholecystectomy.
    Źródło:
    Polish Journal of Surgery; 2015, 87, 8; 402-408
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Comparison of triglyceride-glucose index and HOMA-IR as indicators of insulin resistance in obese women with subclinical hypothyroidism
    Autorzy:
    Onur Kirac, Cem
    Sirikci, Vehbi
    Avni Findikli, Huseyin
    Powiązania:
    https://bibliotekanauki.pl/articles/2216805.pdf
    Data publikacji:
    2022-12-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    HOMA-IR
    insulin resistance
    subclinical hypothyroidism
    triglyceride-glucose index
    Opis:
    Introduction and aim. Thyroid hormones play an important role in glucose metabolism as in many metabolic events. The aim of our study is to evaluate the relationship between subclinical hypothyroidism (SCH) and insulin resistance, especially in obese women. Material and methods. Newly diagnosed SCH patients with body mass index (BMI) ≥30 who applied to our outpatient clinic between March 2021 and October 2021, and euthyroid obese women who applied for routine control were included in the study. In this study, we used homeostasis model assessment of insulin resistance (HOMA-IR) and triglyceride glucose (TyG) indexes, which are noninvasive, simple and useful methods for evaluating insulin sensitivity. Results. The study included 78 female patients between the ages of 19 and 64. A correlational analysis was performed between thyroid stimulating hormone (TSH) and HOMA-IR, TyG, and BMI. The results showed that TSH levels were positively correlated with HOMA-IR (R=0.297, p=0.008), TyG (R=0.316, p=0.005) and BMI (R=0.307, p=0.006). This relationship was stronger for TyG compared to the other variables. As another finding, BMI was positively correlated with HOMA-IR (R=0.359, p=0.001) and TyG (R=0.404, p<0.001). This relationship was stronger for TyG than HOMA-IR. Conclusion. These results show that patients with SCH are at risk of developing diseases that accompany insulin resistance, such as metabolic syndrome and cardiovascular disorders. The most important finding of our study is that the TyG index gives more significant results than HOMA-IR, especially in obese women.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2022, 4; 412-416
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effects of exposure to electromagnetic field radiation (EMFR) generated by activated mobile phones on fasting blood glucose
    Autorzy:
    Meo, Sultan A.
    Al Rubeaan, Khalid
    Powiązania:
    https://bibliotekanauki.pl/articles/2179776.pdf
    Data publikacji:
    2013-04-01
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    mobile phone radiation
    hyperglycemia
    insulin resistance
    β-cell function
    Opis:
    Objective: Extensive use of mobile phones has been accompanied by a common public debate about possible adverse effects on human health. No study has been published so far to establish any association between the fastest growing innovation of mobile phone and fasting blood glucose. The aim was to determine the effects of exposure to electromagnetic field radiation generated by mobile phones on fasting blood glucose in Wistar Albino rats. Materials and Methods: 40 Male Albino rats (Wistar Strain) were divided into 5 equally numerous groups. Group A served as the control one, group B received mobile phone radiation for less than 15 min/day, group C: 15-30 min/day, group D: 31-45 min/day, and group E: 46-60 min/day for a total period of 3 months. Fasting blood glucose was determined by using Spectrophotometer and serum insulin by Enzyme-linked Immunosorbent Assay (ELISA). The Homeostatic Model (HOMA-B) was applied for the assessment of β-cell function and (HOMA-IR) for resistance to insulin. Results: Wister Albino rats exposed to mobile phone radiation for longer than 15 min a day for a total period of 3 months had significantly higher fasting blood glucose (p < 0.015) and serum insulin (p < 0.01) compared to the control group. HOMA-IR for insulin resistance was significantly increased (p < 0.003) in the groups that were exposed for 15-30 and 46-60 min/day compared to the control rats. Conclusion: The results of the present study show an association between long-term exposure to activated mobile phones and increase in fasting blood glucose and serum insulin in Albino rats.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2013, 26, 2; 235-241
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The relationship between working schedule patterns and the markers of the metabolic syndrome: Comparison of shift workers with day workers
    Autorzy:
    Mohebbi, Iraj
    Shateri, Kamran
    Seyedmohammadzad, Mirhosein
    Powiązania:
    https://bibliotekanauki.pl/articles/2180014.pdf
    Data publikacji:
    2012-09-01
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    shift work
    insulin resistance
    metabolic syndrome
    abdominal obesity
    circadian clock
    Opis:
    Objectives: This study examined the effect of shift work on developing the metabolic syndrome by comparing groups of exposed and unexposed Iranian drivers. Methods: We considered as night-shift drivers those drivers whose shifts included at least 15 h per week between 9:00 p.m. and 7:00 a.m. Daytime drivers were defi ned as drivers working regularly without shift work. 3039 shift work drivers were selected. These were matched with non-shift workers. The differences in baseline characteristics and the prevalence of the components of the metabolic syndrome were assessed with Student's t test, and chi-square tests. Results: We found central adiposity in 52.0% of the shift workers versus 42.6% of the day workers (p < 0.0001). The hypertension component was not signifi cantly related to shift work (p > 0.05); but there were signifi cant differences as regards other components of the metabolic syndrome (p < 0.0001). Among the shift workers, the odds ratios of the increased FBS, low HDL-C, higher TG levels, as well as higher waist circumference were 1.992 (95% CI: 1.697-2.337), 1.973 (95% CI: 1.759-2.213), 1.692 (95% CI: 1.527-1.874), and 1.460 (95% CI: 1.320-1.616), respectively. The metabolic syndrome was more common among the shift workers (OR = 1.495; 95% CI: 1.349-1.657). Conclusion: In evaluating such results, further consideration is needed to fi nd pathophysiological clarifi cation; in turn, stress linked to shift work must be considered to likely have had a relevant infl uence on the outcome. In our opinion, shift work acts as an occupational factor for the metabolic syndrome.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2012, 25, 4; 383-391
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Estimation of reference intervals of insulin resistance (HOMA), insulin sensitivity (Matsuda), and insulin secretion sensitivity indices (ISSI-2) in Polish young people
    Autorzy:
    Płaczkowska, S.
    Pawlik-Sobecka, L.
    Kokot, I.
    Piwowar, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/2085608.pdf
    Data publikacji:
    2020
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    insulin resistance
    young adult
    Oral Glucose Tolerance Test
    Reference Interval
    Opis:
    Introduction. Insulin resistance is becoming an increasingly widespread problem worldwide. For its determination indirect indices of insulin resistance or insulin sensitivity have used. Those indices based on simultaneous measurements of blood glucose and insulin concentrations under fasting conditions or during the Oral Glucose Tolerance Test. Objective. The aim of the study was to estimate reliable reference values for the indices used in insulin resistance diagnosis. Materials and method. 191 selected participants, aged 18–31, were enrolled into the reference population. 130 participants from the reference population with fasting glucose ≤5.5 mmol/L, BMI<25 kg/m2, and without metabolic syndrome, were finally included in the reference group. The following insulin resistance indices were calculated: HOMA1-IR, HOMA2, HOMA2 from C-peptide, QUICKI, Matsuda Index and Insulin Secretion-Sensitive Index-2. Determination of reference intervals for indirect indices of insulin resistance was conducted in accordance with the C28-A3 procedure recommended by the Clinical & Laboratory Standards Institute (CLSI). Results. The reference intervals for indirect insulin resistance indices examined according to CLSI protocol were: ≤4.00, ≤2.27, ≤4.10, ≥0.31 for HOMA1-IR, HOMA2, HOMA2 C-pep., and QUICKI, respectively. For insulin sensitivity, the value of the Matsuda Index was established as ≥3.19 and for beta cell pancreatic function ISSI-2 as ≥206. Conclusions. Establishing a reference intervals for these indices enable the proper identification and differentiation of the types of insulin resistance in particular populations. The early detection of metabolic disorders allows for introduction of effective preventive action.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2020, 27, 2; 248-254
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Polimorfizm genu syntetazy acylo-CoA typu 5 (ACSL5) a występowanie nieprawidłowej masy ciała w korelacji do obwodupasa wraz ze wskaźnikiem insulinooporności wśród populacji zamieszkującej region Polski Południowej
    Acyl-CoA type 5 gene polymorphism and inappropriate body mass occurrence related to waist circumference and insulin resistance index among the population living in southern Poland
    Autorzy:
    Zdebska, Magdalena
    Szywacz, Wioletta
    Matuszny, Grzegorz
    Abouda, Alicja
    Szweda, Nikola
    Gola, Mateusz
    Śnit, Mirosław
    Grzeszczak, Władysław
    Powiązania:
    https://bibliotekanauki.pl/articles/1035763.pdf
    Data publikacji:
    2018
    Wydawca:
    Śląski Uniwersytet Medyczny w Katowicach
    Tematy:
    acsl5
    bmi
    kwasy tłuszczowe
    insulinooporność
    fatty acids
    insulin resistance
    Opis:
    INTRODUCTION: Lipid metabolism disorders and the obesity connected with them are problems which occur increasingly more frequently in highly-developed countries. Acyl-CoA synthetase (ACSL) is an important enzyme in lipid metabolism taking part in the activation of fatty acids (FA). This makes determining the correlation between the gene polymorphism for ACSL and the development of obesity a relevant research issue. AIMS: The aim of this study was to examine the dependence of the Acyl-CoA synthetase gene polymorphism on the occurrence of inappropriate body weight and HOMA-IR indicator values. MATERIAL AND METHODS: A total of 506 patients were examined, whose ACSL5 rs2419621 polymorphism was determined using probes binding with a specific DNA matrix. RESULTS: The results of the Hardy-Weinberg equilibrium test showed that the genotype proportions within the population are maintained. Among the patients from the research sample, 177 patients with a proper body weight were identified along with 330 patients with inappropriate Body Mass Index (BMI) values. CONCLUSIONS: It was determined that there are no differences between the statistical variables in the distribution of acyl-CoA of isoform 5 synthetase gene polymorphism genotypes. Based on the results of the study, a correlation between the gene polymorphism for ACSL5 and the development of obesity cannot be determined.
    WSTĘP: Zaburzenia przemian lipidów i związana z nimi otyłość to problem coraz częściej dotykający ludzi w krajach wysoko rozwiniętych. Syntetaza acylo-CoA typu 5 (ACSL5) jest ważnym enzymem metabolizmu lipidów, biorącym udział w aktywacji kwasów tłuszczowych. Prawidłowe funkcjonowanie tego enzymu zapewnia substraty zarówno dla lipogenezy, jak i oksydacji kwasów tłuszczowych, stąd określenie związku między polimorfizmem genu dla ACSL a kształtowaniem otyłości stanowi istotny problem badawczy. CEL PRACY: Celem pracy było wykazanie zależności między nieprawidłową masą ciała oraz wartością wskaźnika HOMA-IR (homeostasis model assessment) a występowaniem polimorfizmu genu syntetazy acylo-CoA izoformy 5. MATERIAŁ I METODY: Przebadano łącznie 506 pacjentów, u których za pomocą sond specyficznie wiążących się z DNA matrycy oznaczono polimorfizm ACSL5 rs2419621. WYNIKI: Za pomocą testu statystycznego Hardy’ego-Weinberga wykazano, że proporcje genotypów w populacji są zachowane. Wśród pacjentów stanowiących próbę badawczą wyróżniono 177 osób o prawidłowej masie ciała oraz 330 osób z nieprawidłową wartością indeksu BMI. WNIOSKI: Wykazano brak zmiennych różnic statystycznych w rozkładzie genotypów polimorfizmu genu syntetazy acylo-CoA izoformy 5. Wyniki przeprowadzonego badania nie pozwalają wykazać zależności między polimorfizmem genu dla ACSL5 a kształtowaniem otyłości.
    Źródło:
    Annales Academiae Medicae Silesiensis; 2018, 72; 121-127
    1734-025X
    Pojawia się w:
    Annales Academiae Medicae Silesiensis
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The effect of calorie restriction on the anthropometric parameters, HOMA-IR index, and lipid profile of female office workers with overweight and obesity: a preliminary study
    Autorzy:
    Sadowska-Krępa, Ewa
    Gdańska, Agnieszka
    Přidalová, Miroslava
    Rozpara, Michał
    Grabara, Małgorzata
    Powiązania:
    https://bibliotekanauki.pl/articles/2152975.pdf
    Data publikacji:
    2022
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    insulin resistance
    lipid profile
    reduction diet
    snacking
    coronavirus pandemic
    low physical activity level
    Opis:
    Objectives This study evaluates the effect of a 3-month calorie restriction (CR) without snacking on the anthropometric parameters, Homeostatic Model Assesment of Insulin Resistance (HOMA-IR), and lipid profiles of female office workers with overweight or obesity, whose physical activity was limited during the COVID-19 pandemic lockdown. Material and Methods Forty-eight women aged 20–38 years (28.9±5.24) with low physical activity levels were divided into a non-snacking (NS) group (N = 21) and a snacking (S) group (N = 27) prior to the dietary intervention. Their daily energy intake during the intervention was lowered by 30% compared with the baseline level, and the proportion of polyunsaturated fatty acids and fiber in their diet was increased (to >30 g/day). The proportion of saturated fatty acids and simple carbohydrates was also reduced. The study participants were assessed at the baseline and post-intervention for anthropometric variables (body weight, body fat percentage BMI, waist circumference, hip circumference, waist-to-hip ratio) and the concentrations of insulin, total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). Moreover, the values for HOMA-IR, the atherogenic index of plasma (AIP), and the ratios of TC/HDL-C, TG/HDL-C, and LDL-C/HDL-C were calculated. Results All anthropometric parameter values obtained post-intervention were lower than the baseline in both groups. The serum insulin concentration and HOMA-IR decreased respectively by an average of 6% and 25% in the NS group and 37% and 45% in the S group. The lipid profiles of all participants improved significantly, with the LDL-C concentration showing a more promising trend in the S group (decrease by 27%) than in the NS group (17%). Conclusions The study showed that CR improved the anthropometric parameters, HOMA-IR index, and lipid profiles of all participants.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2022, 35, 6; 693-706
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Rodzinna ogniskowa lipodystrofia
    Familial partial lipodystrophy
    Autorzy:
    Madej-Pilarczyk, Agnieszka
    Powiązania:
    https://bibliotekanauki.pl/articles/1061206.pdf
    Data publikacji:
    2006
    Wydawca:
    Medical Communications
    Tematy:
    LMNA
    insulin resistance
    lamin A/C
    laminopathy
    lipodystrophy
    laminopatia
    lipodystrofia
    insulinooporność
    lamina A/C
    Opis:
    Familial partial lipodystrophy (Dunnigan type) belongs to group of laminopathies. The main features of the disease include loss of subcutaneous adipose tissue from limbs and trunk, sparring the face and neck, associated with insulin resistant diabetes mellitus and dyslipidemia. Metabolic syndrome is responsible for atherosclerosis which predisposes to coronary heart disease in young people. Hormonal disorders, i.e. polycystic ovarian syndrome and acromegaloid features are found in some patients. Laboratory tests reveal insulin resistance, hyperinsulinemia, hyperglycemia, hypertriglyceridemia and low HDL-cholesterol. Mean FFA level is higher and leptin and adiponectin levels are lower in patients with lipodystrophy type Dunnigan in comparison to healthy people. Women predominance and intrafamilial variability are observed. The disease is characterized by autosomal dominant inheritance. The most frequent mutation is R482W in exon 8, but mutations in exon 11, affecting only lamin A, are also known. Treatment of dyslipidemia and diabetes (diet and pharmacotherapy) are main purposes of therapy.
    Rodzinna ogniskowa lipodystrofia (typu Dunnigana) jest jedną z postaci laminopatii. Charakteryzuje się utratą podskórnej tkanki tłuszczowej na kończynach i tułowiu, z przesunięciem jej na twarz i szyję oraz zaburzeniami metabolicznymi w postaci insulinoopornej cukrzycy i dyslipidemii. Zespół metaboliczny sprzyja rozwojowi miażdżycy, co predysponuje do ujawnienia się choroby wieńcowej w młodym wieku. U niektórych chorych obserwuje się zaburzenia endokrynologiczne pod postacią wielotorbielowatości jajników i cech akromegaloidalnych. W badaniach laboratoryjnych stwierdza się oporność na insulinę, hiperinsulinemię, hiperglikemię, hipertriglicerydemię oraz niskie stężenie cholesterolu HDL. Średnie stężenie wolnych kwasów tłuszczowych jest u chorych na lipodystrofię typu Dunnigana wyższe, zaś stężenie leptyny i adiponektyny niższe niż u osób zdrowych. Na lipodystrofię typu Dunnigana częściej chorują kobiety. Choroba dziedziczy się w sposób autosomalny dominujący. Najczęściej obserwowaną mutacją jest R482W w eksonie 8. genu LMNA, niemniej znane są także mutacje zlokalizowane w eksonie 11., dotyczące wyłącznie laminy A. Obserwuje się dużą wewnątrzrodzinną zmienność fenotypową. Najważniejszym celem w leczeniu lipodystrofii jest terapia zaburzeń lipidowych oraz cukrzycy (dietetyczna i farmakologiczna).
    Źródło:
    Aktualności Neurologiczne; 2006, 6, 1; 32-34
    1641-9227
    2451-0696
    Pojawia się w:
    Aktualności Neurologiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Role of pro-inflammatory cytokines of pancreatic islets and prospects of elaboration of new methods for the diabetes treatment
    Autorzy:
    Cieślak, Marek
    Wojtczak, Andrzej
    Cieślak, Michał
    Powiązania:
    https://bibliotekanauki.pl/articles/1039121.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    interleukin 1β
    interleukin-6
    tumor necrosis factor-α
    pancreatic derived factor
    insulin resistance
    Opis:
    Several relations between cytokines and pathogenesis of diabetes are reviewed. In type 1 and type 2 diabetes an increased synthesis is observed and as well as the release of pro-inflammatory cytokines, which cause the damage of pancreatic islet cells and, in type 2 diabetes, the development of the insulin resistance. That process results in the disturbed balance between pro-inflammatory and protective cytokines. Pro-inflammatory cytokines such as interleukin 1β (IL-1β), tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ), as well as recently discovered pancreatic derived factor PANDER are involved in the apoptosis of pancreatic β-cells. Inside β-cells, cytokines activate different metabolic pathways leading to the cell death. IL-1β activates the mitogen-activated protein kinases (MAPK), affects the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and activates the inducible nitric oxide synthase (iNOS). TNF-α and IFN-γ in a synergic way activate calcium channels, what leads to the mitochondrial dysfunction and activation of caspases. Neutralization of pro-inflammatory cytokines, especially interleukin 1β with the IL-1 receptor antagonist (IL-1Ra) and/or IL-1β antibodies might cause the extinction of the inflammatory process of pancreatic islets, and consequently normalize concentration of glucose in blood and decrease the insulin resistance. In type 1 diabetes interleukin-6 participates in regulation of balance between Th17 and regulatory T cells. In type 2 diabetes and obesity, the long-duration increase of IL-6 concentration in blood above 5 pg/ml leads to the chronic and permanent increase in expression of SOCS3, contributing to the increase in the insulin resistance in cells of the skeletal muscles, liver and adipose tissue.
    Źródło:
    Acta Biochimica Polonica; 2015, 62, 1; 15-21
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    QUERCETIN AMELIORATES INSULIN RESISTANCE CONCOMITANT EARLY CARDIOVASCULAR CHANGES IN EXPERIMENTAL RATS
    Autorzy:
    KUSHWAH, AJAY S.
    GUPTA, GHANSHYAM D.
    Powiązania:
    https://bibliotekanauki.pl/articles/895413.pdf
    Data publikacji:
    2018-08-31
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    insulin resistance
    oxidative stress
    myocardium
    quercetin
    high-fructose diet
    5' Adenosine Monophosphate-activated Protein Kinase
    Opis:
    Quercetin is a dietary flavonoid found in a wide range of fruits and vegetables; it has diverse biological activities, possesses beneficial effects in ameliorating diabetic complications, apart from the effect of quercetin on fructose feed induced insulin resistance (IR) linked cardiac dysfunction have not been entirely revealed. This study aspires to explore the effect of quercetin on metabolism, oxidative stress, cardiomyocytes damage and cardiac function in IR state. Wistar rats either sex weighing 220-250 g (n ꞊8), were divided into four groups, kept on either control diet and high fructose diet and supplement with a quercetin as a test drug and metformin as a standard, at the dose of 50 and 200 mg/ kg; p.o., respectively. Daily measured body weight, feed, and water intake for 35 days, Oral glucose tolerance test (OGTT) performed in animals on the 32nd day. At end of the study (36th day), measured hemodynamic parameters after that estimation of various biochemical parameters. Finally, the animals were sacrificed for isolation of tissues and measured heart weight, the oxidative stress level of heart and histopathological changes. Treatment of quercetin with fructose-fed ameliorated all the parameters revile by the contrast of IR rats. The outcome of quercetin associated improves insulin sensitivity, normalized lipid profile, abolish hemodynamic changes, oxidative stress and cardiac injury markers within fructose-fed, and lesser histopathological changes were observed contrast with IR rats. These beneficial effects of quercetin mediated by improving insulin sensitivity and metabolism; reduced oxidative stress could potentially be used to ameliorate the myocardial damage.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 4; 977-987
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Wykorzystanie produktów prozdrowotnych i suplementów diety w insulinoopornośći®
    The use of pro-healthy products and dietary supplements in insulin resistance®
    Autorzy:
    Kowalska, H.
    Lenart, A.
    Marzec, A.
    Kowalska, J.
    Samborska, K.
    Żebrowska, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/228279.pdf
    Data publikacji:
    2017
    Wydawca:
    Wyższa Szkoła Menedżerska w Warszawie
    Tematy:
    insulino-oporność
    suplementy diety
    produkty o właściwościach prozdrowotnych
    insulin resistance
    dietary supplements
    pro-healthy products
    Opis:
    Przeprowadzono ankietę wśród osób ze zdiagnozowaną insulinoopornością. W badaniach brało udział 60 respondentów. Wykazano, że 90% osób spożywa suplementy diety / produkty o właściwościach prozdrowotnych. Ponadto 62% badanych przyznało, że suplementacja przyniosła korzystne zmiany w ich organizmie, a 20% zauważyło wyraźne zmniejszenie objawów insulinooporności. W przypadku stosowania produktów o właściwościach prozdrowotnych 33% badanych zauważyło korzystne zmiany w organizmie wynikające z ich spożywania, a u 10% osób zmniejszenie insulinooporności. Właściwie skomponowana dieta połączona z aktywnością fizyczną jest najbardziej skuteczna w walce z insulinoopornością i obroną przed wystąpieniem cukrzycy typu 2.
    An internet survey was conducted among people with diagnosed insulin resistance. 60 people participated in the study. The research shows that 90% of people take dietary supplements / pro-healthy products. In addition, 62% of respondents admitted that supplementation had beneficial changes in their body, and 20% noted a marked reduction in insulin resistance. With the use of pro-health products, 33% persons noticed beneficial changes in the body resulting from their consumption and in 10% were reduced insulin resistance. Properly formulated diet combined with physical activity is the most effective against insulin resistance and type 2 diabetes.
    Źródło:
    Postępy Techniki Przetwórstwa Spożywczego; 2017, 2; 46-55
    0867-793X
    2719-3691
    Pojawia się w:
    Postępy Techniki Przetwórstwa Spożywczego
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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